Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T06011 | Target Info | |||
| Target Name | Transforming growth factor beta (TGFB) | ||||
| Synonyms |
TGF-beta
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| Target Type | Clinical trial Target | ||||
| Gene Name | NO-GeName | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Vascular endothelial growth factor receptor 2 (KDR) | Successful Target | ||||
| UniProt ID | VGFR2_HUMAN | |||||
| Gene Name | KDR | |||||
| Synonyms |
VEGFR2; VEGFR-2; VEGF-2 receptor; Protein-tyrosine kinase receptor flk-1; Kinase insert domain receptor; Fetal liver kinase 1; FLK1; FLK-1; CD309
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| Representative Drug(s) | TEW-7197 | Drug Info | IC50 = 97 nM | [1] | ||
| Co-Target Name | TGF-beta receptor type I (TGFBR1) | Clinical trial Target | ||||
| UniProt ID | TGFR1_HUMAN | |||||
| Gene Name | TGFBR1 | |||||
| Synonyms |
Type I TGFbeta receptor kinase; Transforming growth factor-beta receptor type I; TbetaRI; TbetaR-I; TGFR-1; TGF-beta type I receptor; TGF-beta receptor type-1; Serine/threonine-protein kinase receptor R4; SKR4; Activin receptor-like kinase 5; Activin A receptor type II-like protein kinase of 53kD; ALK5; ALK-5
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| Representative Drug(s) | TEW-7197 | Drug Info | Ki = 6.296 nM | [1] | ||
| Co-Target Name | Activin receptor type IB (ACVR1B) | Patented-recorded Target | ||||
| UniProt ID | ACV1B_HUMAN | |||||
| Gene Name | ACVR1B | |||||
| Synonyms |
Serine/threonine-protein kinase receptor R2; SKR2; Activin receptor-like kinase 4; Activin receptor type-1B; ALK4; ALK-4; ACVRLK4; ACTR-IB
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| Representative Drug(s) | TEW-7197 | Drug Info | IC50 = 13 nM | [1] | ||
| Co-Target Name | Serine/threonine-protein kinase RIPK2 (RIPK2) | Co-Target | ||||
| UniProt ID | RIPK2_HUMAN | |||||
| Gene Name | RIPK2 | |||||
| Synonyms |
Receptor-interacting serine/threonine-protein kinase 2; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing IL-1 beta ICE-kinase; RIP-like-interacting CLARP kinase; Receptor-interacting protein 2; RIP-2; Tyrosine-protein kinase RIPK2
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| Representative Drug(s) | TEW-7197 | Drug Info | IC50 = 54 nM | [1] | ||
| References | Top | ||||
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| REF 1 | Discovery of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): a highly potent, selective, and orally bioavailable inhibitor of TGF-beta type I receptor kinase as cancer immunotherapeutic/antifibrotic agent. J Med Chem. 2014 May 22;57(10):4213-38. | ||||
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