Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T66719 | ||||
Target Name | Heat shock protein HSP90 | ||||
Target Type | Clinical Trial |
||||
Drug Potency against Target | SNX-2112 | Drug Info | IC50 = 22 nM | [530621] | |
Geldanamycin | Drug Info | IC50 = 281 nM | [552578] | ||
ZEARALANONE | Drug Info | IC50 = 2197.6 nM | [531262] | ||
RHEIN | Drug Info | IC50 = 3339.3 nM | [531262] | ||
17-desmethoxy-17-aminogeldanamycin | Drug Info | IC50 = 12 nM | [530621] | ||
GNF-PF-67 | Drug Info | IC50 < 1875 nM | [531262] | ||
17-allylamino-17-desmethoxy-geldanamycin | Drug Info | IC50 = 15 nM | [529815] | ||
CCT-018159 | Drug Info | IC50 = 3000 nM | [552620] | ||
VER-49009 | Drug Info | IC50 = 140 nM | [527601] | ||
References | |||||
Ref 530621 | J Med Chem. 2010 Jan 14;53(1):3-17.Heat shock protein 90: inhibitors in clinical trials. | ||||
Ref 552578 | A fluorescence polarization assay for inhibitors of Hsp90. Anal Biochem. 2006 Mar 15;350(2):202-13. Epub 2006 Jan 23. | ||||
Ref 531262 | Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). | ||||
Ref 531262 | Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). | ||||
Ref 530621 | J Med Chem. 2010 Jan 14;53(1):3-17.Heat shock protein 90: inhibitors in clinical trials. | ||||
Ref 531262 | Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). | ||||
Ref 529815 | Bioorg Med Chem. 2009 Mar 15;17(6):2225-35. Epub 2008 Nov 6.Discovery and development of heat shock protein 90 inhibitors. | ||||
Ref 552620 | Discovery and development of pyrazole-scaffold Hsp90 inhibitors. Curr Top Med Chem. 2006;6(11):1193-203. | ||||
Ref 527601 | J Med Chem. 2005 Jun 30;48(13):4212-5.Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design. |
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