Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T23276 | Target Info | |||
| Target Name | Extracellular signal-regulated kinase 1 (ERK1) | ||||
| Synonyms |
PRKM3; P44-MAPK; P44-ERK1; P44 Mitogen-activated protein kinase; Mitogen-activated protein kinase 3; Microtubule-associated protein-2 kinase; Microtubule-associated protein 2 kinase; MAPK 3; MAP kinase isoform p44; MAP kinase 3; Insulin-stimulated MAP2 kinase; ERT2; ERK-1
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| Target Type | Clinical trial Target | ||||
| Gene Name | MAPK3 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Extracellular signal-regulated kinase 2 (ERK2) | Clinical trial Target | ||||
| UniProt ID | MK01_HUMAN | |||||
| Gene Name | MAPK1 | |||||
| Synonyms |
PRKM2; PRKM1; P42-MAPK; P42 Mitogen-activated protein kinase; Mitogen-activated protein kinase 2; Mitogen-activated protein kinase 1; MAPK 2; MAPK 1; MAP kinase isoform p42; MAP kinase 2; MAP kinase 1; ERT1; ERK-2
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| Representative Drug(s) | BVD-523 | Drug Info | IC50 = 0.03 nM | Click to Show More | [1] | |
| 2 | GDC-0994 | Drug Info | IC50 = 0.3 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3788-92. | ||||
| REF 2 | Recent progress on MAP kinase pathway inhibitors. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4047-56. | ||||
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