csChFnd70/05150717532D 40 43 0 0 0 0 0 0 0 0999 V2000 3.9953 7.0077 0.0282 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7568 5.3697 0.0024 N 0 0 0 0 0 0 0 0 0 0 0 0 4.0153 5.4511 0.0092 N 0 0 0 0 0 0 0 0 0 0 0 0 5.4387 7.8187 0.0349 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8495 6.9342 0.0212 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4931 9.4853 0.0546 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3720 9.2690 0.0458 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6559 9.9146 0.0510 O 0 0 0 0 0 0 0 0 0 0 0 0 8.2848 7.6824 0.0267 N 0 0 3 0 0 0 0 0 0 0 0 0 6.9307 10.2219 0.0599 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0275 11.9670 0.0809 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0629 12.8101 -1.3326 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1532 14.4368 -1.3047 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2086 15.2303 0.1202 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1745 14.4015 1.5257 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0768 12.7751 1.5145 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0242 11.7378 3.2797 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.9942 11.8165 -3.1223 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.3669 4.6570 -0.0034 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3201 3.0277 -0.0237 N 0 0 3 0 0 0 0 0 0 0 0 0 9.7376 6.7461 0.0123 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8756 2.2423 0.1098 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0966 0.6450 0.3099 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6169 0.8360 -0.6902 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6772 2.8553 1.0528 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2674 2.0345 1.1473 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2566 0.0924 -0.5671 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8914 7.6440 0.0330 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4170 10.1675 0.0648 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1812 15.0907 -2.3980 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2793 16.5023 0.1356 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2185 15.0281 2.6343 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2894 2.4287 -0.1306 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0950 6.5282 -1.2036 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6681 7.3892 0.6240 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5304 5.6243 0.6057 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.0000 0.3801 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5391 0.3470 -1.4208 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8433 3.9434 1.6945 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3103 2.4779 1.8622 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 28 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 29 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 21 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 30 1 0 0 0 0 14 15 1 0 0 0 0 14 31 1 0 0 0 0 15 16 2 0 0 0 0 15 32 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 22 1 0 0 0 0 20 33 1 0 0 0 0 21 34 1 0 0 0 0 21 35 1 0 0 0 0 21 36 1 0 0 0 0 22 24 2 0 0 0 0 22 25 1 0 0 0 0 23 27 2 0 0 0 0 23 26 1 0 0 0 0 23 37 1 0 0 0 0 24 27 1 0 0 0 0 24 38 1 0 0 0 0 25 26 2 0 0 0 0 25 39 1 0 0 0 0 26 40 1 0 0 0 0 M END > (104) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 40 > (104) PDGFR-beta > (104) 120 > (104) -1 > (104) P > (104) PDGFR-P102 $$$$ csChFnd70/05150717532D 59 62 0 0 0 0 0 0 0 0999 V2000 12.9508 9.3300 0.0173 C 0 0 0 0 0 0 0 0 0 0 0 0 15.9591 7.5470 -0.0031 N 0 0 0 0 0 0 0 0 0 0 0 0 12.9732 7.6348 0.0014 N 0 0 0 0 0 0 0 0 0 0 0 0 14.5226 10.2138 0.0238 C 0 0 0 0 0 0 0 0 0 0 0 0 16.0593 9.2509 0.0128 C 0 0 0 0 0 0 0 0 0 0 0 0 14.5813 12.0289 0.0402 C 0 0 0 0 0 0 0 0 0 0 0 0 17.7167 11.7942 0.0360 C 0 0 0 0 0 0 0 0 0 0 0 0 19.1149 12.4976 0.0419 O 0 0 0 0 0 0 0 0 0 0 0 0 17.6224 10.0663 0.0193 N 0 0 3 0 0 0 0 0 0 0 0 0 16.1468 12.8314 0.0452 C 0 0 0 0 0 0 0 0 0 0 0 0 16.2515 14.7322 0.0618 C 0 0 0 0 0 0 0 0 0 0 0 0 16.2918 15.6452 -1.4807 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3889 17.4169 -1.4563 C 0 0 0 0 0 0 0 0 0 0 0 0 16.4463 18.2864 0.0928 C 0 0 0 0 0 0 0 0 0 0 0 0 16.4076 17.3890 1.6265 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3031 15.6176 1.6201 C 0 0 0 0 0 0 0 0 0 0 0 0 16.2446 14.4942 3.5463 Cl 0 0 0 0 0 0 0 0 0 0 0 0 16.2204 14.5564 -3.4261 Cl 0 0 0 0 0 0 0 0 0 0 0 0 14.4455 6.7703 -0.0085 C 0 0 0 0 0 0 0 0 0 0 0 0 14.3951 4.9961 -0.0252 N 0 0 3 0 0 0 0 0 0 0 0 0 12.8198 4.1396 0.1210 C 0 0 0 0 0 0 0 0 0 0 0 0 19.2048 9.0469 0.0083 C 0 0 0 0 0 0 0 0 0 0 0 0 12.5515 2.6086 -0.7551 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5275 4.8167 1.1483 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9743 3.9713 1.2917 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9974 1.7647 -0.6103 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7047 2.4458 0.4102 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1749 1.6137 0.5526 O 0 0 0 0 0 0 0 0 0 0 0 0 6.9015 2.3879 1.6251 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2807 1.2754 1.6258 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9173 2.1044 2.7740 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3612 1.0361 2.7747 N 0 0 0 0 0 0 0 0 0 0 0 0 1.1402 1.6206 4.0900 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5564 1.0122 1.0676 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7485 10.0227 0.0195 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4091 12.7714 0.0481 H 0 0 0 0 0 0 0 0 0 0 0 0 16.4205 18.1251 -2.6492 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5222 19.6719 0.1050 H 0 0 0 0 0 0 0 0 0 0 0 0 16.4538 18.0755 2.8316 H 0 0 0 0 0 0 0 0 0 0 0 0 15.4511 4.3438 -0.1381 H 0 0 0 0 0 0 0 0 0 0 0 0 19.5962 8.8065 -1.3147 H 0 0 0 0 0 0 0 0 0 0 0 0 20.2171 9.7493 0.6744 H 0 0 0 0 0 0 0 0 0 0 0 0 18.9786 7.8267 0.6573 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5578 2.0784 -1.5501 H 0 0 0 0 0 0 0 0 0 0 0 0 11.7374 6.0041 1.8351 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9672 4.5004 2.0864 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7866 0.5769 -1.2962 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3942 2.4959 2.9316 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5921 3.6633 1.1361 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7880 1.1674 0.3193 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5902 0.0000 2.1148 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4101 2.2123 4.0805 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6078 3.3797 2.2850 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7740 2.9472 3.8306 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.8077 4.0627 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7405 1.5404 5.3528 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4594 0.4898 0.1331 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4074 0.2122 1.1042 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2053 2.3169 0.6986 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 35 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 36 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 37 1 0 0 0 0 14 15 1 0 0 0 0 14 38 1 0 0 0 0 15 16 2 0 0 0 0 15 39 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 40 1 0 0 0 0 21 23 1 0 0 0 0 21 24 2 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 22 43 1 0 0 0 0 23 26 2 0 0 0 0 23 44 1 0 0 0 0 24 25 1 0 0 0 0 24 45 1 0 0 0 0 25 27 2 0 0 0 0 25 46 1 0 0 0 0 26 27 1 0 0 0 0 26 47 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 29 48 1 0 0 0 0 29 49 1 0 0 0 0 30 31 1 0 0 0 0 30 50 1 0 0 0 0 30 51 1 0 0 0 0 31 32 1 0 0 0 0 31 52 1 0 0 0 0 31 53 1 0 0 0 0 32 33 1 0 0 0 0 32 34 1 0 0 0 0 33 54 1 0 0 0 0 33 55 1 0 0 0 0 33 56 1 0 0 0 0 34 57 1 0 0 0 0 34 58 1 0 0 0 0 34 59 1 0 0 0 0 M END > (105) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 61 > (105) PDGFR-beta > (105) 120 > (105) -1 > (105) P > (105) PDGFR-P103 $$$$ csChFnd70/05150717532D 63 66 0 0 0 0 0 0 0 0999 V2000 11.2030 12.8703 -1.0401 C 0 0 0 0 0 0 0 0 0 0 0 0 14.2372 11.5989 0.1447 N 0 0 0 0 0 0 0 0 0 0 0 0 11.3599 11.2474 -0.5758 N 0 0 0 0 0 0 0 0 0 0 0 0 12.6433 13.9475 -0.9127 C 0 0 0 0 0 0 0 0 0 0 0 0 14.1975 13.2480 -0.2933 C 0 0 0 0 0 0 0 0 0 0 0 0 12.5549 15.6970 -1.3911 C 0 0 0 0 0 0 0 0 0 0 0 0 15.5872 15.9298 -0.5943 C 0 0 0 0 0 0 0 0 0 0 0 0 16.8748 16.8089 -0.4576 O 0 0 0 0 0 0 0 0 0 0 0 0 15.6347 14.2584 -0.1489 N 0 0 3 0 0 0 0 0 0 0 0 0 13.9957 16.6953 -1.2436 C 0 0 0 0 0 0 0 0 0 0 0 0 13.9450 18.5335 -1.7351 C 0 0 0 0 0 0 0 0 0 0 0 0 14.3222 19.0266 -3.4169 C 0 0 0 0 0 0 0 0 0 0 0 0 14.2719 20.7422 -3.8667 C 0 0 0 0 0 0 0 0 0 0 0 0 13.8489 21.9707 -2.6542 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4743 21.4906 -0.9845 C 0 0 0 0 0 0 0 0 0 0 0 0 13.5127 19.7785 -0.5198 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0324 19.1778 1.5737 Cl 0 0 0 0 0 0 0 0 0 0 0 0 14.8540 17.4868 -4.9404 Cl 0 0 0 0 0 0 0 0 0 0 0 0 12.8442 10.6329 0.0018 C 0 0 0 0 0 0 0 0 0 0 0 0 12.9375 8.9239 0.4705 N 0 0 3 0 0 0 0 0 0 0 0 0 11.4499 7.9125 0.4845 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5427 6.1826 0.0582 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8821 8.6372 0.9314 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4156 7.6390 0.9448 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0748 5.1861 0.0722 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5081 5.9128 0.5118 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0634 4.9305 0.5258 O 0 0 0 0 0 0 0 0 0 0 0 0 17.2372 13.5117 0.4971 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4943 5.7625 0.9909 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0214 4.4621 0.9344 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7369 2.0601 2.3763 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1175 3.0963 2.7860 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7983 2.2055 2.0517 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9690 0.8490 3.4640 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2291 3.2150 2.3355 N 0 3 0 0 0 0 0 0 0 0 0 0 4.3593 4.1284 3.9731 O 0 5 0 0 0 0 0 0 0 0 0 0 9.9934 13.3580 -1.5135 H 0 0 0 0 0 0 0 0 0 0 0 0 11.3689 16.2382 -1.8661 H 0 0 0 0 0 0 0 0 0 0 0 0 14.5640 21.1256 -5.1678 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8115 23.3107 -3.0123 H 0 0 0 0 0 0 0 0 0 0 0 0 13.1459 22.4561 -0.0437 H 0 0 0 0 0 0 0 0 0 0 0 0 14.0337 8.4242 0.7900 H 0 0 0 0 0 0 0 0 0 0 0 0 12.7623 5.6168 -0.2844 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8099 9.9812 1.2691 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1954 8.2038 1.2874 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1459 3.8419 -0.2646 H 0 0 0 0 0 0 0 0 0 0 0 0 17.9828 13.0074 -0.5757 H 0 0 0 0 0 0 0 0 0 0 0 0 17.9788 14.4986 1.1581 H 0 0 0 0 0 0 0 0 0 0 0 0 16.9419 12.4735 1.3893 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6079 6.2831 2.2859 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2331 6.8030 0.0908 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8009 5.1324 1.0832 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0383 3.7906 -0.2945 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9286 1.0843 3.3622 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5917 1.4409 1.1286 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.2537 2.7388 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2300 3.6511 4.0667 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9689 4.1220 1.8442 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9116 3.0545 2.0829 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7276 1.5738 0.8040 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0397 1.4807 4.7119 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8558 0.0000 3.4330 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1334 0.1000 3.2535 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 37 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 38 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 28 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 39 1 0 0 0 0 14 15 1 0 0 0 0 14 40 1 0 0 0 0 15 16 2 0 0 0 0 15 41 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 42 1 0 0 0 0 21 22 1 0 0 0 0 21 23 2 0 0 0 0 22 25 2 0 0 0 0 22 43 1 0 0 0 0 23 24 1 0 0 0 0 23 44 1 0 0 0 0 24 26 2 0 0 0 0 24 45 1 0 0 0 0 25 26 1 0 0 0 0 25 46 1 0 0 0 0 26 27 1 0 0 0 0 27 29 1 0 0 0 0 28 47 1 0 0 0 0 28 48 1 0 0 0 0 28 49 1 0 0 0 0 29 30 1 0 0 0 0 29 50 1 0 0 0 0 29 51 1 0 0 0 0 30 35 1 0 0 0 0 30 52 1 0 0 0 0 30 53 1 0 0 0 0 31 35 1 0 0 0 0 31 32 1 0 0 0 0 31 54 1 0 0 0 0 31 55 1 0 0 0 0 32 56 1 0 0 0 0 32 57 1 0 0 0 0 32 58 1 0 0 0 0 33 35 1 0 0 0 0 33 34 1 0 0 0 0 33 59 1 0 0 0 0 33 60 1 0 0 0 0 34 61 1 0 0 0 0 34 62 1 0 0 0 0 34 63 1 0 0 0 0 35 36 1 0 0 0 0 M END > (106) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 66 > (106) PDGFR-beta > (106) 120 > (106) -1 > (106) P > (106) PDGFR-P104 $$$$ csChFnd70/05150717532D 53 56 0 0 0 0 0 0 0 0999 V2000 7.9488 13.1015 0.0176 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9836 11.3024 -0.0030 N 0 0 0 0 0 0 0 0 0 0 0 0 7.9714 11.3911 0.0014 N 0 0 0 0 0 0 0 0 0 0 0 0 9.5346 13.9931 0.0241 C 0 0 0 0 0 0 0 0 0 0 0 0 11.0850 13.0216 0.0131 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5938 15.8244 0.0407 C 0 0 0 0 0 0 0 0 0 0 0 0 12.7571 15.5874 0.0346 C 0 0 0 0 0 0 0 0 0 0 0 0 14.1678 16.2972 0.0401 O 0 0 0 0 0 0 0 0 0 0 0 0 12.6619 13.8441 0.0183 N 0 0 3 0 0 0 0 0 0 0 0 0 11.1733 16.6341 0.0457 C 0 0 0 0 0 0 0 0 0 0 0 0 11.2792 18.5517 0.0625 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3198 19.4728 -1.4939 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4178 21.2603 -1.4692 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4759 22.1376 0.0936 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4367 21.2323 1.6410 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3312 19.4450 1.6345 C 0 0 0 0 0 0 0 0 0 0 0 0 11.2721 18.3118 3.5780 Cl 0 0 0 0 0 0 0 0 0 0 0 0 11.2478 18.3743 -3.4567 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.4567 10.5189 -0.0085 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4057 8.7286 -0.0260 N 0 0 3 0 0 0 0 0 0 0 0 0 7.8189 7.8657 0.1207 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5466 6.3209 -0.7635 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5135 8.5473 1.1570 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9477 7.6914 1.2996 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9776 5.4715 -0.6152 C 0 0 0 0 0 0 0 0 0 0 0 0 14.2584 12.8156 0.0067 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6784 6.1573 0.4121 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9682 5.2265 0.5713 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0459 3.9565 2.0928 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3096 3.0116 2.2544 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6948 1.6377 4.6044 O 0 0 0 0 0 0 0 0 0 0 0 0 1.3859 1.7607 3.7530 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.7832 4.1420 O 0 0 0 0 0 0 0 0 0 0 0 0 6.7358 13.8004 0.0198 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4112 16.5737 0.0487 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4498 21.9748 -2.6729 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5525 23.5354 0.1058 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4828 21.9249 2.8568 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4711 8.0703 -0.1400 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5605 5.7849 -1.5663 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7232 9.7453 1.8506 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9305 8.2234 2.1011 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7631 4.2734 -1.3069 H 0 0 0 0 0 0 0 0 0 0 0 0 14.6525 12.5727 -1.3283 H 0 0 0 0 0 0 0 0 0 0 0 0 15.2802 13.5243 0.6778 H 0 0 0 0 0 0 0 0 0 0 0 0 14.0305 11.5846 0.6619 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9387 6.1679 0.7956 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7054 4.5165 -0.6218 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0754 3.0151 1.8684 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3085 4.6665 3.2859 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2800 3.9530 2.4787 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0468 2.3016 1.0613 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1107 0.0000 5.1144 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 34 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 35 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 26 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 36 1 0 0 0 0 14 15 1 0 0 0 0 14 37 1 0 0 0 0 15 16 2 0 0 0 0 15 38 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 39 1 0 0 0 0 21 22 1 0 0 0 0 21 23 2 0 0 0 0 22 25 2 0 0 0 0 22 40 1 0 0 0 0 23 24 1 0 0 0 0 23 41 1 0 0 0 0 24 27 2 0 0 0 0 24 42 1 0 0 0 0 25 27 1 0 0 0 0 25 43 1 0 0 0 0 26 44 1 0 0 0 0 26 45 1 0 0 0 0 26 46 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 28 47 1 0 0 0 0 28 48 1 0 0 0 0 29 30 1 0 0 0 0 29 49 1 0 0 0 0 29 50 1 0 0 0 0 30 32 1 0 0 0 0 30 51 1 0 0 0 0 30 52 1 0 0 0 0 31 32 2 0 0 0 0 32 33 1 0 0 0 0 33 53 1 0 0 0 0 M END > (107) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 72 > (107) PDGFR-beta > (107) 120 > (107) -1 > (107) P > (107) PDGFR-P105 $$$$ csChFnd70/05150717532D 44 47 0 0 0 0 0 0 0 0999 V2000 6.0744 7.8824 0.0146 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7811 6.2779 -0.0031 N 0 0 0 0 0 0 0 0 0 0 0 0 6.0944 6.3570 0.0006 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4886 8.6776 0.0203 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8713 7.8111 0.0109 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5414 10.3110 0.0347 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3627 10.0996 0.0291 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6208 10.7326 0.0335 O 0 0 0 0 0 0 0 0 0 0 0 0 10.2777 8.5447 0.0155 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9501 11.0331 0.0393 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0444 12.7433 0.0536 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0806 13.5645 -1.3345 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1681 15.1587 -1.3129 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2197 15.9414 0.0807 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1847 15.1344 1.4609 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0906 13.5403 1.4556 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0377 12.5301 3.1891 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.0167 12.5843 -3.0848 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4192 5.5791 -0.0081 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3738 3.9823 -0.0226 N 0 0 3 0 0 0 0 0 0 0 0 0 5.9582 3.2126 0.1088 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7169 1.8335 -0.6807 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7978 3.8213 1.0315 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3873 3.0486 1.1586 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3198 1.0682 -0.5548 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1545 1.6677 0.3554 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7016 7.6275 0.0060 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1421 3.6928 2.1344 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3472 4.8943 2.8320 O 0 0 0 0 0 0 0 0 0 0 0 0 0.7794 2.9478 2.2504 O 0 0 0 0 0 0 0 0 0 0 0 0 4.9925 8.5058 0.0164 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4867 10.9791 0.0416 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1967 15.7956 -2.3866 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2880 17.1882 0.0912 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2257 15.7524 2.5451 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3240 3.3952 -0.1241 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6241 1.3588 -1.3954 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9849 4.8896 1.6502 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1375 0.0000 -1.1752 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0645 1.0662 0.4507 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0534 7.4102 -1.1843 H 0 0 0 0 0 0 0 0 0 0 0 0 12.6126 8.2600 0.6044 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4982 6.5300 0.5910 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.4140 2.9025 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 31 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 32 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 27 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 33 1 0 0 0 0 14 15 1 0 0 0 0 14 34 1 0 0 0 0 15 16 2 0 0 0 0 15 35 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 36 1 0 0 0 0 21 22 1 0 0 0 0 21 23 2 0 0 0 0 22 25 2 0 0 0 0 22 37 1 0 0 0 0 23 24 1 0 0 0 0 23 38 1 0 0 0 0 24 26 2 0 0 0 0 24 28 1 0 0 0 0 25 26 1 0 0 0 0 25 39 1 0 0 0 0 26 40 1 0 0 0 0 27 41 1 0 0 0 0 27 42 1 0 0 0 0 27 43 1 0 0 0 0 28 30 1 0 0 0 0 28 29 2 0 0 0 0 30 44 1 0 0 0 0 M END > (112) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 70 > (112) PDGFR-beta > (112) 130 > (112) -1 > (112) P > (112) PDGFR-P110 $$$$ csChFnd70/05150717532D 45 48 0 0 0 0 0 0 0 0999 V2000 5.3987 8.3950 0.0166 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2844 6.6844 -0.0028 N 0 0 0 0 0 0 0 0 0 0 0 0 5.4202 6.7687 0.0014 N 0 0 0 0 0 0 0 0 0 0 0 0 6.9066 9.2428 0.0228 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3808 8.3191 0.0123 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9629 10.9841 0.0386 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9708 10.7588 0.0328 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3121 11.4337 0.0381 O 0 0 0 0 0 0 0 0 0 0 0 0 9.8802 9.1012 0.0174 N 0 0 3 0 0 0 0 0 0 0 0 0 8.4648 11.7540 0.0435 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5653 13.5774 0.0593 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6039 14.4532 -1.4205 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6972 16.1529 -1.3972 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7525 16.9871 0.0889 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7151 16.1262 1.5602 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6149 14.4268 1.5542 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5587 13.3493 3.4020 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.5356 13.4087 -3.2868 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.8325 5.9394 -0.0081 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7841 4.2370 -0.0241 N 0 0 3 0 0 0 0 0 0 0 0 0 5.2753 3.4166 0.1160 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3983 8.1232 0.0064 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5246 1.1397 -0.5829 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0161 1.9472 -0.7244 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0345 4.0651 1.1011 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2891 1.7922 0.3941 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5452 3.2510 1.2373 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1959 3.9571 2.3008 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3482 3.3265 3.9383 O 0 0 0 0 0 0 0 0 0 0 0 0 4.2454 9.0596 0.0188 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8384 11.6966 0.0462 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7277 16.8322 -2.5416 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8253 18.3162 0.1005 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7590 16.7848 2.7163 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7971 3.6111 -0.1325 H 0 0 0 0 0 0 0 0 0 0 0 0 11.7730 7.8922 -1.2631 H 0 0 0 0 0 0 0 0 0 0 0 0 12.3697 8.7971 0.6445 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1816 6.9527 0.6294 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3206 0.0000 -1.2399 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9802 1.4372 -1.4879 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2338 5.2043 1.7603 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1237 1.1582 0.5026 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2994 5.2965 2.3252 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.6095 1.7964 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5179 3.7297 4.6923 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 30 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 31 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 32 1 0 0 0 0 14 15 1 0 0 0 0 14 33 1 0 0 0 0 15 16 2 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 35 1 0 0 0 0 21 24 1 0 0 0 0 21 25 2 0 0 0 0 22 36 1 0 0 0 0 22 37 1 0 0 0 0 22 38 1 0 0 0 0 23 26 1 0 0 0 0 23 24 2 0 0 0 0 23 39 1 0 0 0 0 24 40 1 0 0 0 0 25 27 1 0 0 0 0 25 41 1 0 0 0 0 26 27 2 0 0 0 0 26 42 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 28 43 1 0 0 0 0 28 44 1 0 0 0 0 29 45 1 0 0 0 0 M END > (114) PD166326 > (114) PDGFR-beta > (114) 139 > (114) -1 > (114) P > (114) PDGFR-P112 $$$$ 3-substituted indolin-2-one 11a csChFnd70/05150717532D 38 40 0 0 0 0 0 0 0 0999 V2000 1.7555 3.5421 -0.1495 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1631 2.1007 -1.7533 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2103 3.6993 -1.5211 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9924 4.4184 -0.7115 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3720 6.0952 -0.6547 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8604 6.2416 -1.4776 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2917 4.8179 -1.9543 N 0 0 3 0 0 0 0 0 0 0 0 0 5.5785 7.4435 -1.6909 O 0 0 0 0 0 0 0 0 0 0 0 0 2.5118 7.2691 0.0249 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1339 8.7816 0.1369 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3072 10.1621 0.0479 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6747 9.1590 0.3620 N 0 0 3 0 0 0 0 0 0 0 0 0 0.5790 10.3278 -0.1861 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8065 10.7300 0.4058 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3779 11.3697 0.2167 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7293 1.9560 -0.3916 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9303 1.2415 -1.1903 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0107 13.0824 0.1968 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5173 13.6019 1.8248 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1500 15.3147 1.8049 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2704 16.0449 0.6112 O 0 0 0 0 0 0 0 0 0 0 0 0 1.6891 16.0290 3.1133 O 0 0 0 0 0 0 0 0 0 0 0 0 0.8220 4.0994 0.4781 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0927 1.5301 -2.3747 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2376 4.5991 -2.5278 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3629 7.0283 0.4703 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5230 8.4242 0.4712 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 10.3463 0.9408 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3379 11.4082 -0.8027 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1490 9.3487 -0.8659 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8756 11.3680 0.5680 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7709 1.2713 0.0429 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9022 0.0000 -1.3749 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0391 13.7310 -0.1598 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0678 13.3028 -0.6205 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4889 12.9535 2.1814 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4601 13.3817 2.6421 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4667 17.1285 3.0432 H 0 0 0 0 0 0 0 0 0 0 0 0 1 16 1 0 0 0 0 1 4 2 0 0 0 0 1 23 1 0 0 0 0 2 17 1 0 0 0 0 2 3 2 0 0 0 0 2 24 1 0 0 0 0 3 7 1 0 0 0 0 3 4 1 0 0 0 0 4 5 1 0 0 0 0 5 6 1 0 0 0 0 5 9 2 0 0 0 0 6 7 1 0 0 0 0 6 8 2 0 0 0 0 7 25 1 0 0 0 0 9 10 1 0 0 0 0 9 26 1 0 0 0 0 10 11 2 0 0 0 0 10 12 1 0 0 0 0 11 15 1 0 0 0 0 11 13 1 0 0 0 0 12 14 1 0 0 0 0 12 27 1 0 0 0 0 13 28 1 0 0 0 0 13 29 1 0 0 0 0 13 30 1 0 0 0 0 14 15 2 0 0 0 0 14 31 1 0 0 0 0 15 18 1 0 0 0 0 16 17 2 0 0 0 0 16 32 1 0 0 0 0 17 33 1 0 0 0 0 18 19 1 0 0 0 0 18 34 1 0 0 0 0 18 35 1 0 0 0 0 19 20 1 0 0 0 0 19 36 1 0 0 0 0 19 37 1 0 0 0 0 20 22 1 0 0 0 0 20 21 2 0 0 0 0 22 38 1 0 0 0 0 M END > (115) 3-substituted indolin-2-one 11a > (115) PDGFR-beta > (115) 140 > (115) -1 > (115) P > (115) PDGFR-P113 $$$$ 3-substituted indolin-2-one 11d csChFnd70/05150717532D 42 44 0 0 0 0 0 0 0 0999 V2000 1.7691 5.9140 -0.1482 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1798 4.4807 -1.7517 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2211 6.0761 -1.5190 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0030 6.7906 -0.7103 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3777 8.4662 -0.6536 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8636 8.6164 -1.4754 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2978 7.1962 -1.9515 N 0 0 3 0 0 0 0 0 0 0 0 0 5.5772 9.8182 -1.6884 O 0 0 0 0 0 0 0 0 0 0 0 0 2.5161 9.6356 0.0249 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1335 11.1479 0.1368 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3045 12.5237 0.0480 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6708 11.5286 0.3615 N 0 0 3 0 0 0 0 0 0 0 0 0 0.5788 12.6845 -0.1865 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7984 13.0980 0.4058 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3706 13.7327 0.2170 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7435 4.3310 -0.3879 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9472 3.6161 -1.1885 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9993 15.4419 0.1967 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5044 15.9594 1.8217 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1331 17.6685 1.8014 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2521 18.3978 0.6094 O 0 0 0 0 0 0 0 0 0 0 0 0 1.6703 18.3807 3.1074 O 0 0 0 0 0 0 0 0 0 0 0 0 2.9145 2.0562 -1.4210 O 0 0 0 0 0 0 0 0 0 0 0 0 1.6111 1.2312 -0.8116 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8367 6.4702 0.4783 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1099 3.9143 -2.3726 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2428 6.9803 -2.5243 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3698 9.3922 0.4697 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5197 10.7971 0.4704 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 12.7010 0.9383 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3354 13.7628 -0.8019 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1525 11.7060 -0.8657 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8641 13.7377 0.5678 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7875 3.6471 0.0474 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0246 16.0919 -0.1590 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0579 15.6591 -0.6200 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4791 15.3093 2.1773 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4459 15.7421 2.6384 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4453 19.4780 3.0371 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5486 1.6753 -1.3353 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7296 0.0000 -1.0773 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5609 1.3891 0.4425 H 0 0 0 0 0 0 0 0 0 0 0 0 1 16 1 0 0 0 0 1 4 2 0 0 0 0 1 25 1 0 0 0 0 2 17 1 0 0 0 0 2 3 2 0 0 0 0 2 26 1 0 0 0 0 3 7 1 0 0 0 0 3 4 1 0 0 0 0 4 5 1 0 0 0 0 5 6 1 0 0 0 0 5 9 2 0 0 0 0 6 7 1 0 0 0 0 6 8 2 0 0 0 0 7 27 1 0 0 0 0 9 10 1 0 0 0 0 9 28 1 0 0 0 0 10 11 2 0 0 0 0 10 12 1 0 0 0 0 11 15 1 0 0 0 0 11 13 1 0 0 0 0 12 14 1 0 0 0 0 12 29 1 0 0 0 0 13 30 1 0 0 0 0 13 31 1 0 0 0 0 13 32 1 0 0 0 0 14 15 2 0 0 0 0 14 33 1 0 0 0 0 15 18 1 0 0 0 0 16 17 2 0 0 0 0 16 34 1 0 0 0 0 17 23 1 0 0 0 0 18 19 1 0 0 0 0 18 35 1 0 0 0 0 18 36 1 0 0 0 0 19 20 1 0 0 0 0 19 37 1 0 0 0 0 19 38 1 0 0 0 0 20 22 1 0 0 0 0 20 21 2 0 0 0 0 22 39 1 0 0 0 0 23 24 1 0 0 0 0 24 40 1 0 0 0 0 24 41 1 0 0 0 0 24 42 1 0 0 0 0 M END > (116) 3-substituted indolin-2-one 11d > (116) PDGFR-beta > (116) 140 > (116) -1 > (116) P > (116) PDGFR-P114 $$$$ csChFnd70/05150717532D 65 68 0 0 0 0 0 0 0 0999 V2000 8.8561 13.9107 5.4990 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0155 12.4058 5.6915 N 0 0 0 0 0 0 0 0 0 0 0 0 9.1268 12.3408 4.9077 N 0 0 0 0 0 0 0 0 0 0 0 0 10.2399 14.8067 6.2392 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8616 13.9898 6.3193 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0299 16.4920 6.8944 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0838 16.4275 7.6688 C 0 0 0 0 0 0 0 0 0 0 0 0 14.3268 17.1475 8.2990 O 0 0 0 0 0 0 0 0 0 0 0 0 13.2471 14.8217 7.0335 N 0 0 3 0 0 0 0 0 0 0 0 0 11.4198 17.3128 7.6039 C 0 0 0 0 0 0 0 0 0 0 0 0 11.2417 19.0797 8.3011 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5146 20.5017 7.2369 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3459 22.1453 7.8948 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9073 22.3838 9.6047 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6355 20.9798 10.6668 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7929 19.3293 10.0232 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4416 17.5689 11.3557 Cl 0 0 0 0 0 0 0 0 0 0 0 0 12.0657 20.2051 5.0907 Cl 0 0 0 0 0 0 0 0 0 0 0 0 10.6720 11.6118 5.0048 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8842 9.9653 4.3659 N 0 0 3 0 0 0 0 0 0 0 0 0 9.4566 9.0377 3.7719 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6353 7.8993 2.4044 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8628 9.2503 4.5547 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4555 8.3351 3.9680 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2266 6.9851 1.8192 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6335 7.2037 2.5972 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2471 6.3025 2.0206 O 0 0 0 0 0 0 0 0 0 0 0 0 3.6464 6.5909 2.8813 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2479 5.4726 2.0593 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6111 3.6495 2.4103 N 0 0 0 0 0 0 0 0 0 0 0 0 1.0460 2.6010 2.2372 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3836 0.7948 2.9485 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9877 3.0036 1.2849 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4036 3.1085 -0.5939 C 0 0 0 0 0 0 0 0 0 0 0 0 14.9210 13.9545 7.1068 C 0 0 0 0 0 0 0 0 0 0 0 0 15.9400 14.3543 5.4685 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5976 14.4959 5.4099 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7918 17.1229 6.8359 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5572 23.2470 7.0725 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7769 23.6719 10.1130 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2943 21.1748 12.0010 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0222 9.4516 4.3288 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8754 7.7293 1.7984 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7242 10.1307 5.6223 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2148 8.5042 4.5732 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3642 6.1039 0.7520 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7773 6.2546 4.2378 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2909 7.9440 2.7669 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9983 5.8134 2.6003 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2317 5.6879 0.6723 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.1993 2.9570 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6904 2.5114 0.8824 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2408 0.0000 2.7684 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4667 0.2184 2.2667 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6838 0.8795 4.3171 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1408 3.7845 1.4607 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2722 1.6687 1.6125 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1765 2.4430 -0.7402 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2526 4.4547 -0.9623 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3655 2.5030 -1.4174 H 0 0 0 0 0 0 0 0 0 0 0 0 15.6357 14.4105 8.2254 H 0 0 0 0 0 0 0 0 0 0 0 0 14.7255 12.5682 7.2097 H 0 0 0 0 0 0 0 0 0 0 0 0 17.1853 13.7091 5.5230 H 0 0 0 0 0 0 0 0 0 0 0 0 15.2251 13.8982 4.3499 H 0 0 0 0 0 0 0 0 0 0 0 0 16.1353 15.7405 5.3657 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 37 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 38 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 35 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 39 1 0 0 0 0 14 15 1 0 0 0 0 14 40 1 0 0 0 0 15 16 2 0 0 0 0 15 41 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 42 1 0 0 0 0 21 22 1 0 0 0 0 21 23 2 0 0 0 0 22 25 2 0 0 0 0 22 43 1 0 0 0 0 23 24 1 0 0 0 0 23 44 1 0 0 0 0 24 26 2 0 0 0 0 24 45 1 0 0 0 0 25 26 1 0 0 0 0 25 46 1 0 0 0 0 26 27 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 28 47 1 0 0 0 0 28 48 1 0 0 0 0 29 30 1 0 0 0 0 29 49 1 0 0 0 0 29 50 1 0 0 0 0 30 33 1 0 0 0 0 30 31 1 0 0 0 0 31 32 1 0 0 0 0 31 51 1 0 0 0 0 31 52 1 0 0 0 0 32 53 1 0 0 0 0 32 54 1 0 0 0 0 32 55 1 0 0 0 0 33 34 1 0 0 0 0 33 56 1 0 0 0 0 33 57 1 0 0 0 0 34 58 1 0 0 0 0 34 59 1 0 0 0 0 34 60 1 0 0 0 0 35 36 1 0 0 0 0 35 61 1 0 0 0 0 35 62 1 0 0 0 0 36 63 1 0 0 0 0 36 64 1 0 0 0 0 36 65 1 0 0 0 0 M END > (117) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 64 > (117) PDGFR-beta > (117) 150 > (117) -1 > (117) P > (117) PDGFR-P115 $$$$ Structure2 csChFnd70/05150717532D 43 45 0 0 0 0 0 0 0 0999 V2000 3.8512 12.3495 0.0124 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8754 10.5628 0.0026 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4437 9.6712 -0.0171 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9942 10.5654 -0.0266 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3978 13.2672 0.0026 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9865 12.3764 -0.0167 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5726 15.1343 -0.0096 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8108 15.0135 0.0071 N 0 0 3 0 0 0 0 0 0 0 0 0 8.2587 13.5935 -0.0213 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6359 16.3986 0.0245 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8271 17.7283 1.2223 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6674 19.0922 1.2359 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3164 19.1339 0.0583 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1226 17.8115 -1.1362 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2825 16.4480 -1.1610 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4490 7.9086 -0.0267 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8011 7.0625 -0.0154 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0670 5.0970 -0.0285 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3026 4.1912 -0.0166 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5579 2.3042 -0.0292 N 0 0 0 0 0 0 0 0 0 0 0 0 3.3801 1.7159 1.5846 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9116 1.3948 -0.3271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6299 13.0339 0.0219 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6701 9.8506 0.0108 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2079 9.8678 -0.0410 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2944 16.3339 -0.0104 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8816 17.6959 2.1428 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8154 20.1269 2.1673 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4106 20.2013 0.0721 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0658 17.8476 -2.0539 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1335 15.4182 -2.0977 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0891 7.4336 1.1471 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0670 7.4461 -1.1602 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7792 4.7258 -1.1912 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8012 4.7135 1.1161 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5906 4.5624 1.1459 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5685 4.5748 -1.1612 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5580 2.0546 2.6827 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5539 0.3143 1.5409 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6385 2.3424 1.7276 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3753 1.7877 -1.5738 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1378 0.0000 -0.3302 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.7219 0.7018 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 5 2 0 0 0 0 1 23 1 0 0 0 0 2 3 2 0 0 0 0 2 24 1 0 0 0 0 3 4 1 0 0 0 0 3 16 1 0 0 0 0 4 6 2 0 0 0 0 4 25 1 0 0 0 0 5 8 1 0 0 0 0 5 6 1 0 0 0 0 6 9 1 0 0 0 0 7 9 2 0 0 0 0 7 8 1 0 0 0 0 7 26 1 0 0 0 0 8 10 1 0 0 0 0 10 11 2 0 0 0 0 10 15 1 0 0 0 0 11 12 1 0 0 0 0 11 27 1 0 0 0 0 12 13 2 0 0 0 0 12 28 1 0 0 0 0 13 14 1 0 0 0 0 13 29 1 0 0 0 0 14 15 2 0 0 0 0 14 30 1 0 0 0 0 15 31 1 0 0 0 0 16 17 1 0 0 0 0 17 18 1 0 0 0 0 17 32 1 0 0 0 0 17 33 1 0 0 0 0 18 19 1 0 0 0 0 18 34 1 0 0 0 0 18 35 1 0 0 0 0 19 20 1 0 0 0 0 19 36 1 0 0 0 0 19 37 1 0 0 0 0 20 21 1 0 0 0 0 20 22 1 0 0 0 0 21 38 1 0 0 0 0 21 39 1 0 0 0 0 21 40 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 22 43 1 0 0 0 0 M END > (118) 5-Substituted 1-Phenylbenzimidazole 17 > (118) PDGFR-beta > (118) 150 > (118) -1 > (118) P > (118) PDGFR-P116 $$$$ SU11248 analog 12d csChFnd70/05150717532D 56 58 0 0 0 0 0 0 0 0999 V2000 3.8021 3.5390 -3.6327 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8315 1.8431 -4.2818 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1486 1.3280 -5.4298 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4415 2.4960 -5.9375 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0992 4.7250 -4.1367 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4336 4.2082 -5.2981 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0385 7.0501 -4.6887 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4447 6.5893 -3.6997 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5552 5.6210 -5.5898 N 0 0 3 0 0 0 0 0 0 0 0 0 7.7652 8.4774 -4.6906 O 0 0 0 0 0 0 0 0 0 0 0 0 4.4780 7.6630 -2.6008 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1088 9.3537 -2.1647 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9457 11.5381 -1.5523 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2594 12.2131 -1.4650 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0912 10.8242 -1.8513 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8493 9.8244 -1.9693 N 0 0 3 0 0 0 0 0 0 0 0 0 2.1134 10.9263 -1.9104 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6148 12.5557 -1.2293 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7731 14.0416 -1.0453 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6323 15.1204 -2.2169 O 0 0 0 0 0 0 0 0 0 0 0 0 4.4845 14.5179 0.6368 N 0 0 3 0 0 0 0 0 0 0 0 0 4.0012 16.3350 1.0539 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7512 16.5232 3.0410 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2666 18.3454 3.4592 N 0 0 0 0 0 0 0 0 0 0 0 0 1.5310 18.7839 2.7340 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2975 20.7817 2.7149 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3189 18.6557 5.3646 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2320 18.8144 5.9657 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0729 0.2227 -3.6020 Br 0 0 0 0 0 0 0 0 0 0 0 0 2.7728 3.9439 -2.7423 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1640 0.0000 -5.9319 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4615 2.0787 -6.8328 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5793 5.5812 -6.3490 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2394 7.2099 -2.0748 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8463 9.0415 -2.1100 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5810 10.6334 -0.6125 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7148 12.2456 -2.3037 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6140 9.9741 -2.8577 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0789 13.1164 -2.4637 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3581 13.6095 -0.2925 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6146 11.6772 -0.6980 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5970 13.6574 1.5714 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0421 17.2183 0.6178 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7791 16.6699 0.3848 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7103 15.6401 3.4771 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9734 16.1884 3.7100 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4304 18.2784 1.3969 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5101 18.1914 3.5468 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 21.1061 2.2003 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4232 21.2901 4.0489 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3030 21.3722 1.8819 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6199 19.8687 5.6706 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6940 17.5597 6.0445 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2688 19.1711 7.3533 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8976 17.5593 5.7775 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8926 19.8258 5.1949 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 5 2 0 0 0 0 1 30 1 0 0 0 0 2 3 2 0 0 0 0 2 29 1 0 0 0 0 3 4 1 0 0 0 0 3 31 1 0 0 0 0 4 6 2 0 0 0 0 4 32 1 0 0 0 0 5 8 1 0 0 0 0 5 6 1 0 0 0 0 6 9 1 0 0 0 0 7 9 1 0 0 0 0 7 8 1 0 0 0 0 7 10 2 0 0 0 0 8 11 2 0 0 0 0 9 33 1 0 0 0 0 11 12 1 0 0 0 0 11 34 1 0 0 0 0 12 15 2 0 0 0 0 12 16 1 0 0 0 0 13 16 1 0 0 0 0 13 14 2 0 0 0 0 13 18 1 0 0 0 0 14 15 1 0 0 0 0 14 19 1 0 0 0 0 15 17 1 0 0 0 0 16 35 1 0 0 0 0 17 36 1 0 0 0 0 17 37 1 0 0 0 0 17 38 1 0 0 0 0 18 39 1 0 0 0 0 18 40 1 0 0 0 0 18 41 1 0 0 0 0 19 20 2 0 0 0 0 19 21 1 0 0 0 0 21 22 1 0 0 0 0 21 42 1 0 0 0 0 22 23 1 0 0 0 0 22 43 1 0 0 0 0 22 44 1 0 0 0 0 23 24 1 0 0 0 0 23 45 1 0 0 0 0 23 46 1 0 0 0 0 24 25 1 0 0 0 0 24 27 1 0 0 0 0 25 26 1 0 0 0 0 25 47 1 0 0 0 0 25 48 1 0 0 0 0 26 49 1 0 0 0 0 26 50 1 0 0 0 0 26 51 1 0 0 0 0 27 28 1 0 0 0 0 27 52 1 0 0 0 0 27 53 1 0 0 0 0 28 54 1 0 0 0 0 28 55 1 0 0 0 0 28 56 1 0 0 0 0 M END > (13) SU11248 analog 12d > (13) PDGFR-beta > (13) 5 > (13) -1 > (13) P > (13) PDGFR-P11 $$$$ Structure316 csChFnd70/05150717532D 46 48 0 0 0 0 0 0 0 0999 V2000 12.1836 8.6125 0.0126 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2080 6.8085 0.0026 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7612 5.9255 -0.0164 C 0 0 0 0 0 0 0 0 0 0 0 0 15.3110 6.8375 -0.0264 C 0 0 0 0 0 0 0 0 0 0 0 0 15.2973 8.6590 -0.0171 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7148 9.5393 0.0029 C 0 0 0 0 0 0 0 0 0 0 0 0 17.0399 6.3570 -0.0456 N 0 0 3 0 0 0 0 0 0 0 0 0 17.9956 7.8420 -0.0474 C 0 0 0 0 0 0 0 0 0 0 0 0 16.9770 9.1863 -0.0307 N 0 0 0 0 0 0 0 0 0 0 0 0 17.6862 4.6597 -0.0604 C 0 0 0 0 0 0 0 0 0 0 0 0 18.9311 4.1794 -1.2683 C 0 0 0 0 0 0 0 0 0 0 0 0 19.5663 2.5055 -1.2793 C 0 0 0 0 0 0 0 0 0 0 0 0 18.9630 1.3083 -0.0893 C 0 0 0 0 0 0 0 0 0 0 0 0 17.7227 1.7825 1.1148 C 0 0 0 0 0 0 0 0 0 0 0 0 17.0885 3.4566 1.1375 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6423 9.4673 0.0245 O 0 0 0 0 0 0 0 0 0 0 0 0 9.1062 8.4320 0.0260 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5130 9.6130 0.0401 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8684 8.5045 0.0419 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2752 9.6855 0.0557 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6962 8.6212 0.0574 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5415 7.6324 1.6775 