| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T22839 | ||||
| Target Name | Elastase 1 | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | Acetyl-Pro-Ala-Pro-Ala-trifluoro methane | Drug Info | Ki = 240 nM | [532036] | |
| MOLASSAMIDE | Drug Info | IC50 = 32 nM | [530586] | ||
| Acetyl-Ala-Ala-Pro-Ala-trifluromethane | Drug Info | Ki = 150 nM | [532036] | ||
| GRASSYSTATIN A | Drug Info | IC50 = 10000 nM | [530345] | ||
| References | |||||
| Ref 532036 | J Med Chem. 1990 Jan;33(1):394-407.Synthesis of peptidyl fluoromethyl ketones and peptidyl alpha-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and humanneutrophil cathepsin G. | ||||
| Ref 530586 | J Nat Prod. 2010 Mar 26;73(3):459-62.Molassamide, a depsipeptide serine protease inhibitor from the marine cyanobacterium Dichothrix utahensis. | ||||
| Ref 532036 | J Med Chem. 1990 Jan;33(1):394-407.Synthesis of peptidyl fluoromethyl ketones and peptidyl alpha-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and humanneutrophil cathepsin G. | ||||
| Ref 530345 | J Med Chem. 2009 Sep 24;52(18):5732-47.Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. | ||||
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