| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T27325 | ||||
| Target Name | DNA topoisomerase I | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | 4-hydroxysaprothoquinone | Drug Info | IC50 = 800 nM | [526391] | |
| CHO793076 | Drug Info | IC50 = 2300 nM | [529993] | ||
| (5Z,9Z)-5,9-heptacosadienoic acid | Drug Info | IC50 = 900 nM | [526463] | ||
| TOPOSTATIN | Drug Info | IC50 = 17000 nM | [526096] | ||
| Topotecan | Drug Info | IC50 = 300 nM | |||
| References | |||||
| Ref 526391 | J Nat Prod. 2002 Jul;65(7):1016-20.Bioactive abietane and seco-abietane diterpenoids from Salvia prionitis. | ||||
| Ref 529993 | Bioorg Med Chem Lett. 2009 Apr 1;19(7):2018-21. Epub 2009 Feb 12.Synthesis of new camptothecin analogs with improved antitumor activities. | ||||
| Ref 526463 | J Nat Prod. 2002 Nov;65(11):1715-8.Total synthesis and biological evaluation of (5Z,9Z)-5,9-hexadecadienoic acid, an inhibitor of human topoisomerase I. | ||||
| Ref 526096 | J Nat Prod. 2001 Feb;64(2):204-7.Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. | ||||
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