Target Information
Target General Information | Top | |||||
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Target ID |
T99799
(Former ID: TTDS00143)
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Target Name |
Cholinesterase (BCHE)
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Synonyms |
Pseudocholinesterase; Choline esterase II; CHE1; Butyrylcholine esterase; Acylcholine acylhydrolase
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Gene Name |
BCHE
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Target Type |
Successful target
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[1] | ||||
Disease | [+] 2 Target-related Diseases | + | ||||
1 | Pain [ICD-11: MG30-MG3Z] | |||||
2 | Tonus and reflex abnormality [ICD-11: MB47] | |||||
Function |
Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
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BioChemical Class |
Type-B carboxylesterase/lipase
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UniProt ID | ||||||
EC Number |
EC 3.1.1.8
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Sequence |
MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDC LYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG FLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPG SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEI LLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVY GAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDV VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMT KLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCV GL Click to Show/Hide
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3D Structure | Click to Show 3D Structure of This Target | PDB |
Drugs and Modes of Action | Top | |||||
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Approved Drug(s) | [+] 2 Approved Drugs | + | ||||
1 | Hexafluronium bromide | Drug Info | Approved | Spasm | [2], [3] | |
2 | MEPTAZINOL | Drug Info | Approved | Pain | [2] | |
Clinical Trial Drug(s) | [+] 6 Clinical Trial Drugs | + | ||||
1 | (-)-Phenserine | Drug Info | Phase 3 | Alzheimer disease | [4] | |
2 | Eptastigmine | Drug Info | Phase 3 | Cognitive impairment | [5] | |
3 | JES-9501 | Drug Info | Phase 1 | Alzheimer disease | [6] | |
4 | Plasma derived human butyrylcholinesterase | Drug Info | Phase 1 | Neurotoxicity | [7] | |
5 | Protexia | Drug Info | Phase 1 | Alzheimer disease | [8] | |
6 | RVT-103+RVT-104 | Drug Info | Phase 1 | Alzheimer disease | [9] | |
Mode of Action | [+] 3 Modes of Action | + | ||||
Inhibitor | [+] 233 Inhibitor drugs | + | ||||
1 | Hexafluronium bromide | Drug Info | [1] | |||
2 | MEPTAZINOL | Drug Info | [10] | |||
3 | (-)-Phenserine | Drug Info | [11] | |||
4 | Eptastigmine | Drug Info | [12] | |||
5 | RVT-103+RVT-104 | Drug Info | [9] | |||
6 | Decyle nelycorine dibromo salt derivative 1 | Drug Info | [15] | |||
7 | Di-substituted piperidine derivative 1 | Drug Info | [15] | |||
