Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T25663 Target Info
Target Name Adenosine receptor (ADOR)
Synonyms
P1 receptor
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Target Type Successful Target
Gene Name NO-GeName
Biochemical Class GPCR rhodopsin
UniProt ID
NOUNIPROTAC
Co-Targets of This Target  Top
Co-Target Name P2Y purinoceptor 2 (P2RY2) Clinical trial Target
UniProt ID P2RY2_HUMAN
Gene Name P2RY2
Synonyms
P2Y2; P2U1; P2U receptor; P2U purinoceptor 1; P2U nucleotide receptor; P2RY2; Adenosine P2Y2 receptor
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Representative Drug(s) DIADENOSINE TETRAPHOSPHATE Drug Info EC50 = 145 nM [1]
Co-Target Name P2X purinoceptor 3 (P2RX3) Clinical trial Target
UniProt ID P2RX3_HUMAN
Gene Name P2RX3
Synonyms
P2X3 receptor; P2X3; P2RX3; ATP-gated ion channel P2X(3)
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Representative Drug(s) DIADENOSINE TETRAPHOSPHATE Drug Info EC50 = 500 nM [2]
Co-Target Name P2X purinoceptor 4 (P2RX4) Clinical trial Target
UniProt ID P2RX4_HUMAN
Gene Name P2RX4
Synonyms
P2X4; P2RX4
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Representative Drug(s) DIADENOSINE TETRAPHOSPHATE Drug Info EC50 = 1000 nM [2]
Co-Target Name P2X purinoceptor 1 (P2RX1) Literature-reported Target
UniProt ID P2RX1_HUMAN
Gene Name P2RX1
Synonyms
Purinergic receptor 1; P2X1
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Representative Drug(s) DIADENOSINE TETRAPHOSPHATE Drug Info EC50 = 182 nM [2]
References  Top
REF 1 Key determinants of nucleotide-activated G protein-coupled P2Y(2) receptor function revealed by chemical and pharmacological experiments, mutagenesis and homology modeling. J Med Chem. 2009 May 14;52(9):2762-75.
REF 2 Purine and pyrimidine (P2) receptors as drug targets. J Med Chem. 2002 Sep 12;45(19):4057-93.

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