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1503 9.6930 -0.2381 C 0 0 0 0 0 0 0 0 0 0 0 0 11.0028 6.0963 0.0104 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7716 4.5255 -0.0231 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6892 10.9390 0.0102 H 0 0 0 0 0 0 0 0 0 0 0 0 19.3944 7.8955 -0.0612 H 0 0 0 0 0 0 0 0 0 0 0 0 19.4020 5.1136 -2.1986 H 0 0 0 0 0 0 0 0 0 0 0 0 20.5346 2.1312 -2.2184 H 0 0 0 0 0 0 0 0 0 0 0 0 19.4613 0.0000 -0.1007 H 0 0 0 0 0 0 0 0 0 0 0 0 17.2535 0.8444 2.0419 H 0 0 0 0 0 0 0 0 0 0 0 0 16.1199 3.8263 2.0782 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0825 7.6228 -1.1319 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0935 7.6102 1.1754 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5367 10.4223 1.1980 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5258 10.4349 -1.1092 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8447 7.6952 -1.1161 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8556 7.6827 1.1911 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2989 10.4948 1.2138 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2880 10.5072 -1.0935 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4869 8.5255 2.7710 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3615 6.8558 1.6444 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6610 6.7823 1.8192 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2587 10.3410 -1.4890 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 8.8729 -0.2306 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0454 10.6608 0.7861 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 2 0 0 0 0 1 6 1 0 0 0 0 1 16 1 0 0 0 0 2 3 1 0 0 0 0 2 24 1 0 0 0 0 3 4 2 0 0 0 0 3 25 1 0 0 0 0 4 5 1 0 0 0 0 4 7 1 0 0 0 0 5 6 2 0 0 0 0 5 9 1 0 0 0 0 6 26 1 0 0 0 0 7 8 1 0 0 0 0 7 10 1 0 0 0 0 8 9 2 0 0 0 0 8 27 1 0 0 0 0 10 11 2 0 0 0 0 10 15 1 0 0 0 0 11 12 1 0 0 0 0 11 28 1 0 0 0 0 12 13 2 0 0 0 0 12 29 1 0 0 0 0 13 14 1 0 0 0 0 13 30 1 0 0 0 0 14 15 2 0 0 0 0 14 31 1 0 0 0 0 15 32 1 0 0 0 0 16 17 1 0 0 0 0 17 18 1 0 0 0 0 17 33 1 0 0 0 0 17 34 1 0 0 0 0 18 19 1 0 0 0 0 18 35 1 0 0 0 0 18 36 1 0 0 0 0 19 20 1 0 0 0 0 19 37 1 0 0 0 0 19 38 1 0 0 0 0 20 21 1 0 0 0 0 20 39 1 0 0 0 0 20 40 1 0 0 0 0 21 22 1 0 0 0 0 21 23 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 22 43 1 0 0 0 0 23 44 1 0 0 0 0 23 45 1 0 0 0 0 23 46 1 0 0 0 0 M END > (124) 16230017 -25 > (124) PDGFR-beta > (124) 158 > (124) -1 > (124) P > (124) PDGFR-P122 $$$$ 3-substituted indolin-2-one 11e csChFnd70/05150717532D 48 51 0 0 0 0 0 0 0 0999 V2000 1.7814 8.5093 0.1582 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5854 6.9456 0.1304 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5760 8.5430 0.0817 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1613 9.3239 0.0957 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5307 10.9857 0.0350 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2198 11.0605 -0.0124 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7652 9.6125 0.0172 N 0 0 3 0 0 0 0 0 0 0 0 0 5.9917 12.2307 -0.0692 O 0 0 0 0 0 0 0 0 0 0 0 0 2.5072 12.2051 0.0245 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0570 13.7277 0.1510 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4258 15.0212 -0.5406 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3171 14.2051 0.9906 N 0 0 3 0 0 0 0 0 0 0 0 0 1.0265 15.0635 -1.5664 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4715 15.7509 0.8220 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3315 16.2769 -0.1073 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8011 6.9239 0.2069 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2028 6.1371 0.1934 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0833 17.9271 -0.5842 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9199 18.6837 0.5015 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6717 20.3338 0.0245 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3552 20.8517 -1.0713 O 0 0 0 0 0 0 0 0 0 0 0 0 0.6914 21.2284 0.8172 O 0 0 0 0 0 0 0 0 0 0 0 0 3.2190 4.4300 0.2459 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6148 3.6369 0.2393 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6228 2.0483 0.2883 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2493 1.2431 0.3438 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8607 2.0240 0.3506 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8388 3.6126 0.3086 C 0 0 0 0 0 0 0 0 0 0 0 0 0.6978 9.1198 0.1739 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6660 6.3297 0.1198 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8502 9.3475 -0.0039 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2865 11.9915 -0.0807 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9820 13.5461 1.6000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 15.2433 -0.8665 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1404 16.0029 -2.3911 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9269 13.9748 -2.1833 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3570 16.4499 1.3458 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7321 6.2898 0.2559 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1731 18.5474 -0.5278 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6427 17.9613 -1.7592 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8300 18.0634 0.4450 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3604 18.6495 1.6764 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5703 22.2789 0.4678 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6878 4.2643 0.1957 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7034 1.4327 0.2828 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2611 0.0000 0.3815 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7919 1.3895 0.3940 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7542 4.2214 0.3190 H 0 0 0 0 0 0 0 0 0 0 0 0 1 16 1 0 0 0 0 1 4 2 0 0 0 0 1 29 1 0 0 0 0 2 17 1 0 0 0 0 2 3 2 0 0 0 0 2 30 1 0 0 0 0 3 7 1 0 0 0 0 3 4 1 0 0 0 0 4 5 1 0 0 0 0 5 6 1 0 0 0 0 5 9 2 0 0 0 0 6 7 1 0 0 0 0 6 8 2 0 0 0 0 7 31 1 0 0 0 0 9 10 1 0 0 0 0 9 32 1 0 0 0 0 10 11 2 0 0 0 0 10 12 1 0 0 0 0 11 15 1 0 0 0 0 11 13 1 0 0 0 0 12 14 1 0 0 0 0 12 33 1 0 0 0 0 13 34 1 0 0 0 0 13 35 1 0 0 0 0 13 36 1 0 0 0 0 14 15 2 0 0 0 0 14 37 1 0 0 0 0 15 18 1 0 0 0 0 16 17 2 0 0 0 0 16 38 1 0 0 0 0 17 23 1 0 0 0 0 18 19 1 0 0 0 0 18 39 1 0 0 0 0 18 40 1 0 0 0 0 19 20 1 0 0 0 0 19 41 1 0 0 0 0 19 42 1 0 0 0 0 20 22 1 0 0 0 0 20 21 2 0 0 0 0 22 43 1 0 0 0 0 23 28 2 0 0 0 0 23 24 1 0 0 0 0 24 25 2 0 0 0 0 24 44 1 0 0 0 0 25 26 1 0 0 0 0 25 45 1 0 0 0 0 26 27 2 0 0 0 0 26 46 1 0 0 0 0 27 28 1 0 0 0 0 27 47 1 0 0 0 0 28 48 1 0 0 0 0 M END > (127) 3-substituted indolin-2-one 11e > (127) PDGFR-beta > (127) 160 > (127) -1 > (127) P > (127) PDGFR-P125 $$$$ 1,6-naphthyridin 36 csChFnd70/05150717532D 66 68 0 0 0 0 0 0 0 0999 V2000 1.1207 14.9241 -1.7397 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2298 12.1326 -1.3566 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9409 12.6935 -1.4671 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8100 15.6190 -1.8693 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2674 14.4784 -1.7302 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0993 17.4138 -2.1337 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1919 16.7785 -2.0963 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8099 17.9907 -2.2472 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8977 13.2410 -1.4932 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8921 15.1035 -1.8490 N 0 0 0 0 0 0 0 0 0 0 0 0 5.1879 19.8694 -2.5259 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7465 22.7319 -1.3668 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3938 20.9829 -1.0983 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3467 20.5296 -4.2168 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6997 22.2812 -4.4677 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8962 23.3798 -3.0468 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8910 10.3677 -1.0969 N 0 0 3 0 0 0 0 0 0 0 0 0 3.3403 9.1275 -0.9433 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6149 7.2859 -0.6659 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1021 19.1527 -6.0020 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.2064 20.1722 1.0113 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.1286 5.9907 -0.5055 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4031 4.1493 -0.2283 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8565 2.9057 -0.0743 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2309 1.1844 0.4983 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8192 1.2416 2.4532 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8243 2.7711 -1.7257 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5902 1.8959 -1.3937 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9040 17.3661 -2.2114 N 0 0 3 0 0 0 0 0 0 0 0 0 9.2375 16.2253 -2.0702 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9412 14.6818 -1.8418 O 0 0 0 0 0 0 0 0 0 0 0 0 10.8993 16.7955 -2.1819 N 0 0 3 0 0 0 0 0 0 0 0 0 12.3489 15.5556 -2.0282 C 0 0 0 0 0 0 0 0 0 0 0 0 14.0834 16.5336 -2.2000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 15.7755 -1.8370 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0070 11.7765 -1.3530 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0197 18.3150 -2.2452 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9062 23.5953 -0.2626 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8229 22.7940 -5.7762 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1720 24.7484 -3.2499 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6948 9.9571 -1.0173 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1183 9.1566 -2.1355 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1576 9.4876 0.1656 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8370 7.2568 0.5262 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7976 6.9258 -1.7748 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9065 6.0199 -1.6978 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9459 6.3509 0.6034 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6252 4.1201 0.9639 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5859 3.7891 -1.3372 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0531 0.8427 -0.2249 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2381 0.2080 0.2539 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8954 2.2936 2.7130 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2498 0.0000 2.8550 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0189 1.4723 3.1845 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0754 1.9921 -2.6528 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0336 4.0740 -2.2608 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2887 2.6073 -0.3771 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3821 0.5512 -0.9744 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3577 1.9057 -2.5928 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1404 18.5975 -2.3935 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1358 18.0270 -2.3638 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2905 14.9121 -0.7593 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2501 14.5796 -3.0602 H 0 0 0 0 0 0 0 0 0 0 0 0 14.1417 17.1771 -3.4690 H 0 0 0 0 0 0 0 0 0 0 0 0 14.1823 17.5095 -1.1681 H 0 0 0 0 0 0 0 0 0 0 0 0 15.1619 15.6110 -2.0859 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 35 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 17 1 0 0 0 0 3 5 2 0 0 0 0 3 36 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 37 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 29 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 38 1 0 0 0 0 13 21 1 0 0 0 0 14 15 1 0 0 0 0 14 20 1 0 0 0 0 15 16 2 0 0 0 0 15 39 1 0 0 0 0 16 40 1 0 0 0 0 17 18 1 0 0 0 0 17 41 1 0 0 0 0 18 19 1 0 0 0 0 18 42 1 0 0 0 0 18 43 1 0 0 0 0 19 22 1 0 0 0 0 19 44 1 0 0 0 0 19 45 1 0 0 0 0 22 23 1 0 0 0 0 22 46 1 0 0 0 0 22 47 1 0 0 0 0 23 24 1 0 0 0 0 23 48 1 0 0 0 0 23 49 1 0 0 0 0 24 27 1 0 0 0 0 24 25 1 0 0 0 0 25 26 1 0 0 0 0 25 50 1 0 0 0 0 25 51 1 0 0 0 0 26 52 1 0 0 0 0 26 53 1 0 0 0 0 26 54 1 0 0 0 0 27 28 1 0 0 0 0 27 55 1 0 0 0 0 27 56 1 0 0 0 0 28 57 1 0 0 0 0 28 58 1 0 0 0 0 28 59 1 0 0 0 0 29 30 1 0 0 0 0 29 60 1 0 0 0 0 30 31 2 0 0 0 0 30 32 1 0 0 0 0 32 33 1 0 0 0 0 32 61 1 0 0 0 0 33 34 1 0 0 0 0 33 62 1 0 0 0 0 33 63 1 0 0 0 0 34 64 1 0 0 0 0 34 65 1 0 0 0 0 34 66 1 0 0 0 0 M END > (128) 1,6-naphthyridine 36 > (128) PDGFR-beta > (128) 160 > (128) -1 > (128) P > (128) PDGFR-P126 $$$$ Structure4 csChFnd70/05150717532D 48 51 0 0 0 0 0 0 0 0999 V2000 3.8707 13.5953 0.0124 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8950 11.8085 0.0026 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4633 10.9169 -0.0171 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0140 11.8111 -0.0266 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4175 14.5131 0.0026 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0063 13.6223 -0.0167 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5924 16.3803 -0.0096 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8305 16.2595 0.0071 N 0 0 3 0 0 0 0 0 0 0 0 0 8.2786 14.8394 -0.0213 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6556 17.6447 0.0245 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8468 18.9745 1.2223 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6869 20.3385 1.2360 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3358 20.3802 0.0583 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1420 19.0578 -1.1363 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3020 17.6941 -1.1610 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4687 9.1542 -0.0267 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8207 8.3080 -0.0154 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0866 6.3424 -0.0285 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3221 5.4365 -0.0166 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8733 3.0440 -1.3320 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1552 1.0813 -1.2480 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2410 0.6805 -0.2534 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9297 2.6392 -0.3273 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5774 3.5494 -0.0292 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5333 0.2192 -1.5003 O 0 0 0 0 0 0 0 0 0 0 0 0 2.6494 14.2798 0.0219 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6896 11.0963 0.0108 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2278 11.1135 -0.0410 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3142 17.5800 -0.0104 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9013 18.9421 2.1429 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8350 21.3732 2.1674 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4301 21.4477 0.0721 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0852 19.0938 -2.0540 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1531 16.6642 -2.0978 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1086 8.6792 1.1472 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0866 8.6916 -1.1603 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7988 5.9712 -1.1912 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8209 5.9588 1.1162 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6100 5.8078 1.1460 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5879 5.8201 -1.1613 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0925 3.7077 -1.0671 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4117 3.3999 -2.6193 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0597 0.6907 -2.2610 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6825 0.7340 0.0161 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6836 0.3215 1.0397 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0379 0.0000 -0.5469 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4209 2.9886 -1.5986 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.0072 0.6713 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 5 2 0 0 0 0 1 26 1 0 0 0 0 2 3 2 0 0 0 0 2 27 1 0 0 0 0 3 4 1 0 0 0 0 3 16 1 0 0 0 0 4 6 2 0 0 0 0 4 28 1 0 0 0 0 5 8 1 0 0 0 0 5 6 1 0 0 0 0 6 9 1 0 0 0 0 7 9 2 0 0 0 0 7 8 1 0 0 0 0 7 29 1 0 0 0 0 8 10 1 0 0 0 0 10 11 2 0 0 0 0 10 15 1 0 0 0 0 11 12 1 0 0 0 0 11 30 1 0 0 0 0 12 13 2 0 0 0 0 12 31 1 0 0 0 0 13 14 1 0 0 0 0 13 32 1 0 0 0 0 14 15 2 0 0 0 0 14 33 1 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 17 18 1 0 0 0 0 17 35 1 0 0 0 0 17 36 1 0 0 0 0 18 19 1 0 0 0 0 18 37 1 0 0 0 0 18 38 1 0 0 0 0 19 24 1 0 0 0 0 19 39 1 0 0 0 0 19 40 1 0 0 0 0 20 24 1 0 0 0 0 20 21 1 0 0 0 0 20 41 1 0 0 0 0 20 42 1 0 0 0 0 21 25 1 0 0 0 0 21 43 1 0 0 0 0 21 44 1 0 0 0 0 22 25 1 0 0 0 0 22 23 1 0 0 0 0 22 45 1 0 0 0 0 22 46 1 0 0 0 0 23 24 1 0 0 0 0 23 47 1 0 0 0 0 23 48 1 0 0 0 0 M END > (132) 5-Substituted 1-Phenylbenzimidazole 20 > (132) PDGFR-beta > (132) 170 > (132) -1 > (132) P > (132) PDGFR-P130 $$$$ 3-substituted indolin-2-one 11f csChFnd70/05150717532D 52 55 0 0 0 0 0 0 0 0999 V2000 2.3064 9.4274 0.1582 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1105 7.8636 0.1304 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1010 9.4610 0.0812 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6863 10.2419 0.0955 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0558 11.9038 0.0340 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7449 11.9784 -0.0143 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2902 10.5305 0.0158 N 0 0 3 0 0 0 0 0 0 0 0 0 6.5166 13.1486 -0.0722 O 0 0 0 0 0 0 0 0 0 0 0 0 3.0322 13.1230 0.0236 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5821 14.6457 0.1491 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9504 15.9389 -0.5428 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8425 15.1234 0.9879 N 0 0 3 0 0 0 0 0 0 0 0 0 1.5510 15.9806 -1.5684 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9963 16.6693 0.8193 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8557 17.1949 -0.1096 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3261 7.8418 0.2068 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7279 7.0550 0.1930 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6072 18.8450 -0.5870 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4436 19.6015 0.4987 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1950 21.2515 0.0213 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8784 21.7692 -1.0746 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2144 22.1460 0.8138 O 0 0 0 0 0 0 0 0 0 0 0 0 3.7441 5.3478 0.2450 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3640 4.5313 0.3005 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3869 2.9373 0.3481 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7825 2.1570 0.3405 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1522 2.9662 0.2859 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1401 4.5552 0.2315 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0432 2.1367 0.4030 O 0 0 0 0 0 0 0 0 0 0 0 0 1.1527 0.4953 0.4501 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2228 10.0377 0.1740 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1911 7.2477 0.1197 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3752 10.2655 -0.0050 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8114 12.9094 -0.0807 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5080 14.4647 1.5970 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5246 16.1603 -0.8686 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6647 16.9199 -2.3934 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4517 14.8917 -2.1851 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8820 17.3686 1.3425 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2573 7.2076 0.2559 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6969 19.4655 -0.5306 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1667 18.8789 -1.7619 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3539 18.9809 0.4422 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8841 19.5676 1.6736 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0930 23.1963 0.4641 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2792 5.1399 0.3067 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7980 0.9137 0.3777 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2346 2.3538 0.2806 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2120 5.1841 0.1837 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7475 0.0860 -0.5768 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7942 0.1480 1.4717 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.0000 0.4913 H 0 0 0 0 0 0 0 0 0 0 0 0 1 16 1 0 0 0 0 1 4 2 0 0 0 0 1 31 1 0 0 0 0 2 17 1 0 0 0 0 2 3 2 0 0 0 0 2 32 1 0 0 0 0 3 7 1 0 0 0 0 3 4 1 0 0 0 0 4 5 1 0 0 0 0 5 6 1 0 0 0 0 5 9 2 0 0 0 0 6 7 1 0 0 0 0 6 8 2 0 0 0 0 7 33 1 0 0 0 0 9 10 1 0 0 0 0 9 34 1 0 0 0 0 10 11 2 0 0 0 0 10 12 1 0 0 0 0 11 15 1 0 0 0 0 11 13 1 0 0 0 0 12 14 1 0 0 0 0 12 35 1 0 0 0 0 13 36 1 0 0 0 0 13 37 1 0 0 0 0 13 38 1 0 0 0 0 14 15 2 0 0 0 0 14 39 1 0 0 0 0 15 18 1 0 0 0 0 16 17 2 0 0 0 0 16 40 1 0 0 0 0 17 23 1 0 0 0 0 18 19 1 0 0 0 0 18 41 1 0 0 0 0 18 42 1 0 0 0 0 19 20 1 0 0 0 0 19 43 1 0 0 0 0 19 44 1 0 0 0 0 20 22 1 0 0 0 0 20 21 2 0 0 0 0 22 45 1 0 0 0 0 23 28 2 0 0 0 0 23 24 1 0 0 0 0 24 25 2 0 0 0 0 24 46 1 0 0 0 0 25 26 1 0 0 0 0 25 29 1 0 0 0 0 26 27 2 0 0 0 0 26 47 1 0 0 0 0 27 28 1 0 0 0 0 27 48 1 0 0 0 0 28 49 1 0 0 0 0 29 30 1 0 0 0 0 30 50 1 0 0 0 0 30 51 1 0 0 0 0 30 52 1 0 0 0 0 M END > (133) 3-substituted indolin-2-one 11f > (133) PDGFR-beta > (133) 170 > (133) -1 > (133) P > (133) PDGFR-P131 $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 47 csChFnd70/05150717532D 44 47 0 0 0 0 0 0 0 0999 V2000 4.2843 8.4114 0.0168 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7203 5.9514 -0.0081 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7943 9.2604 0.0230 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2715 8.3348 0.0125 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8511 11.0047 0.0388 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8642 10.7787 0.0325 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2078 11.4546 0.0367 O 0 0 0 0 0 0 0 0 0 0 0 0 7.3557 11.7756 0.0436 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7735 9.1182 0.0174 N 0 0 3 0 0 0 0 0 0 0 0 0 7.1750 6.6977 -0.0028 N 0 0 0 0 0 0 0 0 0 0 0 0 4.3058 6.7820 0.0014 N 0 0 0 0 0 0 0 0 0 0 0 0 5.6716 4.2461 -0.0242 N 0 0 3 0 0 0 0 0 0 0 0 0 4.1601 3.4244 0.1162 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9004 1.9527 -0.7255 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4058 1.1442 -0.5843 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1681 1.7985 0.3933 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4224 3.2634 1.2329 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9169 4.0742 1.1031 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4567 13.6023 0.0595 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9750 16.1892 1.4254 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8777 14.4882 1.4177 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1376 14.4419 -1.2807 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2283 16.1431 -1.2587 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6453 17.0156 0.0891 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2942 8.1386 0.0070 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8213 7.8133 -1.7776 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1289 9.0770 0.0299 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7248 11.7185 0.0464 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6862 3.6191 -0.1327 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8662 1.4417 -1.4898 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2031 0.0000 -1.2383 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.1641 0.5009 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4531 3.7712 1.9949 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1170 5.2151 1.7638 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5271 16.8766 2.4765 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3538 13.8443 2.4614 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5934 13.7621 -2.3334 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7557 16.7948 -2.2957 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7186 18.3471 0.1005 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2672 8.8139 0.6461 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0770 6.9663 0.6314 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0385 8.9855 -2.4022 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9527 7.0844 -1.7854 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8483 7.1380 -2.4169 H 0 0 0 0 0 0 0 0 0 0 0 0 1 11 1 0 0 0 0 1 3 2 0 0 0 0 1 27 1 0 0 0 0 2 11 2 0 0 0 0 2 10 1 0 0 0 0 2 12 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 10 2 0 0 0 0 4 9 1 0 0 0 0 5 8 2 0 0 0 0 5 28 1 0 0 0 0 6 9 1 0 0 0 0 6 8 1 0 0 0 0 6 7 2 0 0 0 0 8 19 1 0 0 0 0 9 25 1 0 0 0 0 12 13 1 0 0 0 0 12 29 1 0 0 0 0 13 14 2 0 0 0 0 13 18 1 0 0 0 0 14 15 1 0 0 0 0 14 30 1 0 0 0 0 15 16 2 0 0 0 0 15 31 1 0 0 0 0 16 17 1 0 0 0 0 16 32 1 0 0 0 0 17 18 2 0 0 0 0 17 33 1 0 0 0 0 18 34 1 0 0 0 0 19 21 1 0 0 0 0 19 22 2 0 0 0 0 20 21 2 0 0 0 0 20 24 1 0 0 0 0 20 35 1 0 0 0 0 21 36 1 0 0 0 0 22 23 1 0 0 0 0 22 37 1 0 0 0 0 23 24 2 0 0 0 0 23 38 1 0 0 0 0 24 39 1 0 0 0 0 25 26 1 0 0 0 0 25 40 1 0 0 0 0 25 41 1 0 0 0 0 26 42 1 0 0 0 0 26 43 1 0 0 0 0 26 44 1 0 0 0 0 M END > (136) pyrido[2,3-d]pyrimidin-7-one deriv. 47 > (136) PDGFR-beta > (136) 180 > (136) -1 > (136) P > (136) PDGFR-P134 $$$$ csChFnd70/05150717532D 56 59 0 0 0 0 0 0 0 0999 V2000 9.4396 12.8261 0.0166 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3265 11.1150 -0.0029 N 0 0 0 0 0 0 0 0 0 0 0 0 9.4610 11.1993 0.0014 N 0 0 0 0 0 0 0 0 0 0 0 0 10.9480 13.6742 0.0228 C 0 0 0 0 0 0 0 0 0 0 0 0 12.4227 12.7501 0.0123 C 0 0 0 0 0 0 0 0 0 0 0 0 11.0043 15.4161 0.0386 C 0 0 0 0 0 0 0 0 0 0 0 0 14.0132 15.1908 0.0345 C 0 0 0 0 0 0 0 0 0 0 0 0 15.3549 15.8659 0.0402 O 0 0 0 0 0 0 0 0 0 0 0 0 13.9226 13.5326 0.0185 N 0 0 3 0 0 0 0 0 0 0 0 0 12.5066 16.1862 0.0434 C 0 0 0 0 0 0 0 0 0 0 0 0 12.6071 18.0103 0.0593 C 0 0 0 0 0 0 0 0 0 0 0 0 12.6457 18.8865 -1.4209 C 0 0 0 0 0 0 0 0 0 0 0 0 12.7389 20.5867 -1.3975 C 0 0 0 0 0 0 0 0 0 0 0 0 12.7940 21.4211 0.0890 C 0 0 0 0 0 0 0 0 0 0 0 0 12.7569 20.5599 1.5609 C 0 0 0 0 0 0 0 0 0 0 0 0 12.6566 18.8599 1.5547 C 0 0 0 0 0 0 0 0 0 0 0 0 12.6005 17.7819 3.4032 Cl 0 0 0 0 0 0 0 0 0 0 0 0 12.5773 17.8416 -3.2879 Cl 0 0 0 0 0 0 0 0 0 0 0 0 10.8740 10.3697 -0.0081 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8256 8.6671 -0.0242 N 0 0 3 0 0 0 0 0 0 0 0 0 9.3138 7.8452 0.1162 C 0 0 0 0 0 0 0 0 0 0 0 0 15.4412 12.5545 0.0080 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0564 6.3759 -0.7247 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0738 8.4950 1.1020 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5831 7.6836 1.2396 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5650 5.5660 -0.5857 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3245 6.2197 0.3937 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8564 5.4211 0.5303 O 0 0 0 0 0 0 0 0 0 0 0 0 3.6344 6.1642 1.5595 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0790 5.0965 1.5602 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4447 3.4975 2.3285 N 0 0 3 0 0 0 0 0 0 0 0 0 0.9763 2.4371 2.3509 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4047 0.7868 3.1583 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2858 13.4908 0.0187 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8794 16.1287 0.0461 H 0 0 0 0 0 0 0 0 0 0 0 0 12.7693 21.2663 -2.5423 H 0 0 0 0 0 0 0 0 0 0 0 0 12.8669 22.7507 0.1007 H 0 0 0 0 0 0 0 0 0 0 0 0 12.8012 21.2187 2.7174 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8389 8.0411 -0.1325 H 0 0 0 0 0 0 0 0 0 0 0 0 15.8168 12.3238 -1.2616 H 0 0 0 0 0 0 0 0 0 0 0 0 16.4126 13.2284 0.6472 H 0 0 0 0 0 0 0 0 0 0 0 0 15.2241 11.3835 0.6308 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0221 5.8671 -1.4875 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2751 9.6344 1.7610 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6167 8.1914 2.0022 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3627 4.4262 -1.2439 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1072 6.2677 2.8133 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3374 7.3881 1.0902 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1103 5.7166 2.2555 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6684 4.9023 0.2953 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3933 2.9334 1.7541 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.0387 3.0516 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5581 2.2245 1.0915 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3152 0.0000 3.1749 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3811 0.1852 2.4576 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8230 0.9995 4.4177 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 34 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 35 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 36 1 0 0 0 0 14 15 1 0 0 0 0 14 37 1 0 0 0 0 15 16 2 0 0 0 0 15 38 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 39 1 0 0 0 0 21 23 1 0 0 0 0 21 24 2 0 0 0 0 22 40 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 26 2 0 0 0 0 23 43 1 0 0 0 0 24 25 1 0 0 0 0 24 44 1 0 0 0 0 25 27 2 0 0 0 0 25 45 1 0 0 0 0 26 27 1 0 0 0 0 26 46 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 29 47 1 0 0 0 0 29 48 1 0 0 0 0 30 31 1 0 0 0 0 30 49 1 0 0 0 0 30 50 1 0 0 0 0 31 32 1 0 0 0 0 31 51 1 0 0 0 0 32 33 1 0 0 0 0 32 52 1 0 0 0 0 32 53 1 0 0 0 0 33 54 1 0 0 0 0 33 55 1 0 0 0 0 33 56 1 0 0 0 0 M END > (137) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 59 > (137) PDGFR-beta > (137) 190 > (137) -1 > (137) P > (137) PDGFR-P135 $$$$ Structure144 csChFnd70/05150717532D 65 67 0 0 0 0 0 0 0 0999 V2000 12.8264 11.0367 -0.5482 N 0 0 0 0 0 0 0 0 0 0 0 0 12.6159 9.3208 -0.5021 C 0 0 0 0 0 0 0 0 0 0 0 0 13.9319 8.2242 -0.5631 N 0 0 0 0 0 0 0 0 0 0 0 0 15.5640 8.8149 -0.6768 C 0 0 0 0 0 0 0 0 0 0 0 0 15.8353 10.6386 -0.7294 C 0 0 0 0 0 0 0 0 0 0 0 0 16.9152 7.7316 -0.7398 N 0 0 0 0 0 0 0 0 0 0 0 0 18.5221 8.3110 -0.8512 C 0 0 0 0 0 0 0 0 0 0 0 0 18.8902 10.1056 -0.9093 C 0 0 0 0 0 0 0 0 0 0 0 0 19.8823 7.1300 -0.9110 N 0 0 3 0 0 0 0 0 0 0 0 0 19.5526 5.4113 -0.8569 C 0 0 0 0 0 0 0 0 0 0 0 0 20.8740 4.2643 -0.9149 N 0 0 3 0 0 0 0 0 0 0 0 0 18.0632 4.8959 -0.7554 O 0 0 0 0 0 0 0 0 0 0 0 0 10.9503 8.6609 -0.3849 N 0 0 3 0 0 0 0 0 0 0 0 0 20.7115 10.7195 -1.0335 C 0 0 0 0 0 0 0 0 0 0 0 0 21.6680 11.0405 0.4716 C 0 0 0 0 0 0 0 0 0 0 0 0 23.3646 11.6118 0.3471 C 0 0 0 0 0 0 0 0 0 0 0 0 24.1149 11.8663 -1.2656 C 0 0 0 0 0 0 0 0 0 0 0 0 23.1731 11.5504 -2.7630 C 0 0 0 0 0 0 0 0 0 0 0 0 21.4780 10.9715 -2.6560 C 0 0 0 0 0 0 0 0 0 0 0 0 14.3821 11.7419 -0.6594 C 0 0 0 0 0 0 0 0 0 0 0 0 17.5350 11.2897 -0.8499 C 0 0 0 0 0 0 0 0 0 0 0 0 20.2985 10.5751 -4.5368 Cl 0 0 0 0 0 0 0 0 0 0 0 0 20.7283 10.7233 2.4970 Cl 0 0 0 0 0 0 0 0 0 0 0 0 22.2276 1.3899 -0.9408 C 0 0 0 0 0 0 0 0 0 0 0 0 20.5156 2.3960 -0.8560 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4610 9.8434 -0.3146 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7818 8.7874 -0.1889 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2262 10.0224 -0.1156 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5472 8.9664 0.0103 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0536 10.1523 0.0807 N 0 0 0 0 0 0 0 0 0 0 0 0 1.1594 8.6839 -2.0114 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4124 9.1970 -0.1079 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8329 12.7215 1.5054 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0682 11.1756 1.6914 C 0 0 0 0 0 0 0 0 0 0 0 0 21.0707 7.5413 -0.9920 H 0 0 0 0 0 0 0 0 0 0 0 0 22.0623 4.6755 -0.9959 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7676 7.4145 -0.3491 H 0 0 0 0 0 0 0 0 0 0 0 0 24.1067 11.8607 1.5115 H 0 0 0 0 0 0 0 0 0 0 0 0 25.4413 12.3140 -1.3561 H 0 0 0 0 0 0 0 0 0 0 0 0 23.7662 11.7520 -4.0185 H 0 0 0 0 0 0 0 0 0 0 0 0 14.5372 13.1358 -0.6959 H 0 0 0 0 0 0 0 0 0 0 0 0 17.7791 12.6706 -0.8922 H 0 0 0 0 0 0 0 0 0 0 0 0 22.9002 1.7036 -2.1467 H 0 0 0 0 0 0 0 0 0 0 0 0 23.0414 1.7494 0.1608 H 0 0 0 0 0 0 0 0 0 0 0 0 21.9610 0.0000 -0.8970 H 0 0 0 0 0 0 0 0 0 0 0 0 19.8430 2.0823 0.3500 H 0 0 0 0 0 0 0 0 0 0 0 0 19.7017 2.0366 -1.9576 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5772 10.6821 0.8202 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4326 10.6370 -1.4871 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6655 7.9487 -1.3238 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8101 7.9938 0.9835 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3425 10.8611 1.0194 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1981 10.8160 -1.2879 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4309 8.1277 -1.1247 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5754 8.1729 1.1827 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0098 9.8509 -2.7990 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2882 7.9548 -2.4577 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 7.8801 -2.1335 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4502 8.0308 0.6943 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3370 10.0200 0.3061 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5034 12.2509 1.3786 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9341 13.5471 2.6513 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1811 13.4681 0.3536 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6470 10.3621 2.7712 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3802 11.6469 1.9393 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 20 2 0 0 0 0 2 3 2 0 0 0 0 2 13 1 0 0 0 0 3 4 1 0 0 0 0 4 6 2 0 0 0 0 4 5 1 0 0 0 0 5 20 1 0 0 0 0 5 21 2 0 0 0 0 6 7 1 0 0 0 0 7 8 2 0 0 0 0 7 9 1 0 0 0 0 8 14 1 0 0 0 0 8 21 1 0 0 0 0 9 10 1 0 0 0 0 9 35 1 0 0 0 0 10 11 1 0 0 0 0 10 12 2 0 0 0 0 11 25 1 0 0 0 0 11 36 1 0 0 0 0 13 26 1 0 0 0 0 13 37 1 0 0 0 0 14 15 2 0 0 0 0 14 19 1 0 0 0 0 15 16 1 0 0 0 0 15 23 1 0 0 0 0 16 17 2 0 0 0 0 16 38 1 0 0 0 0 17 18 1 0 0 0 0 17 39 1 0 0 0 0 18 19 2 0 0 0 0 18 40 1 0 0 0 0 19 22 1 0 0 0 0 20 41 1 0 0 0 0 21 42 1 0 0 0 0 24 25 1 0 0 0 0 24 43 1 0 0 0 0 24 44 1 0 0 0 0 24 45 1 0 0 0 0 25 46 1 0 0 0 0 25 47 1 0 0 0 0 26 27 1 0 0 0 0 26 48 1 0 0 0 0 26 49 1 0 0 0 0 27 28 1 0 0 0 0 27 50 1 0 0 0 0 27 51 1 0 0 0 0 28 29 1 0 0 0 0 28 52 1 0 0 0 0 28 53 1 0 0 0 0 29 30 1 0 0 0 0 29 54 1 0 0 0 0 29 55 1 0 0 0 0 30 32 1 0 0 0 0 30 34 1 0 0 0 0 31 32 1 0 0 0 0 31 56 1 0 0 0 0 31 57 1 0 0 0 0 31 58 1 0 0 0 0 32 59 1 0 0 0 0 32 60 1 0 0 0 0 33 34 1 0 0 0 0 33 61 1 0 0 0 0 33 62 1 0 0 0 0 33 63 1 0 0 0 0 34 64 1 0 0 0 0 34 65 1 0 0 0 0 M END > (138) 9240345-6d > (138) PDGFR-beta > (138) 190 > (138) -1 > (138) P > (138) PDGFR-P136 $$$$ Indolin-2-one deriv. 9a csChFnd70/05150717532D 45 48 0 0 0 0 0 0 0 0999 V2000 5.7690 3.5440 -0.1493 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7419 1.9574 -0.3913 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9429 1.2418 -1.1901 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1767 2.1005 -1.7530 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2249 3.6995 -1.5209 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0069 4.4198 -0.7116 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3865 6.0969 -0.6567 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8751 6.2426 -1.4807 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3073 4.8177 -1.9544 N 0 0 3 0 0 0 0 0 0 0 0 0 9.5927 7.4447 -1.6962 O 0 0 0 0 0 0 0 0 0 0 0 0 6.5268 7.2719 0.0228 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1491 8.7849 0.1329 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3204 10.1670 0.0432 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6925 9.1622 0.3565 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5915 10.3332 -0.1888 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7807 10.3612 1.3944 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0518 10.5274 1.1623 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5225 10.6145 -0.1361 O 0 0 0 0 0 0 0 0 0 0 0 0 1.1000 10.5788 2.3982 O 0 0 0 0 0 0 0 0 0 0 0 0 8.8248 10.7290 0.3967 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3888 11.3689 0.2087 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0712 13.0939 0.1977 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2929 11.6683 0.6130 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9697 13.3444 0.0989 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4860 13.9308 0.8888 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8304 4.1035 0.4695 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7829 1.2731 0.0435 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9142 0.0000 -1.3743 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1065 1.5290 -2.3742 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2533 4.5981 -2.5280 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3780 7.0314 0.4696 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5406 8.4270 0.4668 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3500 11.4133 -0.8064 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1602 9.3532 -0.8671 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0222 9.2811 2.0119 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2120 11.3412 2.0726 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 10.6862 2.1912 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8832 13.4856 -0.9930 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0440 13.3433 0.8969 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6325 11.6544 1.8340 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2223 11.1765 -0.0946 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9440 14.0834 0.4316 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8239 13.3794 -1.1596 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3712 15.1791 0.7021 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5513 13.6937 2.1321 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 6 2 0 0 0 0 1 26 1 0 0 0 0 2 3 2 0 0 0 0 2 27 1 0 0 0 0 3 4 1 0 0 0 0 3 28 1 0 0 0 0 4 5 2 0 0 0 0 4 29 1 0 0 0 0 5 9 1 0 0 0 0 5 6 1 0 0 0 0 6 7 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 9 1 0 0 0 0 8 10 2 0 0 0 0 9 30 1 0 0 0 0 11 12 1 0 0 0 0 11 31 1 0 0 0 0 12 13 2 0 0 0 0 12 14 1 0 0 0 0 13 21 1 0 0 0 0 13 15 1 0 0 0 0 14 20 1 0 0 0 0 14 32 1 0 0 0 0 15 16 1 0 0 0 0 15 33 1 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 16 35 1 0 0 0 0 16 36 1 0 0 0 0 17 19 1 0 0 0 0 17 18 2 0 0 0 0 19 37 1 0 0 0 0 20 23 1 0 0 0 0 20 21 2 0 0 0 0 21 22 1 0 0 0 0 22 25 1 0 0 0 0 22 38 1 0 0 0 0 22 39 1 0 0 0 0 23 24 1 0 0 0 0 23 40 1 0 0 0 0 23 41 1 0 0 0 0 24 25 1 0 0 0 0 24 42 1 0 0 0 0 24 43 1 0 0 0 0 25 44 1 0 0 0 0 25 45 1 0 0 0 0 M END > (153) Indolin-2-one deriv. 9a > (153) PDGFR-beta > (153) 240 > (153) -1 > (153) P > (153) PDGFR-P151 $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7s csChFnd70/05150717532D 66 70 0 0 0 0 0 0 0 0999 V2000 9.8575 5.3915 3.0831 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9209 7.1529 0.8618 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3454 8.0417 0.7023 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2250 6.2186 3.0103 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9629 7.5791 1.7877 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8468 5.7113 4.1368 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2722 6.5544 4.0211 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0439 7.9596 2.7390 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6452 8.7149 2.6299 O 0 0 0 0 0 0 0 0 0 0 0 0 11.1245 5.8786 2.0261 N 0 0 0 0 0 0 0 0 0 0 0 0 6.3753 8.4203 1.6797 N 0 0 3 0 0 0 0 0 0 0 0 0 6.1305 9.8279 0.4026 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8074 6.0485 5.1847 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2320 6.3858 7.8834 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6003 6.8635 6.8049 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6244 4.7603 4.6621 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2618 4.2949 5.7532 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0679 5.1031 7.3605 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0597 8.4737 7.4636 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.8645 3.7457 2.6449 Cl 0 0 0 0 0 0 0 0 0 0 0 0 12.3103 7.6044 -0.2156 N 0 0 3 0 0 0 0 0 0 0 0 0 13.8937 6.6925 -0.0980 C 0 0 0 0 0 0 0 0 0 0 0 0 17.0281 6.6659 -0.2322 C 0 0 0 0 0 0 0 0 0 0 0 0 15.4553 4.0130 0.3761 C 0 0 0 0 0 0 0 0 0 0 0 0 13.8926 4.9117 0.2610 C 0 0 0 0 0 0 0 0 0 0 0 0 15.4665 7.5667 -0.3477 C 0 0 0 0 0 0 0 0 0 0 0 0 17.0260 4.8887 0.1332 C 0 0 0 0 0 0 0 0 0 0 0 0 18.5643 4.0026 0.2462 O 0 0 0 0 0 0 0 0 0 0 0 0 18.4650 2.1751 0.6262 C 0 0 0 0 0 0 0 0 0 0 0 0 20.3120 1.4080 0.7009 C 0 0 0 0 0 0 0 0 0 0 0 0 24.0248 2.3577 3.7975 C 0 0 0 0 0 0 0 0 0 0 0 0 23.0161 1.4097 2.3511 C 0 0 0 0 0 0 0 0 0 0 0 0 20.2861 2.1255 3.7863 C 0 0 0 0 0 0 0 0 0 0 0 0 21.2949 3.0734 5.2326 C 0 0 0 0 0 0 0 0 0 0 0 0 21.2844 2.2189 2.1463 N 0 0 0 0 0 0 0 0 0 0 0 0 23.0265 2.2641 5.4374 N 0 0 0 0 0 0 0 0 0 0 0 0 23.9989 3.0752 6.8828 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0790 4.3533 4.0151 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1968 9.0754 -0.2491 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0352 4.6723 5.0753 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6560 9.2791 -0.8247 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1792 10.7643 0.9039 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3744 10.4880 0.1786 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0701 7.0155 9.1377 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3452 3.2982 5.3503 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 4.7342 8.2088 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1840 8.5517 -1.0501 H 0 0 0 0 0 0 0 0 0 0 0 0 18.2514 7.3467 -0.4211 H 0 0 0 0 0 0 0 0 0 0 0 0 15.4549 2.6294 0.6604 H 0 0 0 0 0 0 0 0 0 0 0 0 12.6699 4.2299 0.4505 H 0 0 0 0 0 0 0 0 0 0 0 0 15.4683 8.9504 -0.6327 H 0 0 0 0 0 0 0 0 0 0 0 0 17.8204 1.9855 1.8837 H 0 0 0 0 0 0 0 0 0 0 0 0 17.7181 1.5172 -0.3946 H 0 0 0 0 0 0 0 0 0 0 0 0 20.2336 0.0000 0.9117 H 0 0 0 0 0 0 0 0 0 0 0 0 20.9846 1.6677 -0.5292 H 0 0 0 0 0 0 0 0 0 0 0 0 25.2950 1.7356 3.9776 H 0 0 0 0 0 0 0 0 0 0 0 0 24.2111 3.7229 3.4311 H 0 0 0 0 0 0 0 0 0 0 0 0 23.7361 1.5099 1.1247 H 0 0 0 0 0 0 0 0 0 0 0 0 22.8608 0.0362 2.7012 H 0 0 0 0 0 0 0 0 0 0 0 0 20.0998 0.7601 4.1526 H 0 0 0 0 0 0 0 0 0 0 0 0 19.0158 2.7475 3.6061 H 0 0 0 0 0 0 0 0 0 0 0 0 21.4501 4.4468 4.8825 H 0 0 0 0 0 0 0 0 0 0 0 0 20.5748 2.9731 6.4590 H 0 0 0 0 0 0 0 0 0 0 0 0 24.2493 4.4451 6.5775 H 0 0 0 0 0 0 0 0 0 0 0 0 23.2304 2.9879 8.0806 H 0 0 0 0 0 0 0 0 0 0 0 0 25.2386 2.3940 7.0628 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 38 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 39 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 40 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 41 1 0 0 0 0 12 42 1 0 0 0 0 12 43 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 44 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 45 1 0 0 0 0 18 46 1 0 0 0 0 21 22 1 0 0 0 0 21 47 1 0 0 0 0 22 25 2 0 0 0 0 22 26 1 0 0 0 0 23 27 1 0 0 0 0 23 26 2 0 0 0 0 23 48 1 0 0 0 0 24 27 2 0 0 0 0 24 25 1 0 0 0 0 24 49 1 0 0 0 0 25 50 1 0 0 0 0 26 51 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 29 52 1 0 0 0 0 29 53 1 0 0 0 0 30 35 1 0 0 0 0 30 54 1 0 0 0 0 30 55 1 0 0 0 0 31 36 1 0 0 0 0 31 32 1 0 0 0 0 31 56 1 0 0 0 0 31 57 1 0 0 0 0 32 35 1 0 0 0 0 32 58 1 0 0 0 0 32 59 1 0 0 0 0 33 35 1 0 0 0 0 33 34 1 0 0 0 0 33 60 1 0 0 0 0 33 61 1 0 0 0 0 34 36 1 0 0 0 0 34 62 1 0 0 0 0 34 63 1 0 0 0 0 36 37 1 0 0 0 0 37 64 1 0 0 0 0 37 65 1 0 0 0 0 37 66 1 0 0 0 0 M END > (158) 1,6-naphthyridin-2(1H)-one deriv. 7s > (158) PDGFR-beta > (158) 260 > (158) -1 > (158) P > (158) PDGFR-P156 $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7u csChFnd70/05150717532D 59 63 0 0 0 0 0 0 0 0999 V2000 6.4584 10.7801 -0.8603 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0410 8.5772 -0.2125 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6985 9.4359 0.0692 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1596 11.7342 -0.6015 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7430 11.0434 -0.1244 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2491 13.3680 -0.8103 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9515 14.2568 -0.5441 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5009 13.5036 -0.0504 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3418 14.2887 0.1879 O 0 0 0 0 0 0 0 0 0 0 0 0 6.3555 9.2634 -0.6604 N 0 0 0 0 0 0 0 0 0 0 0 0 2.4434 11.9455 0.1409 N 0 0 3 0 0 0 0 0 0 0 0 0 0.9852 11.2060 0.6346 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0137 15.9701 -0.7534 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7239 18.2278 -2.3861 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6637 16.6297 -2.1988 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4160 16.9316 0.4956 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4719 18.5278 0.2925 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1295 19.1739 -1.1448 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1544 15.4443 -3.7579 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.8449 16.1233 2.3006 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.0097 6.9711 -0.0227 N 0 0 3 0 0 0 0 0 0 0 0 0 6.3864 6.1055 -0.1638 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6970 3.7480 -0.9004 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1556 5.8950 0.1609 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7981 6.7485 0.2999 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3395 4.6015 -0.7614 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1094 4.3934 -0.4429 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8513 1.0902 -0.0035 C 0 0 0 0 0 0 0 0 0 0 0 0 13.3243 3.4795 -0.2935 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8357 4.4285 -0.0348 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3628 2.0393 0.2552 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4854 3.5282 -0.5835 N 0 0 0 0 0 0 0 0 0 0 0 0 13.2016 1.9907 0.5451 N 0 0 0 0 0 0 0 0 0 0 0 0 14.6459 1.0824 0.3975 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5479 11.2912 -1.2305 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6373 8.8641 0.4329 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3275 13.9063 -1.1745 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9467 11.1509 1.9036 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 11.8870 0.2102 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9241 10.0298 0.1576 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4533 18.7397 -3.5040 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7832 19.2733 1.2582 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1750 20.4228 -1.2974 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0339 6.4480 0.2076 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6611 2.5803 -1.3700 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2541 6.3970 0.5163 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8340 7.9163 0.7690 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2409 4.0994 -1.1168 H 0 0 0 0 0 0 0 0 0 0 0 0 11.7771 0.0000 0.6450 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9842 0.8391 -1.2420 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4739 3.2555 -1.5353 H 0 0 0 0 0 0 0 0 0 0 0 0 14.3238 4.1312 0.1435 H 0 0 0 0 0 0 0 0 0 0 0 0 11.7029 4.6798 1.2036 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9100 5.5189 -0.6832 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3633 1.3877 -0.1818 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2133 2.2634 1.4970 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8298 0.7742 -0.8214 H 0 0 0 0 0 0 0 0 0 0 0 0 15.6267 1.7762 0.8116 H 0 0 0 0 0 0 0 0 0 0 0 0 14.5530 0.0230 1.0930 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 35 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 36 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 37 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 38 1 0 0 0 0 12 39 1 0 0 0 0 12 40 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 41 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 42 1 0 0 0 0 18 43 1 0 0 0 0 21 22 1 0 0 0 0 21 44 1 0 0 0 0 22 25 2 0 0 0 0 22 26 1 0 0 0 0 23 27 1 0 0 0 0 23 26 2 0 0 0 0 23 45 1 0 0 0 0 24 27 2 0 0 0 0 24 25 1 0 0 0 0 24 46 1 0 0 0 0 25 47 1 0 0 0 0 26 48 1 0 0 0 0 27 32 1 0 0 0 0 28 33 1 0 0 0 0 28 31 1 0 0 0 0 28 49 1 0 0 0 0 28 50 1 0 0 0 0 29 33 1 0 0 0 0 29 30 1 0 0 0 0 29 51 1 0 0 0 0 29 52 1 0 0 0 0 30 32 1 0 0 0 0 30 53 1 0 0 0 0 30 54 1 0 0 0 0 31 32 1 0 0 0 0 31 55 1 0 0 0 0 31 56 1 0 0 0 0 33 34 1 0 0 0 0 34 57 1 0 0 0 0 34 58 1 0 0 0 0 34 59 1 0 0 0 0 M END > (159) 1,6-naphthyridin-2(1H)-one deriv. 