Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T21312 Target Info
Target Name Immune checkpoint (ICH)
Target Type Clinical trial Target
Gene Name NO-GeName
UniProt ID
NOUNIPROTAC
Co-Targets of This Target  Top
Co-Target Name Indoleamine 2,3-dioxygenase 1 (IDO1) Successful Target
UniProt ID I23O1_HUMAN
Gene Name IDO1
Synonyms
Indoleamine-pyrrole 2,3-dioxygenase; INDO; IDO-1; IDO
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Representative Drug(s) NLG919 Drug Info Ki = 7 nM [1]
Co-Target Name Albendazole monooxygenase (CYP3A4) Clinical trial Target
UniProt ID CP3A4_HUMAN
Gene Name CYP3A4
Synonyms
Taurochenodeoxycholate 6-alpha-hydroxylase; Quinine 3-monooxygenase; P450-PCN1; Nifedipine oxidase; NF-25; HLp; Cytochrome P450-PCN1; Cytochrome P450 NF-25; Cytochrome P450 HLp; Cytochrome P450 3A4; Cytochrome P450 3A3; CYPIIIA4; CYPIIIA3; CYP3A3; Albendazole sulfoxidase; Albendazole monooxygenase (sulfoxide-forming); 1,8-cineole 2-exo-monooxygenase
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Representative Drug(s) NLG919 Drug Info IC50 = 170 nM [2]
Co-Target Name Tryptophan 2,3-dioxygenase (TDO) Patented-recorded Target
UniProt ID T23O_HUMAN
Gene Name TDO2
Synonyms
Tryptophanase; Tryptophan pyrrolase; Tryptophan oxygenase; Tryptamin 2,3-dioxygenase; TRPO; TO
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Representative Drug(s) NLG919 Drug Info IC50 < 1000 nM [3]
References  Top
REF 1 Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry. Medchemcomm. 2017 May 16;8(7):1378-92.
REF 2 Discovery of Clinical Candidate (1 R,4 r)-4-(( R)-2-(( S)-6-Fluoro-5 H-imidazo[5,1- a]isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol (Navoximod), a Potent and Selective Inhibitor of Indoleamine 2,3-Dioxygenase 1. J Med Chem. 2019 Jul 25;62(14):6705-6733.
REF 3 Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway. J Med Chem. 2015 Nov 25;58(22):8762-82.

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