Target Validation Information
Target ID T30081
Target Name Thymidine kinase
Target Type
Successful
Drug Potency against Target 1-[2-(2-triphenylmethoxyethoxy)ethyl]thymine Drug Info IC50 = 9700 nM [528583]
1-[6-(triphenylmethoxy)hexyl]thymine Drug Info IC50 = 500 nM [528583]
L-5-iodo-2'-deoxyuridine Drug Info IC50 = 2000 nM [528791]
5-propyl-2'-deoxyuridine Drug Info IC50 = 4200 nM [528791]
3'-(1,2,3-Triazol-1-yl)-3'-deoxy-beta-D-thymidine Drug Info IC50 = 4700 nM [530778]
N2-(3-trifluoromethylphenyl)guanine Drug Info IC50 = 3500 nM [528791]
1-[5-(triphenylmethoxy)pentyl]thymine Drug Info IC50 = 2500 nM [528583]
1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine Drug Info Ki = 500 nM [528583]
2-phenylamino-9-(4-hydroxy-butyl)-6-oxopurine Drug Info IC50 = 11500 nM [528791]
Edoxudine Drug Info IC50 = 150 nM [528791]
L-5-(bromovinyl)deoxyuridine Drug Info IC50 = 15000 nM [528791]
1-[7-(triphenylmethoxy)heptyl]thymine Drug Info IC50 = 4700 nM [528583]
References
Ref 528583J Med Chem. 2006 Dec 28;49(26):7766-73.N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.
Ref 528583J Med Chem. 2006 Dec 28;49(26):7766-73.N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.
Ref 528791Antimicrob Agents Chemother. 2007 Jun;51(6):2028-34. Epub 2007 Apr 16.Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
Ref 528791Antimicrob Agents Chemother. 2007 Jun;51(6):2028-34. Epub 2007 Apr 16.Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
Ref 530778J Med Chem. 2010 Apr 8;53(7):2902-12.3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase.
Ref 528791Antimicrob Agents Chemother. 2007 Jun;51(6):2028-34. Epub 2007 Apr 16.Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
Ref 528583J Med Chem. 2006 Dec 28;49(26):7766-73.N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.
Ref 528583J Med Chem. 2006 Dec 28;49(26):7766-73.N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.
Ref 528791Antimicrob Agents Chemother. 2007 Jun;51(6):2028-34. Epub 2007 Apr 16.Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
Ref 528791Antimicrob Agents Chemother. 2007 Jun;51(6):2028-34. Epub 2007 Apr 16.Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
Ref 528791Antimicrob Agents Chemother. 2007 Jun;51(6):2028-34. Epub 2007 Apr 16.Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
Ref 528583J Med Chem. 2006 Dec 28;49(26):7766-73.N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.

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