7u > (159) PDGFR-beta > (159) 260 > (159) -1 > (159) P > (159) PDGFR-P157 $$$$ csChFnd70/05150717532D 42 45 0 0 0 0 0 0 0 0999 V2000 4.3570 7.9099 0.0157 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0756 6.2985 -0.0028 N 0 0 0 0 0 0 0 0 0 0 0 0 4.3772 6.3779 0.0013 N 0 0 0 0 0 0 0 0 0 0 0 0 5.7774 8.7085 0.0215 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1661 7.8383 0.0116 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8305 10.3489 0.0363 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6639 10.1367 0.0304 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9275 10.7726 0.0344 O 0 0 0 0 0 0 0 0 0 0 0 0 8.5787 8.5752 0.0164 N 0 0 3 0 0 0 0 0 0 0 0 0 7.2452 11.0741 0.0409 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3398 12.7918 0.0557 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3762 13.6168 -1.3382 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4640 15.2180 -1.3163 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5159 16.0038 0.0836 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4803 15.1929 1.4697 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3864 13.5920 1.4640 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3333 12.5770 3.2048 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.3119 12.6329 -3.0963 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.7077 5.5966 -0.0077 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6622 3.9933 -0.0227 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2385 3.2193 0.1094 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0088 7.6541 0.0065 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5917 1.0730 -0.5515 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9961 1.8357 -0.6824 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0708 3.8312 1.0377 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6671 3.0672 1.1673 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4233 1.6885 0.3706 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0406 0.9372 0.4986 O 0 0 0 0 0 0 0 0 0 0 0 0 3.2705 8.5358 0.0176 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7712 11.0199 0.0434 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4926 15.8580 -2.3944 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5850 17.2559 0.0945 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5216 15.8134 2.5587 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6165 3.4038 -0.1248 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3620 7.4360 -1.1891 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9238 8.2891 0.6076 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8045 6.5517 0.5938 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4010 0.0000 -1.1718 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9055 1.3566 -1.4008 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2604 4.9042 1.6583 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7568 3.5457 1.8851 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.1955 1.3407 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 29 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 30 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 31 1 0 0 0 0 14 15 1 0 0 0 0 14 32 1 0 0 0 0 15 16 2 0 0 0 0 15 33 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 34 1 0 0 0 0 21 24 1 0 0 0 0 21 25 2 0 0 0 0 22 35 1 0 0 0 0 22 36 1 0 0 0 0 22 37 1 0 0 0 0 23 27 1 0 0 0 0 23 24 2 0 0 0 0 23 38 1 0 0 0 0 24 39 1 0 0 0 0 25 26 1 0 0 0 0 25 40 1 0 0 0 0 26 27 2 0 0 0 0 26 41 1 0 0 0 0 27 28 1 0 0 0 0 28 42 1 0 0 0 0 M END > (167) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 51 > (167) PDGFR-beta > (167) 280 > (167) -1 > (167) P > (167) PDGFR-P165 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 49 csChFnd70/05150717532D 74 77 0 0 0 0 0 0 0 0999 V2000 8.0706 15.7199 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5787 13.1329 -0.0163 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0938 14.0115 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 11.1074 13.9010 -0.0267 N 0 0 0 0 0 0 0 0 0 0 0 0 9.6596 16.6104 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 11.2189 15.6328 -0.0185 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7431 18.4295 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 12.8613 18.1427 -0.0219 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3668 19.1980 -0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 12.7495 16.4386 -0.0294 N 0 0 0 0 0 0 0 0 0 0 0 0 11.5326 21.1127 0.0054 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7802 23.7939 1.5708 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8423 24.6907 0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6259 22.0100 1.5728 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6034 22.0239 -1.5549 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7579 23.8079 -1.5392 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5475 20.8869 3.5213 Cl 0 0 0 0 0 0 0 0 0 0 0 0 11.4984 20.9184 -3.5122 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.8406 10.4499 -0.0128 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1357 8.4885 -0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5170 11.3423 -0.0247 N 0 0 3 0 0 0 0 0 0 0 0 0 6.3849 7.5563 -0.0132 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6800 5.5951 -0.0259 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2917 4.1386 1.5440 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4331 1.9687 -0.4143 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2165 2.8348 -0.3345 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0750 5.0046 1.6238 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9991 4.7002 -0.0141 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5091 2.2732 1.2236 N 0 0 0 0 0 0 0 0 0 0 0 0 0.8281 1.3783 1.2354 C 0 0 0 0 0 0 0 0 0 0 0 0 14.4845 18.9174 -0.0337 N 0 0 3 0 0 0 0 0 0 0 0 0 15.9245 17.9283 -0.0528 C 0 0 0 0 0 0 0 0 0 0 0 0 15.8012 16.3571 -0.0595 O 0 0 0 0 0 0 0 0 0 0 0 0 17.5013 18.6809 -0.0644 N 0 0 3 0 0 0 0 0 0 0 0 0 19.0665 17.6055 -0.0850 C 0 0 0 0 0 0 0 0 0 0 0 0 19.0662 16.4687 -1.7104 C 0 0 0 0 0 0 0 0 0 0 0 0 20.6703 18.7726 -0.0948 C 0 0 0 0 0 0 0 0 0 0 0 0 19.0979 16.4524 1.5284 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8578 16.4194 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5776 19.2054 0.0247 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8530 24.4901 2.7835 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9631 26.0855 0.0247 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8123 24.5151 -2.7464 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1007 10.8223 -1.1575 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1231 10.8107 1.1498 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8532 8.1277 -1.1883 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8756 8.1160 1.1192 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5836 10.6766 -0.0385 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6674 7.9173 1.1494 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6449 7.9288 -1.1579 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3975 5.2343 -1.1887 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4201 5.2226 1.1188 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6189 4.3308 2.7717 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5357 4.7118 0.4968 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6901 2.5173 -1.4838 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5924 0.5790 -0.6145 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9724 2.2615 0.7127 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8893 2.6426 -1.5621 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9157 6.3943 1.8240 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8181 4.4561 2.6933 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.9180 0.2257 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0266 0.0000 0.9952 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2105 1.5528 2.4944 H 0 0 0 0 0 0 0 0 0 0 0 0 14.5829 20.1712 -0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 17.5996 19.9345 -0.0590 H 0 0 0 0 0 0 0 0 0 0 0 0 19.0440 17.2902 -2.8598 H 0 0 0 0 0 0 0 0 0 0 0 0 20.2309 15.6687 -1.7257 H 0 0 0 0 0 0 0 0 0 0 0 0 17.9237 15.6373 -1.7034 H 0 0 0 0 0 0 0 0 0 0 0 0 20.6705 19.5825 1.0632 H 0 0 0 0 0 0 0 0 0 0 0 0 21.8349 17.9726 -0.1102 H 0 0 0 0 0 0 0 0 0 0 0 0 20.6480 19.5942 -1.2443 H 0 0 0 0 0 0 0 0 0 0 0 0 17.9554 15.6209 1.5353 H 0 0 0 0 0 0 0 0 0 0 0 0 20.2625 15.6522 1.5130 H 0 0 0 0 0 0 0 0 0 0 0 0 19.0980 17.2622 2.6864 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 39 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 21 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 40 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 31 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 41 1 0 0 0 0 13 16 1 0 0 0 0 13 42 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 43 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 44 1 0 0 0 0 19 45 1 0 0 0 0 20 22 1 0 0 0 0 20 46 1 0 0 0 0 20 47 1 0 0 0 0 21 48 1 0 0 0 0 22 23 1 0 0 0 0 22 49 1 0 0 0 0 22 50 1 0 0 0 0 23 28 1 0 0 0 0 23 51 1 0 0 0 0 23 52 1 0 0 0 0 24 29 1 0 0 0 0 24 27 1 0 0 0 0 24 53 1 0 0 0 0 24 54 1 0 0 0 0 25 29 1 0 0 0 0 25 26 1 0 0 0 0 25 55 1 0 0 0 0 25 56 1 0 0 0 0 26 28 1 0 0 0 0 26 57 1 0 0 0 0 26 58 1 0 0 0 0 27 28 1 0 0 0 0 27 59 1 0 0 0 0 27 60 1 0 0 0 0 29 30 1 0 0 0 0 30 61 1 0 0 0 0 30 62 1 0 0 0 0 30 63 1 0 0 0 0 31 32 1 0 0 0 0 31 64 1 0 0 0 0 32 33 2 0 0 0 0 32 34 1 0 0 0 0 34 35 1 0 0 0 0 34 65 1 0 0 0 0 35 36 1 0 0 0 0 35 37 1 0 0 0 0 35 38 1 0 0 0 0 36 66 1 0 0 0 0 36 67 1 0 0 0 0 36 68 1 0 0 0 0 37 69 1 0 0 0 0 37 70 1 0 0 0 0 37 71 1 0 0 0 0 38 72 1 0 0 0 0 38 73 1 0 0 0 0 38 74 1 0 0 0 0 M END > (169) 6-arylpyrido[2,3-d]pyrimidine deriv. 49 > (169) PDGFR-beta > (169) 280 > (169) -1 > (169) P > (169) PDGFR-P167 $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 24 csChFnd70/05150717532D 41 44 0 0 0 0 0 0 0 0999 V2000 4.0326 7.9181 0.0158 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3841 5.6024 -0.0077 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4540 8.7172 0.0216 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8444 7.8459 0.0117 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5074 10.3592 0.0375 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3436 10.1464 0.0326 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9238 11.0848 0.0432 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0528 6.3844 0.0013 N 0 0 0 0 0 0 0 0 0 0 0 0 6.7536 6.3050 -0.0027 N 0 0 0 0 0 0 0 0 0 0 0 0 9.6083 10.7826 0.0380 O 0 0 0 0 0 0 0 0 0 0 0 0 8.2583 8.5834 0.0174 N 0 0 3 0 0 0 0 0 0 0 0 0 7.0188 12.8042 0.0594 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5650 15.2384 1.3464 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4733 13.6373 1.3381 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6603 13.5955 -1.2014 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7457 15.1967 -1.1797 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1970 16.0171 0.0896 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6896 7.6612 0.0077 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3385 3.9973 -0.0222 N 0 0 3 0 0 0 0 0 0 0 0 0 3.9156 3.2238 0.1104 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6711 1.8383 -0.6813 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2642 1.0773 -0.5479 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0994 1.6935 0.3724 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3388 3.0729 1.1618 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7457 3.8359 1.0394 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9450 8.5446 0.0282 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4472 11.0311 0.0447 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1425 15.8849 2.3359 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9797 13.0306 2.3200 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0899 12.9561 -2.1926 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2422 15.8108 -2.1554 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2663 17.2705 0.1013 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0436 7.4438 -1.1892 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6053 8.2965 0.6101 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4849 6.5574 0.5946 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2935 3.4070 -0.1245 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5800 1.3570 -1.4009 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0734 0.0000 -1.1631 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.0962 0.4744 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4263 3.5514 1.8788 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9341 4.9100 1.6610 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 26 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 19 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 11 1 0 0 0 0 5 7 2 0 0 0 0 5 27 1 0 0 0 0 6 11 1 0 0 0 0 6 7 1 0 0 0 0 6 10 2 0 0 0 0 7 12 1 0 0 0 0 11 18 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 28 1 0 0 0 0 14 29 1 0 0 0 0 15 16 1 0 0 0 0 15 30 1 0 0 0 0 16 17 2 0 0 0 0 16 31 1 0 0 0 0 17 32 1 0 0 0 0 18 33 1 0 0 0 0 18 34 1 0 0 0 0 18 35 1 0 0 0 0 19 20 1 0 0 0 0 19 36 1 0 0 0 0 20 21 2 0 0 0 0 20 25 1 0 0 0 0 21 22 1 0 0 0 0 21 37 1 0 0 0 0 22 23 2 0 0 0 0 22 38 1 0 0 0 0 23 24 1 0 0 0 0 23 39 1 0 0 0 0 24 25 2 0 0 0 0 24 40 1 0 0 0 0 25 41 1 0 0 0 0 M END > (170) pyrido[2,3-d]pyrimidin-7-one deriv. 24 > (170) PDGFR-beta > (170) 290 > (170) -1 > (170) P > (170) PDGFR-P168 $$$$ Pyrido[2,3-d]pyrimidin-7(8H)-one deriv. 6w csChFnd70/05150717532D 57 60 0 0 0 0 0 0 0 0999 V2000 8.2314 15.2647 -2.9670 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3144 15.8618 -3.0993 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5248 16.4202 -3.2559 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3974 13.0591 -2.3831 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6596 13.5568 -2.5236 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3824 12.3240 -2.2153 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5056 10.3263 -1.6858 C 0 0 0 0 0 0 0 0 0 0 0 0 12.4731 16.8817 -3.3537 O 0 0 0 0 0 0 0 0 0 0 0 0 11.6851 14.2261 -2.6749 N 0 0 3 0 0 0 0 0 0 0 0 0 13.4817 13.6877 -2.5242 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7560 11.4448 -1.9637 N 0 0 0 0 0 0 0 0 0 0 0 0 7.8570 10.7487 -1.8063 N 0 0 0 0 0 0 0 0 0 0 0 0 9.1182 18.2193 -3.7234 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9296 18.6814 -5.4447 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5505 20.3609 -5.8717 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3579 21.5837 -4.5975 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5432 21.1342 -2.8887 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9149 19.4577 -2.4438 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1379 18.8943 -0.2981 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.1715 17.1487 -7.0459 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.9312 8.6576 -1.2538 N 0 0 3 0 0 0 0 0 0 0 0 0 8.6458 7.4862 -0.8369 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9062 6.8850 0.4357 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5659 4.6016 -0.8628 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8341 5.7627 -1.2730 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1787 8.0399 0.0213 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0880 5.1547 -0.0069 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7261 3.9132 0.4353 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1039 3.9140 1.8677 O 0 0 0 0 0 0 0 0 0 0 0 0 2.7452 1.6196 -0.3454 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0614 2.4073 -0.9825 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1719 2.7783 -0.7485 N 0 0 0 0 0 0 0 0 0 0 0 0 4.9959 2.7036 -2.4384 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2785 1.2153 -2.4764 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9038 15.6534 -3.0707 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0391 12.6567 -2.3102 H 0 0 0 0 0 0 0 0 0 0 0 0 13.9360 13.2249 -3.7648 H 0 0 0 0 0 0 0 0 0 0 0 0 14.2626 14.7762 -2.1178 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5833 12.6613 -1.5776 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4046 20.7202 -7.2035 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0618 22.8954 -4.9382 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3917 22.0953 -1.9000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1254 8.3028 -1.2409 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7656 7.3164 1.0971 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7102 3.2656 -1.2069 H 0 0 0 0 0 0 0 0 0 0 0 0 9.9764 5.3363 -1.9344 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0390 9.3769 0.3630 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6764 1.4286 1.0398 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9522 0.3874 -0.9766 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8544 3.6395 -0.3511 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1304 2.5983 -2.3676 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.5451 -0.6825 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0219 2.5055 -3.4242 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6694 3.9063 -2.6826 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1086 1.2856 -1.3513 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5834 0.0000 -2.4681 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0571 1.2996 -3.6368 H 0 0 0 0 0 0 0 0 0 0 0 0 1 5 1 0 0 0 0 1 3 2 0 0 0 0 1 35 1 0 0 0 0 2 9 1 0 0 0 0 2 3 1 0 0 0 0 2 8 2 0 0 0 0 3 13 1 0 0 0 0 4 9 1 0 0 0 0 4 11 2 0 0 0 0 4 5 1 0 0 0 0 5 6 2 0 0 0 0 6 12 1 0 0 0 0 6 36 1 0 0 0 0 7 12 2 0 0 0 0 7 11 1 0 0 0 0 7 21 1 0 0 0 0 9 10 1 0 0 0 0 10 37 1 0 0 0 0 10 38 1 0 0 0 0 10 39 1 0 0 0 0 13 18 2 0 0 0 0 13 14 1 0 0 0 0 14 15 2 0 0 0 0 14 20 1 0 0 0 0 15 16 1 0 0 0 0 15 40 1 0 0 0 0 16 17 2 0 0 0 0 16 41 1 0 0 0 0 17 18 1 0 0 0 0 17 42 1 0 0 0 0 18 19 1 0 0 0 0 21 22 1 0 0 0 0 21 43 1 0 0 0 0 22 25 2 0 0 0 0 22 26 1 0 0 0 0 23 27 1 0 0 0 0 23 26 2 0 0 0 0 23 44 1 0 0 0 0 24 27 2 0 0 0 0 24 25 1 0 0 0 0 24 45 1 0 0 0 0 25 46 1 0 0 0 0 26 47 1 0 0 0 0 27 28 1 0 0 0 0 28 32 1 0 0 0 0 28 29 2 0 0 0 0 30 32 1 0 0 0 0 30 31 1 0 0 0 0 30 48 1 0 0 0 0 30 49 1 0 0 0 0 31 50 1 0 0 0 0 31 51 1 0 0 0 0 31 52 1 0 0 0 0 32 33 1 0 0 0 0 33 34 1 0 0 0 0 33 53 1 0 0 0 0 33 54 1 0 0 0 0 34 55 1 0 0 0 0 34 56 1 0 0 0 0 34 57 1 0 0 0 0 M END > (171) Pyrido[2,3-d]pyrimidin-7(8H)-one deriv. 6w > (171) PDGFR-beta > (171) 290 > (171) -1 > (171) P > (171) PDGFR-P169 $$$$ 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3f csChFnd70/05150717532D 39 41 0 0 0 0 0 0 0 0999 V2000 3.9757 9.6493 0.4550 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3138 7.7713 0.0966 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9930 8.2357 0.4313 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8033 10.5044 0.7638 N 0 0 0 0 0 0 0 0 0 0 0 0 5.3245 10.1188 0.1262 N 0 0 3 0 0 0 0 0 0 0 0 0 6.1601 8.8815 -0.0985 N 0 0 0 0 0 0 0 0 0 0 0 0 5.7674 11.4955 0.0343 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9238 12.4703 0.2566 O 0 0 0 0 0 0 0 0 0 0 0 0 5.7241 6.3353 -0.0243 N 0 0 3 0 0 0 0 0 0 0 0 0 4.6946 5.2473 0.0933 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2861 5.5002 -0.3347 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2714 4.4224 -0.2174 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6561 3.0928 0.3255 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0572 2.8375 0.7529 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0786 3.9085 0.6329 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3789 0.8086 -1.0557 N 0 0 0 0 0 0 0 0 0 0 0 0 1.8622 0.7644 1.5529 O 0 0 0 0 0 0 0 0 0 0 0 0 1.3582 1.7207 0.4732 S 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.4172 0.5417 O 0 0 0 0 0 0 0 0 0 0 0 0 7.2632 11.8179 -0.3329 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8552 11.8489 -0.9725 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2735 13.1560 -0.8139 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8397 13.1653 -0.4583 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6094 10.5356 -0.6755 S 0 0 0 0 0 0 0 0 0 0 0 0 6.9873 14.5241 -0.2293 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8840 10.0669 0.9903 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8984 11.5429 0.7543 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7243 6.0909 -0.1902 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9848 6.5385 -0.7583 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1762 4.6184 -0.5495 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3538 1.7980 1.1771 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1737 3.7069 0.9621 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0362 1.0828 -1.8177 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7339 0.0000 -1.1895 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9654 11.6521 -1.2500 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8864 14.1319 -0.9565 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0477 14.8377 0.8982 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4294 15.3798 -0.8970 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8683 14.3375 -0.5235 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 4 1 0 0 0 0 2 3 1 0 0 0 0 2 6 2 0 0 0 0 2 9 1 0 0 0 0 4 26 1 0 0 0 0 4 27 1 0 0 0 0 5 6 1 0 0 0 0 5 7 1 0 0 0 0 7 8 2 0 0 0 0 7 20 1 0 0 0 0 9 10 1 0 0 0 0 9 28 1 0 0 0 0 10 15 1 0 0 0 0 10 11 2 0 0 0 0 11 12 1 0 0 0 0 11 29 1 0 0 0 0 12 13 2 0 0 0 0 12 30 1 0 0 0 0 13 14 1 0 0 0 0 13 18 1 0 0 0 0 14 15 2 0 0 0 0 14 31 1 0 0 0 0 15 32 1 0 0 0 0 16 18 1 0 0 0 0 16 33 1 0 0 0 0 16 34 1 0 0 0 0 17 18 2 0 0 0 0 18 19 2 0 0 0 0 20 23 2 0 0 0 0 20 24 1 0 0 0 0 21 22 2 0 0 0 0 21 24 1 0 0 0 0 21 35 1 0 0 0 0 22 23 1 0 0 0 0 22 36 1 0 0 0 0 23 25 1 0 0 0 0 25 37 1 0 0 0 0 25 38 1 0 0 0 0 25 39 1 0 0 0 0 M END > (187) 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3f > (187) PDGFR-beta > (187) 310 > (187) -1 > (187) P > (187) PDGFR-P185 $$$$ Structure143 csChFnd70/05150717532D 71 73 0 0 0 0 0 0 0 0999 V2000 12.1645 8.2037 -2.0747 N 0 0 0 0 0 0 0 0 0 0 0 0 12.4471 6.5008 -2.1682 C 0 0 0 0 0 0 0 0 0 0 0 0 13.9768 5.8364 -2.5597 N 0 0 0 0 0 0 0 0 0 0 0 0 15.3303 6.8781 -2.8847 C 0 0 0 0 0 0 0 0 0 0 0 0 15.0741 8.7016 -2.7969 C 0 0 0 0 0 0 0 0 0 0 0 0 16.8893 6.2367 -3.2827 N 0 0 0 0 0 0 0 0 0 0 0 0 18.2224 7.2601 -3.6023 C 0 0 0 0 0 0 0 0 0 0 0 0 18.0645 9.0841 -3.5390 C 0 0 0 0 0 0 0 0 0 0 0 0 19.8174 6.5278 -4.0086 N 0 0 3 0 0 0 0 0 0 0 0 0 19.9900 4.7877 -4.0743 C 0 0 0 0 0 0 0 0 0 0 0 0 21.5392 4.0763 -4.4690 N 0 0 3 0 0 0 0 0 0 0 0 0 18.7479 3.8597 -3.7777 O 0 0 0 0 0 0 0 0 0 0 0 0 11.0820 5.3831 -1.8411 N 0 0 3 0 0 0 0 0 0 0 0 0 19.5877 10.2034 -3.9037 C 0 0 0 0 0 0 0 0 0 0 0 0 20.6858 10.7121 -2.5562 C 0 0 0 0 0 0 0 0 0 0 0 0 22.1031 11.7545 -2.9046 C 0 0 0 0 0 0 0 0 0 0 0 0 22.4342 12.2942 -4.5851 C 0 0 0 0 0 0 0 0 0 0 0 0 21.3505 11.7942 -5.9270 C 0 0 0 0 0 0 0 0 0 0 0 0 19.9331 10.7458 -5.5968 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4150 9.3325 -2.3730 C 0 0 0 0 0 0 0 0 0 0 0 0 16.4734 9.8210 -3.1337 C 0 0 0 0 0 0 0 0 0 0 0 0 18.5747 10.1191 -7.2828 Cl 0 0 0 0 0 0 0 0 0 0 0 0 20.2715 10.0373 -0.4457 Cl 0 0 0 0 0 0 0 0 0 0 0 0 21.7267 2.1847 -4.5406 C 0 0 0 0 0 0 0 0 0 0 0 0 20.4965 1.4488 -5.9159 C 0 0 0 0 0 0 0 0 0 0 0 0 23.6002 1.7223 -5.0126 C 0 0 0 0 0 0 0 0 0 0 0 0 21.2793 1.4073 -2.7680 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3668 6.0792 -1.4029 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0994 4.5786 -1.1053 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3082 5.3056 -0.6477 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0408 3.8052 -0.3501 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3210 4.5030 0.0893 N 0 0 0 0 0 0 0 0 0 0 0 0 1.0647 6.5791 -0.7533 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5684 5.4465 -1.3877 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6138 2.6153 2.5483 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1521 3.1175 0.6826 C 0 0 0 0 0 0 0 0 0 0 0 0 20.8084 7.2683 -4.2452 H 0 0 0 0 0 0 0 0 0 0 0 0 22.5302 4.8166 -4.7057 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2594 4.1377 -1.9018 H 0 0 0 0 0 0 0 0 0 0 0 0 22.9543 12.1493 -1.8623 H 0 0 0 0 0 0 0 0 0 0 0 0 23.5436 13.1099 -4.8508 H 0 0 0 0 0 0 0 0 0 0 0 0 21.6156 12.2202 -7.2364 H 0 0 0 0 0 0 0 0 0 0 0 0 13.1708 10.7110 -2.2934 H 0 0 0 0 0 0 0 0 0 0 0 0 16.3154 11.2132 -3.0761 H 0 0 0 0 0 0 0 0 0 0 0 0 20.8152 2.0026 -7.1787 H 0 0 0 0 0 0 0 0 0 0 0 0 20.6361 0.0414 -5.9691 H 0 0 0 0 0 0 0 0 0 0 0 0 19.1618 1.7782 -5.5797 H 0 0 0 0 0 0 0 0 0 0 0 0 24.4766 2.2465 -4.0328 H 0 0 0 0 0 0 0 0 0 0 0 0 23.7398 0.3149 -5.0658 H 0 0 0 0 0 0 0 0 0 0 0 0 23.9190 2.2760 -6.2754 H 0 0 0 0 0 0 0 0 0 0 0 0 19.9447 1.7368 -2.4317 H 0 0 0 0 0 0 0 0 0 0 0 0 21.4189 0.0000 -2.8212 H 0 0 0 0 0 0 0 0 0 0 0 0 22.1557 1.9316 -1.7882 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4607 6.8581 -0.2250 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8998 6.8873 -2.4669 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0055 3.7998 -2.2833 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5665 3.7706 -0.0414 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4021 6.0845 0.5303 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8411 6.1137 -1.7116 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9470 3.0262 -1.5280 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5079 2.9970 0.7139 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6201 7.4084 -1.8104 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.7519 -0.3229 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5027 7.3837 0.3254 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5596 6.2660 -1.9785 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0902 4.5202 -2.3449 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4628 3.7421 3.3913 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7529 1.5804 2.9852 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9548 2.1655 2.5976 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8141 3.5764 0.6349 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2938 1.9883 -0.1588 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 20 2 0 0 0 0 2 3 2 0 0 0 0 2 13 1 0 0 0 0 3 4 1 0 0 0 0 4 6 2 0 0 0 0 4 5 1 0 0 0 0 5 20 1 0 0 0 0 5 21 2 0 0 0 0 6 7 1 0 0 0 0 7 8 2 0 0 0 0 7 9 1 0 0 0 0 8 14 1 0 0 0 0 8 21 1 0 0 0 0 9 10 1 0 0 0 0 9 37 1 0 0 0 0 10 11 1 0 0 0 0 10 12 2 0 0 0 0 11 24 1 0 0 0 0 11 38 1 0 0 0 0 13 28 1 0 0 0 0 13 39 1 0 0 0 0 14 15 2 0 0 0 0 14 19 1 0 0 0 0 15 16 1 0 0 0 0 15 23 1 0 0 0 0 16 17 2 0 0 0 0 16 40 1 0 0 0 0 17 18 1 0 0 0 0 17 41 1 0 0 0 0 18 19 2 0 0 0 0 18 42 1 0 0 0 0 19 22 1 0 0 0 0 20 43 1 0 0 0 0 21 44 1 0 0 0 0 24 25 1 0 0 0 0 24 26 1 0 0 0 0 24 27 1 0 0 0 0 25 45 1 0 0 0 0 25 46 1 0 0 0 0 25 47 1 0 0 0 0 26 48 1 0 0 0 0 26 49 1 0 0 0 0 26 50 1 0 0 0 0 27 51 1 0 0 0 0 27 52 1 0 0 0 0 27 53 1 0 0 0 0 28 29 1 0 0 0 0 28 54 1 0 0 0 0 28 55 1 0 0 0 0 29 30 1 0 0 0 0 29 56 1 0 0 0 0 29 57 1 0 0 0 0 30 31 1 0 0 0 0 30 58 1 0 0 0 0 30 59 1 0 0 0 0 31 32 1 0 0 0 0 31 60 1 0 0 0 0 31 61 1 0 0 0 0 32 34 1 0 0 0 0 32 36 1 0 0 0 0 33 34 1 0 0 0 0 33 62 1 0 0 0 0 33 63 1 0 0 0 0 33 64 1 0 0 0 0 34 65 1 0 0 0 0 34 66 1 0 0 0 0 35 36 1 0 0 0 0 35 67 1 0 0 0 0 35 68 1 0 0 0 0 35 69 1 0 0 0 0 36 70 1 0 0 0 0 36 71 1 0 0 0 0 M END > (188) 9240345-6c > (188) PDGFR-beta > (188) 310 > (188) -1 > (188) P > (188) PDGFR-P186 $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 26 csChFnd70/05150717532D 40 43 0 0 0 0 0 0 0 0999 V2000 3.8091 8.3102 0.0324 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2317 5.8708 -0.0023 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3065 9.1514 0.0398 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7705 8.2331 0.0245 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3634 10.8808 0.0613 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3506 10.6555 0.0509 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6830 11.3252 0.0554 O 0 0 0 0 0 0 0 0 0 0 0 0 6.8555 11.6446 0.0671 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2600 9.0092 0.0305 N 0 0 3 0 0 0 0 0 0 0 0 0 6.6742 6.6101 0.0038 N 0 0 0 0 0 0 0 0 0 0 0 0 3.8298 6.6948 0.0116 N 0 0 0 0 0 0 0 0 0 0 0 0 5.1828 4.1794 -0.0240 N 0 0 3 0 0 0 0 0 0 0 0 0 3.6887 3.3674 0.1147 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4087 1.9014 -0.7141 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9134 1.1358 -0.5439 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9776 3.1546 1.1964 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4378 3.9959 1.0915 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7674 8.0374 0.0144 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9564 13.4554 0.0890 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4814 16.0158 1.4525 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3842 14.3293 1.4393 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6303 14.2922 -1.2376 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7209 15.9788 -1.2102 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1448 16.8395 0.1298 C 0 0 0 0 0 0 0 0 0 0 0 0 0.7574 1.7736 0.3873 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6637 8.9705 0.0491 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2470 11.5890 0.0726 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1883 3.5578 -0.1356 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3491 1.3734 -1.4787 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6856 0.0000 -1.1812 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.6351 1.9457 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6100 5.1255 1.7567 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1379 7.8122 -1.2474 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7331 8.7041 0.6494 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5524 6.8730 0.6295 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0387 16.6939 2.4976 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8656 13.6876 2.4724 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0808 13.6216 -2.2842 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2429 16.6283 -2.2367 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2187 18.1595 0.1459 H 0 0 0 0 0 0 0 0 0 0 0 0 1 11 1 0 0 0 0 1 3 2 0 0 0 0 1 26 1 0 0 0 0 2 11 2 0 0 0 0 2 10 1 0 0 0 0 2 12 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 10 2 0 0 0 0 4 9 1 0 0 0 0 5 8 2 0 0 0 0 5 27 1 0 0 0 0 6 9 1 0 0 0 0 6 8 1 0 0 0 0 6 7 2 0 0 0 0 8 19 1 0 0 0 0 9 18 1 0 0 0 0 12 13 1 0 0 0 0 12 28 1 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 14 15 1 0 0 0 0 14 29 1 0 0 0 0 15 25 2 0 0 0 0 15 30 1 0 0 0 0 16 25 1 0 0 0 0 16 17 2 0 0 0 0 16 31 1 0 0 0 0 17 32 1 0 0 0 0 18 33 1 0 0 0 0 18 34 1 0 0 0 0 18 35 1 0 0 0 0 19 21 1 0 0 0 0 19 22 2 0 0 0 0 20 21 2 0 0 0 0 20 24 1 0 0 0 0 20 36 1 0 0 0 0 21 37 1 0 0 0 0 22 23 1 0 0 0 0 22 38 1 0 0 0 0 23 24 2 0 0 0 0 23 39 1 0 0 0 0 24 40 1 0 0 0 0 M END > (193) pyrido[2,3-d]pyrimidin-7-one deriv. 26 > (193) PDGFR-beta > (193) 320 > (193) -1 > (193) P > (193) PDGFR-P191 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 34 csChFnd70/05150717532D 75 78 0 0 0 0 0 0 0 0999 V2000 3.7294 14.7252 -0.7401 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8849 12.5805 -0.5926 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1970 13.0563 -0.6248 N 0 0 0 0 0 0 0 0 0 0 0 0 7.1873 13.7303 -0.6729 N 0 0 0 0 0 0 0 0 0 0 0 0 5.0591 16.0108 -0.8297 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8461 15.4572 -0.7923 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6676 17.8158 -0.9552 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8067 18.3443 -0.9937 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0632 18.9907 -1.0377 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1405 16.6446 -0.8756 N 0 0 0 0 0 0 0 0 0 0 0 0 5.7278 20.9109 -1.1717 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2572 23.7172 0.2169 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1008 24.4988 -1.4224 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5698 21.9288 0.3508 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5763 21.7085 -2.8211 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2635 23.4980 -2.9372 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7650 20.9500 2.4095 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.7809 20.4546 -4.7239 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.2904 10.8091 -0.4696 N 0 0 3 0 0 0 0 0 0 0 0 0 4.8753 9.4990 -0.3776 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6759 7.6527 -0.2495 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1980 6.2844 -0.1534 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9986 4.4383 -0.0254 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5795 3.1244 0.0668 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5709 3.0756 -1.5849 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8232 2.1184 -1.2770 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2821 1.3739 0.5029 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7183 1.2956 2.4700 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2002 19.5251 -1.0767 N 0 0 3 0 0 0 0 0 0 0 0 0 10.8729 18.9291 -1.0361 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1607 17.3569 -0.9269 O 0 0 0 0 0 0 0 0 0 0 0 0 12.2266 20.0764 -1.1168 N 0 0 3 0 0 0 0 0 0 0 0 0 14.0449 19.4286 -1.0728 C 0 0 0 0 0 0 0 0 0 0 0 0 15.2567 20.7660 -1.9718 C 0 0 0 0 0 0 0 0 0 0 0 0 17.1557 20.0896 -1.9260 C 0 0 0 0 0 0 0 0 0 0 0 0 17.7341 19.8398 -0.0104 C 0 0 0 0 0 0 0 0 0 0 0 0 16.5222 18.5024 0.8887 C 0 0 0 0 0 0 0 0 0 0 0 0 14.6232 19.1789 0.8426 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3555 15.0958 -0.7710 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3204 18.2738 -0.9867 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1350 24.5069 1.3949 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8563 25.8977 -1.5200 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1456 24.1170 -4.2134 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5120 10.4334 -0.4441 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0644 9.7506 0.7811 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0631 9.5877 -1.5591 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4869 7.4010 -1.4082 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4883 7.5639 0.9319 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3870 6.5361 1.0052 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3857 6.3732 -1.3349 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8096 4.1865 -1.1841 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8109 4.3494 1.1560 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3107 4.4173 -2.0269 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3280 2.3793 -2.5878 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0781 0.7305 -1.0081 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1460 2.7071 -0.1551 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.2358 -2.4485 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3008 0.3726 0.1898 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4739 1.1321 -0.2619 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6924 2.3034 2.7850 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5247 1.5278 3.2348 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2488 0.0000 2.7917 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9705 20.7797 -1.1638 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9969 21.3309 -1.2040 H 0 0 0 0 0 0 0 0 0 0 0 0 14.1223 18.1718 -1.7640 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8448 20.9440 -3.3365 H 0 0 0 0 0 0 0 0 0 0 0 0 15.1794 22.0229 -1.2806 H 0 0 0 0 0 0 0 0 0 0 0 0 17.2332 18.8327 -2.6172 H 0 0 0 0 0 0 0 0 0 0 0 0 18.0192 21.0423 -2.5665 H 0 0 0 0 0 0 0 0 0 0 0 0 19.0869 19.3579 0.0223 H 0 0 0 0 0 0 0 0 0 0 0 0 17.6566 21.0967 0.6808 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5995 17.2455 0.1974 H 0 0 0 0 0 0 0 0 0 0 0 0 16.9341 18.3245 2.2533 H 0 0 0 0 0 0 0 0 0 0 0 0 14.5457 20.4358 1.5340 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7599 18.2262 1.4833 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 39 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 19 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 40 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 29 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 41 1 0 0 0 0 13 16 1 0 0 0 0 13 42 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 43 1 0 0 0 0 19 20 1 0 0 0 0 19 44 1 0 0 0 0 20 21 1 0 0 0 0 20 45 1 0 0 0 0 20 46 1 0 0 0 0 21 22 1 0 0 0 0 21 47 1 0 0 0 0 21 48 1 0 0 0 0 22 23 1 0 0 0 0 22 49 1 0 0 0 0 22 50 1 0 0 0 0 23 24 1 0 0 0 0 23 51 1 0 0 0 0 23 52 1 0 0 0 0 24 25 1 0 0 0 0 24 27 1 0 0 0 0 25 26 1 0 0 0 0 25 53 1 0 0 0 0 25 54 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 26 57 1 0 0 0 0 27 28 1 0 0 0 0 27 58 1 0 0 0 0 27 59 1 0 0 0 0 28 60 1 0 0 0 0 28 61 1 0 0 0 0 28 62 1 0 0 0 0 29 30 1 0 0 0 0 29 63 1 0 0 0 0 30 31 2 0 0 0 0 30 32 1 0 0 0 0 32 33 1 0 0 0 0 32 64 1 0 0 0 0 33 34 1 0 0 0 0 33 38 1 0 0 0 0 33 65 1 0 0 0 0 34 35 1 0 0 0 0 34 66 1 0 0 0 0 34 67 1 0 0 0 0 35 36 1 0 0 0 0 35 68 1 0 0 0 0 35 69 1 0 0 0 0 36 37 1 0 0 0 0 36 70 1 0 0 0 0 36 71 1 0 0 0 0 37 38 1 0 0 0 0 37 72 1 0 0 0 0 37 73 1 0 0 0 0 38 74 1 0 0 0 0 38 75 1 0 0 0 0 M END > (194) 6-arylpyrido[2,3-d]pyrimidine deriv. 34 > (194) PDGFR-beta > (194) 330 > (194) -1 > (194) P > (194) PDGFR-P192 $$$$ Structure55 csChFnd70/05150717532D 41 44 0 0 0 0 0 0 0 0999 V2000 3.9982 10.0469 -0.5999 N 0 0 0 0 0 0 0 0 0 0 0 0 5.1745 10.7774 -0.1926 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4439 10.1361 0.0250 N 0 0 0 0 0 0 0 0 0 0 0 0 6.5871 8.7120 -0.1600 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3607 7.8986 -0.5927 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0404 8.6289 -0.8092 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8979 8.0384 0.0635 N 0 0 3 0 0 0 0 0 0 0 0 0 8.0369 6.5939 -0.1259 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7862 5.7182 -0.5742 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4739 6.3810 -0.8003 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9399 4.1293 -0.7816 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2085 6.0130 0.0771 O 0 0 0 0 0 0 0 0 0 0 0 0 9.1595 8.8989 0.5121 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3272 3.5725 -2.1376 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4692 2.0902 -2.3236 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2280 1.1582 -1.1695 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8434 1.7031 0.1773 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7043 3.1835 0.3796 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2215 3.8652 2.0707 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.6292 4.7403 -3.5877 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.0698 12.2611 0.0109 N 0 0 3 0 0 0 0 0 0 0 0 0 3.7185 12.9478 -0.0877 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4701 12.2284 0.3616 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1370 12.9098 0.2627 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0439 14.3067 -0.2828 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2846 15.0257 -0.7315 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6219 14.3531 -0.6293 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0790 8.0432 -1.1399 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5389 5.7537 -1.1308 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2046 8.9466 1.6945 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1483 8.3947 0.0993 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0642 9.9959 0.0762 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7688 1.6579 -3.3725 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3401 0.0000 -1.3207 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6561 0.9696 1.0739 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9339 12.8263 0.2221 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5421 11.1374 0.7873 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1659 12.3510 0.6114 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 14.8371 -0.3590 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2082 16.1164 -1.1574 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5904 14.9152 -0.9799 H 0 0 0 0 0 0 0 0 0 0 0 0 1 6 1 0 0 0 0 1 2 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 4 2 0 0 0 0 4 7 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 5 6 2 0 0 0 0 6 28 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 9 1 0 0 0 0 8 12 2 0 0 0 0 9 11 1 0 0 0 0 9 10 2 0 0 0 0 10 29 1 0 0 0 0 11 14 2 0 0 0 0 11 18 1 0 0 0 0 13 30 1 0 0 0 0 13 31 1 0 0 0 0 13 32 1 0 0 0 0 14 15 1 0 0 0 0 14 20 1 0 0 0 0 15 16 2 0 0 0 0 15 33 1 0 0 0 0 16 17 1 0 0 0 0 16 34 1 0 0 0 0 17 18 2 0 0 0 0 17 35 1 0 0 0 0 18 19 1 0 0 0 0 21 22 1 0 0 0 0 21 36 1 0 0 0 0 22 23 2 0 0 0 0 22 27 1 0 0 0 0 23 24 1 0 0 0 0 23 37 1 0 0 0 0 24 25 2 0 0 0 0 24 38 1 0 0 0 0 25 26 1 0 0 0 0 25 39 1 0 0 0 0 26 27 2 0 0 0 0 26 40 1 0 0 0 0 27 41 1 0 0 0 0 M END > (195) 9599227-5 > (195) PDGFR-beta > (195) 330 > (195) -1 > (195) P > (195) PDGFR-P193 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 15 csChFnd70/05150717532D 51 53 0 0 0 0 0 0 0 0999 V2000 1.2089 5.0278 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7123 2.4487 -0.0163 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7930 5.9155 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3476 4.9408 -0.0185 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8763 7.7288 0.0111 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9849 7.4431 -0.0195 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4950 8.4948 0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2320 3.3247 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2363 3.2143 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8735 5.7441 -0.0282 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6603 10.4040 0.0090 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9065 13.0734 1.5714 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7527 11.2965 1.5713 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7315 11.3125 -1.5449 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8853 13.0893 -1.5290 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9696 13.9687 0.0253 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6508 0.6638 -0.0252 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6412 10.3561 -3.2392 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6841 10.3229 3.2567 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6028 8.2154 -0.0309 N 0 0 3 0 0 0 0 0 0 0 0 0 9.0385 7.2292 -0.0505 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9155 5.6628 -0.0583 O 0 0 0 0 0 0 0 0 0 0 0 0 10.6103 7.9794 -0.0615 N 0 0 3 0 0 0 0 0 0 0 0 0 12.1709 6.9075 -0.0828 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1706 5.7753 -1.7039 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7697 8.0711 -0.0917 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2022 5.7568 1.5249 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.7251 0.0329 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7146 8.5023 0.0260 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9777 13.7662 2.7810 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9407 13.7945 -2.7322 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0895 15.3593 0.0317 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5443 0.0747 -0.0178 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7142 0.0000 -0.0389 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2962 10.2397 -3.6415 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3644 11.0656 -4.2181 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1977 9.0715 -3.0835 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9907 9.9732 3.6505 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0976 11.1369 4.2456 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9145 9.1545 3.0931 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7009 9.4652 -0.0247 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7084 9.2293 -0.0553 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1484 6.5950 -2.8492 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3317 4.9777 -1.7198 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0316 4.9463 -1.6975 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7698 8.8776 1.0631 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9308 7.2734 -0.1075 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7475 8.8908 -1.2371 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0631 4.9278 1.5312 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3631 4.9593 1.5090 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2023 6.5635 2.6798 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 28 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 17 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 10 1 0 0 0 0 5 7 2 0 0 0 0 5 29 1 0 0 0 0 6 10 2 0 0 0 0 6 7 1 0 0 0 0 6 20 1 0 0 0 0 7 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 30 1 0 0 0 0 13 19 1 0 0 0 0 14 15 1 0 0 0 0 14 18 1 0 0 0 0 15 16 2 0 0 0 0 15 31 1 0 0 0 0 16 32 1 0 0 0 0 17 33 1 0 0 0 0 17 34 1 0 0 0 0 18 35 1 0 0 0 0 18 36 1 0 0 0 0 18 37 1 0 0 0 0 19 38 1 0 0 0 0 19 39 1 0 0 0 0 19 40 1 0 0 0 0 20 21 1 0 0 0 0 20 41 1 0 0 0 0 21 23 1 0 0 0 0 21 22 2 0 0 0 0 23 24 1 0 0 0 0 23 42 1 0 0 0 0 24 25 1 0 0 0 0 24 26 1 0 0 0 0 24 27 1 0 0 0 0 25 43 1 0 0 0 0 25 44 1 0 0 0 0 25 45 1 0 0 0 0 26 46 1 0 0 0 0 26 47 1 0 0 0 0 26 48 1 0 0 0 0 27 49 1 0 0 0 0 27 50 1 0 0 0 0 27 51 1 0 0 0 0 M END > (197) PD089828 analog 15 > (197) PDGFR-beta > (197) 340 > (197) -1 > (197) P > (197) PDGFR-P195 $$$$ 3-substituted indolin-2-one 16f csChFnd70/05150717532D 51 54 0 0 0 0 0 0 0 0999 V2000 1.7815 8.5059 0.1581 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5844 6.9429 0.1301 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5748 8.5396 0.0809 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1607 9.3203 0.0953 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5300 10.9814 0.0338 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2183 