Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T11388 Target Info
Target Name Cathepsin K (CTSK)
Synonyms
Cathepsin X; Cathepsin O2; Cathepsin O; CTSO2; CTSO
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Target Type Clinical trial Target
Gene Name CTSK
Biochemical Class Peptidase
UniProt ID
CATK_HUMAN
Co-Targets of This Target  Top
Co-Target Name Dipeptidyl peptidase I (CTSC) Clinical trial Target
UniProt ID CATC_HUMAN
Gene Name CTSC
Synonyms
Dipeptidyl transferase; Dipeptidyl peptidase 1; DPPI; DPP-I; Cysteine protease dipeptidyl peptidase I; Cathepsin J; Cathepsin C; CPPI
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Representative Drug(s) Odanacatib Drug Info IC50 ~ 10 nM [1]
Co-Target Name Cathepsin S (CTSS) Clinical trial Target
UniProt ID CATS_HUMAN
Gene Name CTSS
Synonyms
Cysteine protease cathepsin S
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Representative Drug(s) Odanacatib Drug Info IC50 = 45 nM [1]
Co-Target Name Cathepsin V (CTSV) Patented-recorded Target
UniProt ID CATL2_HUMAN
Gene Name CTSV
Synonyms
UNQ268/PRO305; Cathepsin U; Cathepsin L2; CTSU; CTSL2; CATL2
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Representative Drug(s) Odanacatib Drug Info IC50 = 762 nM [1]
Co-Target Name Cathepsin F (CTSF) Patented-recorded Target
UniProt ID CATF_HUMAN
Gene Name CTSF
Synonyms
CATSF
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Representative Drug(s) Odanacatib Drug Info IC50 = 795 nM [1]
Co-Target Name Cathepsin H (CTSH) Literature-reported Target
UniProt ID CATH_HUMAN
Gene Name CTSH
Synonyms
Pro-cathepsin H
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Representative Drug(s) Odanacatib Drug Info IC50 ~ 10 nM [1]
Co-Target Name Cathepsin Z (CTSZ) Co-Target
UniProt ID CATZ_HUMAN
Gene Name CTSZ
Synonyms
Cathepsin P; Cathepsin X
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Representative Drug(s) Odanacatib Drug Info IC50 ~ 10 nM [1]
References  Top
REF 1 The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. Bioorg Med Chem Lett. 2008 Feb 1;18(3):923-8.

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