Target Validation Information
Target ID T85435
Target Name Insulin receptor
Target Type
Successful
Drug Potency against Target 4-((1H-indazol-6-ylamino)methyl)benzene-1,2-diol Drug Info IC50 = 2250 nM [528746]
4-((naphthalen-2-ylamino)methyl)benzene-1,2-diol Drug Info IC50 = 5150 nM [528746]
Insulin-detemir Drug Info Afinity = 5 nM [552749]
NVP-TAE684 Drug Info IC50 = 1200 nM [528588]
NVP-AEW541 Drug Info IC50 = 140 nM [530263]
References
Ref 528746Eur J Pharmacol. 2007 May 7;562(1-2):1-11. Epub 2007 Feb 3.ATP non-competitive IGF-1 receptor kinase inhibitors as lead anti-neoplastic and anti-papilloma agents.
Ref 528746Eur J Pharmacol. 2007 May 7;562(1-2):1-11. Epub 2007 Feb 3.ATP non-competitive IGF-1 receptor kinase inhibitors as lead anti-neoplastic and anti-papilloma agents.
Ref 552749NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs. Curr Top Med Chem. 2007;7(17):1721-33.
Ref 528588Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):270-5. Epub 2006 Dec 21.Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK.
Ref 530263J Med Chem. 2009 Aug 27;52(16):4981-5004.Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach.

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