11.0561 -0.0145 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7636 9.6088 0.0154 N 0 0 3 0 0 0 0 0 0 0 0 0 5.9899 12.2259 -0.0725 O 0 0 0 0 0 0 0 0 0 0 0 0 2.5068 12.2002 0.0236 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0565 13.7223 0.1491 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4251 15.0150 -0.5425 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3164 14.1998 0.9875 N 0 0 3 0 0 0 0 0 0 0 0 0 1.0257 15.0568 -1.5671 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4701 15.7451 0.8190 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8010 6.9211 0.2066 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2024 6.1346 0.1927 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7054 16.7205 1.5487 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3300 16.2705 -0.1096 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0814 17.9199 -0.5866 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0305 18.7166 0.5809 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7819 20.3661 0.1038 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3837 20.8542 -1.0514 O 0 0 0 0 0 0 0 0 0 0 0 0 0.8922 21.2929 0.9623 O 0 0 0 0 0 0 0 0 0 0 0 0 3.2186 4.4282 0.2445 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6137 3.6355 0.2377 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6218 2.0476 0.2866 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2489 1.2426 0.3424 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8609 2.0232 0.3488 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8389 3.6112 0.3069 C 0 0 0 0 0 0 0 0 0 0 0 0 0.6983 9.1160 0.1739 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6646 6.3274 0.1196 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8481 9.3440 -0.0053 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2865 11.9865 -0.0806 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9818 13.5413 1.5961 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 15.2367 -0.8671 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1392 15.9954 -2.3919 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9258 13.9682 -2.1832 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7326 6.2872 0.2558 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6964 16.7833 0.7814 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2602 17.8757 1.7526 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0532 16.2076 2.6398 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1858 18.5140 -0.6290 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5460 17.9511 -1.7209 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9261 18.1225 0.6232 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5660 18.6854 1.7153 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7668 22.3414 0.6100 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6863 4.2628 0.1938 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7021 1.4322 0.2810 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2607 0.0000 0.3805 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7925 1.3888 0.3920 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7547 4.2196 0.3172 H 0 0 0 0 0 0 0 0 0 0 0 0 1 15 1 0 0 0 0 1 4 2 0 0 0 0 1 30 1 0 0 0 0 2 16 1 0 0 0 0 2 3 2 0 0 0 0 2 31 1 0 0 0 0 3 7 1 0 0 0 0 3 4 1 0 0 0 0 4 5 1 0 0 0 0 5 6 1 0 0 0 0 5 9 2 0 0 0 0 6 7 1 0 0 0 0 6 8 2 0 0 0 0 7 32 1 0 0 0 0 9 10 1 0 0 0 0 9 33 1 0 0 0 0 10 11 2 0 0 0 0 10 12 1 0 0 0 0 11 18 1 0 0 0 0 11 13 1 0 0 0 0 12 14 1 0 0 0 0 12 34 1 0 0 0 0 13 35 1 0 0 0 0 13 36 1 0 0 0 0 13 37 1 0 0 0 0 14 18 2 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 38 1 0 0 0 0 16 24 1 0 0 0 0 17 39 1 0 0 0 0 17 40 1 0 0 0 0 17 41 1 0 0 0 0 18 19 1 0 0 0 0 19 20 1 0 0 0 0 19 42 1 0 0 0 0 19 43 1 0 0 0 0 20 21 1 0 0 0 0 20 44 1 0 0 0 0 20 45 1 0 0 0 0 21 23 1 0 0 0 0 21 22 2 0 0 0 0 23 46 1 0 0 0 0 24 29 2 0 0 0 0 24 25 1 0 0 0 0 25 26 2 0 0 0 0 25 47 1 0 0 0 0 26 27 1 0 0 0 0 26 48 1 0 0 0 0 27 28 2 0 0 0 0 27 49 1 0 0 0 0 28 29 1 0 0 0 0 28 50 1 0 0 0 0 29 51 1 0 0 0 0 M END > (21) 3-substituted indolin-2-one 16f > (21) PDGFR-beta > (21) 10 > (21) -1 > (21) P > (21) PDGFR-P19 $$$$ SU11248 analog 12e csChFnd70/05150717532D 50 52 0 0 0 0 0 0 0 0999 V2000 2.7899 3.9138 -0.1666 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7601 2.1591 -0.4363 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0860 1.3713 -1.3263 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4452 2.3235 -1.9504 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1545 4.8823 -0.7917 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4971 4.0891 -1.6908 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2148 6.8994 -1.6447 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5731 6.7354 -0.7290 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6916 5.3267 -2.1722 N 0 0 3 0 0 0 0 0 0 0 0 0 7.0066 8.2278 -1.8816 O 0 0 0 0 0 0 0 0 0 0 0 0 3.6254 8.0300 0.0261 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3131 9.7035 0.1490 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1906 11.8291 0.4476 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5892 12.5684 0.2362 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3949 11.2177 0.0494 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0190 10.1128 0.3972 N 0 0 3 0 0 0 0 0 0 0 0 0 1.4850 11.3939 -0.2095 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8522 12.7895 0.6979 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2021 14.4216 0.2114 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2284 15.2069 -1.1383 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8189 15.2455 1.6848 N 0 0 3 0 0 0 0 0 0 0 0 0 3.4341 17.0871 1.6603 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0452 17.6993 3.4866 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6594 19.5461 3.4620 N 0 0 0 0 0 0 0 0 0 0 0 0 1.0595 19.8900 2.5230 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5790 20.2434 5.2132 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4384 1.2113 0.1682 F 0 0 0 0 0 0 0 0 0 0 0 0 1.7553 4.5305 0.5214 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0554 0.0000 -1.5330 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4708 1.6952 -2.6414 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7349 5.0857 -2.8091 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3582 7.7627 0.5227 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9478 9.2912 0.5173 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8452 11.4143 1.0356 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2146 12.5857 -0.8925 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0135 10.3095 -0.9586 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4386 13.0404 -0.5484 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5964 14.0037 1.3461 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7238 12.0192 1.4770 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7978 14.6190 2.7615 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5372 17.7876 1.1582 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3217 17.3206 0.8430 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9421 16.9989 3.9887 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1577 17.4660 4.3038 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 19.2185 3.1445 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8044 21.2666 2.5245 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1870 19.4405 1.2033 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8110 20.0506 5.8493 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2915 21.6124 5.1577 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5745 19.5845 5.9322 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 5 2 0 0 0 0 1 28 1 0 0 0 0 2 3 2 0 0 0 0 2 27 1 0 0 0 0 3 4 1 0 0 0 0 3 29 1 0 0 0 0 4 6 2 0 0 0 0 4 30 1 0 0 0 0 5 8 1 0 0 0 0 5 6 1 0 0 0 0 6 9 1 0 0 0 0 7 9 1 0 0 0 0 7 8 1 0 0 0 0 7 10 2 0 0 0 0 8 11 2 0 0 0 0 9 31 1 0 0 0 0 11 12 1 0 0 0 0 11 32 1 0 0 0 0 12 15 2 0 0 0 0 12 16 1 0 0 0 0 13 16 1 0 0 0 0 13 14 2 0 0 0 0 13 18 1 0 0 0 0 14 15 1 0 0 0 0 14 19 1 0 0 0 0 15 17 1 0 0 0 0 16 33 1 0 0 0 0 17 34 1 0 0 0 0 17 35 1 0 0 0 0 17 36 1 0 0 0 0 18 37 1 0 0 0 0 18 38 1 0 0 0 0 18 39 1 0 0 0 0 19 20 2 0 0 0 0 19 21 1 0 0 0 0 21 22 1 0 0 0 0 21 40 1 0 0 0 0 22 23 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 24 1 0 0 0 0 23 43 1 0 0 0 0 23 44 1 0 0 0 0 24 25 1 0 0 0 0 24 26 1 0 0 0 0 25 45 1 0 0 0 0 25 46 1 0 0 0 0 25 47 1 0 0 0 0 26 48 1 0 0 0 0 26 49 1 0 0 0 0 26 50 1 0 0 0 0 M END > (3) SU11248 analog 12e > (3) PDGFR-beta > (3) .5 > (3) -1 > (3) P > (3) PDGFR-P1 $$$$ Pyrazine-Pyridine Biheteroaryl 7 csChFnd70/05150717532D 43 45 0 0 0 0 0 0 0 0999 V2000 1.0071 10.7751 -0.0812 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2612 8.6909 -0.3371 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5369 9.4575 -0.3670 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2781 11.5496 -0.1101 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0321 9.3696 -0.1951 N 0 0 0 0 0 0 0 0 0 0 0 0 3.5148 10.8738 -0.2523 N 0 0 0 0 0 0 0 0 0 0 0 0 4.9175 8.6954 -0.5259 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1996 9.4525 -0.5569 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5027 7.3794 -0.8139 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2747 6.5453 -0.7868 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9526 7.2083 -0.6402 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4283 8.7813 -0.6978 N 0 0 0 0 0 0 0 0 0 0 0 0 3.5273 13.7958 0.1142 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6390 15.1430 -0.4973 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6865 13.2130 0.8354 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9477 13.9715 0.9372 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0585 15.3105 0.3226 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9045 15.8970 -0.3918 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0462 17.5813 -1.1555 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.2495 13.0304 0.0095 N 0 0 3 0 0 0 0 0 0 0 0 0 6.3661 5.0604 -0.9112 N 0 0 3 0 0 0 0 0 0 0 0 0 7.7632 4.3732 -1.0718 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5645 2.7546 -1.1848 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0235 2.0369 -1.3525 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8379 0.5252 -1.4581 O 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 11.3254 0.0394 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2774 7.5410 -0.4303 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1852 10.6026 -0.4650 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5326 6.8718 -0.9276 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9792 6.5893 -0.6151 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7385 15.6009 -1.0548 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6009 12.1676 1.3164 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8488 13.5185 1.4978 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0460 15.9016 0.4045 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3426 13.5319 0.0204 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5047 4.4847 -0.8915 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2819 4.7690 -2.0363 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4255 4.6193 -0.1460 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0457 2.3589 -0.2202 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9022 2.5086 -2.1106 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5422 2.4326 -2.3171 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6858 2.2829 -0.4267 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7210 0.0000 -1.5668 H 0 0 0 0 0 0 0 0 0 0 0 0 1 5 1 0 0 0 0 1 4 2 0 0 0 0 1 26 1 0 0 0 0 2 5 2 0 0 0 0 2 3 1 0 0 0 0 2 27 1 0 0 0 0 3 6 2 0 0 0 0 3 7 1 0 0 0 0 4 6 1 0 0 0 0 4 20 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 12 2 0 0 0 0 8 28 1 0 0 0 0 9 12 1 0 0 0 0 9 10 2 0 0 0 0 9 29 1 0 0 0 0 10 11 1 0 0 0 0 10 21 1 0 0 0 0 11 30 1 0 0 0 0 13 20 1 0 0 0 0 13 14 2 0 0 0 0 13 15 1 0 0 0 0 14 18 1 0 0 0 0 14 31 1 0 0 0 0 15 16 2 0 0 0 0 15 32 1 0 0 0 0 16 17 1 0 0 0 0 16 33 1 0 0 0 0 17 18 2 0 0 0 0 17 34 1 0 0 0 0 18 19 1 0 0 0 0 20 35 1 0 0 0 0 21 22 1 0 0 0 0 21 36 1 0 0 0 0 22 23 1 0 0 0 0 22 37 1 0 0 0 0 22 38 1 0 0 0 0 23 24 1 0 0 0 0 23 39 1 0 0 0 0 23 40 1 0 0 0 0 24 25 1 0 0 0 0 24 41 1 0 0 0 0 24 42 1 0 0 0 0 25 43 1 0 0 0 0 M END > (203) Pyrazine-Pyridine Biheteroaryl 7 > (203) PDGFR-beta > (203) 360 > (203) -1 > (203) P > (203) PDGFR-P201 $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7r csChFnd70/05150717532D 66 69 0 0 0 0 0 0 0 0999 V2000 9.8486 11.1983 3.8428 C 0 0 0 0 0 0 0 0 0 0 0 0 11.0273 12.9057 1.6386 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5213 13.9103 1.5009 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2819 12.1446 3.7913 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1147 13.5367 2.5887 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8765 11.7255 4.9197 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3684 12.6839 4.8252 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2379 14.1191 3.5633 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8987 14.9770 3.4731 O 0 0 0 0 0 0 0 0 0 0 0 0 11.1421 11.6045 2.7844 N 0 0 0 0 0 0 0 0 0 0 0 0 6.5935 14.4942 2.5018 N 0 0 3 0 0 0 0 0 0 0 0 0 6.4468 15.9330 1.2454 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8768 12.2722 5.9911 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3457 12.6885 8.7034 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7395 13.0782 7.6227 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5991 11.0826 5.4594 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2121 10.7046 6.5527 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0874 11.5028 8.1713 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3173 14.5665 8.2928 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.7525 10.0806 3.4281 Cl 0 0 0 0 0 0 0 0 0 0 0 0 12.4399 13.2676 0.5585 N 0 0 3 0 0 0 0 0 0 0 0 0 13.9036 12.1683 0.5672 C 0 0 0 0 0 0 0 0 0 0 0 0 17.0065 11.7778 0.3280 C 0 0 0 0 0 0 0 0 0 0 0 0 15.1411 9.2976 0.8227 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6965 10.3811 0.8151 C 0 0 0 0 0 0 0 0 0 0 0 0 15.5633 12.8632 0.3200 C 0 0 0 0 0 0 0 0 0 0 0 0 16.7990 9.9938 0.5827 C 0 0 0 0 0 0 0 0 0 0 0 0 18.2209 8.9257 0.5898 O 0 0 0 0 0 0 0 0 0 0 0 0 17.9112 7.1026 0.8592 C 0 0 0 0 0 0 0 0 0 0 0 0 19.6527 6.1181 0.8252 C 0 0 0 0 0 0 0 0 0 0 0 0 19.3212 4.1662 1.1135 C 0 0 0 0 0 0 0 0 0 0 0 0 20.9934 3.2210 1.0810 N 0 0 0 0 0 0 0 0 0 0 0 0 20.7676 1.4023 1.6573 C 0 0 0 0 0 0 0 0 0 0 0 0 20.5527 1.3548 3.6461 C 0 0 0 0 0 0 0 0 0 0 0 0 21.7925 3.2958 -0.6645 C 0 0 0 0 0 0 0 0 0 0 0 0 23.7211 2.7782 -0.5377 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9977 10.1342 4.7595 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4447 14.9647 0.5644 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9925 10.6631 5.8430 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9264 15.4373 0.0142 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5703 16.9299 1.7647 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7345 16.5020 1.0220 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2378 13.3112 9.9664 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2225 9.7841 6.1429 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 11.2026 9.0213 H 0 0 0 0 0 0 0 0 0 0 0 0 12.4131 14.2821 -0.2023 H 0 0 0 0 0 0 0 0 0 0 0 0 18.2978 12.3188 0.1412 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9807 7.9084 1.0209 H 0 0 0 0 0 0 0 0 0 0 0 0 12.4057 9.8389 1.0025 H 0 0 0 0 0 0 0 0 0 0 0 0 15.7251 14.2522 0.1212 H 0 0 0 0 0 0 0 0 0 0 0 0 17.2807 6.9095 2.1230 H 0 0 0 0 0 0 0 0 0 0 0 0 17.0647 6.6066 -0.1748 H 0 0 0 0 0 0 0 0 0 0 0 0 20.2832 6.3113 -0.4386 H 0 0 0 0 0 0 0 0 0 0 0 0 20.4992 6.6141 1.8592 H 0 0 0 0 0 0 0 0 0 0 0 0 18.6909 3.9729 2.3773 H 0 0 0 0 0 0 0 0 0 0 0 0 18.4747 3.6700 0.0795 H 0 0 0 0 0 0 0 0 0 0 0 0 19.6076 0.8490 1.0408 H 0 0 0 0 0 0 0 0 0 0 0 0 21.9130 0.6401 1.2849 H 0 0 0 0 0 0 0 0 0 0 0 0 19.3384 2.0074 4.0085 H 0 0 0 0 0 0 0 0 0 0 0 0 20.5143 0.0000 4.0876 H 0 0 0 0 0 0 0 0 0 0 0 0 21.6525 2.0232 4.2589 H 0 0 0 0 0 0 0 0 0 0 0 0 21.1149 2.3943 -1.5363 H 0 0 0 0 0 0 0 0 0 0 0 0 21.6891 4.6214 -1.1779 H 0 0 0 0 0 0 0 0 0 0 0 0 24.4049 3.6970 0.3108 H 0 0 0 0 0 0 0 0 0 0 0 0 23.8256 1.4635 0.0034 H 0 0 0 0 0 0 0 0 0 0 0 0 24.3067 2.8051 -1.8370 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 37 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 38 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 39 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 40 1 0 0 0 0 12 41 1 0 0 0 0 12 42 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 43 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 44 1 0 0 0 0 18 45 1 0 0 0 0 21 22 1 0 0 0 0 21 46 1 0 0 0 0 22 25 2 0 0 0 0 22 26 1 0 0 0 0 23 27 1 0 0 0 0 23 26 2 0 0 0 0 23 47 1 0 0 0 0 24 27 2 0 0 0 0 24 25 1 0 0 0 0 24 48 1 0 0 0 0 25 49 1 0 0 0 0 26 50 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 29 51 1 0 0 0 0 29 52 1 0 0 0 0 30 31 1 0 0 0 0 30 53 1 0 0 0 0 30 54 1 0 0 0 0 31 32 1 0 0 0 0 31 55 1 0 0 0 0 31 56 1 0 0 0 0 32 33 1 0 0 0 0 32 35 1 0 0 0 0 33 34 1 0 0 0 0 33 57 1 0 0 0 0 33 58 1 0 0 0 0 34 59 1 0 0 0 0 34 60 1 0 0 0 0 34 61 1 0 0 0 0 35 36 1 0 0 0 0 35 62 1 0 0 0 0 35 63 1 0 0 0 0 36 64 1 0 0 0 0 36 65 1 0 0 0 0 36 66 1 0 0 0 0 M END > (204) 1,6-naphthyridin-2(1H)-one deriv. 7r > (204) PDGFR-beta > (204) 360 > (204) -1 > (204) P > (204) PDGFR-P202 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 56 csChFnd70/05150717532D 75 79 0 0 0 0 0 0 0 0999 V2000 3.9952 16.0375 0.0121 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5103 13.4384 -0.0164 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0185 14.3211 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0461 14.2100 -0.0268 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5916 16.9321 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1581 15.9499 -0.0186 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6754 18.7597 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8082 18.4716 -0.0220 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3067 19.5317 -0.0020 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6959 16.7595 -0.0296 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4733 21.4554 0.0055 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7221 24.1491 1.5781 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7845 25.0501 0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5671 22.3569 1.5801 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5444 22.3709 -1.5621 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6997 24.1632 -1.5464 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4883 21.2286 3.5378 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4389 21.2602 -3.5285 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7641 10.7428 -0.0129 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0606 8.7723 -0.0258 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4483 11.6394 -0.0249 N 0 0 3 0 0 0 0 0 0 0 0 0 2.3016 7.8358 -0.0133 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4390 19.2499 -0.0339 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8857 18.2561 -0.0530 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7618 16.6776 -0.0598 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8987 5.4563 -1.3307 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2324 3.4935 -1.2311 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2789 3.0426 -0.2251 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9453 5.0052 -0.3247 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5864 5.9439 -0.0256 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5913 2.5549 -1.5301 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8759 0.6629 -1.5423 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4698 19.0122 -0.0647 N 0 0 3 0 0 0 0 0 0 0 0 0 15.0424 17.9318 -0.0854 C 0 0 0 0 0 0 0 0 0 0 0 0 16.5463 18.9634 -0.8889 C 0 0 0 0 0 0 0 0 0 0 0 0 18.1887 17.8351 -0.9107 C 0 0 0 0 0 0 0 0 0 0 0 0 18.6617 17.3146 0.9538 C 0 0 0 0 0 0 0 0 0 0 0 0 17.1579 16.2831 1.7572 C 0 0 0 0 0 0 0 0 0 0 0 0 15.5154 17.4114 1.7790 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7768 16.7402 0.0217 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5046 19.5392 0.0249 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7953 24.8485 2.7964 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9059 26.4514 0.0249 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7544 24.8737 -2.7592 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0207 11.1170 -1.1629 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0432 11.1053 1.1551 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7815 8.4098 -1.1938 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8040 8.3981 1.1244 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5199 10.9706 -0.0387 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5808 8.1984 1.1547 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5582 8.2100 -1.1633 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5378 20.5095 -0.0285 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1067 6.1557 -1.0719 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4254 5.7910 -2.6265 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1775 3.1227 -2.2232 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7393 3.1637 0.0534 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7523 2.7078 1.0707 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0708 2.3431 -0.4838 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4384 5.3350 -1.6090 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3761 0.6676 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4113 0.2569 -0.2919 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6407 0.0000 -1.7661 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7871 0.3282 -2.5783 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5687 20.2717 -0.0592 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8042 16.7641 -0.8567 H 0 0 0 0 0 0 0 0 0 0 0 0 16.2092 19.3342 -2.2172 H 0 0 0 0 0 0 0 0 0 0 0 0 16.7845 20.1311 -0.1176 H 0 0 0 0 0 0 0 0 0 0 0 0 17.9504 16.6673 -1.6820 H 0 0 0 0 0 0 0 0 0 0 0 0 19.2600 18.5699 -1.4831 H 0 0 0 0 0 0 0 0 0 0 0 0 19.8318 16.5108 0.9383 H 0 0 0 0 0 0 0 0 0 0 0 0 18.8999 18.4824 1.7251 H 0 0 0 0 0 0 0 0 0 0 0 0 16.9196 15.1153 0.9859 H 0 0 0 0 0 0 0 0 0 0 0 0 17.4949 15.9123 3.0856 H 0 0 0 0 0 0 0 0 0 0 0 0 15.7536 18.5792 2.5503 H 0 0 0 0 0 0 0 0 0 0 0 0 14.4441 16.6766 2.3514 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 40 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 21 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 41 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 42 1 0 0 0 0 13 16 1 0 0 0 0 13 43 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 44 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 45 1 0 0 0 0 19 46 1 0 0 0 0 20 22 1 0 0 0 0 20 47 1 0 0 0 0 20 48 1 0 0 0 0 21 49 1 0 0 0 0 22 30 1 0 0 0 0 22 50 1 0 0 0 0 22 51 1 0 0 0 0 23 24 1 0 0 0 0 23 52 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 53 1 0 0 0 0 26 54 1 0 0 0 0 27 31 1 0 0 0 0 27 55 1 0 0 0 0 27 56 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 57 1 0 0 0 0 28 58 1 0 0 0 0 29 30 1 0 0 0 0 29 59 1 0 0 0 0 29 60 1 0 0 0 0 31 32 1 0 0 0 0 32 61 1 0 0 0 0 32 62 1 0 0 0 0 32 63 1 0 0 0 0 33 34 1 0 0 0 0 33 64 1 0 0 0 0 34 35 1 0 0 0 0 34 39 1 0 0 0 0 34 65 1 0 0 0 0 35 36 1 0 0 0 0 35 66 1 0 0 0 0 35 67 1 0 0 0 0 36 37 1 0 0 0 0 36 68 1 0 0 0 0 36 69 1 0 0 0 0 37 38 1 0 0 0 0 37 70 1 0 0 0 0 37 71 1 0 0 0 0 38 39 1 0 0 0 0 38 72 1 0 0 0 0 38 73 1 0 0 0 0 39 74 1 0 0 0 0 39 75 1 0 0 0 0 M END > (206) 6-arylpyrido[2,3-d]pyrimidine deriv. 56 > (206) PDGFR-beta > (206) 370 > (206) -1 > (206) P > (206) PDGFR-P204 $$$$ csChFnd70/05150717532D 44 47 0 0 0 0 0 0 0 0999 V2000 5.5168 9.3778 0.0279 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2645 7.7482 0.0023 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5366 7.8291 0.0090 N 0 0 0 0 0 0 0 0 0 0 0 0 6.9528 10.1847 0.0346 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3565 9.3048 0.0210 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0070 11.8429 0.0542 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8712 11.6278 0.0455 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1486 12.2701 0.0510 O 0 0 0 0 0 0 0 0 0 0 0 0 9.7847 10.0492 0.0265 N 0 0 3 0 0 0 0 0 0 0 0 0 8.4372 12.5757 0.0595 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5335 14.3121 0.0804 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5686 15.1509 -1.3260 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6578 16.7694 -1.2984 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7123 17.5589 0.1195 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6785 16.7345 1.5178 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5826 15.1160 1.5066 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5310 14.0840 3.2630 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.5011 14.1623 -3.1066 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.8816 7.0390 -0.0034 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8351 5.4184 -0.0236 N 0 0 3 0 0 0 0 0 0 0 0 0 11.2301 9.1177 0.0122 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3956 4.6356 0.1095 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1401 3.2385 -0.6860 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2034 5.2472 1.0487 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8015 4.4338 1.1455 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7868 2.4949 -0.5652 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6290 3.0445 0.3096 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2574 2.2380 0.3977 O 0 0 0 0 0 0 0 0 0 0 0 0 1.1536 0.8139 -0.4826 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4185 10.0110 0.0327 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9362 12.5216 0.0643 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6855 17.4200 -2.3860 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7820 18.8247 0.1346 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7218 17.3579 2.6208 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7994 4.8225 -0.1298 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5858 8.9010 -1.1976 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1559 9.7577 0.6207 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0240 8.0015 0.6026 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0590 2.7540 -1.4128 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3706 6.3303 1.6861 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8511 4.8760 1.8584 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.2885 -0.3091 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3244 1.0671 -1.7250 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0572 0.0000 -0.0850 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 30 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 31 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 21 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 32 1 0 0 0 0 14 15 1 0 0 0 0 14 33 1 0 0 0 0 15 16 2 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 22 1 0 0 0 0 20 35 1 0 0 0 0 21 36 1 0 0 0 0 21 37 1 0 0 0 0 21 38 1 0 0 0 0 22 23 2 0 0 0 0 22 24 1 0 0 0 0 23 26 1 0 0 0 0 23 39 1 0 0 0 0 24 25 2 0 0 0 0 24 40 1 0 0 0 0 25 27 1 0 0 0 0 25 41 1 0 0 0 0 26 27 2 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 42 1 0 0 0 0 29 43 1 0 0 0 0 29 44 1 0 0 0 0 M END > (213) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 41 > (213) PDGFR-beta > (213) 400 > (213) -1 > (213) P > (213) PDGFR-P211 $$$$ csChFnd70/05150717532D 42 45 0 0 0 0 0 0 0 0999 V2000 4.2789 8.4037 0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1668 6.6917 -0.0031 N 0 0 0 0 0 0 0 0 0 0 0 0 4.3003 6.7761 0.0010 N 0 0 0 0 0 0 0 0 0 0 0 0 5.7878 9.2521 0.0223 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2631 8.3277 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8443 10.9949 0.0380 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8544 10.7693 0.0318 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1967 11.4447 0.0360 O 0 0 0 0 0 0 0 0 0 0 0 0 8.7637 9.1104 0.0170 N 0 0 3 0 0 0 0 0 0 0 0 0 7.3471 11.7653 0.0428 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4479 13.5901 0.0585 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4865 14.4664 -1.4227 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5799 16.1674 -1.3994 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6350 17.0024 0.0877 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5977 16.1411 1.5603 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4973 14.4402 1.5544 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4410 13.3621 3.4038 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4182 13.4208 -3.2903 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.7138 5.9462 -0.0084 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6653 4.2424 -0.0242 N 0 0 3 0 0 0 0 0 0 0 0 0 4.1553 3.4214 0.1161 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2830 8.1317 0.0068 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4046 1.1399 -0.5873 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8967 1.9505 -0.7254 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9149 4.0706 1.1015 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1656 1.7882 0.3883 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4194 3.2529 1.2371 C 0 0 0 0 0 0 0 0 0 0 0 0 0.2001 3.8883 2.1964 O 0 0 0 0 0 0 0 0 0 0 0 0 3.1245 9.0688 0.0183 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7189 11.7078 0.0455 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6104 16.8471 -2.5449 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7079 18.3325 0.0992 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6416 16.8003 2.7172 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6790 3.6161 -0.1325 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6583 7.9000 -1.2634 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2551 8.8064 0.6453 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0659 6.9606 0.6307 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2036 0.0000 -1.2470 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8630 1.4412 -1.4883 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1146 5.2105 1.7615 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.1516 0.4936 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2269 3.5116 3.3279 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 29 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 30 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 31 1 0 0 0 0 14 15 1 0 0 0 0 14 32 1 0 0 0 0 15 16 2 0 0 0 0 15 33 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 34 1 0 0 0 0 21 24 1 0 0 0 0 21 25 2 0 0 0 0 22 35 1 0 0 0 0 22 36 1 0 0 0 0 22 37 1 0 0 0 0 23 26 1 0 0 0 0 23 24 2 0 0 0 0 23 38 1 0 0 0 0 24 39 1 0 0 0 0 25 27 1 0 0 0 0 25 40 1 0 0 0 0 26 27 2 0 0 0 0 26 41 1 0 0 0 0 27 28 1 0 0 0 0 28 42 1 0 0 0 0 M END > (218) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 50 > (218) PDGFR-beta > (218) 410 > (218) -1 > (218) P > (218) PDGFR-P216 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 51 csChFnd70/05150717532D 65 68 0 0 0 0 0 0 0 0999 V2000 3.9766 15.9630 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4847 13.3759 -0.0163 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9998 14.2546 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0134 14.1441 -0.0267 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5656 16.8535 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1249 15.8759 -0.0185 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6491 18.6725 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7673 18.3858 -0.0219 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2728 19.4410 -0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6555 16.6817 -0.0294 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4386 21.3558 0.0054 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6862 24.0370 1.5708 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7483 24.9338 0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5320 22.2530 1.5728 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5094 22.2670 -1.5549 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6639 24.0510 -1.5392 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4535 21.1300 3.5213 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4044 21.1615 -3.5122 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7467 10.6929 -0.0128 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0417 8.7315 -0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4230 11.5854 -0.0247 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2910 7.7994 -0.0132 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3905 19.1605 -0.0337 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8305 18.1714 -0.0528 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7072 16.6001 -0.0595 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8806 5.4309 -1.3245 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2127 3.4773 -1.2253 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2729 3.0285 -0.2240 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9409 4.9820 -0.3232 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5744 5.9163 -0.0255 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5793 2.5430 -1.5230 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8625 0.6599 -1.5352 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4073 18.9239 -0.0644 N 0 0 3 0 0 0 0 0 0 0 0 0 14.9725 17.8486 -0.0850 C 0 0 0 0 0 0 0 0 0 0 0 0 16.5763 19.0157 -0.0948 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7639 16.6625 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4837 19.4484 0.0247 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7591 24.7331 2.7835 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8692 26.3286 0.0247 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7184 24.7582 -2.7464 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0067 11.0654 -1.1575 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0291 11.0537 1.1498 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7592 8.3707 -1.1883 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7817 8.3591 1.1192 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4897 10.9197 -0.0385 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5734 8.1603 1.1494 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5510 8.1719 -1.1579 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4889 20.4142 -0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0830 6.1271 -1.0669 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4095 5.7641 -2.6143 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1535 3.1082 -2.2129 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7172 3.1490 0.0532 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7441 2.6952 1.0658 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0705 2.3322 -0.4816 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4363 5.3102 -1.6015 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3511 0.6645 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3955 0.2557 -0.2905 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6330 0.0000 -1.7579 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7695 0.3267 -2.5663 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5057 20.1775 -0.0590 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9950 17.0271 1.0643 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9724 17.0387 -1.2430 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5540 19.8372 -1.2443 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5766 19.8255 1.0632 H 0 0 0 0 0 0 0 0 0 0 0 0 17.7410 18.2157 -0.1102 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 36 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 21 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 37 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 38 1 0 0 0 0 13 16 1 0 0 0 0 13 39 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 40 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 41 1 0 0 0 0 19 42 1 0 0 0 0 20 22 1 0 0 0 0 20 43 1 0 0 0 0 20 44 1 0 0 0 0 21 45 1 0 0 0 0 22 30 1 0 0 0 0 22 46 1 0 0 0 0 22 47 1 0 0 0 0 23 24 1 0 0 0 0 23 48 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 49 1 0 0 0 0 26 50 1 0 0 0 0 27 31 1 0 0 0 0 27 51 1 0 0 0 0 27 52 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 53 1 0 0 0 0 28 54 1 0 0 0 0 29 30 1 0 0 0 0 29 55 1 0 0 0 0 29 56 1 0 0 0 0 31 32 1 0 0 0 0 32 57 1 0 0 0 0 32 58 1 0 0 0 0 32 59 1 0 0 0 0 33 34 1 0 0 0 0 33 60 1 0 0 0 0 34 35 1 0 0 0 0 34 61 1 0 0 0 0 34 62 1 0 0 0 0 35 63 1 0 0 0 0 35 64 1 0 0 0 0 35 65 1 0 0 0 0 M END > (220) 6-arylpyrido[2,3-d]pyrimidine deriv. 51 > (220) PDGFR-beta > (220) 420 > (220) -1 > (220) P > (220) PDGFR-P218 $$$$ Structure297 csChFnd70/05150717532D 26 28 0 0 0 0 0 0 0 0999 V2000 1.6449 7.1487 0.0104 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6652 5.6513 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9544 4.9184 -0.0137 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2409 5.6754 -0.0219 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2294 7.1873 -0.0142 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9159 7.9180 0.0024 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6759 5.2766 -0.0379 N 0 0 3 0 0 0 0 0 0 0 0 0 6.4691 6.5092 -0.0394 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6237 7.6250 -0.0255 N 0 0 0 0 0 0 0 0 0 0 0 0 6.2123 3.8677 -0.0501 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2457 3.4691 -1.0527 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7729 2.0797 -1.0618 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2721 1.0859 -0.0741 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2427 1.4795 0.9253 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7162 2.8691 0.9441 C 0 0 0 0 0 0 0 0 0 0 0 0 0.3656 7.8583 0.0203 O 0 0 0 0 0 0 0 0 0 0 0 0 0.6648 5.0602 0.0086 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9630 3.7563 -0.0191 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8946 9.0798 0.0085 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6302 6.5536 -0.0508 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6365 4.2445 -1.8249 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5766 1.7690 -1.8414 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6857 0.0000 -0.0836 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8532 0.7009 1.6948 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9122 3.1760 1.7250 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 8.0584 0.9736 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 2 0 0 0 0 1 6 1 0 0 0 0 1 16 1 0 0 0 0 2 3 1 0 0 0 0 2 17 1 0 0 0 0 3 4 2 0 0 0 0 3 18 1 0 0 0 0 4 5 1 0 0 0 0 4 7 1 0 0 0 0 5 6 2 0 0 0 0 5 9 1 0 0 0 0 6 19 1 0 0 0 0 7 8 1 0 0 0 0 7 10 1 0 0 0 0 8 9 2 0 0 0 0 8 20 1 0 0 0 0 10 11 2 0 0 0 0 10 15 1 0 0 0 0 11 12 1 0 0 0 0 11 21 1 0 0 0 0 12 13 2 0 0 0 0 12 22 1 0 0 0 0 13 14 1 0 0 0 0 13 23 1 0 0 0 0 14 15 2 0 0 0 0 14 24 1 0 0 0 0 15 25 1 0 0 0 0 16 26 1 0 0 0 0 M END > (227) 16230017 -6 > (227) PDGFR-beta > (227) 437 > (227) -1 > (227) P > (227) PDGFR-P225 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 35 csChFnd70/05150717532D 69 72 0 0 0 0 0 0 0 0999 V2000 2.3384 13.7062 0.1098 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6691 11.8832 0.3549 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9836 12.1702 0.4163 N 0 0 0 0 0 0 0 0 0 0 0 0 5.7933 13.0994 -0.0119 N 0 0 0 0 0 0 0 0 0 0 0 0 3.4732 15.0536 -0.2882 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2632 14.7026 -0.3428 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8854 16.7260 -0.6312 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8555 17.5315 -1.0436 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0968 17.9747 -1.0127 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3753 15.9534 -0.7172 N 0 0 0 0 0 0 0 0 0 0 0 0 3.5496 19.7616 -1.3861 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8954 22.6181 -0.4125 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5284 23.1007 -2.0838 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4051 20.9553 -0.0562 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1843 20.2580 -3.0696 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6757 21.9248 -3.4091 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8644 20.3519 2.0425 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.3691 18.7843 -4.7349 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.2665 10.2442 0.6894 N 0 0 3 0 0 0 0 0 0 0 0 0 4.0522 8.8652 1.1014 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0397 7.1937 1.4139 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7714 5.7536 1.8441 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7591 4.0820 2.1567 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5414 2.6993 2.5698 N 0 0 0 0 0 0 0 0 0 0 0 0 2.4418 2.3009 1.0874 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8885 1.2536 1.6861 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4482 1.1571 3.1735 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0509 1.4337 5.0248 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0638 18.7857 -1.4262 N 0 0 3 0 0 0 0 0 0 0 0 0 8.7485 18.3834 -1.4609 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2091 16.9216 -1.1571 O 0 0 0 0 0 0 0 0 0 0 0 0 9.9224 19.6020 -1.8326 N 0 0 3 0 0 0 0 0 0 0 0 0 11.6569 19.1574 -2.0033 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1105 17.5612 -2.6610 C 0 0 0 0 0 0 0 0 0 0 0 0 13.8234 17.1265 -2.8285 C 0 0 0 0 0 0 0 0 0 0 0 0 15.0863 18.2786 -2.3416 C 0 0 0 0 0 0 0 0 0 0 0 0 14.6389 19.8686 -1.6857 C 0 0 0 0 0 0 0 0 0 0 0 0 12.9282 20.3143 -1.5225 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9681 13.9231 0.1577 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5311 17.0290 -0.5991 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7834 23.5437 0.6161 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1298 24.4023 -2.3558 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3920 22.3107 -4.7120 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4899 10.0068 0.6515 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3330 9.2053 2.2546 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1641 8.6901 0.0320 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7588 6.8536 0.2607 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9277 7.3689 2.4833 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0523 6.0937 2.9974 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8835 5.5784 0.7747 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4783 3.7417 1.0035 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6471 4.2572 3.2261 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0018 3.4936 0.4984 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1721 1.5589 0.1501 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3180 0.0000 2.1411 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2412 1.9317 2.7272 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.0829 0.6164 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5822 0.0568 3.1238 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5573 0.9159 2.3523 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7452 0.2990 5.4644 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8971 2.5489 5.0788 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9398 1.6501 5.8503 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6964 19.9522 -1.6686 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5651 20.7870 -1.9817 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1247 16.6606 -3.0407 H 0 0 0 0 0 0 0 0 0 0 0 0 14.1770 15.8854 -3.3400 H 0 0 0 0 0 0 0 0 0 0 0 0 16.4250 17.9354 -2.4735 H 0 0 0 0 0 0 0 0 0 0 0 0 15.6282 20.7654 -1.3062 H 0 0 0 0 0 0 0 0 0 0 0 0 12.5796 21.5586 -1.0154 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 39 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 19 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 40 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 29 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 41 1 0 0 0 0 13 16 1 0 0 0 0 13 42 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 43 1 0 0 0 0 19 20 1 0 0 0 0 19 44 1 0 0 0 0 20 21 1 0 0 0 0 20 45 1 0 0 0 0 20 46 1 0 0 0 0 21 22 1 0 0 0 0 21 47 1 0 0 0 0 21 48 1 0 0 0 0 22 23 1 0 0 0 0 22 49 1 0 0 0 0 22 50 1 0 0 0 0 23 24 1 0 0 0 0 23 51 1 0 0 0 0 23 52 1 0 0 0 0 24 25 1 0 0 0 0 24 27 1 0 0 0 0 25 26 1 0 0 0 0 25 53 1 0 0 0 0 25 54 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 26 57 1 0 0 0 0 27 28 1 0 0 0 0 27 58 1 0 0 0 0 27 59 1 0 0 0 0 28 60 1 0 0 0 0 28 61 1 0 0 0 0 28 62 1 0 0 0 0 29 30 1 0 0 0 0 29 63 1 0 0 0 0 30 31 2 0 0 0 0 30 32 1 0 0 0 0 32 33 1 0 0 0 0 32 64 1 0 0 0 0 33 34 2 0 0 0 0 33 38 1 0 0 0 0 34 35 1 0 0 0 0 34 65 1 0 0 0 0 35 36 2 0 0 0 0 35 66 1 0 0 0 0 36 37 1 0 0 0 0 36 67 1 0 0 0 0 37 38 2 0 0 0 0 37 68 1 0 0 0 0 38 69 1 0 0 0 0 M END > (236) 6-arylpyrido[2,3-d]pyrimidine deriv. 