Target Validation Information
Target ID T20474
Target Name DNA topoisomerase
Target Type
Research
Drug Potency against Target 6-(3-Iodo-phenylamino)-1H-pyrimidine-2,4-dione Drug Info Ki = 4700 nM [533563]
2-Amino-6-(indan-5-ylamino)-3H-pyrimidin-4-one Drug Info Ki = 2000 nM [533419]
6-p-Tolylamino-1H-pyrimidine-2,4-dione Drug Info Ki = 17500 nM [533563]
5-Bromo-6-p-tolylamino-1H-pyrimidine-2,4-dione Drug Info Ki = 14000 nM [533419]
6-Benzylamino-5-iodo-1H-pyrimidine-2,4-dione Drug Info Ki = 9000 nM [533419]
6-(3-Ethyl-phenylamino)-1H-pyrimidine-2,4-dione Drug Info Ki = 2900 nM [533563]
6-(Naphthalen-2-ylamino)-1H-pyrimidine-2,4-dione Drug Info Ki = 6800 nM [533563]
TOPOSTATIN Drug Info IC50 = 17000 nM [526096]
6-(Indan-5-ylamino)-1H-pyrimidine-2,4-dione Drug Info Ki = 420 nM [533563]
6-(3-Bromo-phenylamino)-1H-pyrimidine-2,4-dione Drug Info Ki = 10300 nM [533563]
6-Benzylamino-1H-pyrimidine-2,4-dione Drug Info Ki = 7500 nM [533419]
N*4*-Benzyl-6-chloro-pyrimidine-2,4-diamine Drug Info Ki = 17000 nM [533419]
6-Benzylamino-5-bromo-1H-pyrimidine-2,4-dione Drug Info Ki = 9000 nM [533419]
References
Ref 533563J Med Chem. 1980 Jan;23(1):34-8.Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils.
Ref 533419J Med Chem. 1986 May;29(5):676-81.Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines.
Ref 533563J Med Chem. 1980 Jan;23(1):34-8.Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils.
Ref 533419J Med Chem. 1986 May;29(5):676-81.Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines.
Ref 533419J Med Chem. 1986 May;29(5):676-81.Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines.
Ref 533563J Med Chem. 1980 Jan;23(1):34-8.Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils.
Ref 533563J Med Chem. 1980 Jan;23(1):34-8.Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils.
Ref 526096J Nat Prod. 2001 Feb;64(2):204-7.Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba.
Ref 533563J Med Chem. 1980 Jan;23(1):34-8.Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils.
Ref 533563J Med Chem. 1980 Jan;23(1):34-8.Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils.
Ref 533419J Med Chem. 1986 May;29(5):676-81.Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines.
Ref 533419J Med Chem. 1986 May;29(5):676-81.Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines.
Ref 533419J Med Chem. 1986 May;29(5):676-81.Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines.

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