Co-Target(s) Information
Target General Information | Top | ||||
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Target ID | T08856 | Target Info | |||
Target Name | Matrix metalloproteinase-8 (MMP-8) | ||||
Synonyms |
PMNL-CL; PMNL collagenase; Neutrophil collagenase; CLG1
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Target Type | Clinical trial Target | ||||
Gene Name | MMP8 | ||||
Biochemical Class | Peptidase | ||||
UniProt ID |
Co-Targets of This Target | Top | |||||
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Co-Target Name | Matrix metalloproteinase-1 (MMP-1) | Successful Target | ||||
UniProt ID | MMP1_HUMAN | |||||
Gene Name | MMP1 | |||||
Synonyms |
Interstitial collagenase; Fibroblast collagenase; CLG
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Representative Drug(s) | CIPEMASTAT | Drug Info | Ki = 0.3 nM | [1] | ||
Co-Target Name | Matrix metalloproteinase-7 (MMP-7) | Successful Target | ||||
UniProt ID | MMP7_HUMAN | |||||
Gene Name | MMP7 | |||||
Synonyms |
Uterine metalloproteinase; Pump-1 protease; PUMP1; Matrin; Matrilysin; MPSL1
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Representative Drug(s) | CIPEMASTAT | Drug Info | IC50 = 18.5 nM | [2] | ||
Co-Target Name | Matrix metalloproteinase-2 (MMP-2) | Successful Target | ||||
UniProt ID | MMP2_HUMAN | |||||
Gene Name | MMP2 | |||||
Synonyms |
TBE-1; Matrix metalloproteinase 2; CLG4A; 72 kDa type IV collagenase; 72 kDa gelatinase
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Representative Drug(s) | CIPEMASTAT | Drug Info | IC50 = 154 nM | [3] | ||
Co-Target Name | Matrix metalloproteinase-13 (MMP-13) | Clinical trial Target | ||||
UniProt ID | MMP13_HUMAN | |||||
Gene Name | MMP13 | |||||
Synonyms |
Matrix metalloproteinase 13; Collagenase-3; Collagenase 3
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Representative Drug(s) | CIPEMASTAT | Drug Info | Ki = 0.53 nM | [2] | ||
Co-Target Name | Matrix metalloproteinase-9 (MMP-9) | Clinical trial Target | ||||
UniProt ID | MMP9_HUMAN | |||||
Gene Name | MMP9 | |||||
Synonyms |
Matrix metalloproteinase 9; GELB; CLG4B; 92 kDa type IV collagenase; 92 kDa gelatinase
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Representative Drug(s) | CIPEMASTAT | Drug Info | IC50 = 2.4 nM | [2] | ||
Co-Target Name | Matrix metalloproteinase-14 (MMP-14) | Clinical trial Target | ||||
UniProt ID | MMP14_HUMAN | |||||
Gene Name | MMP14 | |||||
Synonyms |
Membrane-type-1 matrix metalloproteinase; Membrane-type matrix metalloproteinase 1; MTMMP1; MT1MMP; MT1-MMP; MT-MMP 1; MMP-X1
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Representative Drug(s) | CIPEMASTAT | Drug Info | IC50 = 23 nM | [2] | ||
Co-Target Name | TNF alpha converting enzyme (ADAM17) | Clinical trial Target | ||||
UniProt ID | ADA17_HUMAN | |||||
Gene Name | ADAM17 | |||||
Synonyms |
TNFalpha converting enzyme; TNF-alpha-converting enzyme; TNF-alpha converting enzyme; TNF-alpha convertase; TACE; Snake venom-like protease; Disintegrin and metalloproteinase domain-containing protein 17; CSVP; CD156b antigen; CD156b; ADAM 17; A disintegrin and metalloproteinase domain 17
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Representative Drug(s) | CIPEMASTAT | Drug Info | Ki = 230 nM | [1] | ||
Co-Target Name | Matrix metalloproteinase-3 (MMP-3) | Patented-recorded Target | ||||
UniProt ID | MMP3_HUMAN | |||||
Gene Name | MMP3 | |||||
Synonyms |
Transin-1; Stromelysin-1; STMY1; SL-1; MMP-3
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Representative Drug(s) | CIPEMASTAT | Drug Info | Ki = 56 nM | [1] |
References | Top | ||||
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REF 1 | A cassette-dosing approach for improvement of oral bioavailability of dual TACE/MMP inhibitors. Bioorg Med Chem Lett. 2006 May 15;16(10):2632-6. | ||||
REF 2 | Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13. J Med Chem. 2009 Jun 11;52(11):3523-38. | ||||
REF 3 | Stereospecific synthesis of 5-substituted 2-bisarylthiocyclopentane carboxylic acids as specific matrix metalloproteinase inhibitors. J Med Chem. 2003 Aug 28;46(18):3840-52. |
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