Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04JMI
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| Former ID |
DIB000973
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| Drug Name |
Plasma derived human butyrylcholinesterase
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| Synonyms |
Plasma derived human butyrylcholinesterase (im, drug induced neurotoxicity); HuBChE (im, drug induced neurotoxicity), Dynport; Bioscavenger (im, drug induced neurotoxicity), Dynport/Baxter; Plasma derived human butyrylcholinesterase (im, drug induced neurotoxicity), Dynport/Baxter
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| Indication | Neurotoxicity [ICD-11: NE61] | Phase 1 | [1] | |
| Company |
DynPort Vaccine Company LLC
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cholinesterase (BCHE) | Target Info | Modulator | [2] |
| Panther Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | ||||
| Nicotinic acetylcholine receptor signaling pathway | ||||
| WikiPathways | Irinotecan Pathway | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00333528) A Study of Plasma-Derived Human Butyrylcholinesterase Administered Intramuscularly. U.S. National Institutes of Health. | |||
| REF 2 | Acetylcholinesterase-Fc Fusion Protein (AChE-Fc): A Novel Potential Organophosphate Bioscavenger with Extended Plasma Half-Life. Bioconjug Chem. 2015 Aug 19;26(8):1753-8. | |||
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