| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T08074 | ||||
| Target Name | mRNA of PDK-1 | ||||
| Target Type | Research |
||||
| Drug Potency against Target | NU-6102 | Drug Info | IC50 < 500 nM | [527906] | |
| (Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one | Drug Info | IC50 = 1800 nM | [528864] | ||
| BX-201 | Drug Info | IC50 = 18 nM | [528864] | ||
| SU-6689 | Drug Info | IC50 = 1100 nM | [528864] | ||
| BX-517 | Drug Info | IC50 = 5 nM | [528864] | ||
| References | |||||
| Ref 527906 | Bioorg Med Chem Lett. 2006 Mar 1;16(5):1353-7. Epub 2005 Dec 1.Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR. | ||||
| Ref 528864 | Bioorg Med Chem Lett. 2007 Jul 15;17(14):3814-8. Epub 2007 Apr 27.Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity. | ||||
| Ref 528864 | Bioorg Med Chem Lett. 2007 Jul 15;17(14):3814-8. Epub 2007 Apr 27.Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity. | ||||
| Ref 528864 | Bioorg Med Chem Lett. 2007 Jul 15;17(14):3814-8. Epub 2007 Apr 27.Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity. | ||||
| Ref 528864 | Bioorg Med Chem Lett. 2007 Jul 15;17(14):3814-8. Epub 2007 Apr 27.Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity. | ||||
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