8 | Di-substituted piperidine derivative 2 | Drug Info | [15] | |||
9 | Di-substituted piperidine derivative 3 | Drug Info | [15] | |||
10 | Egonol compound 1 | Drug Info | [16] | |||
11 | Indoline derivative 1 | Drug Info | [15] | |||
12 | Isochroman-4-ketone derivative 1 | Drug Info | [15] | |||
13 | PMID29757691-Compound-10 | Drug Info | [15] | |||
14 | PMID29757691-Compound-2a | Drug Info | [15] | |||
15 | PMID29757691-Compound-2a-i | Drug Info | [15] | |||
16 | PMID29757691-Compound-7 | Drug Info | [15] | |||
17 | PMID29757691-Compound-8a | Drug Info | [15] | |||
18 | PMID29757691-Compound-8b | Drug Info | [15] | |||
19 | PMID29757691-Compound-8c | Drug Info | [15] | |||
20 | PMID29757691-Compound-8d | Drug Info | [15] | |||
21 | Quinazoline alkaloid derivative 1 | Drug Info | [15] | |||
22 | Tacrine heterodimer derivative 1 | Drug Info | [15] | |||
23 | Tetra-hydro-isoquinoline derivative 1 | Drug Info | [15] | |||
24 | Tetra-hydro-isoquinoline derivative 2 | Drug Info | [15] | |||
25 | Tetra-hydro-isoquinoline derivative 3 | Drug Info | [15] | |||
26 | Tetra-hydro-isoquinoline derivative 4 | Drug Info | [15] | |||
27 | (-)-DEBROMOFLUSTRAMINE B | Drug Info | [17] | |||
28 | (-)-Phenethylcymserine | Drug Info | [11] | |||
29 | (-)-Tolserine | Drug Info | [11] | |||
30 | (1'H-Phenothiazin-1'-yl)(piperidin-1-yl)methanone | Drug Info | [18] | |||
31 | (10H-phenothiazin-10-yl)(m-tolyl)methanone | Drug Info | [19] | |||
32 | (10H-phenothiazin-10-yl)(o-tolyl)methanone | Drug Info | [19] | |||
33 | (10H-phenothiazin-10-yl)(p-tolyl)methanone | Drug Info | [19] | |||
34 | (10H-phenothiazin-10-yl)(phenyl)methanone | Drug Info | [19] | |||
35 | (1R)-MENTHYL HEXYL PHOSPHONATE GROUP | Drug Info | [20] | |||
36 | (1S)-MENTHYL HEXYL PHOSPHONATE GROUP | Drug Info | [20] | |||
37 | (24S)-ethylcholesta-7,9(11),22(E)-triene-3b-ol | Drug Info | [21] | |||
38 | (3-bromophenyl)(10H-phenothiazin-10-yl)methanone | Drug Info | [19] | |||
39 | (4-bromophenyl)(10H-phenothiazin-10-yl)methanone | Drug Info | [19] | |||
40 | (4-nitrophenyl)(10H-phenothiazin-10-yl)methanone | Drug Info | [19] | |||
41 | (RS)-tacrine(10)-hupyridone | Drug Info | [22] | |||
42 | 1,10-bis(pyridinium)-decane dibromide | Drug Info | [23] | |||
43 | 1,11-bis(pyridinium)-undecane dibromide | Drug Info | [23] | |||
44 | 1,2-bis(2,3-fluorophenyl)ethane-1,2-dione | Drug Info | [24] | |||
45 | 1,2-di(10H-phenothiazin-10-yl)ethane-1,2-dione | Drug Info | [19] | |||
46 | 1,2-Di(berberine-9-O-yl)ethane dibromide | Drug Info | [25] | |||
47 | 1,2-indanedione | Drug Info | [26] | |||
48 | 1,2-NAPHTHOQUINONE | Drug Info | [26] | |||
49 | 1,3-Di(berberine-9-O-yl)ethane dibromide | Drug Info | [25] | |||
50 | 1,4-Di(berberine-9-O-yl)ethane dibromide | Drug Info | [25] | |||
51 | 1,9-bis(pyridinium)-nonane dibromide | Drug Info | [23] | |||
52 | 1-(10H-phenothiazin-10-yl)-2-phenylbutan-1-one | Drug Info | [19] | |||
53 | 1-(10H-phenothiazin-10-yl)-2-phenylethanone | Drug Info | [19] | |||
