| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T51843 | ||||
| Target Name | RNA-dependentRNA polymerase | ||||
| Target Type | Discontinued |
||||
| Drug Potency against Target | T-705 | Drug Info | IC50 = 140 nM | [552499] | |
| Action against Disease Model | T-705 | T-705 showed IC50 values of less than 0.5 |?g/ml in virus yield assays in MDCK cells against all three influenza virus types (A, B, C) with no signs of cytotoxicity. | [552292] | Drug Info | |
| The Effect of Target Knockout, Knockdown or Genetic Variations | RNA-dependent RNA polymerases (RdRPs) have been implicated in posttranscriptional gene silencing (PTGS) and antiviral defense.The knockout mutant acc uMulated higher and more persistent levels of viral RNAs in both the lower, inoculated and in upper, systemically infected leaves than did wild-type plants. These results suggest that the inducible AtRdRP1 is the Arabidopsis ortholog of NtRdRP1 and plays a role in antiviral defense. | [552292] | |||
| References | |||||
| Ref 552292 | In vitro and in vivo activities of anti-influenza virus compound T-705. Antimicrob Agents Chemother. 2002 Apr;46(4):977-81. | ||||
| Ref 552499 | Mechanism of action of T-705 against influenza virus. Antimicrob Agents Chemother. 2005 Mar;49(3):981-6. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.