Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T54644 | ||||
Target Name | Voltage-dependent T-type calcium channel subunit alpha-1H | ||||
Target Type | Successful |
||||
Drug Potency against Target | U-92032 | Drug Info | IC50 = 300 nM | [525864] | |
References | |||||
Ref 525864 | J Med Chem. 2000 Sep 7;43(18):3372-6.Discovery of (2S)-1-(4-amino-2,3,5- trimethylphenoxy)-3-[4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl]-2-propanol dimethanesulfonate (SUN N8075): a dual Na(+) and Ca(2+) channel blocker with antioxidant activity. |
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