Co-Target(s) Information

Content Navigation (  All   None )                                      
Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T10735 Target Info
Target Name Histidine decarboxylase (HDC)
Synonyms
Human histidine decarboxylase
    Click to Show/Hide
Target Type Clinical trial Target
Gene Name HDC
Biochemical Class Carbon-carbon lyase
UniProt ID
DCHS_HUMAN
Co-Targets of This Target  Top
Co-Target Name Vasopressin V2 receptor (V2R) Successful Target
UniProt ID V2R_HUMAN
Gene Name AVPR2
Synonyms
Renal-type arginine vasopressin receptor; DIR3; DIR; Antidiuretic hormone receptor; AVPR V2; ADHR
    Click to Show/Hide
Representative Drug(s) Lixivaptan Drug Info IC50 = 1 nM [1]
Co-Target Name Vasopressin V1a receptor (V1AR) Successful Target
UniProt ID V1AR_HUMAN
Gene Name AVPR1A
Synonyms
Vascular/hepatic-type arginine vasopressin receptor; V1aR; V1a vasopressin receptor; Antidiuretic hormone receptor 1a; AVPR1; AVPR V1a
    Click to Show/Hide
Representative Drug(s) Lixivaptan Drug Info Ki = 44 nM [2]
Co-Target Name Oxytocin receptor (OTR) Successful Target
UniProt ID OXYR_HUMAN
Gene Name OXTR
Synonyms
OT-R
    Click to Show/Hide
Representative Drug(s) Lixivaptan Drug Info IC50 = 519 nM [3]
References  Top
REF 1 (4-Substituted-phenyl)-(5H-10,11-dihydro-pyrrolo [2,1-c][1,4] benzodiazepin-10-yl)-methanone derivatives as vasopressin receptor modulators. Bioorg Med Chem Lett. 2005 Nov 15;15(22):5003-6.
REF 2 Potent nonpeptide vasopressin receptor antagonists based on oxazino- and thiazinobenzodiazepine templates. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2747-52.
REF 3 Identification and synthesis of major metabolites of Vasopressin V2-receptor agonist WAY-151932, and antagonist, Lixivaptan. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5796-800.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.