| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T09215 | ||||
| Target Name | Isocitrate lyase | ||||
| Target Type | Research |
||||
| Drug Potency against Target | Bis(2,3-dibromo-4,5-dihydroxyphenyl)ether | Drug Info | IC50 = 11630 nM | [531190] | |
| 5,5'-methylenebis(3,4-dibromobenzene-1,2-diol) | Drug Info | IC50 = 18440 nM | [531190] | ||
| Bis(3-bromo-4,5-dihydroxyphenyl)methanone | Drug Info | IC50 = 8890 nM | [531190] | ||
| Hydrohalisulfate 1 | Drug Info | IC50 = 15000 nM | [528696] | ||
| Halisulfate 1 | Drug Info | IC50 = 12600 nM | [528696] | ||
| 2,2',3-Tribromo-4,4',5,5'-tetrahydroxybibenzyl | Drug Info | IC50 = 14770 nM | [531190] | ||
| References | |||||
| Ref 531190 | Bioorg Med Chem Lett. 2010 Nov 15;20(22):6644-8. Epub 2010 Sep 21.Bromophenols as Candida albicans isocitrate lyase inhibitors. | ||||
| Ref 531190 | Bioorg Med Chem Lett. 2010 Nov 15;20(22):6644-8. Epub 2010 Sep 21.Bromophenols as Candida albicans isocitrate lyase inhibitors. | ||||
| Ref 531190 | Bioorg Med Chem Lett. 2010 Nov 15;20(22):6644-8. Epub 2010 Sep 21.Bromophenols as Candida albicans isocitrate lyase inhibitors. | ||||
| Ref 528696 | Bioorg Med Chem Lett. 2007 May 1;17(9):2483-6. Epub 2007 Feb 13.Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp. | ||||
| Ref 528696 | Bioorg Med Chem Lett. 2007 May 1;17(9):2483-6. Epub 2007 Feb 13.Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp. | ||||
| Ref 531190 | Bioorg Med Chem Lett. 2010 Nov 15;20(22):6644-8. Epub 2010 Sep 21.Bromophenols as Candida albicans isocitrate lyase inhibitors. | ||||
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