Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T16761 | Target Info | |||
| Target Name | Pneumocystis carinii Dihydropteroate synthase (PC DHPS) | ||||
| Synonyms |
PC DHPS
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| Target Type | Successful Target | ||||
| Gene Name | PC DHPS | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | 5-HT 6 receptor (HTR6) | Clinical trial Target | ||||
| UniProt ID | 5HT6R_HUMAN | |||||
| Gene Name | HTR6 | |||||
| Synonyms |
Serotonin receptor 6; 5-hydroxytryptamine receptor 6; 5-HT6 receptor; 5-HT6; 5-HT-6
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| Representative Drug(s) | Dapsone | Drug Info | Ki = 183 nM | [1] | ||
| Co-Target Name | Myeloperoxidase (MPO) | Clinical trial Target | ||||
| UniProt ID | PERM_HUMAN | |||||
| Gene Name | MPO | |||||
| Synonyms |
MPO
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| Representative Drug(s) | Dapsone | Drug Info | IC50 = 420 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis of substituted diphenyl sulfones and their structure-activity relationship with the antagonism of 5-HT6 receptors. Bioorg Med Chem. 2013 Aug 1;21(15):4614-27. | ||||
| REF 2 | The development of myeloperoxidase inhibitors. Bioorg Med Chem Lett. 2019 Jan 1;29(1):1-7. | ||||
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