| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T99616 | ||||
| Target Name | Trypanothione reductase | ||||
| Target Type | Research |
||||
| Drug Potency against Target | N-(5-chloro-2-(phenylthio)phenyl)butyramide | Drug Info | Ki = 11300 nM | [1] | |
| CEPHARANTINE | Drug Info | Ki = 7600 nM | [2] | ||
| 1-(2'-chlorophenyl)penta-1,4-dien-3-one | Drug Info | IC50 = 2000 nM | [3] | ||
| N1,N2-bis(dihydrocaffeoyl)spermine | Drug Info | Ki = 13000 nM | [2] | ||
| References | |||||
| REF 1 | J Med Chem. 2005 Dec 15;48(25):8087-97.Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfide. | ||||
| REF 2 | Bioorg Med Chem. 2008 Jul 15;16(14):6689-95. Epub 2008 Jun 2.The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors. | ||||
| REF 3 | J Med Chem. 2005 Nov 17;48(23):7400-10.Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate. | ||||
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