54 | 1-(10H-phenothiazin-10-yl)-2-phenylpropan-1-one | Drug Info | [19] | |||
55 | 1-(10H-phenothiazin-10-yl)-3-phenylbutan-1-one | Drug Info | [19] | |||
56 | 1-(10H-phenothiazin-10-yl)-3-phenylpropan-1-one | Drug Info | [19] | |||
57 | 1-(10H-phenothiazin-10-yl)-4-phenylbutan-1-one | Drug Info | [19] | |||
58 | 1-(3,4-dichlorobenzyl)-1H-indole-2,3-dione | Drug Info | [27] | |||
59 | 1-methyl-3-(phenylcarbamoyloxy)pyridinium bromide | Drug Info | [11] | |||
60 | 2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-imine | Drug Info | [28] | |||
61 | 2-(N-Morpholino)-Ethanesulfonic Acid | Drug Info | [29] | |||
62 | 2-biphenyl-4-yl-1-phenothiazin-10-yl-ethanone | Drug Info | [19] | |||
63 | 2-methoxyphenyl 10H-phenothiazine-10-carboxylate | Drug Info | [30] | |||
64 | 2-Methyl-beta-carboline-2-ium iodide | Drug Info | [31] | |||
65 | 2-Propyl-beta-carboline-2-ium iodide | Drug Info | [31] | |||
66 | 24-ethyl-cholest-7-ene-3,5,6-triol | Drug Info | [21] | |||
67 | 24-ethylcholest-6-ene-3,5-diol | Drug Info | [21] | |||
68 | 3,4,5,6-Tetrachloro-[1,2]benzoquinone | Drug Info | [32] | |||
69 | 3-(2-Diethylamino-acetamino)-rutaecarpine | Drug Info | [33] | |||
70 | 3-(2-Diethylamino-propionamino)-rutaecarpine | Drug Info | [33] | |||
71 | 3-(2-N-Piperidyl-propionamino)-rutaecarpine | Drug Info | [33] | |||
72 | 3-(2-N-Pyrrolyl-acetamino)-rutaecarpine | Drug Info | [33] | |||
73 | 3-(2-N-Pyrrolyl-propionamino)-rutaecarpine | Drug Info | [33] | |||
74 | 3-(dimethylamino)phenyl phenylcarbamate | Drug Info | [11] | |||
75 | 3-chlorophenyl 10H-phenothiazine-10-carboxylate | Drug Info | [30] | |||
76 | 3-isopr-sal-cyclosal-d4TMP | Drug Info | [34] | |||
77 | 3-methoxyphenyl 10H-phenothiazine-10-carboxylate | Drug Info | [30] | |||
78 | 3-phenyl-cyclosal-d4TMP | Drug Info | [34] | |||
79 | 3-sal-cyclosal-d4TMP | Drug Info | [34] | |||
80 | 3-[10-(benzylmethylamino)decyloxy]xanthen-9-one | Drug Info | [35] | |||
81 | 3-[11-(benzylmethylamino)undecyloxy]xanthen-9-one | Drug Info | [35] | |||
82 | 3-[12-(benzylmethylamino)dodecyloxy]xanthen-9-one | Drug Info | [35] | |||
83 | 3-[3-(benzylmethylamino)propoxy]xanthen-9-one | Drug Info | [35] | |||
84 | 3-[4-(benzylmethylamino)butoxy]xanthen-9-one | Drug Info | [35] | |||
85 | 3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one | Drug Info | [35] | |||
86 | 3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one | Drug Info | [35] | |||
87 | 3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one | Drug Info | [35] | |||
88 | 3-[8-(benzylmethylamino)octyloxy]xanthen-9-one | Drug Info | [35] | |||
89 | 3-[9-(benzylmethylamino)nonyloxy]xanthen-9-one | Drug Info | [35] | |||
90 | 4-chlorophenyl 10H-phenothiazine-10-carboxylate | Drug Info | [30] | |||
91 | 4-ISOPROPYLPHENSERINE | Drug Info | [36], [37] | |||
92 | 4-methoxyphenyl 10H-phenothiazine-10-carboxylate | Drug Info | [30] | |||
