Co-Target(s) Information

Content Navigation (  All   None )                                      
Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T18876 Target Info
Target Name Prostaglandin E2 receptor EP4 (PTGER4)
Synonyms
Prostanoid EP4 receptor; Prostaglandin E2 receptor EP4 subtype; PTGER2; PGE2 receptor EP4 subtype; PGE receptor EP4 subtype
    Click to Show/Hide
Target Type Clinical trial Target
Gene Name PTGER4
Biochemical Class GPCR rhodopsin
UniProt ID
PE2R4_HUMAN
Co-Targets of This Target  Top
Co-Target Name Thromboxane A2 receptor (TBXA2R) Successful Target
UniProt ID TA2R_HUMAN
Gene Name TBXA2R
Synonyms
TXA2-R; TXA2 receptor; Prostanoid TP receptor
    Click to Show/Hide
Representative Drug(s) PGF2alpha Drug Info IC50 ~ 0.001 nM [1]
Co-Target Name Prostaglandin F2-alpha receptor (PTGFR) Successful Target
UniProt ID PF2R_HUMAN
Gene Name PTGFR
Synonyms
Prostanoid FP receptor; PGF2-alpha receptor; PGF2 alpha receptor; PGF receptor; FP prostanoid receptor; FP prostaglandin receptor
    Click to Show/Hide
Representative Drug(s) PGF2alpha Drug Info IC50 = 2.5 nM [2]
Co-Target Name Prostaglandin E2 receptor EP2 (PTGER2) Successful Target
UniProt ID PE2R2_HUMAN
Gene Name PTGER2
Synonyms
Prostanoid EP2 receptor; Prostaglandin E2 receptor EP2 subtype; PGE2 receptor EP2 subtype; PGE receptor, EP2 subtype; PGE receptor EP2 subtype; EP2 receptor
    Click to Show/Hide
Representative Drug(s) ONO-AE1-437 Drug Info EC50 = 610 nM [3]
Co-Target Name Prostaglandin E2 receptor EP3 (PTGER3) Clinical trial Target
UniProt ID PE2R3_HUMAN
Gene Name PTGER3
Synonyms
Prostanoid EP3 receptor; Prostaglandin E2 receptor EP3 subtype; PGE2-R; PGE2 receptor EP3 subtype; PGE receptor, EP3 subtype; PGE receptor EP3 subtype
    Click to Show/Hide
Representative Drug(s) PGF2alpha Drug Info IC50 = 110 nM [1]
Co-Target Name Prostaglandin E2 receptor EP1 (PTGER1) Clinical trial Target
UniProt ID PE2R1_HUMAN
Gene Name PTGER1
Synonyms
Prostanoid EP1 receptor; Prostaglandin E2 receptor EP1 subtype; PGE2 receptor EP1 subtype; PGE receptor, EP1 subtype; PGE receptor EP1 subtype; EP1 receptor
    Click to Show/Hide
Representative Drug(s) PGF2alpha Drug Info IC50 = 220 nM [1]
References  Top
REF 1 Synthesis and biological evaluation of prostaglandin-F alkylphosphinic acid derivatives as bone anabolic agents for the treatment of osteoporosis. J Med Chem. 2001 Nov 22;44(24):4157-69.
REF 2 Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1519-22.
REF 3 Difluoromethylene at the gamma-Lactam alpha-Position Improves 11-Deoxy-8-aza-PGE 1 Series EP 4 Receptor Binding and Activity: 11-Deoxy-10,10-difluoro-8-aza-PGE 1 Analog (KMN-159) as a Potent EP 4 Agonist. J Med Chem. 2019 May 9;62(9):4731-4741.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.