Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T07601 Target Info
Target Name Calcium signal-modulating cyclophilin ligand (CAML)
Synonyms
cyclophilin
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Target Type Clinical trial Target
Gene Name CAMLG; CAML
UniProt ID
CAMLG_HUMAN
Co-Targets of This Target  Top
Co-Target Name Rotamase A (PPIA) Successful Target
UniProt ID PPIA_HUMAN
Gene Name PPIA
Synonyms
PPIA; Cyclophilin A; CyPA
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Representative Drug(s) Alisporivir Drug Info Ki = 0.34 nM Click to Show More [1]
2 SCY-635 Drug Info Ki = 1.84 nM [2]
Co-Target Name Rotamase B (PPIB) Successful Target
UniProt ID PPIB_HUMAN
Gene Name PPIB
Synonyms
SCYLP; S-cyclophilin; Peptidyl-prolyl cis-trans isomerase B; PPIase B; Cyclophilin B; CYPB; CYP-S1
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Representative Drug(s) SCY-635 Drug Info IC50 = 10.3 nM [3]
Co-Target Name Human immunodeficiency virus Reverse transcriptase (HIV RT) Successful Target
UniProt ID POL_HV1B1
Gene Name HIV RT
Synonyms
HIV p66 RT; HIV Exoribonuclease H
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Representative Drug(s) SCY-635 Drug Info IC50 = 45 nM [4]
Co-Target Name Multidrug resistance protein 1 (ABCB1) Clinical trial Target
UniProt ID MDR1_HUMAN
Gene Name ABCB1
Synonyms
PGY1; P-glycoprotein 1; MDR1; CD243 antigen; CD243; ATP-binding cassette sub-family B member 1
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Representative Drug(s) Alisporivir Drug Info IC50 = 590 nM [5]
Co-Target Name ATP-binding cassette transporter B11 (ABCB11) Literature-reported Target
UniProt ID ABCBB_HUMAN
Gene Name ABCB11
Synonyms
BSEP; ATP-binding cassette, sub-family B, member 11; ATP-binding cassette sub-family B member 11
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Representative Drug(s) Alisporivir Drug Info IC50 = 110 nM [5]
Co-Target Name Liver organic anion transporter 1 (SLCO1B1) Literature-reported Target
UniProt ID SO1B1_HUMAN
Gene Name SLCO1B1
Synonyms
Solute carrier organic anion transporter family member 1B1; Solute carrier family 21 member 6; Sodium-independent organic anion-transporting polypeptide 2; SLC21A6; OATPC; OATP2; OATP-C; OATP-2; Liver-specific organic anion transporter 1; LST1; LST-1
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Representative Drug(s) Alisporivir Drug Info IC50 = 180 nM [5]
Co-Target Name Liver organic anion transporter 2 (SLCO1B3) Literature-reported Target
UniProt ID SO1B3_HUMAN
Gene Name SLCO1B3
Synonyms
Solute carrier organic anion transporter family member 1B3; Solute carrier family 21 member 8; SLC21A8; Organic anion-transporting polypeptide 8; Organic anion transporter 8; OATP8; OATP1B3; OATP-8; Liver-specific organic anion transporter 2; LST2; LST-2
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Representative Drug(s) Alisporivir Drug Info IC50 = 220 nM [5]
References  Top
REF 1 Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent. Antimicrob Agents Chemother. 2008 Apr;52(4):1302-17.
REF 2 SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro. Antimicrob Agents Chemother. 2010 Feb;54(2):660-72.
REF 3 Synthesis and biological evaluation of [D-lysine]8cyclosporin A analogs as potential anti-HCV agents. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6542-6.
REF 4 Synthesis of non-immunosuppressive cyclophilin-Binding cyclosporin A derivatives as potential anti-HIV-1 drugs. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4415-9.
REF 5 Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition. J Med Chem. 2014 Oct 23;57(20):8503-16.

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