93 | 4-[4-(benzyloxy)piperidino]butyl benzoate | Drug Info | [38] | |||
94 | 4-[4-(benzyloxy)piperidino]butyl-3-chlorobenzoate | Drug Info | [38] | |||
95 | 4-[4-(benzyloxy)piperidino]butyl-3-fluorobenzoate | Drug Info | [38] | |||
96 | 4-[4-(benzyloxy)piperidino]butyl-4-chlorobenzoate | Drug Info | [38] | |||
97 | 4-[4-(benzyloxy)piperidino]butyl-4-fluorobenzoate | Drug Info | [38] | |||
98 | 4-[4-(benzyloxy)piperidino]butyl-4-nitrobenzoate | Drug Info | [38] | |||
99 | 5,6-dinitroacenaphthoquinone | Drug Info | [26] | |||
100 | 5-methyl-cyclosal-d4TMP | Drug Info | [34] | |||
101 | 6-chlorotacrine hydrochloride | Drug Info | [39] | |||
102 | 6-hydroxy-1,2,9-trimethyl-9H-beta-carbolin-2-ium | Drug Info | [40] | |||
103 | 6-hydroxy-1,2-dimethyl-9H-beta-carbolin-2-ium | Drug Info | [40] | |||
104 | 6-hydroxy-2-methyl-9H-beta-carbolin-2-ium | Drug Info | [40] | |||
105 | 6-methoxy-1,2-dimethyl-9H-beta-carbolin-2-ium | Drug Info | [40] | |||
106 | 6-methoxy-1,9-dimethyl-9H-pyrido[3,4-b]indole | Drug Info | [40] | |||
107 | 6-methoxy-2-methyl-9H-beta-carbolin-2-ium | Drug Info | [40] | |||
108 | 7-Oxo-7H-dibenzo[de,g]quinoline | Drug Info | [41] | |||
109 | 9-(3-IODOBENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDINE | Drug Info | [20] | |||
110 | 9-Ethyl-2-methyl-beta-carboline-2-ium iodide | Drug Info | [31] | |||
111 | 9-N-Phenylmethylamino-Tacrine | Drug Info | [29] | |||
112 | 9-O-[2-(Phenylol-1-yloxy)ethyl]berberine bromide | Drug Info | [42] | |||
113 | 9-O-[2-(Phenylol-1-yloxy)hexyl]berberine bromide | Drug Info | [42] | |||
114 | 9-O-[3-(2-Pyridinoxyl)butyl]-berberine bromide | Drug Info | [25] | |||
115 | 9-O-[3-(4-Bromo-phenoxyl)butyl]-berberine bromide | Drug Info | [25] | |||
116 | 9-O-[3-(4-Nitro-phenoxyl)butyl]-berberine bromide | Drug Info | [25] | |||
117 | 9-O-[3-(Phenylamino)propyl]-berberine bromide | Drug Info | [25] | |||
118 | 9-O-[3-(Phenylol-1-yloxy)propyl]berberine bromide | Drug Info | [42] | |||
119 | 9-O-[4-(Phenylol-1-yloxy)butyl]berberine bromide | Drug Info | [42] | |||
120 | 9-O-[5-(Phenylol-1-yloxy)pentyl]berberine bromide | Drug Info | [42] | |||
121 | 9-[5-(beta-Carboline-9-yl)pentyl]-beta-carboline | Drug Info | [31] | |||
122 | 9-[9-(beta-Carboline-9-yl)nonyl]-beta-carboline | Drug Info | [31] | |||
123 | ACENAPHTHOQUINONE | Drug Info | [26] | |||
124 | Alpha-D-Mannose | Drug Info | [29] | |||
125 | Anthracen-10-yl(10H-phenothiazin-10-yl)methanone | Drug Info | [19] | |||
126 | AS-1397 | Drug Info | [43] | |||
127 | BENZOQUINONE | Drug Info | [32] | |||
128 | Beta-D-Mannose | Drug Info | [29] | |||
129 | Bis-7-tacrine | Drug Info | [44] | |||
130 | Bis-cyclosal-d4TMP | Drug Info | [34] | |||
131 | Butanoic Acid | Drug Info | [29] | |||
132 | Butyl 10H-phenothiazine-10-carboxylate | Drug Info | [30] | |||
133 | Butyrylthiocholine | Drug Info | [45] | |||
134 | CAPROCTAMINE | Drug Info | [46] | |||
135 | CHF-2819 | Drug Info | [47] | |||
136 | CHLORANIL | Drug Info | [32] | |||
