Target Validation Information
Target ID T72841
Target Name Steroid hormone receptor ERR1
Target Type
Successful
Drug Potency against Target 7-chloro-6H-chromeno[4,3-b]quinoline-3,9-diol Drug Info IC50 = 3.3 nM [528822]
2-(4-Hydroxy-phenyl)-4-vinyl-quinolin-6-ol Drug Info IC50 = 60 nM [528822]
4-Ethyl-2-(4-hydroxy-phenyl)-quinolin-6-ol Drug Info IC50 = 52 nM [528822]
4-Bromo-2-(4-hydroxy-phenyl)-quinolin-6-ol Drug Info IC50 = 4.3 nM [528822]
7-ethyl-6H-chromeno[4,3-b]quinoline-3,9-diol Drug Info IC50 = 46 nM [528822]
4-Ethynyl-2-(4-hydroxy-phenyl)-quinolin-6-ol Drug Info IC50 = 75 nM [528822]
7-bromo-6H-chromeno[4,3-b]quinoline-3,9-diol Drug Info IC50 = 3.6 nM [528822]
7-vinyl-6H-chromeno[4,3-b]quinoline-3,9-diol Drug Info IC50 = 22 nM [528822]
4-Chloro-2-(4-hydroxy-phenyl)-quinolin-6-ol Drug Info IC50 = 4.6 nM [528822]
7-ethynyl-6H-chromeno[4,3-b]quinoline-3,9-diol Drug Info IC50 = 52 nM [528822]
References
Ref 528822Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. Epub 2007 May 4.ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands.
Ref 528822Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. Epub 2007 May 4.ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands.
Ref 528822Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. Epub 2007 May 4.ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands.
Ref 528822Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. Epub 2007 May 4.ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands.
Ref 528822Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. Epub 2007 May 4.ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands.
Ref 528822Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. Epub 2007 May 4.ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands.
Ref 528822Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. Epub 2007 May 4.ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands.
Ref 528822Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. Epub 2007 May 4.ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands.
Ref 528822Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. Epub 2007 May 4.ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands.
Ref 528822Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. Epub 2007 May 4.ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands.

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