35 > (236) PDGFR-beta > (236) 450 > (236) -1 > (236) P > (236) PDGFR-P234 $$$$ 3-substituted indolin-2-one 9c csChFnd70/05150717532D 52 55 0 0 0 0 0 0 0 0999 V2000 5.8538 9.4155 0.1580 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6543 7.8538 0.1302 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6449 9.4491 0.0811 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2319 10.2291 0.0954 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6009 11.8888 0.0339 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2880 11.9634 -0.0143 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8326 10.5173 0.0156 N 0 0 3 0 0 0 0 0 0 0 0 0 10.0587 13.1321 -0.0721 O 0 0 0 0 0 0 0 0 0 0 0 0 6.5786 13.1065 0.0236 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1278 14.6274 0.1490 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4970 15.9189 -0.5421 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3867 15.1045 0.9867 N 0 0 3 0 0 0 0 0 0 0 0 0 5.0993 15.9606 -1.5665 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6603 16.2132 -0.5853 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2627 16.2548 -1.6098 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4031 16.0985 -2.9835 O 0 0 0 0 0 0 0 0 0 0 0 0 0.8617 16.4655 -0.9961 O 0 0 0 0 0 0 0 0 0 0 0 0 8.5403 16.6484 0.8183 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4011 17.1734 -0.1095 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1529 18.8214 -0.5863 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8734 7.8319 0.2065 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2735 7.0461 0.1928 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2897 5.3411 0.2445 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9113 4.5256 0.3001 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9342 2.9336 0.3477 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3280 2.1542 0.3400 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6959 2.9625 0.2855 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6839 4.5494 0.2311 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5921 2.1340 0.4023 O 0 0 0 0 0 0 0 0 0 0 0 0 4.7015 0.4947 0.4495 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7715 10.0250 0.1738 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7335 7.2386 0.1195 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9162 10.2526 -0.0051 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3594 12.8932 -0.0806 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0513 14.4465 1.5950 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2131 16.8984 -2.3907 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9999 14.8729 -2.1821 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5466 15.2753 0.2388 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7598 17.3008 0.0303 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.4838 -1.6991 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4248 17.3468 1.3408 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4048 19.3886 0.2447 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2564 19.4149 -0.6285 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6180 18.8524 -1.7197 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8059 7.1986 0.2556 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8279 5.1334 0.3063 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3435 0.9126 0.3773 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7770 2.3508 0.2802 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7545 5.1776 0.1835 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2956 0.0859 -0.5760 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3422 0.1478 1.4699 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5502 0.0000 0.4907 H 0 0 0 0 0 0 0 0 0 0 0 0 1 21 1 0 0 0 0 1 4 2 0 0 0 0 1 31 1 0 0 0 0 2 22 1 0 0 0 0 2 3 2 0 0 0 0 2 32 1 0 0 0 0 3 7 1 0 0 0 0 3 4 1 0 0 0 0 4 5 1 0 0 0 0 5 6 1 0 0 0 0 5 9 2 0 0 0 0 6 7 1 0 0 0 0 6 8 2 0 0 0 0 7 33 1 0 0 0 0 9 10 1 0 0 0 0 9 34 1 0 0 0 0 10 11 2 0 0 0 0 10 12 1 0 0 0 0 11 19 1 0 0 0 0 11 13 1 0 0 0 0 12 18 1 0 0 0 0 12 35 1 0 0 0 0 13 14 1 0 0 0 0 13 36 1 0 0 0 0 13 37 1 0 0 0 0 14 15 1 0 0 0 0 14 38 1 0 0 0 0 14 39 1 0 0 0 0 15 17 1 0 0 0 0 15 16 2 0 0 0 0 17 40 1 0 0 0 0 18 19 2 0 0 0 0 18 41 1 0 0 0 0 19 20 1 0 0 0 0 20 42 1 0 0 0 0 20 43 1 0 0 0 0 20 44 1 0 0 0 0 21 22 2 0 0 0 0 21 45 1 0 0 0 0 22 23 1 0 0 0 0 23 28 2 0 0 0 0 23 24 1 0 0 0 0 24 25 2 0 0 0 0 24 46 1 0 0 0 0 25 26 1 0 0 0 0 25 29 1 0 0 0 0 26 27 2 0 0 0 0 26 47 1 0 0 0 0 27 28 1 0 0 0 0 27 48 1 0 0 0 0 28 49 1 0 0 0 0 29 30 1 0 0 0 0 30 50 1 0 0 0 0 30 51 1 0 0 0 0 30 52 1 0 0 0 0 M END > (237) 3-substituted indolin-2-one 9c > (237) PDGFR-beta > (237) 450 > (237) -1 > (237) P > (237) PDGFR-P235 $$$$ 1,6-naphthyridin 31 csChFnd70/05150717532D 72 74 0 0 0 0 0 0 0 0999 V2000 1.1966 15.1511 -2.1338 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6142 12.5564 -1.6833 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2199 13.2754 -1.9652 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7650 15.9983 -2.4405 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3261 15.0406 -2.3559 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8337 17.7690 -2.8301 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9326 17.4692 -3.0093 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4371 18.5037 -3.1159 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1796 13.4954 -1.7739 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8397 15.8134 -2.6427 N 0 0 0 0 0 0 0 0 0 0 0 0 4.5822 20.3655 -3.5318 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7059 22.8157 -5.2122 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5653 21.0822 -4.8306 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7309 21.4071 -2.6205 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8605 23.1390 -3.0133 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8529 23.8418 -4.3082 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4936 10.8092 -1.2961 N 0 0 3 0 0 0 0 0 0 0 0 0 4.0585 9.7543 -1.1906 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5690 7.8932 -0.7499 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2034 6.7914 -0.6397 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7140 4.9305 -0.1990 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2832 3.8727 -0.0932 N 0 0 0 0 0 0 0 0 0 0 0 0 7.3682 4.4109 1.3647 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1846 3.6707 1.1416 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8538 2.0302 0.0235 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3207 1.3647 -1.7569 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5361 18.2144 -3.2973 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9759 17.2440 -3.2003 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8707 15.7164 -2.8606 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5323 17.9674 -3.4799 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0974 16.9127 -3.3744 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0015 15.4580 -4.7055 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6762 18.0391 -3.7432 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2492 16.1394 -1.5644 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 15.8631 -2.1879 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3716 12.4949 -1.8862 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6706 18.5330 -2.9046 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9187 23.3724 -6.2183 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6693 20.2824 -5.5373 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5174 20.8600 -1.6087 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7499 23.9474 -2.3081 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9584 25.1979 -4.6109 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3732 10.2886 -1.0957 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7273 9.7828 -2.4275 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9026 10.2667 -0.1893 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9003 7.8648 0.4869 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7249 7.3808 -1.7511 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8723 6.8200 -1.8766 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0476 7.3040 0.3616 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0452 4.9020 1.0379 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8698 4.4181 -1.2003 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4359 5.8151 1.4053 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8116 3.9335 2.5648 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0341 4.2086 2.1251 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1403 2.2714 1.2748 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6736 4.0050 -0.1339 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9774 1.3147 0.4743 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7913 1.8529 0.9277 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9928 0.0000 -1.6684 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2029 2.0869 -2.2120 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3866 1.5333 -2.6589 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6201 19.4334 -3.5684 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6163 19.1864 -3.7509 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8936 16.0089 -5.9950 H 0 0 0 0 0 0 0 0 0 0 0 0 13.1660 14.6732 -4.6270 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8768 14.6555 -4.4428 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7445 19.0754 -2.7949 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8407 17.2542 -3.6647 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5681 18.5899 -5.0327 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1244 15.3369 -1.3016 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4135 15.3547 -1.4859 H 0 0 0 0 0 0 0 0 0 0 0 0 12.3174 17.1758 -0.6161 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 35 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 17 1 0 0 0 0 3 5 2 0 0 0 0 3 36 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 37 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 27 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 38 1 0 0 0 0 13 39 1 0 0 0 0 14 15 1 0 0 0 0 14 40 1 0 0 0 0 15 16 2 0 0 0 0 15 41 1 0 0 0 0 16 42 1 0 0 0 0 17 18 1 0 0 0 0 17 43 1 0 0 0 0 18 19 1 0 0 0 0 18 44 1 0 0 0 0 18 45 1 0 0 0 0 19 20 1 0 0 0 0 19 46 1 0 0 0 0 19 47 1 0 0 0 0 20 21 1 0 0 0 0 20 48 1 0 0 0 0 20 49 1 0 0 0 0 21 22 1 0 0 0 0 21 50 1 0 0 0 0 21 51 1 0 0 0 0 22 25 1 0 0 0 0 22 23 1 0 0 0 0 23 24 1 0 0 0 0 23 52 1 0 0 0 0 23 53 1 0 0 0 0 24 54 1 0 0 0 0 24 55 1 0 0 0 0 24 56 1 0 0 0 0 25 26 1 0 0 0 0 25 57 1 0 0 0 0 25 58 1 0 0 0 0 26 59 1 0 0 0 0 26 60 1 0 0 0 0 26 61 1 0 0 0 0 27 28 1 0 0 0 0 27 62 1 0 0 0 0 28 29 2 0 0 0 0 28 30 1 0 0 0 0 30 31 1 0 0 0 0 30 63 1 0 0 0 0 31 32 1 0 0 0 0 31 33 1 0 0 0 0 31 34 1 0 0 0 0 32 64 1 0 0 0 0 32 65 1 0 0 0 0 32 66 1 0 0 0 0 33 67 1 0 0 0 0 33 68 1 0 0 0 0 33 69 1 0 0 0 0 34 70 1 0 0 0 0 34 71 1 0 0 0 0 34 72 1 0 0 0 0 M END > (238) 1,6-naphthyridine 31 > (238) PDGFR-beta > (238) 450 > (238) -1 > (238) P > (238) PDGFR-P236 $$$$ PD0179483 csChFnd70/05150717532D 61 64 0 0 0 0 0 0 0 0999 V2000 5.9193 15.3438 -4.9093 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1216 18.2617 -5.1773 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3283 16.5112 -4.7217 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3117 15.9528 -5.5634 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1226 17.7065 -6.0142 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5226 18.8581 -5.8191 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3360 15.7651 -3.9164 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.5535 14.5092 -5.8107 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.6066 5.9226 -1.1457 N 0 0 3 0 0 0 0 0 0 0 0 0 6.3861 5.3442 0.5930 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6791 5.8444 3.7008 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9500 4.2005 4.0314 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4462 3.1262 2.6402 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6632 3.6957 0.9249 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8970 6.4157 1.9863 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1317 13.4642 -4.4236 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7622 12.9099 -2.7463 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7310 12.1811 -5.7355 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0567 12.6621 -7.2323 O 0 0 0 0 0 0 0 0 0 0 0 0 6.9244 10.4722 -5.2951 N 0 0 3 0 0 0 0 0 0 0 0 0 7.5331 9.2066 -6.6207 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3946 7.6847 -1.5527 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5640 9.9056 -3.6158 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9769 11.1082 -2.3226 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6160 10.4736 -0.6235 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8400 8.7785 -0.3026 N 0 0 0 0 0 0 0 0 0 0 0 0 6.7518 8.2219 -3.1748 N 0 0 0 0 0 0 0 0 0 0 0 0 5.7358 3.6387 5.7200 O 0 0 0 0 0 0 0 0 0 0 0 0 4.9766 1.9323 5.9637 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8412 1.5322 7.9357 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6030 2.7644 8.7590 N 0 0 3 0 0 0 0 0 0 0 0 0 1.7271 2.3193 8.8689 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3956 1.2075 10.5186 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1897 4.3075 9.4152 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9494 5.5007 10.4072 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7158 4.7359 9.2072 O 0 0 0 0 0 0 0 0 0 0 0 0 8.2110 19.1666 -5.0328 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8791 18.1796 -6.5207 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3679 20.2282 -6.1736 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9081 5.0860 -2.0643 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0706 6.6802 4.7845 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8787 1.8464 2.8987 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2705 2.8593 -0.1580 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4651 7.6955 1.7291 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3140 13.8353 -1.7617 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4002 8.6500 -7.3069 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3844 9.8751 -7.5656 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2673 8.1535 -5.9758 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1651 11.3539 0.4006 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6651 1.9034 5.3780 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8057 0.9443 5.3305 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3720 0.1868 8.1203 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1351 1.6757 8.5436 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9518 3.5267 8.9413 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3430 1.5725 7.7030 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1711 0.0000 10.4462 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7799 1.9541 11.6844 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.8763 10.6004 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6807 4.8457 10.5676 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5020 5.7977 11.6997 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7685 6.7216 9.6715 H 0 0 0 0 0 0 0 0 0 0 0 0 1 16 1 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 2 3 1 0 0 0 0 2 6 2 0 0 0 0 2 37 1 0 0 0 0 3 7 1 0 0 0 0 4 5 2 0 0 0 0 4 8 1 0 0 0 0 5 6 1 0 0 0 0 5 38 1 0 0 0 0 6 39 1 0 0 0 0 9 22 1 0 0 0 0 9 10 1 0 0 0 0 9 40 1 0 0 0 0 10 14 2 0 0 0 0 10 15 1 0 0 0 0 11 12 1 0 0 0 0 11 15 2 0 0 0 0 11 41 1 0 0 0 0 12 13 2 0 0 0 0 12 28 1 0 0 0 0 13 14 1 0 0 0 0 13 42 1 0 0 0 0 14 43 1 0 0 0 0 15 44 1 0 0 0 0 16 18 1 0 0 0 0 16 17 2 0 0 0 0 17 24 1 0 0 0 0 17 45 1 0 0 0 0 18 20 1 0 0 0 0 18 19 2 0 0 0 0 20 23 1 0 0 0 0 20 21 1 0 0 0 0 21 46 1 0 0 0 0 21 47 1 0 0 0 0 21 48 1 0 0 0 0 22 26 2 0 0 0 0 22 27 1 0 0 0 0 23 27 2 0 0 0 0 23 24 1 0 0 0 0 24 25 2 0 0 0 0 25 26 1 0 0 0 0 25 49 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 29 50 1 0 0 0 0 29 51 1 0 0 0 0 30 31 1 0 0 0 0 30 52 1 0 0 0 0 30 53 1 0 0 0 0 31 32 1 0 0 0 0 31 34 1 0 0 0 0 32 33 1 0 0 0 0 32 54 1 0 0 0 0 32 55 1 0 0 0 0 33 56 1 0 0 0 0 33 57 1 0 0 0 0 33 58 1 0 0 0 0 34 35 1 0 0 0 0 34 36 2 0 0 0 0 35 59 1 0 0 0 0 35 60 1 0 0 0 0 35 61 1 0 0 0 0 M END > (243) PD179483 > (243) PDGFR-beta > (243) 463 > (243) -1 > (243) P > (243) PDGFR-P241 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 47 csChFnd70/05150717532D 71 74 0 0 0 0 0 0 0 0999 V2000 3.9531 15.8339 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4473 13.2705 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9761 14.1411 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 6.9620 14.0316 -0.0265 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5275 16.7162 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0725 15.7475 -0.0184 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6102 18.5186 0.0099 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6999 18.2345 -0.0217 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2191 19.2801 -0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5891 16.5460 -0.0292 N 0 0 0 0 0 0 0 0 0 0 0 0 7.3834 21.1773 0.0054 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6287 23.8339 1.5564 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6902 24.7225 0.0191 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4758 22.0663 1.5584 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4535 22.0802 -1.5406 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6066 23.8478 -1.5251 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3981 20.9535 3.4891 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.3494 20.9847 -3.4800 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7252 10.6121 -0.0127 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0176 8.6686 -0.0254 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2828 7.7451 -0.0131 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3862 11.4964 -0.0245 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2096 3.4508 1.1074 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2780 3.0158 0.1677 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9511 4.9505 0.2918 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5636 5.8792 -0.0253 N 0 0 0 0 0 0 0 0 0 0 0 0 3.8827 5.3854 1.2314 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3082 19.0021 -0.0334 N 0 0 3 0 0 0 0 0 0 0 0 0 11.7350 18.0220 -0.0523 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6129 16.4652 -0.0590 O 0 0 0 0 0 0 0 0 0 0 0 0 13.2974 18.7677 -0.0638 N 0 0 3 0 0 0 0 0 0 0 0 0 14.8480 16.5758 -1.6948 C 0 0 0 0 0 0 0 0 0 0 0 0 14.8483 17.7022 -0.0843 C 0 0 0 0 0 0 0 0 0 0 0 0 16.4374 18.8586 -0.0939 C 0 0 0 0 0 0 0 0 0 0 0 0 14.8794 16.5596 1.5144 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5970 2.5220 1.4244 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8778 0.6561 1.4123 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7514 16.5270 0.0214 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4554 19.2874 0.0245 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7009 24.5237 2.7580 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8099 26.1045 0.0245 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6605 24.5485 -2.7212 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9920 10.9811 -1.1469 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0142 10.9696 1.1392 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7285 8.3112 -1.1774 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7507 8.2996 1.1089 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5719 8.1027 1.1388 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5496 8.1141 -1.1473 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4431 10.8368 -0.0381 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6847 3.1384 -0.1721 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1606 3.0754 2.0638 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0917 2.3233 0.4392 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7197 2.6985 -1.1224 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3258 -0.6646 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4759 5.2628 1.5713 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4410 5.7027 2.5216 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0689 6.0779 0.9600 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4057 20.2444 -0.0281 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3948 20.0098 -0.0584 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8259 17.3898 -2.8336 H 0 0 0 0 0 0 0 0 0 0 0 0 16.0020 15.7831 -1.7099 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7160 15.7521 -1.6878 H 0 0 0 0 0 0 0 0 0 0 0 0 16.4376 19.6611 1.0534 H 0 0 0 0 0 0 0 0 0 0 0 0 17.5913 18.0660 -0.1092 H 0 0 0 0 0 0 0 0 0 0 0 0 16.4152 19.6726 -1.2329 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7473 15.7357 1.5212 H 0 0 0 0 0 0 0 0 0 0 0 0 16.0334 15.7668 1.4992 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8795 17.3621 2.6618 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7961 0.3158 2.4130 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6640 0.0000 1.6501 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3816 0.2681 0.1649 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 38 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 22 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 39 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 28 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 40 1 0 0 0 0 13 16 1 0 0 0 0 13 41 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 42 1 0 0 0 0 19 22 1 0 0 0 0 19 20 1 0 0 0 0 19 43 1 0 0 0 0 19 44 1 0 0 0 0 20 21 1 0 0 0 0 20 45 1 0 0 0 0 20 46 1 0 0 0 0 21 26 1 0 0 0 0 21 47 1 0 0 0 0 21 48 1 0 0 0 0 22 49 1 0 0 0 0 23 27 1 0 0 0 0 23 36 1 0 0 0 0 23 50 1 0 0 0 0 23 51 1 0 0 0 0 24 36 1 0 0 0 0 24 25 1 0 0 0 0 24 52 1 0 0 0 0 24 53 1 0 0 0 0 25 26 1 0 0 0 0 25 54 1 0 0 0 0 25 55 1 0 0 0 0 26 27 1 0 0 0 0 27 56 1 0 0 0 0 27 57 1 0 0 0 0 28 29 1 0 0 0 0 28 58 1 0 0 0 0 29 30 2 0 0 0 0 29 31 1 0 0 0 0 31 33 1 0 0 0 0 31 59 1 0 0 0 0 32 33 1 0 0 0 0 32 60 1 0 0 0 0 32 61 1 0 0 0 0 32 62 1 0 0 0 0 33 34 1 0 0 0 0 33 35 1 0 0 0 0 34 63 1 0 0 0 0 34 64 1 0 0 0 0 34 65 1 0 0 0 0 35 66 1 0 0 0 0 35 67 1 0 0 0 0 35 68 1 0 0 0 0 36 37 1 0 0 0 0 37 69 1 0 0 0 0 37 70 1 0 0 0 0 37 71 1 0 0 0 0 M END > (244) 6-arylpyrido[2,3-d]pyrimidine deriv. 47 > (244) PDGFR-beta > (244) 470 > (244) -1 > (244) P > (244) PDGFR-P242 $$$$ Structure142 csChFnd70/05150717532D 68 71 0 0 0 0 0 0 0 0999 V2000 13.0718 9.6843 -0.1819 N 0 0 0 0 0 0 0 0 0 0 0 0 13.0900 7.9718 0.0535 C 0 0 0 0 0 0 0 0 0 0 0 0 14.5411 7.0702 0.1807 N 0 0 0 0 0 0 0 0 0 0 0 0 16.0829 7.8666 0.0741 C 0 0 0 0 0 0 0 0 0 0 0 0 16.1109 9.6927 -0.1774 C 0 0 0 0 0 0 0 0 0 0 0 0 17.5673 6.9826 0.1994 N 0 0 0 0 0 0 0 0 0 0 0 0 19.0853 7.7647 0.0954 C 0 0 0 0 0 0 0 0 0 0 0 0 19.2134 9.5751 -0.1536 C 0 0 0 0 0 0 0 0 0 0 0 0 20.5915 6.7863 0.2357 N 0 0 3 0 0 0 0 0 0 0 0 0 20.4916 5.0555 0.4739 C 0 0 0 0 0 0 0 0 0 0 0 0 21.9547 4.1052 0.6101 N 0 0 3 0 0 0 0 0 0 0 0 0 19.0816 4.3516 0.5661 O 0 0 0 0 0 0 0 0 0 0 0 0 11.5243 7.1029 0.1700 N 0 0 3 0 0 0 0 0 0 0 0 0 20.9397 10.4199 -0.2646 C 0 0 0 0 0 0 0 0 0 0 0 0 21.7502 11.0327 1.2345 C 0 0 0 0 0 0 0 0 0 0 0 0 23.3588 11.8180 1.1226 C 0 0 0 0 0 0 0 0 0 0 0 0 24.1656 11.9976 -0.4719 C 0 0 0 0 0 0 0 0 0 0 0 0 23.3686 11.3927 -1.9632 C 0 0 0 0 0 0 0 0 0 0 0 0 21.7634 10.5983 -1.8677 C 0 0 0 0 0 0 0 0 0 0 0 0 14.5227 10.5828 -0.3028 C 0 0 0 0 0 0 0 0 0 0 0 0 17.7119 10.5574 -0.2945 C 0 0 0 0 0 0 0 0 0 0 0 0 20.7656 9.8391 -3.7409 Cl 0 0 0 0 0 0 0 0 0 0 0 0 20.7391 10.8099 3.2369 Cl 0 0 0 0 0 0 0 0 0 0 0 0 21.8460 2.2237 0.8692 C 0 0 0 0 0 0 0 0 0 0 0 0 20.8790 1.3999 -0.6581 C 0 0 0 0 0 0 0 0 0 0 0 0 23.6781 1.4637 0.9804 C 0 0 0 0 0 0 0 0 0 0 0 0 20.8675 1.8429 2.5557 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5189 7.5162 0.0532 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1939 6.5869 0.0589 N 0 0 3 0 0 0 0 0 0 0 0 0 5.2184 5.4802 1.6325 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2704 5.2525 2.0783 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6556 7.8123 0.0622 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3628 6.8066 0.2044 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5434 6.9825 1.6193 N 0 0 3 0 0 0 0 0 0 0 0 0 9.8896 8.0661 0.0339 C 0 0 0 0 0 0 0 0 0 0 0 0 0.6752 6.8637 1.2535 C 0 0 0 0 0 0 0 0 0 0 0 0 21.7164 7.3480 0.1623 H 0 0 0 0 0 0 0 0 0 0 0 0 23.0796 4.6667 0.5368 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5077 5.8553 0.3419 H 0 0 0 0 0 0 0 0 0 0 0 0 23.9878 12.2931 2.2824 H 0 0 0 0 0 0 0 0 0 0 0 0 25.4228 12.6135 -0.5527 H 0 0 0 0 0 0 0 0 0 0 0 0 24.0049 11.5372 -3.2045 H 0 0 0 0 0 0 0 0 0 0 0 0 14.4922 11.9718 -0.4937 H 0 0 0 0 0 0 0 0 0 0 0 0 17.7714 11.9453 -0.4856 H 0 0 0 0 0 0 0 0 0 0 0 0 21.5759 1.6711 -1.8595 H 0 0 0 0 0 0 0 0 0 0 0 0 20.7980 0.0000 -0.4653 H 0 0 0 0 0 0 0 0 0 0 0 0 19.5736 1.9413 -0.7372 H 0 0 0 0 0 0 0 0 0 0 0 0 24.3671 2.0508 2.0685 H 0 0 0 0 0 0 0 0 0 0 0 0 23.5974 0.0640 1.1731 H 0 0 0 0 0 0 0 0 0 0 0 0 24.3753 1.7351 -0.2210 H 0 0 0 0 0 0 0 0 0 0 0 0 19.5623 2.3843 2.4764 H 0 0 0 0 0 0 0 0 0 0 0 0 20.7868 0.4432 2.7484 H 0 0 0 0 0 0 0 0 0 0 0 0 21.5566 2.4299 3.6437 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7457 8.9129 0.0831 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7851 7.1743 -1.1077 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8149 4.2279 1.3517 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8984 6.1316 2.6891 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6876 4.2345 1.2864 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0969 4.9824 3.4567 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6471 8.5600 -1.1395 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5322 8.6907 1.1651 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4247 6.1573 1.4604 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4294 5.8418 -0.8290 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8230 9.0308 1.0673 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8277 8.7153 -1.2222 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 6.3799 2.3994 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1776 8.1456 0.9188 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4619 5.9774 0.1709 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 20 2 0 0 0 0 2 3 2 0 0 0 0 2 13 1 0 0 0 0 3 4 1 0 0 0 0 4 6 2 0 0 0 0 4 5 1 0 0 0 0 5 20 1 0 0 0 0 5 21 2 0 0 0 0 6 7 1 0 0 0 0 7 8 2 0 0 0 0 7 9 1 0 0 0 0 8 14 1 0 0 0 0 8 21 1 0 0 0 0 9 10 1 0 0 0 0 9 37 1 0 0 0 0 10 11 1 0 0 0 0 10 12 2 0 0 0 0 11 24 1 0 0 0 0 11 38 1 0 0 0 0 13 35 1 0 0 0 0 13 39 1 0 0 0 0 14 15 2 0 0 0 0 14 19 1 0 0 0 0 15 16 1 0 0 0 0 15 23 1 0 0 0 0 16 17 2 0 0 0 0 16 40 1 0 0 0 0 17 18 1 0 0 0 0 17 41 1 0 0 0 0 18 19 2 0 0 0 0 18 42 1 0 0 0 0 19 22 1 0 0 0 0 20 43 1 0 0 0 0 21 44 1 0 0 0 0 24 25 1 0 0 0 0 24 26 1 0 0 0 0 24 27 1 0 0 0 0 25 45 1 0 0 0 0 25 46 1 0 0 0 0 25 47 1 0 0 0 0 26 48 1 0 0 0 0 26 49 1 0 0 0 0 26 50 1 0 0 0 0 27 51 1 0 0 0 0 27 52 1 0 0 0 0 27 53 1 0 0 0 0 28 29 1 0 0 0 0 28 34 1 0 0 0 0 28 54 1 0 0 0 0 28 55 1 0 0 0 0 29 30 1 0 0 0 0 29 32 1 0 0 0 0 30 31 1 0 0 0 0 30 56 1 0 0 0 0 30 57 1 0 0 0 0 31 34 1 0 0 0 0 31 58 1 0 0 0 0 31 59 1 0 0 0 0 32 33 1 0 0 0 0 32 60 1 0 0 0 0 32 61 1 0 0 0 0 33 35 1 0 0 0 0 33 62 1 0 0 0 0 33 63 1 0 0 0 0 34 36 1 0 0 0 0 35 64 1 0 0 0 0 35 65 1 0 0 0 0 36 66 1 0 0 0 0 36 67 1 0 0 0 0 36 68 1 0 0 0 0 M END > (245) 9240345-6b > (245) PDGFR-beta > (245) 470 > (245) -1 > (245) P > (245) PDGFR-P243 $$$$ 1,6-naphthyridin 37 csChFnd70/05150717532D 72 74 0 0 0 0 0 0 0 0999 V2000 1.2032 15.2350 -2.1456 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6286 12.6259 -1.6926 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2432 13.3490 -1.9760 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7803 16.0868 -2.4541 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3499 15.1240 -2.3689 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8493 17.8674 -2.8458 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9654 17.5659 -3.0259 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4615 18.6062 -3.1331 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1861 13.5700 -1.7838 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8719 15.9009 -2.6574 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6074 20.4779 -3.5513 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9323 23.4355 -2.6222 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7963 21.6936 -2.2240 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5640 21.0301 -5.2742 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7012 22.7759 -5.6553 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8821 23.9753 -4.3329 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5073 10.8689 -1.3032 N 0 0 3 0 0 0 0 0 0 0 0 0 4.0808 9.8082 -1.1972 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5887 7.9369 -0.7540 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3387 19.5265 -6.9359 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.8597 21.0186 -0.0762 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.2321 6.8291 -0.6432 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7400 4.9577 -0.2001 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3179 3.8941 -0.0937 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4089 4.4354 1.3723 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2355 3.6911 1.1479 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8862 2.0416 0.0236 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3502 1.3724 -1.7666 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5778 18.3152 -3.3156 N 0 0 3 0 0 0 0 0 0 0 0 0 9.0256 17.3394 -3.2180 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9197 15.8032 -2.8764 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5906 18.0667 -3.4991 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0680 15.5434 -4.7315 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7519 18.1386 -3.7639 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1644 17.0061 -3.3931 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3168 16.2286 -1.5731 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 15.9508 -2.2001 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4013 12.5642 -1.8966 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6799 18.6356 -2.9207 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0785 24.3780 -1.5957 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6679 23.2051 -6.9887 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9889 25.3388 -4.6375 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3808 10.3454 -1.1017 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7534 9.8368 -2.4409 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9297 10.3235 -0.1903 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9163 7.9083 0.4896 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7400 7.4216 -1.7608 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9047 6.8578 -1.8869 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0810 7.3443 0.3636 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0676 4.9292 1.0436 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8913 4.4425 -1.2070 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4770 5.8474 1.4131 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8492 3.9552 2.5790 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1909 2.2839 1.2818 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7272 4.0271 -0.1347 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0896 4.2318 2.1368 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0160 1.3220 0.4769 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8177 1.8632 0.9328 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0205 0.0000 -1.6776 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2261 2.0984 -2.2242 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4218 1.5418 -2.6735 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6623 19.5408 -3.5881 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6752 19.2924 -3.7716 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9592 16.0973 -6.0281 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2387 14.7542 -4.6526 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9369 14.7366 -4.4673 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8205 19.1807 -2.8103 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9228 17.3495 -3.6850 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6433 18.6926 -5.0605 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1859 15.4217 -1.3088 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4877 15.4394 -1.4941 H 0 0 0 0 0 0 0 0 0 0 0 0 12.3856 17.2706 -0.6195 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 37 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 17 1 0 0 0 0 3 5 2 0 0 0 0 3 38 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 39 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 29 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 40 1 0 0 0 0 13 21 1 0 0 0 0 14 15 1 0 0 0 0 14 20 1 0 0 0 0 15 16 2 0 0 0 0 15 41 1 0 0 0 0 16 42 1 0 0 0 0 17 18 1 0 0 0 0 17 43 1 0 0 0 0 18 19 1 0 0 0 0 18 44 1 0 0 0 0 18 45 1 0 0 0 0 19 22 1 0 0 0 0 19 46 1 0 0 0 0 19 47 1 0 0 0 0 22 23 1 0 0 0 0 22 48 1 0 0 0 0 22 49 1 0 0 0 0 23 24 1 0 0 0 0 23 50 1 0 0 0 0 23 51 1 0 0 0 0 24 27 1 0 0 0 0 24 25 1 0 0 0 0 25 26 1 0 0 0 0 25 52 1 0 0 0 0 25 53 1 0 0 0 0 26 54 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 27 28 1 0 0 0 0 27 57 1 0 0 0 0 27 58 1 0 0 0 0 28 59 1 0 0 0 0 28 60 1 0 0 0 0 28 61 1 0 0 0 0 29 30 1 0 0 0 0 29 62 1 0 0 0 0 30 31 2 0 0 0 0 30 32 1 0 0 0 0 32 35 1 0 0 0 0 32 63 1 0 0 0 0 33 35 1 0 0 0 0 33 64 1 0 0 0 0 33 65 1 0 0 0 0 33 66 1 0 0 0 0 34 35 1 0 0 0 0 34 67 1 0 0 0 0 34 68 1 0 0 0 0 34 69 1 0 0 0 0 35 36 1 0 0 0 0 36 70 1 0 0 0 0 36 71 1 0 0 0 0 36 72 1 0 0 0 0 M END > (247) 1,6-naphthyridine 37 > (247) PDGFR-beta > (247) 480 > (247) -1 > (247) P > (247) PDGFR-P245 $$$$ SU5402 csChFnd70/05150717532D 38 40 0 0 0 0 0 0 0 0999 V2000 5.7693 3.5438 -0.1494 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7422 1.9573 -0.3914 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9431 1.2418 -1.1904 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1768 2.1005 -1.7533 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2249 3.6995 -1.5212 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0070 4.4196 -0.7117 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3867 6.0968 -0.6568 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8750 6.2425 -1.4808 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3073 4.8176 -1.9546 N 0 0 3 0 0 0 0 0 0 0 0 0 9.5928 7.4445 -1.6965 O 0 0 0 0 0 0 0 0 0 0 0 0 6.5270 7.2716 0.0228 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1493 8.7846 0.1329 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3224 10.1654 0.0435 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6909 9.1622 0.3564 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5937 10.3309 -0.1901 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7814 10.3585 1.3924 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0528 10.5241 1.1588 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5245 10.6111 -0.1402 O 0 0 0 0 0 0 0 0 0 0 0 0 1.0998 10.5749 2.3937 O 0 0 0 0 0 0 0 0 0 0 0 0 8.8227 10.7338 0.3989 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3935 11.3735 0.2106 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0261 13.0866 0.1896 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8309 4.1034 0.4695 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7833 1.2731 0.0434 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9143 0.0000 -1.3746 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1064 1.5291 -2.3746 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2532 4.5982 -2.5283 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3784 7.0312 0.4697 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5394 8.4274 0.4652 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3524 11.4109 -0.8077 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1633 9.3509 -0.8688 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0228 9.2785 2.0100 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2118 11.3385 2.0710 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 10.6820 2.1857 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8920 11.3720 0.5603 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7756 13.4794 1.3682 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0205 13.7264 -0.2666 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0165 13.2931 -0.5481 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 6 2 0 0 0 0 1 23 1 0 0 0 0 2 3 2 0 0 0 0 2 24 1 0 0 0 0 3 4 1 0 0 0 0 3 25 1 0 0 0 0 4 5 2 0 0 0 0 4 26 1 0 0 0 0 5 9 1 0 0 0 0 5 6 1 0 0 0 0 6 7 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 9 1 0 0 0 0 8 10 2 0 0 0 0 9 27 1 0 0 0 0 11 12 1 0 0 0 0 11 28 1 0 0 0 0 12 13 2 0 0 0 0 12 14 1 0 0 0 0 13 21 1 0 0 0 0 13 15 1 0 0 0 0 14 20 1 0 0 0 0 14 29 1 0 0 0 0 15 16 1 0 0 0 0 15 30 1 0 0 0 0 15 31 1 0 0 0 0 16 17 1 0 0 0 0 16 32 1 0 0 0 0 16 33 1 0 0 0 0 17 19 1 0 0 0 0 17 18 2 0 0 0 0 19 34 1 0 0 0 0 20 21 2 0 0 0 0 20 35 1 0 0 0 0 21 22 1 0 0 0 0 22 36 1 0 0 0 0 22 37 1 0 0 0 0 22 38 1 0 0 0 0 M END > (250) SU5402 > (250) PDGFR-beta > (250) 510 > (250) -1 > (250) P > (250) PDGFR-P248 $$$$ csChFnd70/05150717532D 45 48 0 0 0 0 0 0 0 0999 V2000 6.4559 8.4044 0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3438 6.6925 -0.0031 N 0 0 0 0 0 0 0 0 0 0 0 0 6.4773 6.7769 0.0010 N 0 0 0 0 0 0 0 0 0 0 0 0 7.9648 9.2529 0.0223 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4401 8.3284 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0213 10.9956 0.0380 C 0 0 0 0 0 0 0 0 0 0 0 0 11.0314 10.7700 0.0318 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3737 11.4454 0.0365 O 0 0 0 0 0 0 0 0 0 0 0 0 10.9407 9.1111 0.0170 N 0 0 3 0 0 0 0 0 0 0 0 0 9.5241 11.7660 0.0428 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6249 13.5908 0.0591 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6633 14.4676 -1.4217 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7567 16.1686 -1.3979 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8120 17.0031 0.0894 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7749 16.1413 1.5617 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6745 14.4405 1.5553 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6186 13.3618 3.4044 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.5946 13.4227 -3.2897 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.8908 5.9469 -0.0084 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8423 4.2431 -0.0242 N 0 0 3 0 0 0 0 0 0 0 0 0 6.3323 3.4222 0.1161 C 0 0 0 0 0 0 0 0 0 0 0 0 12.4600 8.1324 0.0068 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5817 1.1404 -0.5869 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3426 1.7889 0.3883 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0737 1.9513 -0.7254 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0919 4.0714 1.1015 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5964 3.2537 1.2371 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3767 3.8896 2.1955 O 0 0 0 0 0 0 0 0 0 0 0 0 0.8655 2.9854 2.2724 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3015 9.0695 0.0183 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8959 11.7085 0.0455 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7869 16.8488 -2.5431 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8849 18.3333 0.1013 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8190 16.8001 2.7188 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8560 3.6168 -0.1325 H 0 0 0 0 0 0 0 0 0 0 0 0 12.8353 7.9007 -1.2634 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4321 8.8072 0.6453 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2429 6.9614 0.6307 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3812 0.0000 -1.2458 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1772 1.1519 0.4942 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0397 1.4422 -1.4887 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2916 5.2112 1.7615 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.6266 3.0771 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3402 2.8847 1.0388 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1037 1.7551 2.7598 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 30 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 31 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 32 1 0 0 0 0 14 15 1 0 0 0 0 14 33 1 0 0 0 0 15 16 2 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 35 1 0 0 0 0 21 25 1 0 0 0 0 21 26 2 0 0 0 0 22 36 1 0 0 0 0 22 37 1 0 0 0 0 22 38 1 0 0 0 0 23 24 1 0 0 0 0 23 25 2 0 0 0 0 23 39 1 0 0 0 0 24 27 2 0 0 0 0 24 40 1 0 0 0 0 25 41 1 0 0 0 0 26 27 1 0 0 0 0 26 42 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 43 1 0 0 0 0 29 44 1 0 0 0 0 29 45 1 0 0 0 0 M END > (252) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 48 > (252) PDGFR-beta > (252) 530 > (252) -1 > (252) P > (252) PDGFR-P250 $$$$ 1,6-naphthyridin 33 csChFnd70/05150717532D 66 69 0 0 0 0 0 0 0 0999 V2000 1.2228 16.2730 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7134 13.6638 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3129 14.4681 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7815 17.2075 0.0021 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3767 16.2867 -0.0180 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8075 19.0304 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9357 18.8482 -0.0203 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4042 19.8508 -0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2458 14.5705 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8822 17.1425 -0.0284 N 0 0 0 0 0 0 0 0 0 0 0 0 4.5052 21.7701 0.0076 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6625 24.4577 1.5738 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5678 22.6696 1.5752 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5455 22.6837 -1.5525 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6403 24.4719 -1.5363 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6956 25.3564 0.0225 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6344 11.8634 -0.0258 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2361 10.8427 -0.0464 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7885 8.9102 -0.0533 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4612 7.8443 -0.0749 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4776 21.5758 -3.5103 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5262 21.5439 3.5237 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.6903 5.5942 1.2125 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2066 3.6736 1.0939 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1032 3.0063 0.0882 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5869 4.9269 0.2068 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0315 5.9890 -0.0815 N 0 0 0 0 0 0 0 0 0 0 0 0 4.7619 2.6115 1.3822 N 0 0 0 0 0 0 0 0 0 0 0 0 4.3323 0.7562 1.3756 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5324 19.6792 -0.0316 N 0 0 3 0 0 0 0 0 0 0 0 0 9.0057 18.7405 -0.0507 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9369 17.1659 -0.0579 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5556 19.5473 -0.0617 N 0 0 3 0 0 0 0 0 0 0 0 0 12.1573 18.5267 -0.0823 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7198 19.7486 -0.0914 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.9548 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4916 13.7127 -0.0419 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6178 19.7684 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7109 25.1557 2.7867 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6715 25.1807 -2.7434 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7697 26.7546 0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5190 11.2828 -0.0187 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9805 11.1578 -1.2054 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0020 11.1447 1.1019 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0441 8.5951 1.1057 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0226 8.6081 -1.2018 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2057 8.1596 -1.2339 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2271 8.1464 1.0736 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5460 6.3848 0.9619 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1850 5.8767 2.5057 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2389 3.3693 2.0778 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6789 3.3985 -0.1879 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6084 2.7237 -1.2049 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2473 2.2157 0.3389 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1145 5.2020 1.4886 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5544 5.2312 -0.7771 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7704 0.4072 0.1269 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5063 0.0000 1.5918 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4012 0.4846 2.4034 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5872 20.9356 -0.0259 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6106 20.8035 -0.0559 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2078 17.7059 1.0668 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1854 17.7176 -1.2405 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9115 18.9893 -0.1068 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6692 20.5692 -1.2407 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6917 20.5577 1.0667 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 36 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 17 1 0 0 0 0 3 5 2 0 0 0 0 3 37 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 38 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 30 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 39 1 0 0 0 0 13 22 1 0 0 0 0 14 15 1 0 0 0 0 14 21 1 0 0 0 0 15 16 2 0 0 0 0 15 40 1 0 0 0 0 16 41 1 0 0 0 0 17 18 1 0 0 0 0 17 42 1 0 0 0 0 18 19 1 0 0 0 0 18 43 1 0 0 0 0 18 44 1 0 0 0 0 19 20 1 0 0 0 0 19 45 1 0 0 0 0 19 46 1 0 0 0 0 20 27 1 0 0 0 0 20 47 1 0 0 0 0 20 48 1 0 0 0 0 23 27 1 0 0 0 0 23 24 1 0 0 0 0 23 49 1 0 0 0 0 23 50 1 0 0 0 0 24 28 1 0 0 0 0 24 51 1 0 0 0 0 24 52 1 0 0 0 0 25 28 1 0 0 0 0 25 26 1 0 0 0 0 25 53 1 0 0 0 0 25 54 1 0 0 0 0 26 27 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 28 29 1 0 0 0 0 29 57 1 0 0 0 0 29 58 1 0 0 0 0 29 59 1 0 0 0 0 30 31 1 0 0 0 0 30 60 1 0 0 0 0 31 32 2 0 0 0 0 31 33 1 0 0 0 0 33 34 1 0 0 0 0 33 61 1 0 0 0 0 34 35 1 0 0 0 0 34 62 1 0 0 0 0 34 63 1 0 0 0 0 35 64 1 0 0 0 0 35 65 1 0 0 0 0 35 66 1 0 0 0 0 M END > (254) 1,6-naphthyridine 33 > (254) PDGFR-beta > (254) 540 > (254) -1 > (254) P > (254) PDGFR-P252 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 53 csChFnd70/05150717532D 68 71 0 0 0 0 0 0 0 0999 V2000 3.9898 16.0158 0.0121 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5029 13.4202 -0.0164 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0131 14.3018 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0366 14.1909 -0.0268 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5840 16.9093 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1485 15.9284 -0.0186 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6678 18.7344 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7963 18.4467 -0.0220 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2969 19.5054 -0.0020 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6842 16.7369 -0.0295 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4633 21.4265 0.0054 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7117 24.1166 1.5760 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7740 25.0164 0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5569 22.3267 1.5780 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5343 22.3407 -1.5600 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6893 24.1306 -1.5443 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4782 21.1999 3.5330 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4289 21.2315 -3.5238 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7591 10.7283 -0.0129 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0551 8.7604 -0.0258 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4410 11.6237 -0.0248 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2985 7.8252 -0.0133 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4249 19.2239 -0.0338 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8697 18.2315 -0.0529 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7460 16.6551 -0.0597 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8934 5.4489 -1.3289 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2267 3.4888 -1.2294 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2771 3.0385 -0.2248 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9440 4.9985 -0.3242 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5829 5.9359 -0.0256 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5878 2.5514 -1.5280 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8720 0.6620 -1.5402 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4517 18.9866 -0.0646 N 0 0 3 0 0 0 0 0 0 0 0 0 15.0221 17.9077 -0.0853 C 0 0 0 0 0 0 0 0 0 0 0 0 16.5240 18.9378 -0.8877 C 0 0 0 0 0 0 0 0 0 0 0 0 15.4945 17.3879 1.7766 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7730 16.7177 0.0217 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4985 19.5128 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7848 24.8150 2.7927 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8952 26.4158 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7439 24.8401 -2.7555 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0166 11.1020 -1.1614 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0391 11.0903 1.1536 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7750 8.3985 -1.1922 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7975 8.3867 1.1229 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5112 10.9558 -0.0386 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5786 8.1874 1.1532 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5561 8.1989 -1.1617 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5236 20.4818 -0.0285 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0998 6.1474 -1.0704 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4208 5.7832 -2.6229 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1706 3.1185 -2.2202 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7329 3.1595 0.0533 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7499 2.7041 1.0693 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0707 2.3399 -0.4832 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4378 5.3278 -1.6069 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3688 0.6667 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4067 0.2565 -0.2915 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6384 0.0000 -1.7637 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7820 0.3278 -2.5748 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5504 20.2443 -0.0592 H 0 0 0 0 0 0 0 0 0 0 0 0 14.7842 16.7415 -0.8556 H 0 0 0 0 0 0 0 0 0 0 0 0 16.7619 20.1040 -0.1175 H 0 0 0 0 0 0 0 0 0 0 0 0 17.6925 18.1350 -0.9032 H 0 0 0 0 0 0 0 0 0 0 0 0 16.1874 19.3081 -2.2143 H 0 0 0 0 0 0 0 0 0 0 0 0 14.4246 16.6541 2.3482 H 0 0 0 0 0 0 0 0 0 0 0 0 16.6630 16.5853 1.7611 H 0 0 0 0 0 0 0 0 0 0 0 0 15.7324 18.5541 2.5468 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 37 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 21 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 38 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 39 1 0 0 0 0 13 16 1 0 0 0 0 13 40 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 41 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 42 1 0 0 0 0 19 43 1 0 0 0 0 20 22 1 0 0 0 0 20 44 1 0 0 0 0 20 45 1 0 0 0 0 21 46 1 0 0 0 0 22 30 1 0 0 0 0 22 47 1 0 0 0 0 22 48 1 0 0 0 0 23 24 1 0 0 0 0 23 49 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 50 1 0 0 0 0 26 51 1 0 0 0 0 27 31 1 0 0 0 0 27 52 1 0 0 0 0 27 53 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 54 1 0 0 0 0 28 55 1 0 0 0 0 29 30 1 0 0 0 0 29 56 1 0 0 0 0 29 57 1 0 0 0 0 31 32 1 0 0 0 0 32 58 1 0 0 0 0 32 59 1 0 0 0 0 32 60 1 0 0 0 0 33 34 1 0 0 0 0 33 61 1 0 0 0 0 34 35 1 0 0 0 0 34 36 1 0 0 0 0 34 62 1 0 0 0 0 35 63 1 0 0 0 0 35 64 1 0 0 0 0 35 65 1 0 0 0 0 36 66 1 0 0 0 0 36 67 1 0 0 0 0 36 68 1 0 0 0 0 M END > (256) 6-arylpyrido[2,3-d]pyrimidine deriv. 