Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T04820 | ||||
Target Name | Cyclin-dependent protein kinase Pfmrk | ||||
Target Type | Research |
||||
Drug Potency against Target | 5-Nitro-1H-indole-2,3-dione | Drug Info | IC50 = 5900 nM | [527246] | |
WR-289009 | Drug Info | IC50 = 8200 nM | [529988] | ||
3-[3-(2-Hydroxy-ethoxy)-phenyl]-1H-quinolin-2-one | Drug Info | IC50 = 18000 nM | [527246] | ||
WR-089120 | Drug Info | IC50 = 10000 nM | [529988] | ||
WR-289016 | Drug Info | IC50 = 1300 nM | [529988] | ||
WR-289010 | Drug Info | IC50 = 9000 nM | [529988] | ||
WR-289012 | Drug Info | IC50 = 19000 nM | [529988] | ||
WR-080539 | Drug Info | IC50 = 17000 nM | [529988] | ||
KENPAULLONE | Drug Info | IC50 = 15000 nM | [527246] | ||
N'-(2-fluorobenzoyl)-2-naphthohydrazide | Drug Info | IC50 = 400 nM | |||
2,5-dichloro-N-p-tolylthiophene-3-sulfonamide | Drug Info | IC50 = 600 nM | |||
N-(2-aminoethyl)isoquinoline-5-sulfonamide | Drug Info | IC50 = 700 nM | [528918] | ||
2-chloro-N-(o-tolylcarbamoyl)benzamide | Drug Info | IC50 = 200 nM | |||
WR-190706 | Drug Info | IC50 = 12000 nM | [529988] | ||
2,5-dichloro-N-phenylthiophene-3-sulfonamide | Drug Info | IC50 = 14900 nM | |||
WR-203581 | Drug Info | IC50 = 18000 nM | [529988] | ||
APIGENIN | Drug Info | IC50 = 7000 nM | [527246] | ||
(E)-1-(4-Nitro-phenyl)-3-pyridin-2-yl-propenone | Drug Info | IC50 = 18000 nM | [527246] | ||
5-chloro-4-nitrothiophene-2-sulfonamide | Drug Info | IC50 = 17400 nM | |||
References | |||||
Ref 527246 | J Med Chem. 2004 Oct 21;47(22):5418-26.A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors. | ||||
Ref 529988 | Bioorg Med Chem Lett. 2009 Apr 1;19(7):1982-5. Epub 2009 Feb 13.Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones. | ||||
Ref 527246 | J Med Chem. 2004 Oct 21;47(22):5418-26.A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors. | ||||
Ref 529988 | Bioorg Med Chem Lett. 2009 Apr 1;19(7):1982-5. Epub 2009 Feb 13.Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones. | ||||
Ref 529988 | Bioorg Med Chem Lett. 2009 Apr 1;19(7):1982-5. Epub 2009 Feb 13.Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones. | ||||
Ref 529988 | Bioorg Med Chem Lett. 2009 Apr 1;19(7):1982-5. Epub 2009 Feb 13.Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones. | ||||
Ref 529988 | Bioorg Med Chem Lett. 2009 Apr 1;19(7):1982-5. Epub 2009 Feb 13.Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones. | ||||
Ref 529988 | Bioorg Med Chem Lett. 2009 Apr 1;19(7):1982-5. Epub 2009 Feb 13.Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones. | ||||
Ref 527246 | J Med Chem. 2004 Oct 21;47(22):5418-26.A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors. | ||||
Ref 528918 | Bioorg Med Chem Lett. 2007 Sep 1;17(17):4961-6. Epub 2007 Jun 12.Evaluation of broad spectrum protein kinase inhibitors to probe the architecture of the malarial cyclin dependent protein kinase Pfmrk. | ||||
Ref 529988 | Bioorg Med Chem Lett. 2009 Apr 1;19(7):1982-5. Epub 2009 Feb 13.Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones. | ||||
Ref 529988 | Bioorg Med Chem Lett. 2009 Apr 1;19(7):1982-5. Epub 2009 Feb 13.Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones. | ||||
Ref 527246 | J Med Chem. 2004 Oct 21;47(22):5418-26.A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors. | ||||
Ref 527246 | J Med Chem. 2004 Oct 21;47(22):5418-26.A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.