Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T01447 | Target Info | |||
| Target Name | NEDD8-activating enzyme (NAE) | ||||
| Synonyms |
NEDD8-activating enzyme E1
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| Target Type | Clinical trial Target | ||||
| Gene Name | NAE1; UBA3 | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Ubiquitin-like protein Nedd8 (NEDD8) | Clinical trial Target | ||||
| UniProt ID | NEDD8_HUMAN | |||||
| Gene Name | NEDD8 | |||||
| Synonyms |
Neural precursor cell expressed developmentally down-regulated protein 8; Neddylin; NEDD-8
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| Representative Drug(s) | MLN4924 | Drug Info | IC50 = 4.7 nM | [1] | ||
| Co-Target Name | NEDD8-activating enzyme E1C (UBA3) | Literature-reported Target | ||||
| UniProt ID | UBA3_HUMAN | |||||
| Gene Name | UBA3 | |||||
| Synonyms |
Ubiquitin-like modifier-activating enzyme 3; Ubiquitin-activating enzyme E1C; Ubiquitin-activating enzyme 3; UBE1C; NEDD8-activating enzyme E1 catalytic subunit
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| Representative Drug(s) | MLN4924 | Drug Info | IC50 = 5 nM | [2] | ||
| Co-Target Name | Autophagy-related protein 7 (ATG7) | Literature-reported Target | ||||
| UniProt ID | ATG7_HUMAN | |||||
| Gene Name | ATG7 | |||||
| Synonyms |
hAGP7; Ubiquitin-like modifier-activating enzyme ATG7; Ubiquitin-activating enzyme E1-like protein; ATG12-activating enzyme E1 ATG7; APG7L; APG7-like
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| Representative Drug(s) | MLN4924 | Drug Info | IC50 ~ 1000 nM | [1] | ||
| Co-Target Name | Ubiquitin-like modifier-activating enzyme 6 (UBA6) | Co-Target | ||||
| UniProt ID | UBA6_HUMAN | |||||
| Gene Name | UBA6 | |||||
| Synonyms |
Ubiquitin-activating enzyme 6; Monocyte protein 4; MOP-4; Ubiquitin-activating enzyme E1-like protein 2; E1-L2
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| Representative Drug(s) | MLN4924 | Drug Info | IC50 ~ 1000 nM | [1] | ||
| References | Top | ||||
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| REF 1 | Interrogating the Roles of Post-Translational Modifications of Non-Histone Proteins. J Med Chem. 2018 Apr 26;61(8):3239-52. | ||||
| REF 2 | Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J Med Chem. 2018 Apr 12;61(7):2680-93. | ||||
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