| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T35640 | ||||
| Target Name | Lymphocyte function-associated antigen 1 | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | A-286982 | Drug Info | IC50 = 44 nM | [531049] | |
| BMS-587101 | Drug Info | IC50 = 150 nM | [530861] | ||
| References | |||||
| Ref 531049 | Bioorg Med Chem Lett. 2010 Sep 1;20(17):5269-73. Epub 2010 Jul 23.Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists. | ||||
| Ref 530861 | J Med Chem. 2010 May 13;53(9):3814-30.Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521). | ||||
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