53 > (256) PDGFR-beta > (256) 550 > (256) -1 > (256) P > (256) PDGFR-P254 $$$$ 3-substituted indolin-2-one 16e csChFnd70/05150717532D 45 47 0 0 0 0 0 0 0 0999 V2000 1.7708 5.9237 -0.1484 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1848 4.4880 -1.7552 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2267 6.0858 -1.5217 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0068 6.8016 -0.7115 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3820 8.4798 -0.6551 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8701 8.6302 -1.4784 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3051 7.2075 -1.9552 N 0 0 3 0 0 0 0 0 0 0 0 0 5.5852 9.8338 -1.6918 O 0 0 0 0 0 0 0 0 0 0 0 0 2.5191 9.6512 0.0244 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1375 11.1659 0.1361 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3073 12.5440 0.0471 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6774 11.5473 0.3609 N 0 0 3 0 0 0 0 0 0 0 0 0 0.5786 12.7049 -0.1863 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8053 13.1192 0.4040 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7449 4.3382 -0.3885 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9504 3.6220 -1.1904 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2949 14.0133 0.6296 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3751 13.7550 0.2149 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0033 15.4667 0.1940 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6494 16.0168 1.8480 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2775 17.7286 1.8271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2938 18.4361 0.6138 O 0 0 0 0 0 0 0 0 0 0 0 0 1.9282 18.4674 3.1564 O 0 0 0 0 0 0 0 0 0 0 0 0 2.9177 2.0595 -1.4229 O 0 0 0 0 0 0 0 0 0 0 0 0 1.6125 1.2333 -0.8120 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8371 6.4808 0.4792 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1158 3.9207 -2.3777 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2517 6.9912 -2.5284 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3710 9.4074 0.4702 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5276 10.8147 0.4702 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 12.7223 0.9408 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3343 13.7845 -0.8031 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1509 11.7244 -0.8655 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7874 3.6532 0.0475 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8223 14.2470 -0.4986 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0450 15.1094 1.2143 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0945 13.3302 1.3363 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9960 16.1091 -0.2614 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9936 15.6706 -0.5439 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6568 15.3744 2.3035 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6592 15.8129 2.5859 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6979 19.5654 3.0847 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5481 1.6778 -1.3364 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7312 0.0000 -1.0777 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5626 1.3917 0.4442 H 0 0 0 0 0 0 0 0 0 0 0 0 1 15 1 0 0 0 0 1 4 2 0 0 0 0 1 26 1 0 0 0 0 2 16 1 0 0 0 0 2 3 2 0 0 0 0 2 27 1 0 0 0 0 3 7 1 0 0 0 0 3 4 1 0 0 0 0 4 5 1 0 0 0 0 5 6 1 0 0 0 0 5 9 2 0 0 0 0 6 7 1 0 0 0 0 6 8 2 0 0 0 0 7 28 1 0 0 0 0 9 10 1 0 0 0 0 9 29 1 0 0 0 0 10 11 2 0 0 0 0 10 12 1 0 0 0 0 11 18 1 0 0 0 0 11 13 1 0 0 0 0 12 14 1 0 0 0 0 12 30 1 0 0 0 0 13 31 1 0 0 0 0 13 32 1 0 0 0 0 13 33 1 0 0 0 0 14 18 2 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 34 1 0 0 0 0 16 24 1 0 0 0 0 17 35 1 0 0 0 0 17 36 1 0 0 0 0 17 37 1 0 0 0 0 18 19 1 0 0 0 0 19 20 1 0 0 0 0 19 38 1 0 0 0 0 19 39 1 0 0 0 0 20 21 1 0 0 0 0 20 40 1 0 0 0 0 20 41 1 0 0 0 0 21 23 1 0 0 0 0 21 22 2 0 0 0 0 23 42 1 0 0 0 0 24 25 1 0 0 0 0 25 43 1 0 0 0 0 25 44 1 0 0 0 0 25 45 1 0 0 0 0 M END > (257) 3-substituted indolin-2-one 16e > (257) PDGFR-beta > (257) 550 > (257) -1 > (257) P > (257) PDGFR-P255 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 61 csChFnd70/05150717532D 69 73 0 0 0 0 0 0 0 0999 V2000 3.9442 15.8478 1.4063 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4196 13.2836 1.6318 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9605 14.1748 1.6607 N 0 0 0 0 0 0 0 0 0 0 0 0 6.9273 14.0042 1.3505 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5126 16.6874 1.1000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0440 15.6982 1.0780 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6016 18.4669 0.8169 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6708 18.1221 0.5213 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2032 19.1861 0.5247 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5540 16.4557 0.7903 N 0 0 0 0 0 0 0 0 0 0 0 0 7.3737 21.0577 0.2174 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7851 23.9181 1.2994 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6933 24.5546 -0.3567 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6267 22.1759 1.5942 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2890 21.7068 -1.4502 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4493 23.4518 -1.7279 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7415 21.3795 3.6736 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.9836 20.3248 -3.1730 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.6980 10.6918 2.2238 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9811 8.7651 2.4867 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3520 11.5314 1.9077 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2537 7.8882 2.8168 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2716 18.8471 0.2276 N 0 0 3 0 0 0 0 0 0 0 0 0 11.6858 17.8486 0.2198 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5582 16.3126 0.4700 O 0 0 0 0 0 0 0 0 0 0 0 0 3.6807 5.3382 1.7507 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0114 3.4355 2.1178 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2134 3.2066 3.4532 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8825 5.1093 3.0861 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5255 6.0383 3.0692 N 0 0 0 0 0 0 0 0 0 0 0 0 2.3684 2.5065 2.1348 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6403 0.6566 2.3872 C 0 0 0 0 0 0 0 0 0 0 0 0 13.2410 18.5530 -0.0655 N 0 0 3 0 0 0 0 0 0 0 0 0 14.7212 17.5400 0.0499 C 0 0 0 0 0 0 0 0 0 0 0 0 14.6824 15.8373 -0.4797 C 0 0 0 0 0 0 0 0 0 0 0 0 16.1455 14.8410 -0.3646 C 0 0 0 0 0 0 0 0 0 0 0 0 17.6479 15.5371 0.2778 C 0 0 0 0 0 0 0 0 0 0 0 0 17.6907 17.2320 0.8068 C 0 0 0 0 0 0 0 0 0 0 0 0 16.2339 18.2373 0.6876 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7523 16.5569 1.4269 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4571 19.2504 0.8261 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9816 24.7851 2.3642 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8174 25.9179 -0.5804 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3836 23.9562 -3.0184 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8547 10.8938 1.1247 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1091 11.2378 3.3705 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5700 8.2191 1.3399 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8245 8.5630 3.5857 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3999 10.8575 1.8922 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6648 8.4342 3.9635 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4103 8.0902 1.7177 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3734 20.0727 0.0280 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8939 6.0362 1.7745 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0874 5.4745 0.4900 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8380 2.9043 1.1206 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6364 3.3019 3.3634 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8065 3.0703 4.7140 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.5086 3.4294 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2575 5.2429 1.8405 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0559 5.6405 4.0833 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2894 0.4427 3.6090 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4038 0.0000 2.3946 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4292 0.1544 1.3454 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3345 19.7621 -0.3509 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5092 15.2926 -0.9807 H 0 0 0 0 0 0 0 0 0 0 0 0 16.1163 13.5167 -0.7764 H 0 0 0 0 0 0 0 0 0 0 0 0 18.7903 14.7553 0.3669 H 0 0 0 0 0 0 0 0 0 0 0 0 18.8659 17.7718 1.3085 H 0 0 0 0 0 0 0 0 0 0 0 0 16.2696 19.5625 1.0958 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 40 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 21 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 41 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 42 1 0 0 0 0 13 16 1 0 0 0 0 13 43 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 44 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 45 1 0 0 0 0 19 46 1 0 0 0 0 20 22 1 0 0 0 0 20 47 1 0 0 0 0 20 48 1 0 0 0 0 21 49 1 0 0 0 0 22 30 1 0 0 0 0 22 50 1 0 0 0 0 22 51 1 0 0 0 0 23 24 1 0 0 0 0 23 52 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 53 1 0 0 0 0 26 54 1 0 0 0 0 27 31 1 0 0 0 0 27 55 1 0 0 0 0 27 56 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 57 1 0 0 0 0 28 58 1 0 0 0 0 29 30 1 0 0 0 0 29 59 1 0 0 0 0 29 60 1 0 0 0 0 31 32 1 0 0 0 0 32 61 1 0 0 0 0 32 62 1 0 0 0 0 32 63 1 0 0 0 0 33 34 1 0 0 0 0 33 64 1 0 0 0 0 34 35 2 0 0 0 0 34 39 1 0 0 0 0 35 36 1 0 0 0 0 35 65 1 0 0 0 0 36 37 2 0 0 0 0 36 66 1 0 0 0 0 37 38 1 0 0 0 0 37 67 1 0 0 0 0 38 39 2 0 0 0 0 38 68 1 0 0 0 0 39 69 1 0 0 0 0 M END > (260) 6-arylpyrido[2,3-d]pyrimidine deriv. 61 > (260) PDGFR-beta > (260) 570 > (260) -1 > (260) P > (260) PDGFR-P258 $$$$ PD089828 analog 9 csChFnd70/05150717532D 45 47 0 0 0 0 0 0 0 0999 V2000 1.2014 4.9966 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6958 2.4336 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7761 5.8791 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3208 4.9106 -0.0184 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8588 7.6812 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4675 8.4427 0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2244 3.3043 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2102 3.1945 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8373 5.7090 -0.0280 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6349 0.6595 -0.0244 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6317 10.3399 0.0103 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8845 12.9929 1.5649 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6872 11.2460 -1.5341 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8405 13.0137 -1.5161 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9388 13.8845 0.0289 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9481 7.3973 -0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5563 8.1649 -0.0302 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9831 7.1846 -0.0491 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8608 5.6280 -0.0568 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5453 7.9302 -0.0595 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0965 5.7395 -1.6910 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6852 8.0211 -0.0884 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0962 6.8648 -0.0800 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1265 5.7212 1.5178 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7241 11.2267 1.5643 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6391 10.0116 3.6656 Br 0 0 0 0 0 0 0 0 0 0 0 0 4.5647 10.1547 -3.4747 Cl 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.6896 0.0327 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7042 8.4498 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5351 0.0741 -0.0167 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6917 0.0000 -0.0381 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9566 13.6808 2.7673 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8840 13.7168 -2.7110 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0638 15.2660 0.0362 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6540 9.4069 -0.0240 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6429 9.1723 -0.0533 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0749 6.5542 -2.8294 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2504 4.9468 -1.7065 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9644 4.9157 -1.6852 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6851 8.8227 1.0594 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8391 7.2283 -0.1036 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6636 8.8358 -1.2266 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9945 4.8975 1.5237 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2805 4.9284 1.5025 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1263 6.5229 2.6655 H 0 0 0 0 0 0 0 0 0 0 0 0 1 7 2 0 0 0 0 1 3 1 0 0 0 0 1 28 1 0 0 0 0 2 7 1 0 0 0 0 2 8 2 0 0 0 0 2 10 1 0 0 0 0 3 5 1 0 0 0 0 3 4 2 0 0 0 0 4 8 1 0 0 0 0 4 9 1 0 0 0 0 5 6 2 0 0 0 0 5 29 1 0 0 0 0 6 16 1 0 0 0 0 6 11 1 0 0 0 0 9 16 2 0 0 0 0 10 30 1 0 0 0 0 10 31 1 0 0 0 0 11 25 1 0 0 0 0 11 13 2 0 0 0 0 12 25 2 0 0 0 0 12 15 1 0 0 0 0 12 32 1 0 0 0 0 13 14 1 0 0 0 0 13 27 1 0 0 0 0 14 15 2 0 0 0 0 14 33 1 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 17 18 1 0 0 0 0 17 35 1 0 0 0 0 18 20 1 0 0 0 0 18 19 2 0 0 0 0 20 23 1 0 0 0 0 20 36 1 0 0 0 0 21 23 1 0 0 0 0 21 37 1 0 0 0 0 21 38 1 0 0 0 0 21 39 1 0 0 0 0 22 23 1 0 0 0 0 22 40 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 24 1 0 0 0 0 24 43 1 0 0 0 0 24 44 1 0 0 0 0 24 45 1 0 0 0 0 25 26 1 0 0 0 0 M END > (271) PD089828 analog 9 > (271) PDGFR-beta > (271) 620 > (271) -1 > (271) P > (271) PDGFR-P269 $$$$ SU11248 analog 12a csChFnd70/05150717532D 56 58 0 0 0 0 0 0 0 0999 V2000 3.8642 3.5931 -3.6879 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8952 1.8718 -4.3472 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2327 1.3489 -5.5121 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5464 2.5352 -6.0273 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1810 4.7987 -4.1993 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5374 4.2746 -5.3783 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1512 7.1606 -4.7576 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5317 6.6919 -3.7539 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6756 5.7097 -5.6742 N 0 0 3 0 0 0 0 0 0 0 0 0 7.8890 8.6103 -4.7588 O 0 0 0 0 0 0 0 0 0 0 0 0 4.5498 7.7817 -2.6370 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1904 9.4986 -2.1928 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0561 11.7170 -1.5684 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3432 12.4025 -1.4799 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1567 10.9921 -1.8739 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9583 9.9766 -1.9935 N 0 0 3 0 0 0 0 0 0 0 0 0 2.1478 11.0962 -1.9354 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7512 12.7500 -1.2386 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8491 14.2594 -1.0526 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7065 15.3559 -2.2419 O 0 0 0 0 0 0 0 0 0 0 0 0 4.5554 14.7421 0.6563 N 0 0 3 0 0 0 0 0 0 0 0 0 4.0644 16.5876 1.0810 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8097 16.7772 3.0993 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3174 18.6278 3.5252 N 0 0 0 0 0 0 0 0 0 0 0 0 1.5548 19.0737 2.7884 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3178 21.1029 2.7703 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3700 18.9416 5.4610 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3130 19.1024 6.0722 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8183 4.0035 -2.7836 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8751 0.9314 -3.9534 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2486 0.0000 -6.0220 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5830 2.1112 -6.9359 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7165 5.6694 -6.4442 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2917 7.3210 -2.1031 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9710 9.1817 -2.1372 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6059 10.7974 -0.6179 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7435 12.4365 -2.3340 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6413 10.1299 -2.8989 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2234 13.3207 -2.4916 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4900 13.8197 -0.2864 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7664 11.8573 -0.6989 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6692 13.8674 1.6050 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1218 17.4849 0.6390 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8233 16.9281 0.4012 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7524 15.8798 3.5415 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0510 16.4367 3.7792 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4530 18.5610 1.4299 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5177 18.4713 3.6132 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4449 21.6184 4.1256 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3393 21.7032 1.9250 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 21.4328 2.2475 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6600 20.1734 5.7722 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7352 17.8279 6.1504 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9891 17.8277 5.8801 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9842 20.1302 5.2902 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3499 19.4637 7.4817 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 5 2 0 0 0 0 1 29 1 0 0 0 0 2 3 2 0 0 0 0 2 30 1 0 0 0 0 3 4 1 0 0 0 0 3 31 1 0 0 0 0 4 6 2 0 0 0 0 4 32 1 0 0 0 0 5 8 1 0 0 0 0 5 6 1 0 0 0 0 6 9 1 0 0 0 0 7 9 1 0 0 0 0 7 8 1 0 0 0 0 7 10 2 0 0 0 0 8 11 2 0 0 0 0 9 33 1 0 0 0 0 11 12 1 0 0 0 0 11 34 1 0 0 0 0 12 15 2 0 0 0 0 12 16 1 0 0 0 0 13 16 1 0 0 0 0 13 14 2 0 0 0 0 13 18 1 0 0 0 0 14 15 1 0 0 0 0 14 19 1 0 0 0 0 15 17 1 0 0 0 0 16 35 1 0 0 0 0 17 36 1 0 0 0 0 17 37 1 0 0 0 0 17 38 1 0 0 0 0 18 39 1 0 0 0 0 18 40 1 0 0 0 0 18 41 1 0 0 0 0 19 20 2 0 0 0 0 19 21 1 0 0 0 0 21 22 1 0 0 0 0 21 42 1 0 0 0 0 22 23 1 0 0 0 0 22 43 1 0 0 0 0 22 44 1 0 0 0 0 23 24 1 0 0 0 0 23 45 1 0 0 0 0 23 46 1 0 0 0 0 24 25 1 0 0 0 0 24 27 1 0 0 0 0 25 26 1 0 0 0 0 25 47 1 0 0 0 0 25 48 1 0 0 0 0 26 49 1 0 0 0 0 26 50 1 0 0 0 0 26 51 1 0 0 0 0 27 28 1 0 0 0 0 27 52 1 0 0 0 0 27 53 1 0 0 0 0 28 54 1 0 0 0 0 28 55 1 0 0 0 0 28 56 1 0 0 0 0 M END > (28) SU11248 analog 12a > (28) PDGFR-beta > (28) 17 > (28) -1 > (28) P > (28) PDGFR-P26 $$$$ 1,6-naphthyridin 34 csChFnd70/05150717532D 72 75 0 0 0 0 0 0 0 0999 V2000 1.2228 16.2728 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7134 13.6636 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3129 14.4679 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7814 17.2072 0.0021 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3767 16.2865 -0.0180 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8075 19.0301 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9356 18.8480 -0.0203 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4041 19.8505 -0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2458 14.5703 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8822 17.1423 -0.0284 N 0 0 0 0 0 0 0 0 0 0 0 0 4.5051 21.7698 0.0076 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6624 24.4574 1.5738 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5677 22.6693 1.5751 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5454 22.6834 -1.5524 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6402 24.4715 -1.5362 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6956 25.3561 0.0225 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6344 11.8632 -0.0258 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2360 10.8425 -0.0464 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7885 8.9101 -0.0533 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4611 7.8442 -0.0749 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4775 21.5755 -3.5103 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5261 21.5436 3.5236 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.6902 5.5941 1.2125 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2065 3.6735 1.0939 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1031 3.0062 0.0882 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5868 4.9269 0.2068 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0315 5.9889 -0.0815 N 0 0 0 0 0 0 0 0 0 0 0 0 4.7618 2.6115 1.3822 N 0 0 0 0 0 0 0 0 0 0 0 0 4.3322 0.7562 1.3756 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5323 19.6790 -0.0316 N 0 0 3 0 0 0 0 0 0 0 0 0 9.0056 18.7402 -0.0507 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9368 17.1656 -0.0579 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5555 19.5470 -0.0617 N 0 0 3 0 0 0 0 0 0 0 0 0 12.1572 18.5265 -0.0823 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1966 17.3907 -1.7080 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7196 19.7483 -0.0914 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2280 17.3745 1.5308 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.9546 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4916 13.7125 -0.0419 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6178 19.7682 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7109 25.1554 2.7866 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6715 25.1804 -2.7433 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7696 26.7542 0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5190 11.2827 -0.0187 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9804 11.1577 -1.2054 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0019 11.1446 1.1019 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0441 8.5949 1.1057 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0226 8.6080 -1.2018 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2056 8.1595 -1.2339 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2270 8.1463 1.0735 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5460 6.3847 0.9619 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1849 5.8766 2.5057 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2389 3.3693 2.0778 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6789 3.3984 -0.1878 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6084 2.7236 -1.2049 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2472 2.2157 0.3389 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1144 5.2020 1.4885 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5543 5.2311 -0.7771 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7703 0.4072 0.1269 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5062 0.0000 1.5917 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4011 0.4846 2.4034 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5871 20.9353 -0.0259 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6104 20.8032 -0.0559 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1460 18.2114 -2.8573 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3883 16.6315 -1.7234 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0835 16.5203 -1.7017 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6915 20.5574 1.0667 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9113 18.9890 -0.1068 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6691 20.5690 -1.2407 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1149 16.5039 1.5373 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4196 16.6152 1.5154 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2000 18.1835 2.6890 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 38 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 17 1 0 0 0 0 3 5 2 0 0 0 0 3 39 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 40 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 30 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 41 1 0 0 0 0 13 22 1 0 0 0 0 14 15 1 0 0 0 0 14 21 1 0 0 0 0 15 16 2 0 0 0 0 15 42 1 0 0 0 0 16 43 1 0 0 0 0 17 18 1 0 0 0 0 17 44 1 0 0 0 0 18 19 1 0 0 0 0 18 45 1 0 0 0 0 18 46 1 0 0 0 0 19 20 1 0 0 0 0 19 47 1 0 0 0 0 19 48 1 0 0 0 0 20 27 1 0 0 0 0 20 49 1 0 0 0 0 20 50 1 0 0 0 0 23 27 1 0 0 0 0 23 24 1 0 0 0 0 23 51 1 0 0 0 0 23 52 1 0 0 0 0 24 28 1 0 0 0 0 24 53 1 0 0 0 0 24 54 1 0 0 0 0 25 28 1 0 0 0 0 25 26 1 0 0 0 0 25 55 1 0 0 0 0 25 56 1 0 0 0 0 26 27 1 0 0 0 0 26 57 1 0 0 0 0 26 58 1 0 0 0 0 28 29 1 0 0 0 0 29 59 1 0 0 0 0 29 60 1 0 0 0 0 29 61 1 0 0 0 0 30 31 1 0 0 0 0 30 62 1 0 0 0 0 31 32 2 0 0 0 0 31 33 1 0 0 0 0 33 34 1 0 0 0 0 33 63 1 0 0 0 0 34 35 1 0 0 0 0 34 36 1 0 0 0 0 34 37 1 0 0 0 0 35 64 1 0 0 0 0 35 65 1 0 0 0 0 35 66 1 0 0 0 0 36 67 1 0 0 0 0 36 68 1 0 0 0 0 36 69 1 0 0 0 0 37 70 1 0 0 0 0 37 71 1 0 0 0 0 37 72 1 0 0 0 0 M END > (272) 1,6-naphthyridine 34 > (272) PDGFR-beta > (272) 620 > (272) -1 > (272) P > (272) PDGFR-P270 $$$$ 3-substituted indolin-2-one 9b csChFnd70/05150717532D 38 40 0 0 0 0 0 0 0 0999 V2000 5.7116 3.5081 -0.1480 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8747 1.2292 -1.1797 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0949 2.0804 -1.7373 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1417 3.6632 -1.5072 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9364 4.3754 -0.7050 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3121 6.0357 -0.6496 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7853 6.1807 -1.4654 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2124 4.7710 -1.9373 N 0 0 3 0 0 0 0 0 0 0 0 0 9.4960 7.3708 -1.6772 O 0 0 0 0 0 0 0 0 0 0 0 0 6.4609 7.1980 0.0238 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0767 8.6957 0.1337 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2579 10.0626 0.0456 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6026 9.0697 0.3555 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5467 10.2263 -0.1852 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7431 10.2533 1.3815 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0317 10.4171 1.1507 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5086 10.5033 -0.1349 O 0 0 0 0 0 0 0 0 0 0 0 0 1.0887 10.4670 2.3734 O 0 0 0 0 0 0 0 0 0 0 0 0 8.7329 10.6253 0.3985 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3181 11.2584 0.2120 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9542 12.9543 0.1920 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6851 1.9368 -0.3879 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0238 0.7499 0.3660 Br 0 0 0 0 0 0 0 0 0 0 0 0 4.7877 4.0603 0.4740 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8470 0.0000 -1.3629 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0151 1.5157 -2.3532 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1484 4.5544 -2.5058 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3239 6.9596 0.4661 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4427 8.3423 0.4631 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3075 11.2955 -0.7962 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1206 9.2563 -0.8570 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9821 9.1840 1.9927 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1692 11.2233 2.0534 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 10.5730 2.1678 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7913 11.2572 0.5586 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7059 13.3425 1.3588 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9386 13.5880 -0.2590 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9549 13.1589 -0.5383 H 0 0 0 0 0 0 0 0 0 0 0 0 1 22 1 0 0 0 0 1 5 2 0 0 0 0 1 24 1 0 0 0 0 2 22 2 0 0 0 0 2 3 1 0 0 0 0 2 25 1 0 0 0 0 3 4 2 0 0 0 0 3 26 1 0 0 0 0 4 8 1 0 0 0 0 4 5 1 0 0 0 0 5 6 1 0 0 0 0 6 7 1 0 0 0 0 6 10 2 0 0 0 0 7 8 1 0 0 0 0 7 9 2 0 0 0 0 8 27 1 0 0 0 0 10 11 1 0 0 0 0 10 28 1 0 0 0 0 11 12 2 0 0 0 0 11 13 1 0 0 0 0 12 20 1 0 0 0 0 12 14 1 0 0 0 0 13 19 1 0 0 0 0 13 29 1 0 0 0 0 14 15 1 0 0 0 0 14 30 1 0 0 0 0 14 31 1 0 0 0 0 15 16 1 0 0 0 0 15 32 1 0 0 0 0 15 33 1 0 0 0 0 16 18 1 0 0 0 0 16 17 2 0 0 0 0 18 34 1 0 0 0 0 19 20 2 0 0 0 0 19 35 1 0 0 0 0 20 21 1 0 0 0 0 21 36 1 0 0 0 0 21 37 1 0 0 0 0 21 38 1 0 0 0 0 22 23 1 0 0 0 0 M END > (273) 3-substituted indolin-2-one 9b > (273) PDGFR-beta > (273) 620 > (273) -1 > (273) P > (273) PDGFR-P271 $$$$ Pyrido[2,3-d]pyrimidin-7(8H)-one deriv. 6v csChFnd70/05150717532D 54 58 0 0 0 0 0 0 0 0999 V2000 8.7271 13.8593 0.0404 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7429 13.7713 0.0355 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1927 14.6970 0.0466 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2655 11.2609 0.0131 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7500 12.1167 0.0234 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2825 11.2012 0.0160 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8269 8.8127 -0.0099 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0523 14.5068 0.0403 O 0 0 0 0 0 0 0 0 0 0 0 0 11.7281 12.1108 0.0187 N 0 0 3 0 0 0 0 0 0 0 0 0 13.2896 11.2030 0.0060 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2440 9.6236 -0.0028 N 0 0 0 0 0 0 0 0 0 0 0 0 7.3780 9.5768 -0.0005 N 0 0 0 0 0 0 0 0 0 0 0 0 10.2100 16.5234 0.0637 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2094 17.4013 -1.4157 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2258 19.1038 -1.3912 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2433 19.9388 0.0958 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2441 19.0759 1.5669 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2201 17.3732 1.5596 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2120 16.2927 3.4071 Cl 0 0 0 0 0 0 0 0 0 0 0 0 10.1888 16.3558 -3.2832 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.8561 7.1100 -0.0270 N 0 0 3 0 0 0 0 0 0 0 0 0 7.3829 6.2198 0.1121 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6625 5.9342 1.2352 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7413 3.8636 -0.5932 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1934 4.7411 -0.7302 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1144 6.8121 1.0976 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4703 4.4592 0.3874 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9820 2.2782 2.3632 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4026 1.1587 -0.3369 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0590 2.0546 -0.4668 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6341 3.1855 2.2608 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9989 3.5690 0.5273 N 0 0 0 0 0 0 0 0 0 0 0 0 1.0504 0.8304 1.3593 O 0 0 0 0 0 0 0 0 0 0 0 0 7.5710 14.5199 0.0540 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0997 11.8126 0.0239 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6741 10.9911 -1.2641 H 0 0 0 0 0 0 0 0 0 0 0 0 14.2297 11.9200 0.6450 H 0 0 0 0 0 0 0 0 0 0 0 0 13.1267 10.0228 0.6277 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2253 19.7848 -2.5353 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2570 21.2702 0.1084 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2579 19.7351 2.7237 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8968 6.5310 -0.1354 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6743 6.3973 1.9982 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5920 2.7163 -1.2525 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1818 4.2781 -1.4928 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2639 7.9593 1.7570 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7401 1.9291 3.6383 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.0833 1.9235 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4327 1.9312 -0.8553 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4648 0.0000 -1.0148 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0381 1.2560 -0.0092 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2991 2.3699 -1.7508 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5642 4.3263 2.9677 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6065 2.4049 2.7620 H 0 0 0 0 0 0 0 0 0 0 0 0 1 5 1 0 0 0 0 1 3 2 0 0 0 0 1 34 1 0 0 0 0 2 9 1 0 0 0 0 2 3 1 0 0 0 0 2 8 2 0 0 0 0 3 13 1 0 0 0 0 4 9 1 0 0 0 0 4 11 2 0 0 0 0 4 5 1 0 0 0 0 5 6 2 0 0 0 0 6 12 1 0 0 0 0 6 35 1 0 0 0 0 7 12 2 0 0 0 0 7 11 1 0 0 0 0 7 21 1 0 0 0 0 9 10 1 0 0 0 0 10 36 1 0 0 0 0 10 37 1 0 0 0 0 10 38 1 0 0 0 0 13 18 2 0 0 0 0 13 14 1 0 0 0 0 14 15 2 0 0 0 0 14 20 1 0 0 0 0 15 16 1 0 0 0 0 15 39 1 0 0 0 0 16 17 2 0 0 0 0 16 40 1 0 0 0 0 17 18 1 0 0 0 0 17 41 1 0 0 0 0 18 19 1 0 0 0 0 21 22 1 0 0 0 0 21 42 1 0 0 0 0 22 25 2 0 0 0 0 22 26 1 0 0 0 0 23 27 1 0 0 0 0 23 26 2 0 0 0 0 23 43 1 0 0 0 0 24 27 2 0 0 0 0 24 25 1 0 0 0 0 24 44 1 0 0 0 0 25 45 1 0 0 0 0 26 46 1 0 0 0 0 27 32 1 0 0 0 0 28 33 1 0 0 0 0 28 31 1 0 0 0 0 28 47 1 0 0 0 0 28 48 1 0 0 0 0 29 33 1 0 0 0 0 29 30 1 0 0 0 0 29 49 1 0 0 0 0 29 50 1 0 0 0 0 30 32 1 0 0 0 0 30 51 1 0 0 0 0 30 52 1 0 0 0 0 31 32 1 0 0 0 0 31 53 1 0 0 0 0 31 54 1 0 0 0 0 M END > (275) PD173952 > (275) PDGFR-beta > (275) 636 > (275) -1 > (275) P > (275) PDGFR-P273 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 13 csChFnd70/05150717532D 68 70 0 0 0 0 0 0 0 0999 V2000 7.3687 12.7410 0.5075 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1677 9.8508 0.4293 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1324 13.1932 0.6252 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3912 11.8462 0.6384 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6769 14.9309 0.7300 C 0 0 0 0 0 0 0 0 0 0 0 0 12.6194 13.8509 0.8491 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4430 15.2561 0.8431 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9557 11.0829 0.4140 N 0 0 0 0 0 0 0 0 0 0 0 0 9.8418 10.2001 0.5377 N 0 0 0 0 0 0 0 0 0 0 0 0 12.0770 12.2316 0.7494 N 0 0 0 0 0 0 0 0 0 0 0 0 12.0915 17.0652 0.9562 C 0 0 0 0 0 0 0 0 0 0 0 0 12.9147 19.5396 2.6689 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3101 17.8537 2.5723 C 0 0 0 0 0 0 0 0 0 0 0 0 12.4928 17.9835 -0.5525 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0963 19.6688 -0.4385 C 0 0 0 0 0 0 0 0 0 0 0 0 13.3037 20.4456 1.1676 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8225 16.7187 4.4579 Cl 0 0 0 0 0 0 0 0 0 0 0 0 12.2348 17.0103 -2.5695 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.6515 8.1350 0.3276 N 0 0 3 0 0 0 0 0 0 0 0 0 5.8028 7.7035 0.2059 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5883 5.7306 0.1101 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6575 5.2799 -0.0169 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4514 3.3857 -0.1088 N 0 0 0 0 0 0 0 0 0 0 0 0 4.0046 2.5580 1.5184 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2739 0.6133 1.2140 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6540 2.9137 -0.5393 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3365 3.2139 -2.4773 C 0 0 0 0 0 0 0 0 0 0 0 0 14.3866 14.1823 0.9625 N 0 0 3 0 0 0 0 0 0 0 0 0 15.5271 12.8548 0.9698 C 0 0 0 0 0 0 0 0 0 0 0 0 15.0074 11.3671 0.8769 O 0 0 0 0 0 0 0 0 0 0 0 0 17.2439 13.1767 1.0799 N 0 0 3 0 0 0 0 0 0 0 0 0 18.2975 10.6916 -0.5934 C 0 0 0 0 0 0 0 0 0 0 0 0 20.3321 12.4495 1.2222 C 0 0 0 0 0 0 0 0 0 0 0 0 18.4836 11.7338 1.0878 C 0 0 0 0 0 0 0 0 0 0 0 0 18.1158 10.5533 2.6429 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3739 13.7295 0.4997 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7476 15.9813 0.7224 H 0 0 0 0 0 0 0 0 0 0 0 0 13.0844 20.1514 3.9193 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4075 20.3812 -1.6058 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7761 21.7635 1.2500 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5135 7.2165 0.3367 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1270 8.1967 1.3478 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2559 8.2946 -0.9579 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2639 5.2374 -1.0316 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1352 5.1394 1.2741 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9817 5.7731 1.1249 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1105 5.8710 -1.1808 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2188 3.1399 1.9547 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0089 2.7475 2.5063 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0263 0.0000 0.9483 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1376 0.4238 0.1088 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8498 0.0304 2.3682 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4380 1.5490 -0.2317 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7626 3.7141 0.2144 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.8728 -2.7950 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5619 4.5765 -2.7869 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2214 2.4062 -3.2312 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8013 15.3693 1.0365 H 0 0 0 0 0 0 0 0 0 0 0 0 17.6585 14.3637 1.1539 H 0 0 0 0 0 0 0 0 0 0 0 0 18.5596 11.5326 -1.7014 H 0 0 0 0 0 0 0 0 0 0 0 0 19.2200 9.6181 -0.5876 H 0 0 0 0 0 0 0 0 0 0 0 0 16.9807 10.1816 -0.6891 H 0 0 0 0 0 0 0 0 0 0 0 0 20.4645 13.1920 2.4200 H 0 0 0 0 0 0 0 0 0 0 0 0 21.2544 11.3760 1.2280 H 0 0 0 0 0 0 0 0 0 0 0 0 20.5940 13.2906 0.1143 H 0 0 0 0 0 0 0 0 0 0 0 0 16.7990 10.0433 2.5472 H 0 0 0 0 0 0 0 0 0 0 0 0 19.0383 9.4796 2.6488 H 0 0 0 0 0 0 0 0 0 0 0 0 18.2484 11.2958 3.8407 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 36 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 19 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 10 1 0 0 0 0 5 7 2 0 0 0 0 5 37 1 0 0 0 0 6 10 2 0 0 0 0 6 7 1 0 0 0 0 6 28 1 0 0 0 0 7 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 38 1 0 0 0 0 13 17 1 0 0 0 0 14 15 1 0 0 0 0 14 18 1 0 0 0 0 15 16 2 0 0 0 0 15 39 1 0 0 0 0 16 40 1 0 0 0 0 19 20 1 0 0 0 0 19 41 1 0 0 0 0 20 21 1 0 0 0 0 20 42 1 0 0 0 0 20 43 1 0 0 0 0 21 22 1 0 0 0 0 21 44 1 0 0 0 0 21 45 1 0 0 0 0 22 23 1 0 0 0 0 22 46 1 0 0 0 0 22 47 1 0 0 0 0 23 24 1 0 0 0 0 23 26 1 0 0 0 0 24 25 1 0 0 0 0 24 48 1 0 0 0 0 24 49 1 0 0 0 0 25 50 1 0 0 0 0 25 51 1 0 0 0 0 25 52 1 0 0 0 0 26 27 1 0 0 0 0 26 53 1 0 0 0 0 26 54 1 0 0 0 0 27 55 1 0 0 0 0 27 56 1 0 0 0 0 27 57 1 0 0 0 0 28 29 1 0 0 0 0 28 58 1 0 0 0 0 29 31 1 0 0 0 0 29 30 2 0 0 0 0 31 34 1 0 0 0 0 31 59 1 0 0 0 0 32 34 1 0 0 0 0 32 60 1 0 0 0 0 32 61 1 0 0 0 0 32 62 1 0 0 0 0 33 34 1 0 0 0 0 33 63 1 0 0 0 0 33 64 1 0 0 0 0 33 65 1 0 0 0 0 34 35 1 0 0 0 0 35 66 1 0 0 0 0 35 67 1 0 0 0 0 35 68 1 0 0 0 0 M END > (279) 6-arylpyrido[2,3-d]pyrimidine deriv. 13 > (279) PDGFR-beta > (279) 660 > (279) -1 > (279) P > (279) PDGFR-P277 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 67 csChFnd70/05150717532D 73 77 0 0 0 0 0 0 0 0999 V2000 3.9625 15.9182 0.0501 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4627 13.3434 0.0816 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9849 14.2187 0.0775 N 0 0 0 0 0 0 0 0 0 0 0 0 6.9839 14.1067 0.0589 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5445 16.8035 0.0249 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0957 15.8302 0.0301 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6281 18.6134 -0.0058 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7311 18.3267 -0.0228 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2441 19.3773 -0.0298 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6191 16.6310 0.0061 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4098 21.2824 -0.0632 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6530 23.9835 1.4371 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7191 24.8422 -0.1257 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4987 22.2087 1.4770 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4849 22.1554 -1.6350 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6390 23.9305 -1.6574 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4151 21.1334 3.4397 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.3851 21.0132 -3.5589 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 10.6746 0.1370 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0252 8.7229 0.1668 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4007 11.5618 0.1112 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2826 7.7964 0.1938 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3464 19.0964 -0.0470 N 0 0 3 0 0 0 0 0 0 0 0 0 11.7792 18.1114 -0.0406 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6557 16.5481 -0.0138 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8675 5.4116 -1.0559 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1969 3.4700 -0.9149 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2685 3.0455 0.0822 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9390 4.9872 -0.0588 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5640 5.9225 0.2223 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5720 2.5347 -1.1960 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8533 0.6608 -1.1674 C 0 0 0 0 0 0 0 0 0 0 0 0 13.3485 18.8593 -0.0641 N 0 0 3 0 0 0 0 0 0 0 0 0 14.8375 17.8402 0.0528 C 0 0 0 0 0 0 0 0 0 0 0 0 14.7993 16.1324 -0.4784 C 0 0 0 0 0 0 0 0 0 0 0 0 16.2696 15.1297 -0.3619 C 0 0 0 0 0 0 0 0 0 0 0 0 17.7796 15.8251 0.2833 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8272 17.5271 0.8159 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3618 18.5425 0.6960 C 0 0 0 0 0 0 0 0 0 0 0 0 16.4090 20.2187 1.2115 O 0 0 0 0 0 0 0 0 0 0 0 0 18.0158 20.8509 1.8570 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7559 16.6146 0.0411 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4686 19.3858 -0.0110 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7224 24.7022 2.6286 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8398 26.2300 -0.1500 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6968 24.6079 -2.8734 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9992 11.0211 -1.0119 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0149 11.0584 1.2838 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7425 8.3391 -0.9802 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7581 8.3765 1.3157 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4620 10.8989 0.1147 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5653 8.1802 1.3406 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5497 8.1429 -0.9553 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4449 20.3438 -0.0684 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0634 6.1094 -0.8109 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4025 5.7159 -2.3476 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1359 3.0817 -1.8868 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6951 3.1704 0.3655 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7335 2.7412 1.3739 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0725 2.3477 -0.1628 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4408 5.2868 -1.3391 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3755 0.9132 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3798 0.2848 0.0811 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6302 0.0000 -1.3785 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7587 0.3071 -2.1835 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4476 20.1029 -0.1618 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6211 15.5857 -0.9825 H 0 0 0 0 0 0 0 0 0 0 0 0 16.2382 13.7997 -0.7754 H 0 0 0 0 0 0 0 0 0 0 0 0 18.9251 15.0371 0.3719 H 0 0 0 0 0 0 0 0 0 0 0 0 19.0087 18.0662 1.3202 H 0 0 0 0 0 0 0 0 0 0 0 0 17.8754 22.2016 2.2218 H 0 0 0 0 0 0 0 0 0 0 0 0 18.3974 20.0987 2.9822 H 0 0 0 0 0 0 0 0 0 0 0 0 19.0001 20.7345 0.8597 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 42 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 21 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 43 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 44 1 0 0 0 0 13 16 1 0 0 0 0 13 45 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 46 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 47 1 0 0 0 0 19 48 1 0 0 0 0 20 22 1 0 0 0 0 20 49 1 0 0 0 0 20 50 1 0 0 0 0 21 51 1 0 0 0 0 22 30 1 0 0 0 0 22 52 1 0 0 0 0 22 53 1 0 0 0 0 23 24 1 0 0 0 0 23 54 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 27 31 1 0 0 0 0 27 57 1 0 0 0 0 27 58 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 59 1 0 0 0 0 28 60 1 0 0 0 0 29 30 1 0 0 0 0 29 61 1 0 0 0 0 29 62 1 0 0 0 0 31 32 1 0 0 0 0 32 63 1 0 0 0 0 32 64 1 0 0 0 0 32 65 1 0 0 0 0 33 34 1 0 0 0 0 33 66 1 0 0 0 0 34 35 2 0 0 0 0 34 39 1 0 0 0 0 35 36 1 0 0 0 0 35 67 1 0 0 0 0 36 37 2 0 0 0 0 36 68 1 0 0 0 0 37 38 1 0 0 0 0 37 69 1 0 0 0 0 38 39 2 0 0 0 0 38 70 1 0 0 0 0 39 40 1 0 0 0 0 40 41 1 0 0 0 0 41 71 1 0 0 0 0 41 72 1 0 0 0 0 41 73 1 0 0 0 0 M END > (280) 6-arylpyrido[2,3-d]pyrimidine deriv. 