Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T15439 | Target Info | |||
| Target Name | C5a anaphylatoxin chemotactic receptor (C5AR1) | ||||
| Synonyms |
CD88; C5aR; C5a-R; C5a anaphylatoxin chemotactic receptor 1; C5R1
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| Target Type | Successful Target | ||||
| Gene Name | C5AR1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Melanocortin receptor 4 (MC4R) | Successful Target | ||||
| UniProt ID | MC4R_HUMAN | |||||
| Gene Name | MC4R | |||||
| Synonyms |
MC4-R
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| Representative Drug(s) | PMX-53 | Drug Info | IC50 = 400 nM | [1] | ||
| Co-Target Name | Vasopressin V1a receptor (V1AR) | Successful Target | ||||
| UniProt ID | V1AR_HUMAN | |||||
| Gene Name | AVPR1A | |||||
| Synonyms |
Vascular/hepatic-type arginine vasopressin receptor; V1aR; V1a vasopressin receptor; Antidiuretic hormone receptor 1a; AVPR1; AVPR V1a
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| Representative Drug(s) | PMX-53 | Drug Info | IC50 = 740 nM | [1] | ||
| Co-Target Name | Substance-K receptor (TACR2) | Clinical trial Target | ||||
| UniProt ID | NK2R_HUMAN | |||||
| Gene Name | TACR2 | |||||
| Synonyms |
Tachykinin receptor 2; Tachykinin neurokinin 2 receptor; TACR2; SKR; Neurokinin A receptor; NK-2R; NK-2 receptor
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| Representative Drug(s) | PMX-53 | Drug Info | IC50 = 87 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5088-92. | ||||
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