| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T81183 | ||||
| Target Name | Alpha-1 adrenergic receptor | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | Tamsulosin | Drug Info | pKi = 9.13 | [553282] | |
| Prazosin | Drug Info | pKi = 6.11 | [552671] | ||
| Carvedilol | Drug Info | Ki = 0.4 nM | [552672] | ||
| Action against Disease Model | Tamsulosin | IC50 on tension responses to electrical field stimulation (0.3 ms duration, 80 V and 20 Hz) in h uMan hyperplastic prostate: 0.193nM | [553235] | Drug Info | |
| References | |||||
| Ref 553282 | Tamsulosin: assessment of affinity of 3H-prazosin bindings to two alpha1-adrenoceptor subtypes (alpha1H and alpha1L) in bovine prostate and rat heart and brain. Gen Pharmacol. 1998 Oct;31(4):597-600. | ||||
| Ref 552671 | Agonists and antagonists targeting the different alpha2-adrenoceptor subtypes. Curr Top Med Chem. 2007;7(2):163-86. | ||||
| Ref 552672 | Recent advances in identification and characterization of beta-adrenoceptor agonists and antagonists. Curr Top Med Chem. 2007;7(2):207-16. | ||||
| Ref 553235 | Inhibition by tamsulosin of tension responses of human hyperplastic prostate to electrical field stimulation. Eur J Pharmacol. 1996 Jun 3;305(1-3):177-80. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.