Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T08813 | ||||
Target Name | CAMP-dependent protein kinase type I-alpha regulatory chain | ||||
Target Type | Research |
||||
Drug Potency against Target | AdcAhxArg6 | Drug Info | IC50 = 700 nM | [526704] | |
AdoC(betaAsp)2AlaArg6 | Drug Info | IC50 = 11100 nM | [525511] | ||
AdoC(GABA)Arg6 | Drug Info | IC50 = 1300 nM | [525511] | ||
AdcAhxArg4Lys(biotin)-PEG-OMe | Drug Info | IC50 = 1200 nM | [526704] | ||
AdoC(Aun)Arg6 | Drug Info | IC50 = 330 nM | [525511] | ||
5-(2-methylpiperazin-1-ylsulfonyl)isoquinoline | Drug Info | Ki = 3000 nM | [534220] | ||
RO-316233 | Drug Info | IC50 = 11800 nM | [528701] | ||
AdoCGlyArg6 | Drug Info | IC50 = 4000 nM | [525511] | ||
AdcAhxArg4Lys-PEGOMe | Drug Info | IC50 = 460 nM | [526704] | ||
AdoC(beta-Ala)Arg6 | Drug Info | IC50 = 1800 nM | [525511] | ||
AdoC(Dpr)2AlaArg6 | Drug Info | IC50 = 2600 nM | [525511] | ||
AdoC(beta-Ala)2AlaArg6 | Drug Info | IC50 = 4300 nM | [525511] | ||
AdoC(Aoc)Arg6 | Drug Info | IC50 = 240 nM | [525511] | ||
AdcAhxArg4NH(CH2)6NH2 | Drug Info | IC50 = 680 nM | [526704] | ||
AdoC(Ahx)Arg6 | Drug Info | IC50 = 120 nM | [525511] | ||
References | |||||
Ref 526704 | Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9.Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase. | ||||
Ref 525511 | Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. | ||||
Ref 525511 | Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. | ||||
Ref 526704 | Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9.Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase. | ||||
Ref 525511 | Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. | ||||
Ref 534220 | J Biol Chem. 1996 Oct 18;271(42):26157-64.Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity. | ||||
Ref 528701 | J Med Chem. 1992 Jan;35(1):177-84.Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. | ||||
Ref 525511 | Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. | ||||
Ref 526704 | Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9.Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase. | ||||
Ref 525511 | Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. | ||||
Ref 525511 | Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. | ||||
Ref 525511 | Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. | ||||
Ref 525511 | Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. | ||||
Ref 526704 | Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9.Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase. | ||||
Ref 525511 | Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. |
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