67 > (280) PDGFR-beta > (280) 660 > (280) -1 > (280) P > (280) PDGFR-P278 $$$$ csChFnd70/05150717532D 45 48 0 0 0 0 0 0 0 0999 V2000 6.7679 8.2220 0.0163 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5937 6.5471 -0.0029 N 0 0 0 0 0 0 0 0 0 0 0 0 6.7889 6.6295 0.0013 N 0 0 0 0 0 0 0 0 0 0 0 0 8.2444 9.0522 0.0223 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6879 8.1477 0.0121 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2995 10.7573 0.0378 C 0 0 0 0 0 0 0 0 0 0 0 0 11.2448 10.5368 0.0316 C 0 0 0 0 0 0 0 0 0 0 0 0 12.5582 11.1977 0.0357 O 0 0 0 0 0 0 0 0 0 0 0 0 11.1562 8.9136 0.0170 N 0 0 3 0 0 0 0 0 0 0 0 0 9.7701 11.5111 0.0425 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8685 13.2966 0.0579 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9062 14.1542 -1.3910 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9975 15.8186 -1.3682 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0514 16.6354 0.0869 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0145 15.7925 1.5277 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9169 14.1283 1.5217 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8617 13.0733 3.3312 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.8394 13.1314 -3.2185 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.1719 5.8175 -0.0080 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1246 4.1509 -0.0236 N 0 0 3 0 0 0 0 0 0 0 0 0 6.6448 3.3463 0.1137 C 0 0 0 0 0 0 0 0 0 0 0 0 12.6427 7.9561 0.0067 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9329 1.1154 -0.5733 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3928 1.9081 -0.7093 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4309 3.9824 1.0787 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9718 3.1882 1.2134 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7185 1.7552 0.3853 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2812 0.9741 0.5183 O 0 0 0 0 0 0 0 0 0 0 0 0 1.0849 1.7015 1.5256 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6385 8.8727 0.0183 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1984 11.4548 0.0451 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0272 16.4838 -2.4889 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1232 17.9368 0.0982 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0574 16.4374 2.6597 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1165 3.5381 -0.1297 H 0 0 0 0 0 0 0 0 0 0 0 0 13.0098 7.7294 -1.2361 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5938 8.6162 0.6316 H 0 0 0 0 0 0 0 0 0 0 0 0 12.4304 6.8102 0.6172 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7347 0.0000 -1.2181 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3380 1.4101 -1.4561 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6280 5.0978 1.7238 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0256 3.6856 1.9595 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5475 1.8019 2.7531 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7949 2.8999 1.0668 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.9574 1.5254 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 30 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 31 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 32 1 0 0 0 0 14 15 1 0 0 0 0 14 33 1 0 0 0 0 15 16 2 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 35 1 0 0 0 0 21 24 1 0 0 0 0 21 25 2 0 0 0 0 22 36 1 0 0 0 0 22 37 1 0 0 0 0 22 38 1 0 0 0 0 23 27 1 0 0 0 0 23 24 2 0 0 0 0 23 39 1 0 0 0 0 24 40 1 0 0 0 0 25 26 1 0 0 0 0 25 41 1 0 0 0 0 26 27 2 0 0 0 0 26 42 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 43 1 0 0 0 0 29 44 1 0 0 0 0 29 45 1 0 0 0 0 M END > (282) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 49 > (282) PDGFR-beta > (282) 680 > (282) -1 > (282) P > (282) PDGFR-P280 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 69 csChFnd70/05150717532D 73 77 0 0 0 0 0 0 0 0999 V2000 3.9455 15.8492 1.4067 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4208 13.2846 1.6322 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9617 14.1760 1.6611 N 0 0 0 0 0 0 0 0 0 0 0 0 6.9288 14.0052 1.3509 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5140 16.6888 1.1003 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0454 15.6993 1.0782 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6032 18.4685 0.8170 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6725 18.1235 0.5214 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2050 19.1875 0.5247 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5558 16.4568 0.7905 N 0 0 0 0 0 0 0 0 0 0 0 0 7.3756 21.0593 0.2175 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7865 23.9201 1.2995 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6940 24.5567 -0.3567 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6286 22.1776 1.5943 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2908 21.7085 -1.4503 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4506 23.4537 -1.7280 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7443 21.3812 3.6740 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.9859 20.3261 -3.1734 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.6989 10.6927 2.2244 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9819 8.7658 2.4873 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3531 11.5322 1.9083 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2543 7.8890 2.8175 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2738 18.8484 0.2282 N 0 0 3 0 0 0 0 0 0 0 0 0 11.6879 17.8499 0.2209 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5604 16.3137 0.4713 O 0 0 0 0 0 0 0 0 0 0 0 0 3.6812 5.3386 1.7514 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0118 3.4357 2.1185 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2135 3.2070 3.4542 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8828 5.1099 3.0871 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5260 6.0389 3.0700 N 0 0 0 0 0 0 0 0 0 0 0 0 2.3686 2.5067 2.1356 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6403 0.6566 2.3882 C 0 0 0 0 0 0 0 0 0 0 0 0 13.2435 18.5543 -0.0638 N 0 0 3 0 0 0 0 0 0 0 0 0 14.7259 17.5396 0.0525 C 0 0 0 0 0 0 0 0 0 0 0 0 14.6856 15.8374 -0.4776 C 0 0 0 0 0 0 0 0 0 0 0 0 16.1469 14.8383 -0.3625 C 0 0 0 0 0 0 0 0 0 0 0 0 17.6546 15.5352 0.2823 C 0 0 0 0 0 0 0 0 0 0 0 0 17.6955 17.2357 0.8127 C 0 0 0 0 0 0 0 0 0 0 0 0 16.2373 18.2384 0.6911 C 0 0 0 0 0 0 0 0 0 0 0 0 19.0929 14.5507 0.3952 O 0 0 0 0 0 0 0 0 0 0 0 0 20.5999 15.3513 1.0715 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7534 16.5585 1.4273 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4586 19.2522 0.8263 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9830 24.7873 2.3644 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8182 25.9201 -0.5805 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3848 23.9580 -3.0187 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8553 10.8949 1.1252 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1100 11.2389 3.3712 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5708 8.2197 1.3405 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8254 8.5637 3.5865 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4010 10.8583 1.8927 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6654 8.4350 3.9644 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4108 8.0910 1.7184 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3755 20.0741 0.0286 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8946 6.0366 1.7751 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0879 5.4748 0.4907 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8385 2.9044 1.1213 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6370 3.3021 3.3643 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8068 3.0707 4.7151 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.5090 3.4306 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2577 5.2435 1.8413 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0561 5.6412 4.0844 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2896 0.4428 3.6100 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4039 0.0000 2.3955 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4293 0.1543 1.3463 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3370 19.7635 -0.3492 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5117 15.2946 -0.9793 H 0 0 0 0 0 0 0 0 0 0 0 0 16.1155 13.5139 -0.7744 H 0 0 0 0 0 0 0 0 0 0 0 0 18.8695 17.7773 1.3156 H 0 0 0 0 0 0 0 0 0 0 0 0 16.2711 19.5642 1.0982 H 0 0 0 0 0 0 0 0 0 0 0 0 20.9517 16.4403 0.2650 H 0 0 0 0 0 0 0 0 0 0 0 0 20.3465 15.7980 2.3742 H 0 0 0 0 0 0 0 0 0 0 0 0 21.6509 14.4265 1.0915 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 42 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 21 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 43 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 44 1 0 0 0 0 13 16 1 0 0 0 0 13 45 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 46 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 47 1 0 0 0 0 19 48 1 0 0 0 0 20 22 1 0 0 0 0 20 49 1 0 0 0 0 20 50 1 0 0 0 0 21 51 1 0 0 0 0 22 30 1 0 0 0 0 22 52 1 0 0 0 0 22 53 1 0 0 0 0 23 24 1 0 0 0 0 23 54 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 27 31 1 0 0 0 0 27 57 1 0 0 0 0 27 58 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 59 1 0 0 0 0 28 60 1 0 0 0 0 29 30 1 0 0 0 0 29 61 1 0 0 0 0 29 62 1 0 0 0 0 31 32 1 0 0 0 0 32 63 1 0 0 0 0 32 64 1 0 0 0 0 32 65 1 0 0 0 0 33 34 1 0 0 0 0 33 66 1 0 0 0 0 34 35 2 0 0 0 0 34 39 1 0 0 0 0 35 36 1 0 0 0 0 35 67 1 0 0 0 0 36 37 2 0 0 0 0 36 68 1 0 0 0 0 37 38 1 0 0 0 0 37 40 1 0 0 0 0 38 39 2 0 0 0 0 38 69 1 0 0 0 0 39 70 1 0 0 0 0 40 41 1 0 0 0 0 41 71 1 0 0 0 0 41 72 1 0 0 0 0 41 73 1 0 0 0 0 M END > (283) 6-arylpyrido[2,3-d]pyrimidine deriv. 69 > (283) PDGFR-beta > (283) 680 > (283) -1 > (283) P > (283) PDGFR-P281 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 37 csChFnd70/05150717532D 62 64 0 0 0 0 0 0 0 0999 V2000 3.9152 12.2586 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4094 9.6952 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9382 10.5658 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 6.9241 10.4563 -0.0265 N 0 0 0 0 0 0 0 0 0 0 0 0 5.4896 13.1409 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0346 12.1722 -0.0184 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5723 14.9433 0.0099 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6620 14.6592 -0.0217 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1812 15.7048 -0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5512 12.9707 -0.0292 N 0 0 0 0 0 0 0 0 0 0 0 0 7.3455 17.6020 0.0054 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5908 20.2586 1.5564 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6523 21.1472 0.0191 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4380 18.4910 1.5584 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4156 18.5049 -1.5406 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5687 20.2725 -1.5251 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3602 17.3782 3.4891 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.3115 17.4094 -3.4800 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.3483 7.9211 -0.0245 N 0 0 3 0 0 0 0 0 0 0 0 0 3.6873 7.0368 -0.0127 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9797 5.0933 -0.0254 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2449 4.1698 -0.0131 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3492 1.7336 1.5738 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5257 2.3039 -0.0253 N 0 0 0 0 0 0 0 0 0 0 0 0 0.9079 1.3785 -0.3201 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2703 15.4268 -0.0334 N 0 0 3 0 0 0 0 0 0 0 0 0 11.6971 14.4467 -0.0523 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5750 12.8899 -0.0590 O 0 0 0 0 0 0 0 0 0 0 0 0 13.2595 15.1924 -0.0638 N 0 0 3 0 0 0 0 0 0 0 0 0 14.8104 14.1269 -0.0843 C 0 0 0 0 0 0 0 0 0 0 0 0 14.8101 13.0005 -1.6948 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3995 15.2833 -0.0939 C 0 0 0 0 0 0 0 0 0 0 0 0 14.8415 12.9843 1.5144 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7135 12.9517 0.0214 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4176 15.7121 0.0245 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6630 20.9484 2.7580 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7721 22.5292 0.0245 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6227 20.9732 -2.7212 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4052 7.2614 -0.0381 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9763 7.3943 1.1392 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9541 7.4058 -1.1469 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6906 4.7359 -1.1774 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7129 4.7243 1.1089 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5340 4.5274 1.1388 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5117 4.5388 -1.1473 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5297 2.0571 2.6620 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5422 0.3474 1.5309 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5868 2.3729 1.7152 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3706 1.7598 -1.5555 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1525 0.0000 -0.3229 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.6894 0.6995 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3678 16.6691 -0.0281 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3570 16.4345 -0.0584 H 0 0 0 0 0 0 0 0 0 0 0 0 14.7880 13.8145 -2.8336 H 0 0 0 0 0 0 0 0 0 0 0 0 15.9641 12.2078 -1.7099 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6781 12.1767 -1.6878 H 0 0 0 0 0 0 0 0 0 0 0 0 16.3997 16.0858 1.0534 H 0 0 0 0 0 0 0 0 0 0 0 0 17.5534 14.4907 -0.1092 H 0 0 0 0 0 0 0 0 0 0 0 0 16.3774 16.0973 -1.2329 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7094 12.1604 1.5212 H 0 0 0 0 0 0 0 0 0 0 0 0 15.9955 12.1915 1.4992 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8416 13.7868 2.6618 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 34 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 19 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 35 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 26 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 36 1 0 0 0 0 13 16 1 0 0 0 0 13 37 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 38 1 0 0 0 0 19 20 1 0 0 0 0 19 39 1 0 0 0 0 20 21 1 0 0 0 0 20 40 1 0 0 0 0 20 41 1 0 0 0 0 21 22 1 0 0 0 0 21 42 1 0 0 0 0 21 43 1 0 0 0 0 22 24 1 0 0 0 0 22 44 1 0 0 0 0 22 45 1 0 0 0 0 23 24 1 0 0 0 0 23 46 1 0 0 0 0 23 47 1 0 0 0 0 23 48 1 0 0 0 0 24 25 1 0 0 0 0 25 49 1 0 0 0 0 25 50 1 0 0 0 0 25 51 1 0 0 0 0 26 27 1 0 0 0 0 26 52 1 0 0 0 0 27 29 1 0 0 0 0 27 28 2 0 0 0 0 29 30 1 0 0 0 0 29 53 1 0 0 0 0 30 31 1 0 0 0 0 30 32 1 0 0 0 0 30 33 1 0 0 0 0 31 54 1 0 0 0 0 31 55 1 0 0 0 0 31 56 1 0 0 0 0 32 57 1 0 0 0 0 32 58 1 0 0 0 0 32 59 1 0 0 0 0 33 60 1 0 0 0 0 33 61 1 0 0 0 0 33 62 1 0 0 0 0 M END > (284) 6-arylpyrido[2,3-d]pyrimidine deriv. 37 > (284) PDGFR-beta > (284) 680 > (284) -1 > (284) P > (284) PDGFR-P282 $$$$ Indolin-2-one deriv. 9g csChFnd70/05150717532D 59 63 0 0 0 0 0 0 0 0999 V2000 5.8611 9.4248 0.1582 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8807 7.8397 0.2069 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2821 7.0530 0.1933 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6644 7.8615 0.1308 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6549 9.4584 0.0821 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2407 10.2391 0.0957 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6100 11.9006 0.0331 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2987 11.9752 -0.0153 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8439 10.5276 0.0165 N 0 0 3 0 0 0 0 0 0 0 0 0 10.0702 13.1449 -0.0740 O 0 0 0 0 0 0 0 0 0 0 0 0 6.5868 13.1195 0.0220 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1366 14.6418 0.1467 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5037 15.9355 -0.5469 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3981 15.1198 0.9860 N 0 0 3 0 0 0 0 0 0 0 0 0 5.1043 15.9774 -1.5718 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6643 16.2307 -0.5895 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2650 16.2726 -1.6144 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4051 16.1159 -2.9896 O 0 0 0 0 0 0 0 0 0 0 0 0 0.8628 16.4839 -0.9996 O 0 0 0 0 0 0 0 0 0 0 0 0 8.5528 16.6603 0.8163 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4063 17.1851 -0.1155 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1969 18.8500 -0.5637 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7722 17.6812 1.5199 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7876 19.2146 0.6454 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1461 19.8478 0.5414 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2983 5.3463 0.2464 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9189 4.5304 0.3029 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9418 2.9363 0.3523 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3367 2.1564 0.3460 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7063 2.9658 0.2904 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6943 4.5537 0.2332 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5984 2.1360 0.4076 O 0 0 0 0 0 0 0 0 0 0 0 0 4.7079 0.4951 0.4565 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7774 10.0348 0.1635 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8121 7.2058 0.2558 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7446 7.2457 0.1207 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9286 10.2626 -0.0040 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3663 12.9059 -0.0823 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0627 14.4612 1.5959 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2182 16.9160 -2.3971 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0043 14.8886 -2.1879 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5505 15.2921 0.2358 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7644 17.3195 0.0266 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.5024 -1.7031 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5970 19.0246 -1.7403 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9842 19.1615 -0.4785 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5052 17.8868 2.7288 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8943 17.1278 1.4225 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5137 20.0364 1.2556 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2423 19.0324 -0.5099 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1780 21.0283 0.1165 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6199 19.8272 1.6805 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8344 5.1388 0.3087 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3521 0.9136 0.3850 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7886 2.3534 0.2864 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7659 5.1824 0.1837 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3029 0.0847 -0.5693 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3490 0.1490 1.4785 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5555 0.0000 0.4980 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 6 2 0 0 0 0 1 34 1 0 0 0 0 2 3 2 0 0 0 0 2 35 1 0 0 0 0 3 4 1 0 0 0 0 3 26 1 0 0 0 0 4 5 2 0 0 0 0 4 36 1 0 0 0 0 5 9 1 0 0 0 0 5 6 1 0 0 0 0 6 7 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 9 1 0 0 0 0 8 10 2 0 0 0 0 9 37 1 0 0 0 0 11 12 1 0 0 0 0 11 38 1 0 0 0 0 12 13 2 0 0 0 0 12 14 1 0 0 0 0 13 21 1 0 0 0 0 13 15 1 0 0 0 0 14 20 1 0 0 0 0 14 39 1 0 0 0 0 15 16 1 0 0 0 0 15 40 1 0 0 0 0 15 41 1 0 0 0 0 16 17 1 0 0 0 0 16 42 1 0 0 0 0 16 43 1 0 0 0 0 17 19 1 0 0 0 0 17 18 2 0 0 0 0 19 44 1 0 0 0 0 20 23 1 0 0 0 0 20 21 2 0 0 0 0 21 22 1 0 0 0 0 22 25 1 0 0 0 0 22 45 1 0 0 0 0 22 46 1 0 0 0 0 23 24 1 0 0 0 0 23 47 1 0 0 0 0 23 48 1 0 0 0 0 24 25 1 0 0 0 0 24 49 1 0 0 0 0 24 50 1 0 0 0 0 25 51 1 0 0 0 0 25 52 1 0 0 0 0 26 31 1 0 0 0 0 26 27 2 0 0 0 0 27 28 1 0 0 0 0 27 53 1 0 0 0 0 28 29 2 0 0 0 0 28 32 1 0 0 0 0 29 30 1 0 0 0 0 29 54 1 0 0 0 0 30 31 2 0 0 0 0 30 55 1 0 0 0 0 31 56 1 0 0 0 0 32 33 1 0 0 0 0 33 57 1 0 0 0 0 33 58 1 0 0 0 0 33 59 1 0 0 0 0 M END > (285) Indolin-2-one deriv. 9g > (285) PDGFR-beta > (285) 680 > (285) -1 > (285) P > (285) PDGFR-P283 $$$$ csChFnd70/05150717532D 26 28 0 0 0 0 0 0 0 0999 V2000 1.2471 7.7946 0.0101 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7867 7.8625 -0.0137 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5467 5.6264 -0.0138 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8208 6.3875 -0.0218 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9216 4.2147 -0.0246 N 0 0 3 0 0 0 0 0 0 0 0 0 4.8831 5.4249 -0.0379 N 0 0 0 0 0 0 0 0 0 0 0 0 4.3571 4.1547 -0.0382 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5043 8.5558 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2668 6.3395 0.0021 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4694 9.9911 0.0097 O 0 0 0 0 0 0 0 0 0 0 0 0 1.1088 10.6431 0.0256 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9909 3.0554 -0.0210 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9262 2.9361 0.9004 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1020 1.9500 -0.9769 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1353 0.9373 -0.8270 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.3586 0.5806 S 0 0 0 0 0 0 0 0 0 0 0 0 0.2500 8.3477 0.0273 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7594 8.4577 -0.0194 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9707 3.1936 -0.0488 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2876 5.7551 0.0087 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2318 11.7874 0.0303 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5196 10.3243 -0.9102 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5372 10.3149 0.9692 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6746 3.6926 1.7158 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9097 1.9131 -1.7811 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0611 0.0000 -1.4722 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 8 2 0 0 0 0 1 17 1 0 0 0 0 2 8 1 0 0 0 0 2 4 2 0 0 0 0 2 18 1 0 0 0 0 3 9 2 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 12 1 0 0 0 0 6 7 2 0 0 0 0 7 19 1 0 0 0 0 8 10 1 0 0 0 0 9 20 1 0 0 0 0 10 11 1 0 0 0 0 11 21 1 0 0 0 0 11 22 1 0 0 0 0 11 23 1 0 0 0 0 12 13 2 0 0 0 0 12 14 1 0 0 0 0 13 16 1 0 0 0 0 13 24 1 0 0 0 0 14 15 2 0 0 0 0 14 25 1 0 0 0 0 15 16 1 0 0 0 0 15 26 1 0 0 0 0 M END > (287) 1-Phenylbenzimidazole deriv. 95 > (287) PDGFR-beta > (287) 700 > (287) -1 > (287) P > (287) PDGFR-P285 $$$$ csChFnd70/05150717532D 63 66 0 0 0 0 0 0 0 0999 V2000 5.3737 18.8994 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4091 17.1016 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 5.3969 17.1887 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 6.9590 19.7917 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5097 18.8210 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0174 21.6234 0.0104 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1807 21.3878 -0.0216 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5911 22.0982 -0.0319 O 0 0 0 0 0 0 0 0 0 0 0 0 10.0862 19.6443 -0.0296 N 0 0 3 0 0 0 0 0 0 0 0 0 11.6831 18.6165 -0.0497 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5964 22.4337 -0.0009 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7014 24.3516 0.0083 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7280 25.2675 -1.5515 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8255 27.0552 -1.5337 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8972 27.9378 0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8719 27.0377 1.5764 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7666 25.2502 1.5769 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7255 24.1234 3.5247 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.6396 24.1622 -3.5098 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.8826 16.3173 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8325 14.5281 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 5.1619 13.6250 -0.0156 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4697 11.6655 -0.0296 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7250 10.7222 -0.0187 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0326 8.7627 -0.0327 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2880 7.8194 -0.0218 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3044 3.0399 0.1568 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9619 4.9901 0.2834 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9174 5.4474 1.2332 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2598 3.4972 1.1067 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5834 5.9382 -0.0352 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6384 2.5491 1.4254 N 0 0 0 0 0 0 0 0 0 0 0 0 2.9338 0.6679 1.4119 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1603 19.5978 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8345 22.3721 0.0253 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0664 18.3679 -1.3869 H 0 0 0 0 0 0 0 0 0 0 0 0 12.7100 19.3286 0.6099 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4611 17.3882 0.6128 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8461 27.7656 -2.7400 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9738 29.3358 0.0324 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9288 27.7344 2.7896 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9035 13.8693 -0.0398 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4416 13.9803 1.1470 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4201 13.9934 -1.1603 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1899 11.3101 -1.1921 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2116 11.2970 1.1151 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0046 11.0776 1.1439 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9831 11.0907 -1.1634 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7530 8.4074 -1.1953 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7746 8.3943 1.1120 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5676 8.1747 1.1408 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5461 8.1879 -1.1666 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1116 2.3331 0.4298 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7530 2.7234 -1.1452 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3634 -0.6820 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4798 5.3013 1.5747 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4688 5.7638 2.5353 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1102 6.1542 0.9604 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7419 3.1860 -0.1846 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2217 3.1239 2.0721 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3622 0.2676 0.1261 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9267 0.3402 2.3624 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7318 0.0000 1.7372 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 34 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 35 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 36 1 0 0 0 0 10 37 1 0 0 0 0 10 38 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 39 1 0 0 0 0 15 16 1 0 0 0 0 15 40 1 0 0 0 0 16 17 2 0 0 0 0 16 41 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 42 1 0 0 0 0 22 23 1 0 0 0 0 22 43 1 0 0 0 0 22 44 1 0 0 0 0 23 24 1 0 0 0 0 23 45 1 0 0 0 0 23 46 1 0 0 0 0 24 25 1 0 0 0 0 24 47 1 0 0 0 0 24 48 1 0 0 0 0 25 26 1 0 0 0 0 25 49 1 0 0 0 0 25 50 1 0 0 0 0 26 31 1 0 0 0 0 26 51 1 0 0 0 0 26 52 1 0 0 0 0 27 32 1 0 0 0 0 27 28 1 0 0 0 0 27 53 1 0 0 0 0 27 54 1 0 0 0 0 28 31 1 0 0 0 0 28 55 1 0 0 0 0 28 56 1 0 0 0 0 29 31 1 0 0 0 0 29 30 1 0 0 0 0 29 57 1 0 0 0 0 29 58 1 0 0 0 0 30 32 1 0 0 0 0 30 59 1 0 0 0 0 30 60 1 0 0 0 0 32 33 1 0 0 0 0 33 61 1 0 0 0 0 33 62 1 0 0 0 0 33 63 1 0 0 0 0 M END > (293) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 33 > (293) PDGFR-beta > (293) 710 > (293) -1 > (293) P > (293) PDGFR-P291 $$$$ Pyrazine-Pyridine Biheteroaryl 58 csChFnd70/05150717532D 48 51 0 0 0 0 0 0 0 0999 V2000 1.0493 13.9809 -0.0846 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3562 11.8092 -0.3512 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6854 12.6080 -0.3824 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3738 14.7879 -0.1148 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0754 12.5164 -0.2033 N 0 0 0 0 0 0 0 0 0 0 0 0 3.6624 14.0837 -0.2629 N 0 0 0 0 0 0 0 0 0 0 0 0 5.1240 11.8139 -0.5479 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4600 12.6027 -0.5803 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8177 10.4426 -0.8481 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5381 9.5734 -0.8198 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1606 10.2643 -0.6671 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7402 11.9034 -0.7271 N 0 0 0 0 0 0 0 0 0 0 0 0 3.6754 17.1284 0.1190 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7918 18.5323 -0.5182 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8833 16.5212 0.8705 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1975 17.3115 0.9765 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3129 18.7067 0.3362 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1105 19.3179 -0.4082 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2581 21.0729 -1.2040 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.3440 16.3309 0.0099 N 0 0 3 0 0 0 0 0 0 0 0 0 8.0892 7.3102 -1.1168 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6334 8.0263 -0.9495 N 0 0 3 0 0 0 0 0 0 0 0 0 7.8822 5.6236 -1.2346 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4024 4.8757 -1.4093 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7011 2.3706 -2.6175 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5438 0.9806 -1.0314 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2042 3.2608 -1.5221 N 0 0 3 0 0 0 0 0 0 0 0 0 8.4576 2.3353 -0.5070 N 0 0 0 0 0 0 0 0 0 0 0 0 9.2970 1.0056 -2.3089 N 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 14.5543 0.0411 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3730 10.6110 -0.4484 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4450 13.8011 -0.4845 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8909 9.9137 -0.9665 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1463 9.6193 -0.6409 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8535 19.0093 -1.0991 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7941 15.4318 1.3716 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1364 16.8394 1.5607 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3419 19.3227 0.4215 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3990 16.8535 0.0213 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6297 7.7226 -2.1219 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7794 7.5666 -0.1522 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7358 7.4263 -0.9289 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3416 5.2113 -0.2294 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1921 5.3672 -2.1992 H 0 0 0 0 0 0 0 0 0 0 0 0 9.9429 5.2881 -2.4144 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0925 5.1321 -0.4446 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3211 2.7215 -3.5860 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0795 0.0000 -0.5131 H 0 0 0 0 0 0 0 0 0 0 0 0 1 5 1 0 0 0 0 1 4 2 0 0 0 0 1 30 1 0 0 0 0 2 5 2 0 0 0 0 2 3 1 0 0 0 0 2 31 1 0 0 0 0 3 6 2 0 0 0 0 3 7 1 0 0 0 0 4 6 1 0 0 0 0 4 20 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 12 2 0 0 0 0 8 32 1 0 0 0 0 9 12 1 0 0 0 0 9 10 2 0 0 0 0 9 33 1 0 0 0 0 10 11 1 0 0 0 0 10 22 1 0 0 0 0 11 34 1 0 0 0 0 13 20 1 0 0 0 0 13 14 2 0 0 0 0 13 15 1 0 0 0 0 14 18 1 0 0 0 0 14 35 1 0 0 0 0 15 16 2 0 0 0 0 15 36 1 0 0 0 0 16 17 1 0 0 0 0 16 37 1 0 0 0 0 17 18 2 0 0 0 0 17 38 1 0 0 0 0 18 19 1 0 0 0 0 20 39 1 0 0 0 0 21 22 1 0 0 0 0 21 23 1 0 0 0 0 21 40 1 0 0 0 0 21 41 1 0 0 0 0 22 42 1 0 0 0 0 23 24 1 0 0 0 0 23 43 1 0 0 0 0 23 44 1 0 0 0 0 24 27 1 0 0 0 0 24 45 1 0 0 0 0 24 46 1 0 0 0 0 25 27 1 0 0 0 0 25 29 2 0 0 0 0 25 47 1 0 0 0 0 26 28 2 0 0 0 0 26 29 1 0 0 0 0 26 48 1 0 0 0 0 27 28 1 0 0 0 0 M END > (296) Pyrazine-Pyridine Biheteroaryl 58 > (296) PDGFR-beta > (296) 725 > (296) -1 > (296) P > (296) PDGFR-P294 $$$$ csChFnd70/05150717532D 49 51 0 0 0 0 0 0 0 0999 V2000 4.1360 15.3286 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1711 13.5309 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 4.1592 13.6180 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.7211 16.2208 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2717 15.2501 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7796 18.0523 0.0104 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9426 17.8168 -0.0216 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3528 18.5271 -0.0319 O 0 0 0 0 0 0 0 0 0 0 0 0 8.8481 16.0734 -0.0296 N 0 0 3 0 0 0 0 0 0 0 0 0 10.4448 15.0457 -0.0496 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3584 18.8626 -0.0009 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4634 20.7803 0.0083 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4900 21.6961 -1.5514 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5875 23.4837 -1.5336 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6592 24.3662 0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6339 23.4662 1.5763 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5286 21.6789 1.5768 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4875 20.5522 3.5244 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4016 20.5909 -3.5095 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.6447 12.7467 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5947 10.9577 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 3.9242 10.0546 -0.0156 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2319 8.0952 -0.0296 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4874 7.1521 -0.0187 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7950 5.1927 -0.0327 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0505 4.2495 -0.0218 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8150 1.7566 -0.0525 O 0 0 0 0 0 0 0 0 0 0 0 0 1.3536 2.3197 -0.0356 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.2264 -0.0292 O 0 0 0 0 0 0 0 0 0 0 0 0 2.9227 16.0269 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5967 18.8010 0.0253 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8282 14.7971 -1.3868 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4716 15.7578 0.6099 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2229 13.8175 0.6127 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6081 24.1941 -2.7398 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7358 25.7641 0.0324 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6908 24.1628 2.7893 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6656 10.2989 -0.0398 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2040 10.4099 1.1469 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1825 10.4230 -1.1602 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9522 7.7399 -1.1920 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9738 7.7268 1.1150 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7671 7.5074 1.1438 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7456 7.5205 -1.1633 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5154 4.8374 -1.1952 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5369 4.8244 1.1119 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3302 4.6048 1.1407 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3087 4.6180 -1.1665 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2590 0.0000 -0.0386 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 30 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 31 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 32 1 0 0 0 0 10 33 1 0 0 0 0 10 34 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 35 1 0 0 0 0 15 16 1 0 0 0 0 15 36 1 0 0 0 0 16 17 2 0 0 0 0 16 37 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 38 1 0 0 0 0 22 23 1 0 0 0 0 22 39 1 0 0 0 0 22 40 1 0 0 0 0 23 24 1 0 0 0 0 23 41 1 0 0 0 0 23 42 1 0 0 0 0 24 25 1 0 0 0 0 24 43 1 0 0 0 0 24 44 1 0 0 0 0 25 26 1 0 0 0 0 25 45 1 0 0 0 0 25 46 1 0 0 0 0 26 28 1 0 0 0 0 26 47 1 0 0 0 0 26 48 1 0 0 0 0 27 28 2 0 0 0 0 28 29 1 0 0 0 0 29 49 1 0 0 0 0 M END > (297) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 37 > (297) PDGFR-beta > (297) 730 > (297) -1 > (297) P > (297) PDGFR-P295 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 45 csChFnd70/05150717532D 72 75 0 0 0 0 0 0 0 0999 V2000 5.3442 14.8755 -0.4152 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7759 12.2502 -0.5138 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3233 13.1690 -0.3813 N 0 0 0 0 0 0 0 0 0 0 0 0 8.3145 12.9746 -0.6858 N 0 0 0 0 0 0 0 0 0 0 0 0 6.9459 15.7204 -0.5958 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4700 14.7008 -0.7338 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0756 17.5344 -0.6436 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1662 17.1614 -0.9554 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7086 18.2566 -0.8257 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0114 15.4629 -0.9074 N 0 0 0 0 0 0 0 0 0 0 0 0 8.9225 20.1639 -0.8845 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3821 22.8717 0.5782 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3222 23.7279 -0.9943 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1836 21.0948 0.6416 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8709 21.0341 -2.4668 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0710 22.8113 -2.5129 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2585 20.0227 2.6165 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.5564 19.8860 -4.3742 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.9802 9.6196 -0.2787 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2229 7.6529 -0.2667 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4595 6.7710 -0.0680 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6686 10.4641 -0.4690 N 0 0 3 0 0 0 0 0 0 0 0 0 2.3458 2.0398 -0.4679 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9439 2.3722 1.4260 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5538 4.3121 1.5406 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6925 4.8828 -0.0563 N 0 0 3 0 0 0 0 0 0 0 0 0 3.2477 1.3774 1.1693 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0311 3.9894 -0.2984 C 0 0 1 0 0 0 0 0 0 0 0 0 1.1534 4.6620 -1.9428 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7987 17.8897 -1.1377 N 0 0 3 0 0 0 0 0 0 0 0 0 13.2040 16.8618 -1.2633 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0411 15.2965 -1.2169 O 0 0 0 0 0 0 0 0 0 0 0 0 14.7899 17.5694 -1.4404 N 0 0 3 0 0 0 0 0 0 0 0 0 16.1373 15.2779 -3.1629 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3174 16.4522 -1.5769 C 0 0 0 0 0 0 0 0 0 0 0 0 17.9407 17.5727 -1.7656 C 0 0 0 0 0 0 0 0 0 0 0 0 16.4694 15.3388 0.0553 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1569 15.6076 -0.3123 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9378 18.3415 -0.5418 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5849 23.5938 1.7588 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4780 25.1172 -1.0370 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0308 23.4867 -3.7371 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1473 9.9843 -1.3587 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3839 10.0277 0.9341 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8192 7.2449 -1.4795 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0558 7.2883 0.8134 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8632 7.1790 1.1449 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6266 7.1357 -1.1479 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7112 9.7696 -0.5634 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1645 1.7905 -1.5907 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1106 1.3751 -0.6274 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8034 2.1280 0.3330 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5649 1.9450 2.6196 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7087 4.5576 2.6443 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7609 5.0256 1.7047 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4079 1.5809 2.2857 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5248 0.0000 1.0308 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1978 4.2364 0.8140 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0485 4.5595 -3.0296 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.8926 -2.2089 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7862 6.0130 -1.7613 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9288 19.1387 -1.1747 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9198 18.8184 -1.4774 H 0 0 0 0 0 0 0 0 0 0 0 0 16.0290 16.0711 -4.3257 H 0 0 0 0 0 0 0 0 0 0 0 0 17.2738 14.4467 -3.2645 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9808 14.4796 -3.0285 H 0 0 0 0 0 0 0 0 0 0 0 0 18.0690 18.4093 -0.6357 H 0 0 0 0 0 0 0 0 0 0 0 0 19.0772 16.7415 -1.8671 H 0 0 0 0 0 0 0 0 0 0 0 0 17.8324 18.3660 -2.9284 H 0 0 0 0 0 0 0 0 0 0 0 0 15.3129 14.5404 0.1897 H 0 0 0 0 0 0 0 0 0 0 0 0 17.6059 14.5074 -0.0462 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5977 16.1752 1.1853 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 38 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 22 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 39 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 30 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 40 1 0 0 0 0 13 16 1 0 0 0 0 13 41 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 42 1 0 0 0 0 19 22 1 0 0 0 0 19 20 1 0 0 0 0 19 43 1 0 0 0 0 19 44 1 0 0 0 0 20 21 1 0 0 0 0 20 45 1 0 0 0 0 20 46 1 0 0 0 0 21 26 1 0 0 0 0 21 47 1 0 0 0 0 21 48 1 0 0 0 0 22 49 1 0 0 0 0 23 28 1 0 0 0 0 23 27 1 0 0 0 0 23 50 1 0 0 0 0 23 51 1 0 0 0 0 24 27 1 0 0 0 0 24 25 1 0 0 0 0 24 52 1 0 0 0 0 24 53 1 0 0 0 0 25 26 1 0 0 0 0 25 54 1 0 0 0 0 25 55 1 0 0 0 0 26 28 1 0 0 0 0 27 56 1 0 0 0 0 27 57 1 0 0 0 0 28 29 1 0 0 0 0 28 58 1 0 0 0 0 29 59 1 0 0 0 0 29 60 1 0 0 0 0 29 61 1 0 0 0 0 30 31 1 0 0 0 0 30 62 1 0 0 0 0 31 32 2 0 0 0 0 31 33 1 0 0 0 0 33 35 1 0 0 0 0 33 63 1 0 0 0 0 34 35 1 0 0 0 0 34 64 1 0 0 0 0 34 65 1 0 0 0 0 34 66 1 0 0 0 0 35 36 1 0 0 0 0 35 37 1 0 0 0 0 36 67 1 0 0 0 0 36 68 1 0 0 0 0 36 69 1 0 0 0 0 37 70 1 0 0 0 0 37 71 1 0 0 0 0 37 72 1 0 0 0 0 M END > (299) 6-arylpyrido[2,3-d]pyrimidine deriv. 