| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T46456 | ||||
| Target Name | Retinoic acid receptor RXR-gamma | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | Bexarotene | Drug Info | Ki = 21 nM | [552986] | |
| AGN-34 | Drug Info | IC50 < 10 nM | [527690] | ||
| References | |||||
| Ref 552986 | Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). J Med Chem. 2009 Oct 8;52(19):5950-66. doi: 10.1021/jm900496b. | ||||
| Ref 527690 | J Med Chem. 2005 Aug 25;48(17):5383-403.Farnesoid X receptor: from structure to potential clinical applications. | ||||
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