Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T15855 Target Info
Target Name Dipeptidyl peptidase 8 (DPP-8)
Synonyms
Prolyl dipeptidase DPP8; MSTP141; MSTP135; MSTP097; Dipeptidyl peptidase VIII; Dipeptidyl peptidase IV-related protein 1; DPRP1; DPRP-1; DPP VIII; DP8
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Target Type Clinical trial Target
Gene Name DPP8
Biochemical Class Peptidase
UniProt ID
DPP8_HUMAN
Co-Targets of This Target  Top
Co-Target Name Dipeptidyl peptidase 4 (DPP-4) Successful Target
UniProt ID DPP4_HUMAN
Gene Name DPP4
Synonyms
Tcell activation antigen CD26; TP103; T-cell activation antigen CD26; Dipeptidyl peptidase IV; Dipeptidyl peptidase 4 soluble form; DPP-IV; DPP IV; DPP 4; CD26; Adenosine deaminase complexing protein-2; Adenosine deaminase complexing protein 2; ADCP2; ADCP-2; ADABP
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Representative Drug(s) Talabostat Drug Info IC50 = 0.1 nM [1]
Co-Target Name Dipeptidyl peptidase 9 (DPP-9) Clinical trial Target
UniProt ID DPP9_HUMAN
Gene Name DPP9
Synonyms
Dipeptidyl peptidase-like protein 9; Dipeptidyl peptidase IX; Dipeptidyl peptidase IV-related protein 2; DPRP2; DPRP-2; DPP IX; DPLP9; DP9
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Representative Drug(s) Talabostat Drug Info Ki = 0.76 nM [2]
Co-Target Name Prolyl endopeptidase FAP (FAP) Clinical trial Target
UniProt ID SEPR_HUMAN
Gene Name FAP
Synonyms
Integral membrane serine protease; Fibroblast activation protein alpha; FAP; Antiplasmin-cleaving enzyme; APCE; 170-kDa melanoma membrane-bound gelatinase
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Representative Drug(s) Talabostat Drug Info IC50 = 12 nM [3]
Co-Target Name Prolyl endopeptidase (PREP) Clinical trial Target
UniProt ID PPCE_HUMAN
Gene Name PREP
Synonyms
Post-proline cleaving enzyme; PREP; PE
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Representative Drug(s) Talabostat Drug Info IC50 = 73 nM [3]
Co-Target Name Dipeptidyl-peptidase 7 (DPP7) Patented-recorded Target
UniProt ID DPP2_HUMAN
Gene Name DPP7
Synonyms
Quiescent cell proline dipeptidase; QPP; Dipeptidyl peptidase II; Dipeptidyl peptidase 7; Dipeptidyl peptidase 2; Dipeptidyl aminopeptidase II; DPP2; DPP II
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Representative Drug(s) Talabostat Drug Info IC50 = 15 nM [4]
References  Top
REF 1 Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor. Bioorg Med Chem Lett. 2007 Jan 15;17(2):507-10.
REF 2 Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. J Med Chem. 2008 Oct 9;51(19):6005-13.
REF 3 Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase. J Med Chem. 2013 May 9;56(9):3467-77.
REF 4 Structure-activity relationships of boronic acid inhibitors of dipeptidyl peptidase IV. 1. Variation of the P2 position of Xaa-boroPro dipeptides. J Med Chem. 1996 May 10;39(10):2087-94.

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