137 | Cyclopentyl 10H-phenothiazine-10-carboxylate | Drug Info | [30] | |||
138 | Cyclosal-d4TMP | Drug Info | [34] | |||
139 | DEMETHYLDEBROMOFLUSTRAMINE B | Drug Info | [17] | |||
140 | Diethylphosphono Group | Drug Info | [29] | |||
141 | Dodecanesulfonate ion | Drug Info | [20] | |||
142 | Ethyl Dihydrogen Phosphate | Drug Info | [29] | |||
143 | ETHYL HYDROGEN DIETHYLAMIDOPHOSPHATE | Drug Info | [20] | |||
144 | Fucose | Drug Info | [29] | |||
145 | HALOXYSTEROL A | Drug Info | [21] | |||
146 | HALOXYSTEROL B | Drug Info | [21] | |||
147 | Haloxysterol C | Drug Info | [21] | |||
148 | Haloxysterol D | Drug Info | [21] | |||
149 | Huprine X | Drug Info | [48] | |||
150 | Huprine-Tacrine Heterodimer | Drug Info | [49] | |||
151 | Iso-OMPA | Drug Info | [50] | |||
152 | Isopropyl 10H-phenothiazine-10-carboxylate | Drug Info | [30] | |||
153 | Isosorbide-2-(benzylcarbamate)-5-benzoate | Drug Info | [50] | |||
154 | Isosorbide-2-(benzylcarbamate)-5-mononitrate | Drug Info | [50] | |||
155 | Isosorbide-2-(butylcarbamate)-5-benzoate | Drug Info | [50] | |||
156 | Isosorbide-2-(butylcarbamate)-5-mononitrate | Drug Info | [50] | |||
157 | Isosorbide-2-(cyclohexylcarbamate)-5-mononitrate | Drug Info | [50] | |||
158 | Isosorbide-2-(ethylcarbamate)-5-mononitrate | Drug Info | [50] | |||
159 | Isosorbide-2-(methylcarbamate)-5-benzoate | Drug Info | [50] | |||
160 | Isosorbide-2-(methylcarbamate)-5-mononitrate | Drug Info | [50] | |||
161 | Isosorbide-2-(propylcarbamate)-5-mononitrate | Drug Info | [50] | |||
162 | Isosorbide-2-benzyl carbamate | Drug Info | [51] | |||
163 | Isosorbide-2-benzylcarbamate-5-(o-toluate) | Drug Info | [51] | |||
164 | Isosorbide-2-benzylcarbamate-5-acetate | Drug Info | [50] | |||
165 | Isosorbide-2-benzylcarbamate-5-cyclopentanoate | Drug Info | [50] | |||
166 | Isosorbide-2-benzylcarbamate-5-cyclopropanoate | Drug Info | [50] | |||
167 | Isosorbide-2-benzylcarbamate-5-isonicotinate | Drug Info | [50] | |||
168 | Isosorbide-2-benzylcarbamate-5-nicotinate | Drug Info | [50] | |||
169 | Isosorbide-2-benzylcarbamate-5-pentanoate | Drug Info | [50] | |||
170 | Isosorbide-2-benzylcarbamate-5-propionate | Drug Info | [50] | |||
171 | Isosorbide-2-benzylcarbamate-5-triflate | Drug Info | [50] | |||
172 | Isosorbide-di-(benzylcarbamate) | Drug Info | [52] | |||
173 | Isosorbide-di-(butylcarbamate) | Drug Info | [52] | |||
174 | Isosorbide-di-(ethylcarbamate) | Drug Info | [52] | |||
175 | Isosorbide-di-(propylcarbamate) | Drug Info | [52] | |||
176 | LAWSARITOL | Drug Info | [21] | |||
177 | LIPOCRINE | Drug Info | [53] | |||
178 | M-tolyl 10H-phenothiazine-10-carboxylate | Drug Info | [30] | |||
179 | MEMOQUIN | Drug Info | [53] | |||
180 | Methyl 10H-phenothiazine-10-carboxylate | Drug Info | [30] | |||
181 | Methyl Phosphinic Acid | Drug Info | [29] | |||
182 | MF-8623 | Drug Info | [36] | |||
183 | Monoisopropyl Ester Phosphonic Acid Group | Drug Info | [29] | |||
