Co-Target(s) Information
Target General Information | Top | ||||
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Target ID | T11822 | Target Info | |||
Target Name | Retinoic acid receptor (RAR) | ||||
Synonyms |
Retinoic acid receptor
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Target Type | Successful Target | ||||
Gene Name | NO-GeName | ||||
UniProt ID |
Co-Targets of This Target | Top | |||||
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Co-Target Name | Retinoic acid receptor RXR-alpha (RXRA) | Successful Target | ||||
UniProt ID | RXRA_HUMAN | |||||
Gene Name | RXRA | |||||
Synonyms |
Retinoid X receptor alpha; RXRalpha; Nuclear receptor subfamily 2 group B member 1; NR2B1
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Representative Drug(s) | Tretinoin | Drug Info | EC50 ~ 0.001 nM | [1] | ||
Co-Target Name | Retinoic acid receptor RXR-beta (RXRB) | Successful Target | ||||
UniProt ID | RXRB_HUMAN | |||||
Gene Name | RXRB | |||||
Synonyms |
Retinoid X receptor beta; Nuclear receptor subfamily 2 group B member 2; NR2B2
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Representative Drug(s) | Tretinoin | Drug Info | Ki = 0.5 nM | [2] | ||
Co-Target Name | Retinoic acid receptor RXR-gamma (RXRG) | Successful Target | ||||
UniProt ID | RXRG_HUMAN | |||||
Gene Name | RXRG | |||||
Synonyms |
Retinoid X receptor gamma; Nuclear receptor subfamily 2 group B member 3; NR2B3
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Representative Drug(s) | Tretinoin | Drug Info | Ki = 1.4 nM | [2] | ||
Co-Target Name | Nuclear receptor ROR-gamma (RORG) | Clinical trial Target | ||||
UniProt ID | RORG_HUMAN | |||||
Gene Name | RORC | |||||
Synonyms |
Retinoid-related orphan receptor-gamma; RZRG; RORG; RAR-related orphan receptor C; Nuclear receptor subfamily 1 group F member 3; Nuclear receptor RZR-gamma; NR1F3
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Representative Drug(s) | Tretinoin | Drug Info | IC50 = 199.53 nM | [3] | ||
Co-Target Name | Rotamase Pin1 (PIN1) | Clinical trial Target | ||||
UniProt ID | PIN1_HUMAN | |||||
Gene Name | PIN1 | |||||
Synonyms |
Prolyl isomerase Pin1; Peptidyl-prolyl cis-trans isomerase Pin1; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl prolyl cis/trans isomerase Pin1; PPIase Pin1
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Representative Drug(s) | Tretinoin | Drug Info | IC50 = 820 nM | [4] | ||
Co-Target Name | RAR-related orphan receptor-beta (RORB) | Patented-recorded Target | ||||
UniProt ID | RORB_HUMAN | |||||
Gene Name | RORB | |||||
Synonyms |
Retinoid-related orphan receptor-beta; RZRB; Nuclear receptor subfamily 1 group F member 2; Nuclear receptor RZR-beta; Nuclear receptor ROR-beta; NR1F2
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Representative Drug(s) | Tretinoin | Drug Info | IC50 = 0.15 nM | [5] | ||
Co-Target Name | Nuclear receptor ROR-alpha (RORA) | Patented-recorded Target | ||||
UniProt ID | RORA_HUMAN | |||||
Gene Name | RORA | |||||
Synonyms |
Retinoid-related orphan receptor-alpha; Retinoic acid-related orphan receptor alpha; RZRA; RAR-related orphan receptor A; Nuclear receptor subfamily 1 group F member 1; Nuclear receptor RZR-alpha; NR1F1
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Representative Drug(s) | Tretinoin | Drug Info | IC50 = 199.53 nM | [3] |
References | Top | ||||
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REF 1 | Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids. J Med Chem. 1995 Jul 21;38(15):2820-9. | ||||
REF 2 | An improved synthesis of the C-linked glucuronide of N-(4-hydroxyphenyl)retinamide. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2447-50. | ||||
REF 3 | Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORbeta and RORgammat. Bioorg Med Chem Lett. 2014 Nov 15;24(22):5265-7. | ||||
REF 4 | Synthesis and biological evaluation of pyrimidine derivatives as novel human Pin1 inhibitors. Bioorg Med Chem. 2018 May 1;26(8):2186-2197. | ||||
REF 5 | Synthetic modulators of the retinoic acid receptor-related orphan receptors. Medchemcomm. 2013;4:764-76. |
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