Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T25258 | ||||
Target Name | Multidrug resistance protein 1 | ||||
Target Type | Successful |
||||
Drug Potency against Target | ELACRIDAR | Drug Info | IC50 = 2000 nM | [529846] | |
XR-9504 | Drug Info | IC50 = 260 nM | [529220] | ||
[1,1':2',1'']-terphenyl-4,3'',5''-triol | Drug Info | IC50 = 12000 nM | [528198] | ||
TRISMETHOXYRESVERATROL | Drug Info | IC50 = 8000 nM | [528198] | ||
4,3'',5''-trimethoxy-[1,1':2',1'']-terphenyl | Drug Info | IC50 = 16000 nM | [528198] | ||
XR-9544 | Drug Info | IC50 = 50 nM | [529220] | ||
XR-9577 | Drug Info | IC50 = 320 nM | [529220] | ||
6-(3,5-dimethoxy-phenyl)-naphthalen-2-ol | Drug Info | IC50 = 16000 nM | [528198] | ||
XR-9456 | Drug Info | IC50 = 300 nM | [529220] | ||
References | |||||
Ref 529846 | J Med Chem. 2008 Dec 11;51(23):7602-13.2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties. | ||||
Ref 529220 | Bioorg Med Chem. 2008 Mar 1;16(5):2448-62. Epub 2007 Nov 28.Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. | ||||
Ref 528198 | J Med Chem. 2006 May 18;49(10):3012-8.Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. | ||||
Ref 528198 | J Med Chem. 2006 May 18;49(10):3012-8.Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. | ||||
Ref 528198 | J Med Chem. 2006 May 18;49(10):3012-8.Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. | ||||
Ref 529220 | Bioorg Med Chem. 2008 Mar 1;16(5):2448-62. Epub 2007 Nov 28.Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. | ||||
Ref 529220 | Bioorg Med Chem. 2008 Mar 1;16(5):2448-62. Epub 2007 Nov 28.Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. | ||||
Ref 528198 | J Med Chem. 2006 May 18;49(10):3012-8.Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. | ||||
Ref 529220 | Bioorg Med Chem. 2008 Mar 1;16(5):2448-62. Epub 2007 Nov 28.Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. |
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