| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T19011 | ||||
| Target Name | M-phase inducer phosphatase 3 | ||||
| Target Type | Discontinued |
||||
| Drug Potency against Target | BN-82685 | Drug Info | IC50 = 150 nM | [527791] | |
| NSC-663284 | Drug Info | IC50 = 250 nM | [527791] | ||
| BN-82002 | Drug Info | IC50 = 5400 nM | [527263] | ||
| References | |||||
| Ref 527791 | Bioorg Med Chem Lett. 2006 Jan 1;16(1):171-5. Epub 2005 Oct 10.Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C. | ||||
| Ref 527791 | Bioorg Med Chem Lett. 2006 Jan 1;16(1):171-5. Epub 2005 Oct 10.Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C. | ||||
| Ref 527263 | Bioorg Med Chem Lett. 2004 Dec 6;14(23):5809-12.Synthesis of small molecule CDC25 phosphatases inhibitors. | ||||
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