| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T76158 | ||||
| Target Name | Glutathione reductase, mitochondrial | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | 3,7-Bis-dimethylamino-phenothiazin-5-ylium | Drug Info | IC50 = 16000 nM | [527284] | |
| Trans-(1S(R),2S(R))-2-Hydroxycyclooctyl nitrate | Drug Info | IC50 = 14200 nM | [530143] | ||
| Trans-(R(S))-2-Hydroxy-1-phenylethyl nitrate | Drug Info | IC50 = 16000 nM | [530143] | ||
| 1-(2'-chlorophenyl)penta-1,4-dien-3-one | Drug Info | IC50 = 5000 nM | [527860] | ||
| References | |||||
| Ref 527284 | J Med Chem. 2004 Nov 18;47(24):5972-83.5-substituted tetrazoles as bioisosteres of carboxylic acids. Bioisosterism and mechanistic studies on glutathione reductase inhibitors as antimalarials. | ||||
| Ref 530143 | Bioorg Med Chem Lett. 2009 Jul 1;19(13):3661-3. Epub 2009 Apr 24.In vitro inhibition of human erythrocyte glutathione reductase by some new organic nitrates. | ||||
| Ref 530143 | Bioorg Med Chem Lett. 2009 Jul 1;19(13):3661-3. Epub 2009 Apr 24.In vitro inhibition of human erythrocyte glutathione reductase by some new organic nitrates. | ||||
| Ref 527860 | J Med Chem. 2005 Nov 17;48(23):7400-10.Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate. | ||||
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