184 | Morpholino(1'H-phenothiazin-1'-yl)methanone | Drug Info | [18] | |||
185 | N,N'-(1',10'-decylene)-bis-(-)-nor-MEP | Drug Info | [10] | |||
186 | N,N'-(1',11'-undecydene)-bis-(-)-nor-MEP | Drug Info | [10] | |||
187 | N,N'-(1',12'-dodecydene)-bis-(-)-nor-MEP | Drug Info | [10] | |||
188 | N,N'-(1',2'-ethylene)-bis-(-)-nor-MEP | Drug Info | [10] | |||
189 | N,N'-(1',3'-propylene)-bis-(-)-nor-MEP | Drug Info | [10] | |||
190 | N,N'-(1',4'-butylene)-bis-(-)-nor-MEP | Drug Info | [10] | |||
191 | N,N'-(1',5'-pentylene)-bis-(-)-nor-MEP | Drug Info | [10] | |||
192 | N,N'-(1',6-hexylene)-bis-(-)-nor-MEP | Drug Info | [10] | |||
193 | N,N'-(1',7'-heptylene)-bis-(-)-nor-MEP | Drug Info | [10] | |||
194 | N,N'-(1',8'-octylene)-bis-(-)-nor-MEP | Drug Info | [10] | |||
195 | N,N'-(1',9'-nonylene)-bis-(-)-nor-MEP | Drug Info | [10] | |||
196 | N,N-Diethyl-1'H-phenothiazine-1'-carboxamide | Drug Info | [18] | |||
197 | N,N-Diisopropyl-1'H-phenothiazine-1'-carboxamide | Drug Info | [18] | |||
198 | N,N-Dimethyl-1'H-phenothiazine-1'-carboxamide | Drug Info | [18] | |||
199 | N,N-Dipropyl-1'H-phenothiazine-1'-carboxamide | Drug Info | [18] | |||
200 | N-(Adamant-1-yl)-1'H-phenothiazine-1'-carboxamide | Drug Info | [18] | |||
201 | N-Benzyl-1'H-phenothiazine-1'-carboxamide | Drug Info | [18] | |||
202 | N-benzyl-2-thiomorpholinopyrimidin-4-amine | Drug Info | [44] | |||
203 | N-Cyclobutyl-1'H-phenothiazine-1'-carboxamide | Drug Info | [18] | |||
204 | N-Cyclohexyl-1'H-phenothiazine-1'-carboxamide | Drug Info | [18] | |||
205 | N-Cyclopentyl-1'H-phenothiazine-1'-carboxamide | Drug Info | [18] | |||
206 | N-Isopropyl-1'H-phenothiazine-1'-carboxamide | Drug Info | [18] | |||
207 | N-Methyl-1'H-phenothiazine-1'-carboxamide | Drug Info | [18] | |||
208 | N-n-heptyl-7-methoxytacrine hydrochloride | Drug Info | [54] | |||
209 | N-n-hexyl-7-methoxytacrine hydrochloride | Drug Info | [54] | |||
210 | N-n-nonyl-7-methoxytacrine hydrochloride | Drug Info | [54] | |||
211 | N-n-octyl-7-methoxytacrine hydrochloride | Drug Info | [54] | |||
212 | N-n-pentyl-7-methoxytacrine hydrochloride | Drug Info | [54] | |||
213 | N-Neopentyl-1'H-phenothiazine-1'-carboxamide | Drug Info | [18] | |||
214 | N-o-Tolyl-1'H-phenothiazine-1'-carboxamide | Drug Info | [18] | |||
215 | N-p-Tolyl-1'H-phenothiazine-1'-carboxamide | Drug Info | [18] | |||
216 | N-phenethyl-2-(pyrrolidin-1-yl)pyrimidin-4-amine | Drug Info | [44] | |||
217 | N-Phenyl-1'H-phenothiazine-1'-carboxamide | Drug Info | [18] | |||
218 | N-tert-Butyl-1'H-phenothiazine-1'-carboxamide | Drug Info | [18] | |||
219 | Naphthalen-1-yl 10H-phenothiazine-10-carboxylate | Drug Info | [30] | |||
220 | Naphthalen-1-yl(10H-phenothiazin-10-yl)methanone | Drug Info | [19] | |||
221 | Naphthalen-2-yl 10H-phenothiazine-10-carboxylate | Drug Info | [30] | |||
222 | Naphthalen-2-yl(10H-phenothiazin-10-yl)methanone | Drug Info | [19] | |||
223 | NOSTOCARBOLINE | Drug Info | [56] | |||
