Drug Information
Drug General Information | Top | |||
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Drug ID |
D01LYX
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Former ID |
DIB009619
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Drug Name |
Eptastigmine
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Synonyms |
heptastigmine; Heptylphysostigmine; Physostigmine heptyl; Eptastigmine [INN]; (-)-Heptylphysostigmine; Eptastigminum [INN-Latin]; Eptastigmina [INN-Spanish]; UNII-6PZZ52D76Q; N-Demethyl-N-heptylphysostigmine; 101246-68-8; BRN 4883778; CHEMBL433041; 6PZZ52D76Q; Heptylstigmine; heptyl-physostigmine; Eptastigminum; Eptastigmina; heptyl physostigmine; Carbamic acid, heptyl-, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-yl ester, (3aS-cis)-; AC1Q60XA; SCHEMBL195028; BDBM10972; Epiastigmine; Eptastigmine tartrate; Heptylstigmine tartrate; Heptyl-physostigmine; L-693487; MF-201; HEPTYPHYSOSTIGMINE
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Drug Type |
Small molecular drug
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Indication | Cognitive impairment [ICD-11: 6D71; ICD-10: F06.7] | Phase 3 | [1] | |
Company |
Consiglio Nazionale delle Ricerche
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Structure |
Download2D MOL |
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Formula |
C21H33N3O2
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Canonical SMILES |
CCCCCCCNC(=O)OC1=CC2=C(C=C1)N(C3C2(CCN3C)C)C
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InChI |
1S/C21H33N3O2/c1-5-6-7-8-9-13-22-20(25)26-16-10-11-18-17(15-16)21(2)12-14-23(3)19(21)24(18)4/h10-11,15,19H,5-9,12-14H2,1-4H3,(H,22,25)/t19-,21+/m1/s1
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InChIKey |
RRGMXBQMCUKRLH-CTNGQTDRSA-N
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CAS Number |
CAS 101246-68-8
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Acetylcholinesterase (AChE) | Target Info | Inhibitor | [1], [2] |
Cholinesterase (BCHE) | Target Info | Inhibitor | [3] | |
KEGG Pathway | Glycerophospholipid metabolism | |||
Cholinergic synapse | ||||
Panther Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||
Muscarinic acetylcholine receptor 2 and 4 signaling pathway | ||||
Nicotinic acetylcholine receptor signaling pathway | ||||
Pathwhiz Pathway | Phospholipid Biosynthesis | |||
Pathway Interaction Database | ATF-2 transcription factor network | |||
WikiPathways | Monoamine Transport | |||
Biogenic Amine Synthesis | ||||
Acetylcholine Synthesis | ||||
Integrated Pancreatic Cancer Pathway | ||||
Irinotecan Pathway |
References | Top | |||
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REF 1 | Eptastigmine: ten years of pharmacology, toxicology, pharmacokinetic, and clinical studies. CNS Drug Rev. 2001 Winter;7(4):369-86. | |||
REF 2 | Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based vi... J Med Chem. 2010 Sep 9;53(17):6490-505. | |||
REF 3 | Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. J Med Chem. 2006 Apr 6;49(7):2174-85. |
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