Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T20474 | ||||
Target Name | DNA topoisomerase | ||||
Target Type | Research |
||||
Drug Potency against Target | 6-(3-Iodo-phenylamino)-1H-pyrimidine-2,4-dione | Drug Info | Ki = 4700 nM | [533563] | |
2-Amino-6-(indan-5-ylamino)-3H-pyrimidin-4-one | Drug Info | Ki = 2000 nM | [533419] | ||
6-p-Tolylamino-1H-pyrimidine-2,4-dione | Drug Info | Ki = 17500 nM | [533563] | ||
5-Bromo-6-p-tolylamino-1H-pyrimidine-2,4-dione | Drug Info | Ki = 14000 nM | [533419] | ||
6-Benzylamino-5-iodo-1H-pyrimidine-2,4-dione | Drug Info | Ki = 9000 nM | [533419] | ||
6-(3-Ethyl-phenylamino)-1H-pyrimidine-2,4-dione | Drug Info | Ki = 2900 nM | [533563] | ||
6-(Naphthalen-2-ylamino)-1H-pyrimidine-2,4-dione | Drug Info | Ki = 6800 nM | [533563] | ||
TOPOSTATIN | Drug Info | IC50 = 17000 nM | [526096] | ||
6-(Indan-5-ylamino)-1H-pyrimidine-2,4-dione | Drug Info | Ki = 420 nM | [533563] | ||
6-(3-Bromo-phenylamino)-1H-pyrimidine-2,4-dione | Drug Info | Ki = 10300 nM | [533563] | ||
6-Benzylamino-1H-pyrimidine-2,4-dione | Drug Info | Ki = 7500 nM | [533419] | ||
N*4*-Benzyl-6-chloro-pyrimidine-2,4-diamine | Drug Info | Ki = 17000 nM | [533419] | ||
6-Benzylamino-5-bromo-1H-pyrimidine-2,4-dione | Drug Info | Ki = 9000 nM | [533419] | ||
References | |||||
Ref 533563 | J Med Chem. 1980 Jan;23(1):34-8.Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. | ||||
Ref 533419 | J Med Chem. 1986 May;29(5):676-81.Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. | ||||
Ref 533563 | J Med Chem. 1980 Jan;23(1):34-8.Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. | ||||
Ref 533419 | J Med Chem. 1986 May;29(5):676-81.Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. | ||||
Ref 533419 | J Med Chem. 1986 May;29(5):676-81.Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. | ||||
Ref 533563 | J Med Chem. 1980 Jan;23(1):34-8.Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. | ||||
Ref 533563 | J Med Chem. 1980 Jan;23(1):34-8.Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. | ||||
Ref 526096 | J Nat Prod. 2001 Feb;64(2):204-7.Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. | ||||
Ref 533563 | J Med Chem. 1980 Jan;23(1):34-8.Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. | ||||
Ref 533563 | J Med Chem. 1980 Jan;23(1):34-8.Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. | ||||
Ref 533419 | J Med Chem. 1986 May;29(5):676-81.Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. | ||||
Ref 533419 | J Med Chem. 1986 May;29(5):676-81.Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. | ||||
Ref 533419 | J Med Chem. 1986 May;29(5):676-81.Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. |
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