224 | NP-0336 | Drug Info | [55] | |||
225 | NSC-23180 | Drug Info | [26] | |||
226 | O-tolyl 10H-phenothiazine-10-carboxylate | Drug Info | [30] | |||
227 | P-tolyl 10H-phenothiazine-10-carboxylate | Drug Info | [30] | |||
228 | Phenanthrene-9,10-dione | Drug Info | [26] | |||
229 | Phenyl 10H-phenothiazine-10-carboxylate | Drug Info | [30] | |||
230 | Tert-butyl 10H-phenothiazine-10-carboxylate | Drug Info | [30] | |||
231 | TOLSERINE | Drug Info | [12] | |||
232 | VAGANINE D | Drug Info | [57] | |||
233 | XANTHOSTIGMINE | Drug Info | [58] | |||
Modulator | [+] 5 Modulator drugs | + | ||||
1 | JES-9501 | Drug Info | [6] | |||
2 | Plasma derived human butyrylcholinesterase | Drug Info | [13] | |||
3 | Protexia | Drug Info | [14] | |||
4 | Non-PEGylated butyrylcholinesterase | Drug Info | [55] | |||
5 | Recombinant human butyrylcholinesterase | Drug Info | [55] | |||
Reactivator | [+] 1 Reactivator drugs | + | ||||
1 | Oxime derivative 1 | Drug Info | [15] |
Chemical Structure based Activity Landscape of Target | Top |
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Drug Property Profile of Target | Top | |
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(1) Molecular Weight (mw) based Drug Clustering | (2) Octanol/Water Partition Coefficient (xlogp) based Drug Clustering | |
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(3) Hydrogen Bond Donor Count (hbonddonor) based Drug Clustering | (4) Hydrogen Bond Acceptor Count (hbondacc) based Drug Clustering | |
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(5) Rotatable Bond Count (rotbonds) based Drug Clustering | (6) Topological Polar Surface Area (polararea) based Drug Clustering | |
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"RO5" indicates the cutoff set by lipinski's rule of five; "D123AB" colored in GREEN denotes the no violation of any cutoff in lipinski's rule of five; "D123AB" colored in PURPLE refers to the violation of only one cutoff in lipinski's rule of five; "D123AB" colored in BLACK represents the violation of more than one cutoffs in lipinski's rule of five |
Co-Targets | Top | |||||
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Co-Targets |
Target Poor or Non Binders | Top | |||||
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Target Poor or Non Binders |
Target Affiliated Biological Pathways | Top | |||||
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Panther Pathway | [+] 3 Panther Pathways | + | ||||
1 | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||||
2 | Muscarinic acetylcholine receptor 2 and 4 signaling pathway | |||||
3 | Nicotinic acetylcholine receptor signaling pathway | |||||
WikiPathways | [+] 1 WikiPathways | + | ||||
1 | Irinotecan Pathway |
Target-Related Models and Studies | Top | |||||
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Target Validation |
References | Top | |||||
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