| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T72335 | ||||
| Target Name | Lethal factor | ||||
| Target Type | Clinical Trial |
||||
| Drug Potency against Target | N-hydroxy-4-(oleamidomethyl)benzamide | Drug Info | Ki = 6200 nM | [529351] | |
| N,N-Dimethylsphingosine | Drug Info | IC50 = 2300 nM | [528823] | ||
| GF-109203 | Drug Info | IC50 = 1500 nM | [528823] | ||
| N-hydroxy-4-(2-oleamidoethyl)benzamide | Drug Info | Ki = 6000 nM | [528901] | ||
| 3-(2,5-dimethyl-1H-pyrrol-1-yl)benzoic acid | Drug Info | IC50 = 15000 nM | [528374] | ||
| NSC-622445 | Drug Info | Ki = 4900 nM | [528374] | ||
| N-oleoyl-dopamine | Drug Info | Ki = 3000 nM | [528901] | ||
| N-(3,4,5-trihydroxyphenethyl)oleamide | Drug Info | Ki = 1700 nM | [528901] | ||
| N-(3,4-dihydroxybenzyl)oleamide | Drug Info | IC50 = 15000 nM | [529351] | ||
| MMI270 | Drug Info | IC50 = 12000 nM | [527922] | ||
| GNF-PF-600 | Drug Info | IC50 = 3000 nM | [527949] | ||
| References | |||||
| Ref 529351 | Bioorg Med Chem Lett. 2008 Apr 1;18(7):2467-70. Epub 2008 Feb 20.Inhibitors of anthrax lethal factor based upon N-oleoyldopamine. | ||||
| Ref 528823 | Antimicrob Agents Chemother. 2007 Jul;51(7):2403-11. Epub 2007 May 7.Amiodarone and bepridil inhibit anthrax toxin entry into host cells. | ||||
| Ref 528823 | Antimicrob Agents Chemother. 2007 Jul;51(7):2403-11. Epub 2007 May 7.Amiodarone and bepridil inhibit anthrax toxin entry into host cells. | ||||
| Ref 528901 | Bioorg Med Chem Lett. 2007 Aug 15;17(16):4575-8. Epub 2007 Jun 6.Inhibitors of anthrax lethal factor. | ||||
| Ref 528374 | J Med Chem. 2006 Aug 24;49(17):5232-44.Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening. | ||||
| Ref 528374 | J Med Chem. 2006 Aug 24;49(17):5232-44.Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening. | ||||
| Ref 528901 | Bioorg Med Chem Lett. 2007 Aug 15;17(16):4575-8. Epub 2007 Jun 6.Inhibitors of anthrax lethal factor. | ||||
| Ref 528901 | Bioorg Med Chem Lett. 2007 Aug 15;17(16):4575-8. Epub 2007 Jun 6.Inhibitors of anthrax lethal factor. | ||||
| Ref 529351 | Bioorg Med Chem Lett. 2008 Apr 1;18(7):2467-70. Epub 2008 Feb 20.Inhibitors of anthrax lethal factor based upon N-oleoyldopamine. | ||||
| Ref 527922 | Bioorg Med Chem Lett. 2006 Feb 15;16(4):964-8. Epub 2005 Dec 9.The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection. | ||||
| Ref 527949 | J Med Chem. 2006 Jan 12;49(1):27-30.Anthrax lethal factor protease inhibitors: synthesis, SAR, and structure-based 3D QSAR studies. | ||||
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