Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T14558 | Target Info | |||
| Target Name | Tryptase alpha/beta-1 (Tryptase) | ||||
| Synonyms |
Tryptase-1; Tryptase alpha-1; Tryptase I; TPSB1; TPS2; TPS1
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| Target Type | Successful Target | ||||
| Gene Name | TPSAB1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Solute carrier family 47 member 1 (SLC47A1) | Successful Target | ||||
| UniProt ID | S47A1_HUMAN | |||||
| Gene Name | SLC47A1 | |||||
| Synonyms |
hMATE-1; Multidrug and toxin extrusion protein 1; MATE1; MATE-1
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| Representative Drug(s) | Pentamidine | Drug Info | IC50 = 410 nM | [1] | ||
| Co-Target Name | Diamine oxidase (AOC1) | Literature-reported Target | ||||
| UniProt ID | AOC1_HUMAN | |||||
| Gene Name | AOC1 | |||||
| Synonyms |
Kidney amine oxidase; KAO; Histaminase; Amiloride-binding protein; AOC1; ABP
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| Representative Drug(s) | Pentamidine | Drug Info | Ki = 290 nM | [2] | ||
| Co-Target Name | Protein tyrosine phosphatase IVA 1 (PRL-1) | Literature-reported Target | ||||
| UniProt ID | TP4A1_HUMAN | |||||
| Gene Name | PTP4A1 | |||||
| Synonyms |
Protein-tyrosine phosphatase of regenerating liver 1; Protein-tyrosine phosphatase 4a1; Protein tyrosine phosphatase type IVA 1; PTPCAAX1; PTP(CAAXI); PRL1
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| Representative Drug(s) | Pentamidine | Drug Info | IC50 = 300 nM | [3] | ||
| Co-Target Name | Protein tyrosine phosphatase IVA 2 (PRL-2) | Literature-reported Target | ||||
| UniProt ID | TP4A2_HUMAN | |||||
| Gene Name | PTP4A2 | |||||
| Synonyms |
Protein-tyrosine phosphatase of regenerating liver 2; Protein-tyrosine phosphatase 4a2; Protein tyrosine phosphatase type IVA 2; PTPCAAX2; PTP(CAAXII); PRL2; OV-1; HU-PP-1; BM-008
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| Representative Drug(s) | Pentamidine | Drug Info | IC50 = 300 nM | [3] | ||
| Co-Target Name | Protein tyrosine phosphatase IVA 3 (PRL-3) | Literature-reported Target | ||||
| UniProt ID | TP4A3_HUMAN | |||||
| Gene Name | PTP4A3 | |||||
| Synonyms |
Protein-tyrosine phosphatase of regenerating liver 3; Protein-tyrosine phosphatase 4a3; Protein tyrosine phosphatase type IVA 3; PRL3; PRL-3
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| Representative Drug(s) | Pentamidine | Drug Info | IC50 = 300 nM | [3] | ||
| Co-Target Name | Glutamate NMDA receptor GRIN1/GRIN2A (GRIN1/GRIN2A) | Co-Target | ||||
| UniProt ID | NMDE1_HUMAN-NMDZ1_HUMAN | |||||
| Gene Name | GRIN2A-GRIN1 | |||||
| Representative Drug(s) | Pentamidine | Drug Info | IC50 = 720 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J Med Chem. 2013 Feb 14;56(3):781-795. | ||||
| REF 2 | Some non-conventional biomolecular targets for diamidines. A short survey. Bioorg Med Chem. 2014 Apr 1;22(7):1983-92. | ||||
| REF 3 | Tapping the therapeutic potential of protein tyrosine phosphatase 4A with small molecule inhibitors. Bioorg Med Chem Lett. 2019 Aug 15;29(16):2008-2015. | ||||
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