| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T45993 | ||||
| Target Name | Calcium channel | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | Nisoldipine | Drug Info | IC50 = 80 nM | [552383] | |
| Felodipine | Drug Info | IC50 = 1.45 nM | [553239] | ||
| Nicardipine | Drug Info | Ki = 280 nM | [552597] | ||
| Nimodipine | Drug Info | IC50 = 14.9 nM | [553239] | ||
| References | |||||
| Ref 552383 | Block of cardiac delayed-rectifier and inward-rectifier K+ currents by nisoldipine. Br J Pharmacol. 2003 Nov;140(5):863-70. Epub 2003 Oct 6. | ||||
| Ref 553239 | Synthesis, biological evaluation, calcium channel antagonist activity, and anticonvulsant activity of felodipine coupled to a dihydropyridine-pyridinium salt redox chemical delivery system. J Med Chem. 1996 Nov 8;39(23):4576-82. | ||||
| Ref 552597 | Development and validation of an in silico P450 profiler based on pharmacophore models. Curr Drug Discov Technol. 2006 Mar;3(1):1-48. | ||||
| Ref 553239 | Synthesis, biological evaluation, calcium channel antagonist activity, and anticonvulsant activity of felodipine coupled to a dihydropyridine-pyridinium salt redox chemical delivery system. J Med Chem. 1996 Nov 8;39(23):4576-82. | ||||
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