Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T03691 Target Info
Target Name Leukotriene A-4 hydrolase (LTA4H)
Synonyms
Leukotriene A4 hydrolase; Leukotriene A(4)Leukotriene A-4 hydrolase hydrolase; Leukotriene A(4) hydrolase; LTA4; LTA-H; LTA-4hydrolase; LTA-4 hydrolase
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Target Type Successful Target
Gene Name LTA4H
Biochemical Class Ether bond hydrolase
UniProt ID
LKHA4_HUMAN
Co-Targets of This Target  Top
Co-Target Name Dipeptidyl peptidase 4 (DPP-4) Successful Target
UniProt ID DPP4_HUMAN
Gene Name DPP4
Synonyms
Tcell activation antigen CD26; TP103; T-cell activation antigen CD26; Dipeptidyl peptidase IV; Dipeptidyl peptidase 4 soluble form; DPP-IV; DPP IV; DPP 4; CD26; Adenosine deaminase complexing protein-2; Adenosine deaminase complexing protein 2; ADCP2; ADCP-2; ADABP
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Representative Drug(s) Bestatin Drug Info IC50 ~ 100 ug.mL-1 [1]
Co-Target Name Aminopeptidase N (ANPEP) Clinical trial Target
UniProt ID AMPN_HUMAN
Gene Name ANPEP
Synonyms
Myeloid plasma membrane glycoprotein CD13; Microsomal aminopeptidase; HAPN; Gp150; Aminopeptidase M; Alanyl aminopeptidase; ANPEP
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Representative Drug(s) Bestatin Drug Info IC50 = 0.81 ug.mL-1 [2]
Co-Target Name Plasmodium M1-family aminopeptidase (Malaria MFA) Literature-reported Target
UniProt ID AMP1_PLAFQ
Gene Name Malaria MFA
Synonyms
Pfa-M1
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Representative Drug(s) Bestatin Drug Info Ki = 190 nM [3]
References  Top
REF 1 Nonpeptide small-molecular inhibitors of dipeptidyl peptidase IV: N-phenylphthalimide analogs. Bioorg Med Chem Lett. 1999 Feb 22;9(4):559-62.
REF 2 Novel potent nonpeptide aminopeptidase N inhibitors with a cyclic imide skeleton. J Med Chem. 1998 Jan 29;41(3):263-5.
REF 3 Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase. J Med Chem. 2011 Mar 24;54(6):1655-66.

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