Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0L7LC
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| Former ID |
DCL000317
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| Drug Name |
Romidepsin
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| Synonyms |
Chromadax; Istodax; Antibiotic FR 901228; FK 228; FK228; FR 901228; FR901228; HDInhib_000006; Chromadax (TN); FK-228; FK-901228; FR-901228; Istodax (TN); Romidepsin (USAN); Cyclo((2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl), cyclic (35)-disulfide; L-Valine, N-((3S,4E)-3-hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoxyl-, (4-1)-lactone, cyclic (1-2)-disulfide; (1S,4S,7Z,10S,16E,21R)-7-Ethylidene-4,21-bis(1-methylethyl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo(8.7.6)tricos-16-ene-3,6,9,19,22-pentone; (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone; (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
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| Drug Type |
Small molecular drug
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| Indication | Cutaneous T-cell lymphoma [ICD-11: 2B01; ICD-10: C84.8; ICD-9: 202.1, 202.2] | Approved | [1], [2] | |
| Peripheral T-cell lymphoma [ICD-11: 2A90.C; ICD-10: C84.4; ICD-9: 202.7] | Phase 3 | [3] | ||
| Renal cell carcinoma [ICD-11: 2C90; ICD-10: C64] | Phase 3 | [1], [2] | ||
| Company |
Gloucester Pharmaceuticals; Fujisawa Pharmaceutical Ltd.
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| Structure |
 |
Download2D MOL |
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| Formula |
C24H36N4O6S2
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| Canonical SMILES |
CC=C1C(=O)NC(C(=O)OC2CC(=O)NC(C(=O)NC(CSSCCC=C2)C(=O)N1)C(C)C)C(C)C
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| InChI |
1S/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H3,(H,25,31)(H,26,32)(H,27,29)(H,28,30)/b9-7+,16-6-/t15-,17-,19-,20+/m1/s1
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| InChIKey |
OHRURASPPZQGQM-GCCNXGTGSA-N
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| CAS Number |
CAS 128517-07-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
494874, 8139716, 11650994, 12014448, 14763476, 14763478, 35018633, 46519185, 47208288, 47721651, 47944836, 48394948, 50062237, 50260193, 53788098, 57361456, 87226502, 103393180, 104222481, 113905898, 127325932, 127325933, 131408687, 134338801, 134338973, 134340279, 137156420, 139110210, 152159610, 163620827, 163686155, 164233439, 175266198, 176484649, 178103585, 184816960, 198992824, 224274473, 226087966, 226972555, 251894761, 252430794, 252450287, 252473284
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| ChEBI ID |
CHEBI:61080
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| ADReCS Drug ID | BADD_D01964 | |||
| SuperDrug ATC ID |
L01XX39
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7006). | |||
| REF 2 | Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. | |||
| REF 3 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
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