Co-Target(s) Information

Content Navigation (  All   None )                                      
Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T15610 Target Info
Target Name Puromycin-sensitive aminopeptidase (NPEPPS)
Synonyms
NPEPPS
    Click to Show/Hide
Target Type Clinical trial Target
Gene Name NPEPPS
Biochemical Class Peptidase
UniProt ID
PSA_HUMAN
Co-Targets of This Target  Top
Co-Target Name Matrix metalloproteinase-2 (MMP-2) Successful Target
UniProt ID MMP2_HUMAN
Gene Name MMP2
Synonyms
TBE-1; Matrix metalloproteinase 2; CLG4A; 72 kDa type IV collagenase; 72 kDa gelatinase
    Click to Show/Hide
Representative Drug(s) CHR-2797 Drug Info IC50 = 190 nM [1]
Co-Target Name Aminopeptidase N (ANPEP) Clinical trial Target
UniProt ID AMPN_HUMAN
Gene Name ANPEP
Synonyms
Myeloid plasma membrane glycoprotein CD13; Microsomal aminopeptidase; HAPN; Gp150; Aminopeptidase M; Alanyl aminopeptidase; ANPEP
    Click to Show/Hide
Representative Drug(s) CHR-2797 Drug Info IC50 = 680 nM [2]
References  Top
REF 1 Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions. J Med Chem. 2019 Aug 8;62(15):7185-7209.
REF 2 Puromycin based inhibitors of aminopeptidases for the potential treatment of hematologic malignancies. Eur J Med Chem. 2017 Oct 20;139:325-336.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.