Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T00043 | Target Info | |||
| Target Name | HUMAN cyclin G-associated kinase (GAK) | ||||
| Synonyms |
cyclin G associated kinase
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| Gene Name | GAK | ||||
| Biochemical Class | Ser/Thr protein kinase family | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Janus kinase 2 (JAK-2) | Successful Target | ||||
| UniProt ID | JAK2_HUMAN | |||||
| Gene Name | JAK2 | |||||
| Synonyms |
Tyrosine-protein kinase JAK2
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| Representative Drug(s) | Baricitinib | Drug Info | IC50 = 0.8 nM | [1] | ||
| Co-Target Name | Janus kinase 1 (JAK-1) | Successful Target | ||||
| UniProt ID | JAK1_HUMAN | |||||
| Gene Name | JAK1 | |||||
| Synonyms |
Tyrosine-protein kinase JAK1; JAK1B; JAK1A
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| Representative Drug(s) | Baricitinib | Drug Info | IC50 = 0.99 nM | [1] | ||
| Co-Target Name | Janus kinase 3 (JAK-3) | Successful Target | ||||
| UniProt ID | JAK3_HUMAN | |||||
| Gene Name | JAK3 | |||||
| Synonyms |
Tyrosine-protein kinase JAK3; Leukocyte janus kinase; L-JAK
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| Representative Drug(s) | Baricitinib | Drug Info | IC50 = 25 nM | [1] | ||
| Co-Target Name | TYK2 tyrosine kinase (TYK2) | Successful Target | ||||
| UniProt ID | TYK2_HUMAN | |||||
| Gene Name | TYK2 | |||||
| Synonyms |
Non-receptor tyrosine-protein kinase TYK2
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| Representative Drug(s) | Baricitinib | Drug Info | IC50 = 8.7 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-Based Design and Synthesis of 3-Amino-1,5-dihydro-4H-pyrazolopyridin-4-one Derivatives as Tyrosine Kinase 2 Inhibitors. J Med Chem. 2016 Jan 28;59(2):733-49. | ||||
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