45 > (299) PDGFR-beta > (299) 730 > (299) -1 > (299) P > (299) PDGFR-P297 $$$$ SU11248 analog 12f csChFnd70/05150717532D 54 57 0 0 0 0 0 0 0 0999 V2000 3.8102 3.9749 -0.1692 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7799 2.1928 -0.4431 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1266 1.3927 -1.3471 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5071 2.3598 -1.9809 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1961 4.9586 -0.8040 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5598 4.1530 -1.7173 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2887 7.0072 -1.6704 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6213 6.8406 -0.7404 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7729 5.4099 -2.2062 N 0 0 3 0 0 0 0 0 0 0 0 0 8.0929 8.3564 -1.9110 O 0 0 0 0 0 0 0 0 0 0 0 0 4.6588 8.1555 0.0265 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3572 9.8552 0.1513 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2640 12.0140 0.4546 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6377 12.7648 0.2399 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4247 11.3931 0.0502 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0898 10.2709 0.4035 N 0 0 3 0 0 0 0 0 0 0 0 0 2.4849 11.5720 -0.2127 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9517 12.9894 0.7088 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2445 14.6469 0.2147 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2713 15.4446 -1.1561 O 0 0 0 0 0 0 0 0 0 0 0 0 4.8553 15.4837 1.7111 N 0 0 3 0 0 0 0 0 0 0 0 0 4.4645 17.3541 1.6862 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0695 17.9759 3.5411 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4376 1.2302 0.1709 F 0 0 0 0 0 0 0 0 0 0 0 0 2.9913 20.4349 5.2153 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1960 21.2794 4.8751 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2966 21.7925 2.9202 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3783 20.2680 2.1532 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6777 19.8516 3.5161 N 0 0 0 0 0 0 0 0 0 0 0 0 2.7595 4.6013 0.5296 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0956 0.0000 -1.5569 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5487 1.7217 -2.6827 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8325 5.1652 -2.8530 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3718 7.8840 0.5309 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0331 9.4364 0.5254 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8352 11.5926 1.0518 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2103 12.7824 -0.9064 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0061 10.4706 -0.9736 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5472 13.2442 -0.5570 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6919 14.2226 1.3672 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8369 12.2070 1.5001 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8339 14.8474 2.8046 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5849 18.0656 1.1763 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3347 17.5913 0.8562 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9492 17.2645 4.0510 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1994 17.7389 4.3711 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8735 21.3896 5.7914 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8445 19.3206 6.0860 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1497 20.3422 5.0957 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0202 22.4318 5.6891 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 21.8402 2.3387 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9733 23.0319 2.7532 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5434 19.1442 1.9054 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0294 20.6758 0.9568 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 5 2 0 0 0 0 1 30 1 0 0 0 0 2 3 2 0 0 0 0 2 24 1 0 0 0 0 3 4 1 0 0 0 0 3 31 1 0 0 0 0 4 6 2 0 0 0 0 4 32 1 0 0 0 0 5 8 1 0 0 0 0 5 6 1 0 0 0 0 6 9 1 0 0 0 0 7 9 1 0 0 0 0 7 8 1 0 0 0 0 7 10 2 0 0 0 0 8 11 2 0 0 0 0 9 33 1 0 0 0 0 11 12 1 0 0 0 0 11 34 1 0 0 0 0 12 15 2 0 0 0 0 12 16 1 0 0 0 0 13 16 1 0 0 0 0 13 14 2 0 0 0 0 13 18 1 0 0 0 0 14 15 1 0 0 0 0 14 19 1 0 0 0 0 15 17 1 0 0 0 0 16 35 1 0 0 0 0 17 36 1 0 0 0 0 17 37 1 0 0 0 0 17 38 1 0 0 0 0 18 39 1 0 0 0 0 18 40 1 0 0 0 0 18 41 1 0 0 0 0 19 20 2 0 0 0 0 19 21 1 0 0 0 0 21 22 1 0 0 0 0 21 42 1 0 0 0 0 22 23 1 0 0 0 0 22 43 1 0 0 0 0 22 44 1 0 0 0 0 23 29 1 0 0 0 0 23 45 1 0 0 0 0 23 46 1 0 0 0 0 25 29 1 0 0 0 0 25 26 1 0 0 0 0 25 47 1 0 0 0 0 25 48 1 0 0 0 0 26 27 1 0 0 0 0 26 49 1 0 0 0 0 26 50 1 0 0 0 0 27 28 1 0 0 0 0 27 51 1 0 0 0 0 27 52 1 0 0 0 0 28 29 1 0 0 0 0 28 53 1 0 0 0 0 28 54 1 0 0 0 0 M END > (4) SU11248 analog 12f > (4) PDGFR-beta > (4) 1 > (4) -1 > (4) P > (4) PDGFR-P2 $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7g csChFnd70/05150717532D 61 63 0 0 0 0 0 0 0 0999 V2000 1.3395 16.2096 2.0564 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2275 13.7979 1.5726 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7345 14.8850 1.5056 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7858 17.4025 2.0081 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5285 16.7218 1.7253 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5237 19.2662 2.2360 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9748 20.3845 2.1778 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7638 19.6349 1.8822 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0610 20.6236 1.8305 O 0 0 0 0 0 0 0 0 0 0 0 0 1.6062 14.4811 1.8409 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9807 17.8554 1.6693 N 0 0 3 0 0 0 0 0 0 0 0 0 7.7773 17.1221 1.3751 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7379 22.3410 2.4117 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5969 24.9240 4.3274 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8188 23.0990 4.1185 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4404 23.4350 0.9253 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2206 25.2579 1.1527 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2953 25.9998 2.8491 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1972 21.7511 5.9755 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.3477 22.5066 -1.2050 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.4179 11.9622 1.3543 N 0 0 3 0 0 0 0 0 0 0 0 0 5.1969 11.1887 1.0572 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0335 9.1550 0.8607 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8915 8.3471 0.5504 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7281 6.3135 0.3539 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5860 5.5056 0.0437 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4292 3.5531 -0.1451 N 0 0 0 0 0 0 0 0 0 0 0 0 10.1255 2.7651 -0.7567 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3696 3.1375 -2.7575 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8349 2.7272 1.5394 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1832 0.8190 1.1722 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.7098 2.2775 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0453 14.3128 1.2870 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1960 19.7987 2.4524 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0586 17.0835 -0.0572 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7633 17.9676 2.0422 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8464 15.7698 1.9214 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6588 25.5122 5.6477 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9903 26.1061 0.0035 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1227 27.4261 3.0196 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3731 11.1908 1.3984 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7748 11.7504 -0.1604 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0591 11.5000 2.1939 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4556 8.5932 2.0783 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1714 8.8435 -0.2758 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4695 8.9089 -0.6671 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7536 8.6585 1.6871 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1502 5.7517 1.5715 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8659 6.0020 -0.7827 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1639 6.0674 -1.1739 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4482 5.8171 1.1803 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2335 3.3574 -0.0127 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1022 1.3229 -0.5294 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3259 2.4488 -3.5116 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2776 4.5744 -2.9998 H 0 0 0 0 0 0 0 0 0 0 0 0 11.6791 2.6543 -3.1863 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9494 2.6879 2.4821 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7436 3.5132 2.1084 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6268 0.2505 2.3966 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1537 0.8470 0.1369 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3047 0.0000 0.7211 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 32 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 33 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 34 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 35 1 0 0 0 0 12 36 1 0 0 0 0 12 37 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 38 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 39 1 0 0 0 0 18 40 1 0 0 0 0 21 22 1 0 0 0 0 21 41 1 0 0 0 0 22 23 1 0 0 0 0 22 42 1 0 0 0 0 22 43 1 0 0 0 0 23 24 1 0 0 0 0 23 44 1 0 0 0 0 23 45 1 0 0 0 0 24 25 1 0 0 0 0 24 46 1 0 0 0 0 24 47 1 0 0 0 0 25 26 1 0 0 0 0 25 48 1 0 0 0 0 25 49 1 0 0 0 0 26 27 1 0 0 0 0 26 50 1 0 0 0 0 26 51 1 0 0 0 0 27 30 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 28 52 1 0 0 0 0 28 53 1 0 0 0 0 29 54 1 0 0 0 0 29 55 1 0 0 0 0 29 56 1 0 0 0 0 30 31 1 0 0 0 0 30 57 1 0 0 0 0 30 58 1 0 0 0 0 31 59 1 0 0 0 0 31 60 1 0 0 0 0 31 61 1 0 0 0 0 M END > (302) 1,6-naphthyridin-2(1H)-one deriv. 7g > (302) PDGFR-beta > (302) 740 > (302) -1 > (302) P > (302) PDGFR-P300 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 52 csChFnd70/05150717532D 66 69 0 0 0 0 0 0 0 0999 V2000 3.9898 16.0158 0.0121 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5029 13.4202 -0.0164 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0131 14.3018 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0366 14.1909 -0.0268 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5840 16.9093 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1485 15.9284 -0.0186 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6678 18.7344 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7963 18.4467 -0.0220 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2969 19.5054 -0.0020 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6842 16.7369 -0.0295 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4633 21.4265 0.0054 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7117 24.1166 1.5760 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7740 25.0164 0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5569 22.3267 1.5780 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5343 22.3407 -1.5600 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6893 24.1306 -1.5443 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4782 21.1999 3.5330 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4289 21.2315 -3.5238 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7591 10.7283 -0.0129 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0551 8.7604 -0.0258 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4410 11.6237 -0.0248 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2985 7.8252 -0.0133 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4249 19.2239 -0.0338 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8697 18.2315 -0.0529 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7460 16.6551 -0.0597 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8934 5.4489 -1.3289 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2267 3.4888 -1.2294 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2771 3.0385 -0.2248 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9440 4.9985 -0.3242 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5829 5.9359 -0.0256 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5878 2.5514 -1.5280 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8720 0.6620 -1.5402 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4517 18.9866 -0.0646 N 0 0 3 0 0 0 0 0 0 0 0 0 15.0221 17.9077 -0.0853 C 0 0 0 0 0 0 0 0 0 0 0 0 16.6070 19.0611 -0.0949 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8057 18.8719 1.1012 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7730 16.7177 0.0217 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4985 19.5128 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7848 24.8150 2.7927 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8952 26.4158 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7439 24.8401 -2.7555 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0166 11.1020 -1.1614 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0391 11.0903 1.1536 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7750 8.3985 -1.1922 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7975 8.3867 1.1229 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5112 10.9558 -0.0386 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5786 8.1874 1.1532 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5561 8.1989 -1.1617 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5236 20.4818 -0.0285 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0998 6.1474 -1.0704 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4208 5.7832 -2.6229 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1706 3.1185 -2.2202 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7329 3.1595 0.0533 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7499 2.7041 1.0693 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0707 2.3399 -0.4832 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4378 5.3278 -1.6069 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3688 0.6667 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4067 0.2565 -0.2915 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6384 0.0000 -1.7637 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7820 0.3278 -2.5748 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5504 20.2443 -0.0592 H 0 0 0 0 0 0 0 0 0 0 0 0 15.0446 17.0834 1.0678 H 0 0 0 0 0 0 0 0 0 0 0 0 15.0220 17.0951 -1.2471 H 0 0 0 0 0 0 0 0 0 0 0 0 16.7547 20.0435 -1.0880 H 0 0 0 0 0 0 0 0 0 0 0 0 18.9414 19.6984 1.0943 H 0 0 0 0 0 0 0 0 0 0 0 0 17.6579 17.8893 2.0942 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 37 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 21 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 38 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 39 1 0 0 0 0 13 16 1 0 0 0 0 13 40 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 41 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 42 1 0 0 0 0 19 43 1 0 0 0 0 20 22 1 0 0 0 0 20 44 1 0 0 0 0 20 45 1 0 0 0 0 21 46 1 0 0 0 0 22 30 1 0 0 0 0 22 47 1 0 0 0 0 22 48 1 0 0 0 0 23 24 1 0 0 0 0 23 49 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 50 1 0 0 0 0 26 51 1 0 0 0 0 27 31 1 0 0 0 0 27 52 1 0 0 0 0 27 53 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 54 1 0 0 0 0 28 55 1 0 0 0 0 29 30 1 0 0 0 0 29 56 1 0 0 0 0 29 57 1 0 0 0 0 31 32 1 0 0 0 0 32 58 1 0 0 0 0 32 59 1 0 0 0 0 32 60 1 0 0 0 0 33 34 1 0 0 0 0 33 61 1 0 0 0 0 34 35 1 0 0 0 0 34 62 1 0 0 0 0 34 63 1 0 0 0 0 35 36 2 0 0 0 0 35 64 1 0 0 0 0 36 65 1 0 0 0 0 36 66 1 0 0 0 0 M END > (309) 6-arylpyrido[2,3-d]pyrimidine deriv. 52 > (309) PDGFR-beta > (309) 760 > (309) -1 > (309) P > (309) PDGFR-P307 $$$$ 1,6-naphthyridin-2(1H)-one deriv. 8r csChFnd70/05150717532D 63 66 0 0 0 0 0 0 0 0999 V2000 9.8497 11.1902 3.8493 C 0 0 0 0 0 0 0 0 0 0 0 0 11.0277 12.9005 1.6474 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5214 13.9043 1.5105 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2826 12.1356 3.7986 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1148 13.5289 2.5975 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8773 11.7147 4.9262 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3688 12.6724 4.8324 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2379 14.1087 3.5722 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8979 14.9656 3.4822 O 0 0 0 0 0 0 0 0 0 0 0 0 11.1431 11.5982 2.7917 N 0 0 0 0 0 0 0 0 0 0 0 0 6.5934 14.4856 2.5115 N 0 0 3 0 0 0 0 0 0 0 0 0 3.8774 12.2588 5.9975 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3454 12.6718 8.7096 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7393 13.0627 7.6299 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6005 11.0691 5.4644 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2131 10.6897 6.5567 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0877 11.4861 8.1759 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3166 14.5504 8.3022 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.7551 10.0689 3.4324 Cl 0 0 0 0 0 0 0 0 0 0 0 0 12.4403 13.2641 0.5680 N 0 0 3 0 0 0 0 0 0 0 0 0 13.9044 12.1656 0.5756 C 0 0 0 0 0 0 0 0 0 0 0 0 17.0075 11.7771 0.3372 C 0 0 0 0 0 0 0 0 0 0 0 0 16.8008 9.9929 0.5907 C 0 0 0 0 0 0 0 0 0 0 0 0 15.1433 9.2955 0.8290 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6981 10.3783 0.8217 C 0 0 0 0 0 0 0 0 0 0 0 0 15.5637 12.8616 0.3295 C 0 0 0 0 0 0 0 0 0 0 0 0 18.2232 8.9257 0.5981 O 0 0 0 0 0 0 0 0 0 0 0 0 17.9145 7.1025 0.8662 C 0 0 0 0 0 0 0 0 0 0 0 0 19.6565 6.1191 0.8328 C 0 0 0 0 0 0 0 0 0 0 0 0 19.3261 4.1670 1.1199 C 0 0 0 0 0 0 0 0 0 0 0 0 20.9987 3.2228 1.0878 N 0 0 0 0 0 0 0 0 0 0 0 0 20.7735 1.4039 1.6629 C 0 0 0 0 0 0 0 0 0 0 0 0 20.5573 1.3550 3.6513 C 0 0 0 0 0 0 0 0 0 0 0 0 21.7990 3.2991 -0.6568 C 0 0 0 0 0 0 0 0 0 0 0 0 23.7276 2.7826 -0.5289 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9990 10.1252 4.7648 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4445 14.9599 0.5755 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9937 10.6513 5.8483 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4959 15.4390 1.6806 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2370 13.2930 9.9732 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2237 9.7697 6.1455 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 11.1853 9.0250 H 0 0 0 0 0 0 0 0 0 0 0 0 12.4131 14.2795 -0.1917 H 0 0 0 0 0 0 0 0 0 0 0 0 18.2984 12.3190 0.1522 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9835 7.9063 1.0262 H 0 0 0 0 0 0 0 0 0 0 0 0 12.4077 9.8352 1.0078 H 0 0 0 0 0 0 0 0 0 0 0 0 15.7248 14.2507 0.1318 H 0 0 0 0 0 0 0 0 0 0 0 0 17.2834 6.9080 2.1294 H 0 0 0 0 0 0 0 0 0 0 0 0 17.0691 6.6065 -0.1687 H 0 0 0 0 0 0 0 0 0 0 0 0 20.2877 6.3135 -0.4302 H 0 0 0 0 0 0 0 0 0 0 0 0 20.5019 6.6150 1.8677 H 0 0 0 0 0 0 0 0 0 0 0 0 18.6949 3.9725 2.3829 H 0 0 0 0 0 0 0 0 0 0 0 0 18.4807 3.6710 0.0850 H 0 0 0 0 0 0 0 0 0 0 0 0 19.6144 0.8502 1.0453 H 0 0 0 0 0 0 0 0 0 0 0 0 21.9197 0.6426 1.2908 H 0 0 0 0 0 0 0 0 0 0 0 0 21.6563 2.0236 4.2653 H 0 0 0 0 0 0 0 0 0 0 0 0 19.3424 2.0065 4.0133 H 0 0 0 0 0 0 0 0 0 0 0 0 20.5194 0.0000 4.0920 H 0 0 0 0 0 0 0 0 0 0 0 0 21.1225 2.3978 -1.5297 H 0 0 0 0 0 0 0 0 0 0 0 0 21.6951 4.6250 -1.1695 H 0 0 0 0 0 0 0 0 0 0 0 0 24.4102 3.7013 0.3205 H 0 0 0 0 0 0 0 0 0 0 0 0 23.8325 1.4678 0.0114 H 0 0 0 0 0 0 0 0 0 0 0 0 24.3140 2.8107 -1.8278 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 36 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 20 1 0 0 0 0 3 5 2 0 0 0 0 3 37 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 38 1 0 0 0 0 7 8 1 0 0 0 0 7 12 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 39 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 40 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 41 1 0 0 0 0 17 42 1 0 0 0 0 20 21 1 0 0 0 0 20 43 1 0 0 0 0 21 25 2 0 0 0 0 21 26 1 0 0 0 0 22 23 1 0 0 0 0 22 26 2 0 0 0 0 22 44 1 0 0 0 0 23 24 2 0 0 0 0 23 27 1 0 0 0 0 24 25 1 0 0 0 0 24 45 1 0 0 0 0 25 46 1 0 0 0 0 26 47 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 28 48 1 0 0 0 0 28 49 1 0 0 0 0 29 30 1 0 0 0 0 29 50 1 0 0 0 0 29 51 1 0 0 0 0 30 31 1 0 0 0 0 30 52 1 0 0 0 0 30 53 1 0 0 0 0 31 32 1 0 0 0 0 31 34 1 0 0 0 0 32 33 1 0 0 0 0 32 54 1 0 0 0 0 32 55 1 0 0 0 0 33 56 1 0 0 0 0 33 57 1 0 0 0 0 33 58 1 0 0 0 0 34 35 1 0 0 0 0 34 59 1 0 0 0 0 34 60 1 0 0 0 0 35 61 1 0 0 0 0 35 62 1 0 0 0 0 35 63 1 0 0 0 0 M END > (311) 1,6-naphthyridin-2(1H)-one deriv. 8r > (311) PDGFR-beta > (311) 790 > (311) -1 > (311) P > (311) PDGFR-P309 $$$$ csChFnd70/05150717532D 44 47 0 0 0 0 0 0 0 0999 V2000 4.2846 8.4107 0.0168 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1759 6.6967 -0.0028 N 0 0 0 0 0 0 0 0 0 0 0 0 4.3060 6.7811 0.0014 N 0 0 0 0 0 0 0 0 0 0 0 0 5.7953 9.2601 0.0230 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2724 8.3346 0.0125 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8518 11.0049 0.0388 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8655 10.7791 0.0352 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2095 11.4551 0.0415 O 0 0 0 0 0 0 0 0 0 0 0 0 8.7749 9.1181 0.0186 N 0 0 3 0 0 0 0 0 0 0 0 0 7.3565 11.7763 0.0437 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4574 13.6033 0.0608 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4956 14.4817 -1.4213 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5897 16.1848 -1.3967 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6461 17.0195 0.0928 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6092 16.1560 1.5664 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5075 14.4532 1.5591 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4509 13.3724 3.4100 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4257 13.4365 -3.2920 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.7211 5.9502 -0.0081 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6725 4.2445 -0.0248 N 0 0 3 0 0 0 0 0 0 0 0 0 4.1608 3.4224 0.1150 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1682 1.7954 0.3916 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4062 1.1417 -0.5866 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9013 1.9506 -0.7274 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9171 4.0719 1.1021 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4250 3.2567 1.2375 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2958 8.1383 0.0075 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8236 7.8146 -1.7778 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1289 9.0766 0.0190 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7250 11.7187 0.0464 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6199 16.8663 -2.5430 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7196 18.3513 0.1052 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6541 16.8150 2.7252 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6875 3.6173 -0.1334 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.1606 0.4992 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2020 0.0000 -1.2453 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8674 1.4397 -1.4919 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1169 5.2129 1.7635 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4555 3.7639 2.0005 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2690 8.8131 0.6478 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0785 6.9652 0.6310 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8503 7.1398 -2.4181 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0409 8.9878 -2.4012 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9552 7.0856 -1.7860 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 29 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 30 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 27 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 31 1 0 0 0 0 14 15 1 0 0 0 0 14 32 1 0 0 0 0 15 16 2 0 0 0 0 15 33 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 34 1 0 0 0 0 21 24 1 0 0 0 0 21 25 2 0 0 0 0 22 23 1 0 0 0 0 22 26 2 0 0 0 0 22 35 1 0 0 0 0 23 24 2 0 0 0 0 23 36 1 0 0 0 0 24 37 1 0 0 0 0 25 26 1 0 0 0 0 25 38 1 0 0 0 0 26 39 1 0 0 0 0 27 28 1 0 0 0 0 27 40 1 0 0 0 0 27 41 1 0 0 0 0 28 42 1 0 0 0 0 28 43 1 0 0 0 0 28 44 1 0 0 0 0 M END > (314) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 39 > (314) PDGFR-beta > (314) 800 > (314) -1 > (314) P > (314) PDGFR-P312 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 17 csChFnd70/05150717532D 74 76 0 0 0 0 0 0 0 0999 V2000 4.8668 13.2119 1.1043 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4065 10.6363 1.0385 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9154 11.5077 0.9452 N 0 0 0 0 0 0 0 0 0 0 0 0 7.9164 11.4082 1.2929 N 0 0 0 0 0 0 0 0 0 0 0 0 6.4348 14.1063 1.3776 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0015 13.1365 1.4702 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4908 15.9214 1.5592 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5985 15.6468 1.9021 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0953 16.6940 1.8244 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5129 13.9461 1.7280 N 0 0 0 0 0 0 0 0 0 0 0 0 8.2319 18.6054 2.0243 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2398 21.1382 3.8453 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6140 21.4337 0.7648 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4865 22.1743 2.3976 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1118 19.3585 3.6672 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8424 18.2314 5.2457 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4880 19.6554 0.5709 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6276 18.8503 -1.2085 C 0 0 0 0 0 0 0 0 0 0 0 0 11.2023 16.4258 2.1673 N 0 0 3 0 0 0 0 0 0 0 0 0 12.6506 15.4441 2.2443 C 0 0 0 0 0 0 0 0 0 0 0 0 12.5513 13.8760 2.0812 O 0 0 0 0 0 0 0 0 0 0 0 0 14.2087 16.2009 2.5018 N 0 0 3 0 0 0 0 0 0 0 0 0 15.7829 15.1337 2.5853 C 0 0 0 0 0 0 0 0 0 0 0 0 16.0056 14.1460 0.8745 C 0 0 0 0 0 0 0 0 0 0 0 0 17.3616 16.3042 2.8854 C 0 0 0 0 0 0 0 0 0 0 0 0 15.6254 13.8365 4.0836 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3718 8.8497 0.8621 N 0 0 3 0 0 0 0 0 0 0 0 0 4.7167 7.9532 0.5789 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0397 5.9972 0.4287 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3112 5.0609 0.1329 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6213 3.1831 -0.0112 N 0 0 0 0 0 0 0 0 0 0 0 0 1.9768 2.2143 0.0129 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2731 2.1497 1.8711 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6326 2.7751 -1.5778 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3641 0.9322 -1.4331 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6499 13.9061 1.0208 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3193 16.6912 1.4937 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1474 21.7230 5.1177 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8124 22.2485 -0.3603 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5858 23.5666 2.5431 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1000 17.8495 5.7733 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1197 18.9556 6.2251 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1125 17.0740 4.8803 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3395 18.7662 -1.7912 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4635 19.6511 -2.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1812 17.5514 -1.0969 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2815 17.6768 2.2974 H 0 0 0 0 0 0 0 0 0 0 0 0 14.2878 17.4519 2.6319 H 0 0 0 0 0 0 0 0 0 0 0 0 16.1178 15.0703 -0.1929 H 0 0 0 0 0 0 0 0 0 0 0 0 17.1768 13.3521 0.9367 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8808 13.3124 0.6609 H 0 0 0 0 0 0 0 0 0 0 0 0 17.2029 17.0078 4.1042 H 0 0 0 0 0 0 0 0 0 0 0 0 18.5328 15.5103 2.9475 H 0 0 0 0 0 0 0 0 0 0 0 0 17.4738 17.2283 1.8179 H 0 0 0 0 0 0 0 0 0 0 0 0 14.5006 13.0027 3.8700 H 0 0 0 0 0 0 0 0 0 0 0 0 16.7966 13.0426 4.1459 H 0 0 0 0 0 0 0 0 0 0 0 0 15.4667 14.5401 5.3026 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4435 8.1893 0.9258 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8500 8.2060 1.6701 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1218 8.4265 -0.6160 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9065 5.7444 -0.6625 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6347 5.5239 1.6237 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4445 5.3139 1.2241 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7163 5.5343 -1.0620 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0361 2.8600 -0.8260 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1988 0.8957 -0.4540 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.5291 1.8724 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1612 1.4067 2.6867 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1567 3.4670 2.3780 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7951 2.8624 -2.7166 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6995 3.6979 -1.7046 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2128 0.6731 -2.5370 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1030 0.8105 -0.2309 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2979 0.0000 -1.4282 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 36 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 27 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 37 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 19 1 0 0 0 0 9 11 1 0 0 0 0 11 15 2 0 0 0 0 11 17 1 0 0 0 0 12 15 1 0 0 0 0 12 14 2 0 0 0 0 12 38 1 0 0 0 0 13 17 2 0 0 0 0 13 14 1 0 0 0 0 13 39 1 0 0 0 0 14 40 1 0 0 0 0 15 16 1 0 0 0 0 16 41 1 0 0 0 0 16 42 1 0 0 0 0 16 43 1 0 0 0 0 17 18 1 0 0 0 0 18 44 1 0 0 0 0 18 45 1 0 0 0 0 18 46 1 0 0 0 0 19 20 1 0 0 0 0 19 47 1 0 0 0 0 20 22 1 0 0 0 0 20 21 2 0 0 0 0 22 23 1 0 0 0 0 22 48 1 0 0 0 0 23 24 1 0 0 0 0 23 25 1 0 0 0 0 23 26 1 0 0 0 0 24 49 1 0 0 0 0 24 50 1 0 0 0 0 24 51 1 0 0 0 0 25 52 1 0 0 0 0 25 53 1 0 0 0 0 25 54 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 26 57 1 0 0 0 0 27 28 1 0 0 0 0 27 58 1 0 0 0 0 28 29 1 0 0 0 0 28 59 1 0 0 0 0 28 60 1 0 0 0 0 29 30 1 0 0 0 0 29 61 1 0 0 0 0 29 62 1 0 0 0 0 30 31 1 0 0 0 0 30 63 1 0 0 0 0 30 64 1 0 0 0 0 31 32 1 0 0 0 0 31 34 1 0 0 0 0 32 33 1 0 0 0 0 32 65 1 0 0 0 0 32 66 1 0 0 0 0 33 67 1 0 0 0 0 33 68 1 0 0 0 0 33 69 1 0 0 0 0 34 35 1 0 0 0 0 34 70 1 0 0 0 0 34 71 1 0 0 0 0 35 72 1 0 0 0 0 35 73 1 0 0 0 0 35 74 1 0 0 0 0 M END > (321) 6-arylpyrido[2,3-d]pyrimidine deriv. 17 > (321) PDGFR-beta > (321) 800 > (321) -1 > (321) P > (321) PDGFR-P319 $$$$ Indolin-2-one deriv. 9d csChFnd70/05150717532D 48 51 0 0 0 0 0 0 0 0999 V2000 5.7174 4.6178 -0.1496 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6905 3.0271 -0.3930 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8982 2.3190 -1.1947 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1121 3.1783 -1.7442 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1531 4.7668 -1.5093 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9424 5.4807 -0.7056 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3198 7.1442 -0.6496 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7960 7.2859 -1.4656 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2217 5.8734 -1.9367 N 0 0 3 0 0 0 0 0 0 0 0 0 9.5102 8.4762 -1.6775 O 0 0 0 0 0 0 0 0 0 0 0 0 6.4680 8.3096 0.0235 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0867 9.8089 0.1337 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2666 11.1801 0.0447 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6171 10.1812 0.3564 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5530 11.3468 -0.1863 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7483 11.3749 1.3828 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0346 11.5416 1.1517 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5107 11.6290 -0.1358 O 0 0 0 0 0 0 0 0 0 0 0 0 1.0901 11.5929 2.3764 O 0 0 0 0 0 0 0 0 0 0 0 0 8.7499 11.7344 0.3970 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3271 12.3704 0.2100 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0141 14.0810 0.1994 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2063 12.6639 0.6130 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8879 14.3262 0.1041 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4172 14.9088 0.8859 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3941 2.0963 0.1931 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3471 2.7136 0.8891 O 0 0 0 0 0 0 0 0 0 0 0 0 4.3709 0.5613 -0.0433 O 0 0 0 0 0 0 0 0 0 0 0 0 4.7871 5.1733 0.4634 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8771 1.0884 -1.3828 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0380 2.6193 -2.3605 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1602 5.6558 -2.5045 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3286 8.0724 0.4652 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4570 9.4513 0.4660 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3152 12.4181 -0.7983 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1247 10.3761 -0.8594 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9861 10.3036 1.9947 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1765 12.3456 2.0559 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 11.7008 2.1705 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8288 14.4700 -0.9809 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9956 14.3290 0.8922 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5419 12.6490 1.8236 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1275 12.1758 -0.0882 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8543 15.0577 0.4350 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7442 14.3618 -1.1436 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3049 16.1466 0.7012 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4808 14.6733 2.1184 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4974 0.0000 0.3623 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 6 2 0 0 0 0 1 29 1 0 0 0 0 2 3 2 0 0 0 0 2 26 1 0 0 0 0 3 4 1 0 0 0 0 3 30 1 0 0 0 0 4 5 2 0 0 0 0 4 31 1 0 0 0 0 5 9 1 0 0 0 0 5 6 1 0 0 0 0 6 7 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 9 1 0 0 0 0 8 10 2 0 0 0 0 9 32 1 0 0 0 0 11 12 1 0 0 0 0 11 33 1 0 0 0 0 12 13 2 0 0 0 0 12 14 1 0 0 0 0 13 21 1 0 0 0 0 13 15 1 0 0 0 0 14 20 1 0 0 0 0 14 34 1 0 0 0 0 15 16 1 0 0 0 0 15 35 1 0 0 0 0 15 36 1 0 0 0 0 16 17 1 0 0 0 0 16 37 1 0 0 0 0 16 38 1 0 0 0 0 17 19 1 0 0 0 0 17 18 2 0 0 0 0 19 39 1 0 0 0 0 20 23 1 0 0 0 0 20 21 2 0 0 0 0 21 22 1 0 0 0 0 22 25 1 0 0 0 0 22 40 1 0 0 0 0 22 41 1 0 0 0 0 23 24 1 0 0 0 0 23 42 1 0 0 0 0 23 43 1 0 0 0 0 24 25 1 0 0 0 0 24 44 1 0 0 0 0 24 45 1 0 0 0 0 25 46 1 0 0 0 0 25 47 1 0 0 0 0 26 27 2 0 0 0 0 26 28 1 0 0 0 0 28 48 1 0 0 0 0 M END > (33) Indolin-2-one deriv. 9d > (33) PDGFR-beta > (33) 20 > (33) -1 > (33) P > (33) PDGFR-P31 $$$$ csChFnd70/05150717532D 31 33 0 0 0 0 0 0 0 0999 V2000 2.5165 7.0100 0.0109 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5379 5.4374 0.0023 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9412 4.6381 -0.0154 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3286 5.4440 -0.0244 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8906 7.8334 0.0023 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3106 7.0496 -0.0155 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2462 9.3831 0.0073 N 0 0 3 0 0 0 0 0 0 0 0 0 3.1924 10.6066 0.0248 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9803 10.6355 -1.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9431 11.8427 -0.9988 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4346 8.1402 -0.0205 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8126 9.5039 -0.0071 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3545 11.7890 1.0905 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3136 12.9931 1.1053 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1114 13.0220 0.0597 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9483 2.9376 -0.0241 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1637 2.2427 -0.0394 O 0 0 0 0 0 0 0 0 0 0 0 0 2.6069 2.1556 -0.0149 O 0 0 0 0 0 0 0 0 0 0 0 0 2.7015 0.4849 -0.0242 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4295 7.6160 0.0195 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4661 4.8047 0.0096 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4106 4.8292 -0.0377 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8487 9.7152 -1.8469 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 11.8659 -1.8107 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4451 10.5759 -0.0070 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2932 11.7670 1.9075 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4418 13.9156 1.9309 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2989 13.9648 0.0734 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3063 0.1057 -1.0577 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3264 0.0953 0.9934 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5427 0.0000 -0.0153 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 5 2 0 0 0 0 1 20 1 0 0 0 0 2 3 2 0 0 0 0 2 21 1 0 0 0 0 3 4 1 0 0 0 0 3 16 1 0 0 0 0 4 6 2 0 0 0 0 4 22 1 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 11 1 0 0 0 0 7 12 1 0 0 0 0 7 8 1 0 0 0 0 8 13 2 0 0 0 0 8 9 1 0 0 0 0 9 10 2 0 0 0 0 9 23 1 0 0 0 0 10 15 1 0 0 0 0 10 24 1 0 0 0 0 11 12 2 0 0 0 0 12 25 1 0 0 0 0 13 14 1 0 0 0 0 13 26 1 0 0 0 0 14 15 2 0 0 0 0 14 27 1 0 0 0 0 15 28 1 0 0 0 0 16 17 2 0 0 0 0 16 18 1 0 0 0 0 18 19 1 0 0 0 0 19 29 1 0 0 0 0 19 30 1 0 0 0 0 19 31 1 0 0 0 0 M END > (324) 1-Phenylbenzimidazole deriv. 68 > (324) PDGFR-beta > (324) 830 > (324) -1 > (324) P > (324) PDGFR-P322 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 43 csChFnd70/05150717532D 67 70 0 0 0 0 0 0 0 0999 V2000 3.9711 13.6327 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4791 11.0458 -0.0163 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9943 11.9244 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0077 11.8139 -0.0267 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5600 14.5231 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1192 13.5456 -0.0185 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6434 16.3421 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7615 16.0554 -0.0219 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2671 17.1105 -0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6497 14.3514 -0.0294 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4329 19.0252 0.0054 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6805 21.7062 1.5707 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7426 22.6030 0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5262 19.9224 1.5727 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5036 19.9364 -1.5548 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6582 21.7202 -1.5391 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4478 18.7994 3.5211 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.3986 18.8309 -3.5119 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7411 8.3630 -0.0128 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0362 6.4017 -0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2855 5.4696 -0.0132 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4174 9.2554 -0.0247 N 0 0 3 0 0 0 0 0 0 0 0 0 10.3846 16.8300 -0.0337 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8245 15.8409 -0.0528 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7012 14.2698 -0.0595 O 0 0 0 0 0 0 0 0 0 0 0 0 13.4012 16.5935 -0.0644 N 0 0 3 0 0 0 0 0 0 0 0 0 14.9664 15.5182 -0.0850 C 0 0 0 0 0 0 0 0 0 0 0 0 14.9661 14.3814 -1.7103 C 0 0 0 0 0 0 0 0 0 0 0 0 16.5700 16.6852 -0.0947 C 0 0 0 0 0 0 0 0 0 0 0 0 14.9977 14.3651 1.5283 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8719 3.1005 -1.3283 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1829 1.1422 -1.2441 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2754 0.6983 -0.2490 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9349 2.6521 -0.3232 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5689 3.5866 -0.0255 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5741 0.2561 -1.4959 O 0 0 0 0 0 0 0 0 0 0 0 0 2.7584 14.3322 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4781 17.1179 0.0247 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7533 22.4023 2.7833 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8634 23.9977 0.0247 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7126 22.4274 -2.7462 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0012 8.7354 -1.1575 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0236 8.7237 1.1497 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7537 6.0409 -1.1882 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7761 6.0292 1.1191 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5680 5.8305 1.1493 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5456 5.8420 -1.1578 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4840 8.5897 -0.0385 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4830 18.0837 -0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4996 17.8470 -0.0590 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9438 15.2029 -2.8596 H 0 0 0 0 0 0 0 0 0 0 0 0 16.1307 13.5815 -1.7256 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8236 13.5501 -1.7033 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5703 17.4950 1.0631 H 0 0 0 0 0 0 0 0 0 0 0 0 17.7346 15.8853 -0.1102 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5477 17.5067 -1.2442 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8553 13.5337 1.5352 H 0 0 0 0 0 0 0 0 0 0 0 0 16.1623 13.5650 1.5129 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9979 15.1749 2.6862 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0810 3.7821 -1.0636 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4050 3.4491 -2.6156 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0931 0.7649 -2.2570 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7156 0.8031 0.0200 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7234 0.3462 1.0440 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0826 0.0000 -0.5422 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4209 2.9934 -1.5943 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.0064 0.6752 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 37 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 22 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 38 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 39 1 0 0 0 0 13 16 1 0 0 0 0 13 40 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 41 1 0 0 0 0 19 22 1 0 0 0 0 19 20 1 0 0 0 0 19 42 1 0 0 0 0 19 43 1 0 0 0 0 20 21 1 0 0 0 0 20 44 1 0 0 0 0 20 45 1 0 0 0 0 21 35 1 0 0 0 0 21 46 1 0 0 0 0 21 47 1 0 0 0 0 22 48 1 0 0 0 0 23 24 1 0 0 0 0 23 49 1 0 0 0 0 24 26 1 0 0 0 0 24 25 2 0 0 0 0 26 27 1 0 0 0 0 26 50 1 0 0 0 0 27 28 1 0 0 0 0 27 29 1 0 0 0 0 27 30 1 0 0 0 0 28 51 1 0 0 0 0 28 52 1 0 0 0 0 28 53 1 0 0 0 0 29 54 1 0 0 0 0 29 55 1 0 0 0 0 29 56 1 0 0 0 0 30 57 1 0 0 0 0 30 58 1 0 0 0 0 30 59 1 0 0 0 0 31 35 1 0 0 0 0 31 32 1 0 0 0 0 31 60 1 0 0 0 0 31 61 1 0 0 0 0 32 36 1 0 0 0 0 32 62 1 0 0 0 0 32 63 1 0 0 0 0 33 36 1 0 0 0 0 33 34 1 0 0 0 0 33 64 1 0 0 0 0 33 65 1 0 0 0 0 34 35 1 0 0 0 0 34 66 1 0 0 0 0 34 67 1 0 0 0 0 M END > (328) 6-arylpyrido[2,3-d]pyrimidine deriv. 43 > (328) PDGFR-beta > (328) 840 > (328) -1 > (328) P > (328) PDGFR-P326 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 66 csChFnd70/05150717532D 72 76 0 0 0 0 0 0 0 0999 V2000 3.9441 15.8489 1.4064 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4196 13.2844 1.6319 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9604 14.1757 1.6607 N 0 0 0 0 0 0 0 0 0 0 0 0 6.9274 14.0051 1.3507 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5126 16.6886 1.1000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0441 15.6993 1.0781 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6016 18.4683 0.8169 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6710 18.1234 0.5214 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2033 19.1874 0.5247 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5542 16.4569 0.7903 N 0 0 0 0 0 0 0 0 0 0 0 0 7.3738 21.0592 0.2175 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7846 23.9199 1.2995 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6921 24.5565 -0.3566 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6268 22.1775 1.5943 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2890 21.7085 -1.4503 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4487 23.4536 -1.7280 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7426 21.3810 3.6739 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.9843 20.3262 -3.1733 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.6979 10.6927 2.2251 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9812 8.7658 2.4887 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3520 11.5322 1.9085 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2537 7.8890 2.8193 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2720 18.8485 0.2276 N 0 0 3 0 0 0 0 0 0 0 0 0 11.6862 17.8499 0.2198 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5587 16.3138 0.4700 O 0 0 0 0 0 0 0 0 0 0 0 0 3.6805 5.3384 1.7538 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0113 3.4357 2.1215 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2133 3.2073 3.4576 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8825 5.1099 3.0900 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5256 6.0389 3.0724 N 0 0 0 0 0 0 0 0 0 0 0 0 2.3684 2.5066 2.1391 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6402 0.6566 2.3921 C 0 0 0 0 0 0 0 0 0 0 0 0 13.2416 18.5543 -0.0655 N 0 0 3 0 0 0 0 0 0 0 0 0 14.7219 17.5412 0.0500 C 0 0 0 0 0 0 0 0 0 0 0 0 14.6831 15.8384 -0.4797 C 0 0 0 0 0 0 0 0 0 0 0 0 16.1464 14.8420 -0.3647 C 0 0 0 0 0 0 0 0 0 0 0 0 16.2348 18.2386 0.6877 C 0 0 0 0 0 0 0 0 0 0 0 0 17.6489 15.5382 0.2778 C 0 0 0 0 0 0 0 0 0 0 0 0 17.6937 17.2355 0.7996 C 0 0 0 0 0 0 0 0 0 0 0 0 19.2429 14.4470 0.4028 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7521 16.5581 1.4271 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4569 19.2518 0.8262 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9810 24.7871 2.3645 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8162 25.9200 -0.5803 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3829 23.9579 -3.0187 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8543 10.8944 1.1261 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1093 11.2390 3.3719 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5699 8.2195 1.3419 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8248 8.5642 3.5876 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3999 10.8583 1.8930 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6650 8.4353 3.9661 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4100 8.0907 1.7203 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3737 20.0741 0.0280 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8939 6.0365 1.7771 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0870 5.4743 0.4931 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8379 2.9041 1.1242 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6368 3.3024 3.3671 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8069 3.0714 4.7183 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.5091 3.4344 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2572 5.2432 1.8444 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0560 5.6415 4.0873 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2897 0.4432 3.6139 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4037 0.0000 2.4000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4290 0.1540 1.3503 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3351 19.7635 -0.3509 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5098 15.2936 -0.9808 H 0 0 0 0 0 0 0 0 0 0 0 0 16.1171 13.5176 -0.7765 H 0 0 0 0 0 0 0 0 0 0 0 0 16.2706 19.5641 1.0954 H 0 0 0 0 0 0 0 0 0 0 0 0 18.8693 17.7757 1.3004 H 0 0 0 0 0 0 0 0 0 0 0 0 19.9764 14.5544 -0.7849 H 0 0 0 0 0 0 0 0 0 0 0 0 20.0265 14.8867 1.4765 H 0 0 0 0 0 0 0 0 0 0 0 0 18.8788 13.1106 0.6073 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 41 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 21 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 42 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 43 1 0 0 0 0 13 16 1 0 0 0 0 13 44 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 45 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 46 1 0 0 0 0 19 47 1 0 0 0 0 20 22 1 0 0 0 0 20 48 1 0 0 0 0 20 49 1 0 0 0 0 21 50 1 0 0 0 0 22 30 1 0 0 0 0 22 51 1 0 0 0 0 22 52 1 0 0 0 0 23 24 1 0 0 0 0 23 53 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 54 1 0 0 0 0 26 55 1 0 0 0 0 27 31 1 0 0 0 0 27 56 1 0 0 0 0 27 57 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 58 1 0 0 0 0 28 59 1 0 0 0 0 29 30 1 0 0 0 0 29 60 1 0 0 0 0 29 61 1 0 0 0 0 31 32 1 0 0 0 0 32 62 1 0 0 0 0 32 63 1 0 0 0 0 32 64 1 0 0 0 0 33 34 1 0 0 0 0 33 65 1 0 0 0 0 34 35 2 0 0 0 0 34 37 1 0 0 0 0 35 36 1 0 0 0 0 35 66 1 0 0 0 0 36 38 2 0 0 0 0 36 67 1 0 0 0 0 37 39 2 0 0 0 0 37 68 1 0 0 0 0 38 39 1 0 0 0 0 38 40 1 0 0 0 0 39 69 1 0 0 0 0 40 70 1 0 0 0 0 40 71 1 0 0 0 0 40 72 1 0 0 0 0 M END > (329) 6-arylpyrido[2,3-d]pyrimidine deriv. 66 > (329) PDGFR-beta > (329) 840 > (329) -1 > (329) P > (329) PDGFR-P327 $$$$ Indolin-2-one deriv. 9h csChFnd70/05150717532D 59 63 0 0 0 0 0 0 0 0999 V2000 6.5597 9.5233 0.1770 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5816 7.7498 0.2312 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1501 6.8694 0.2159 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6969 7.7745 0.1457 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6859 9.5615 0.0907 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1032 10.4347 0.1068 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5162 12.2939 0.0374 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4059 12.3777 -0.0170 C 0 0 0 0 0 0 0 0 0 0 0 0 11.0160 10.7580 0.0165 N 0 0 3 0 0 0 0 0 0 0 0 0 11.2691 13.6869 -0.0823 O 0 0 0 0 0 0 0 0 0 0 0 0 7.3712 13.6578 0.0255 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9862 15.3614 0.1654 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2778 16.8090 -0.6102 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3979 15.8961 1.1045 N 0 0 3 0 0 0 0 0 0 0 0 0 5.7118 16.8559 -1.7569 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1004 17.1389 -0.6572 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5344 17.1858 -1.8039 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6910 17.0109 -3.3427 O 0 0 0 0 0 0 0 0 0 0 0 0 0.9656 17.4220 -1.1157 O 0 0 0 0 0 0 0 0 0 0 0 0 9.5708 17.6200 0.9151 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2877 18.2074 -0.1271 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0531 20.0706 -0.6283 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9354 18.7624 1.7022 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9525 20.4782 0.7238 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1152 21.1869 0.6084 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1684 4.9605 0.2751 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2030 4.0843 1.5186 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2279 2.2998 1.5644 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2038 1.3908 0.3848 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1605 2.2541 -0.8473 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1420 4.0307 -0.9127 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2448 4.9794 2.6778 O 0 0 0 0 0 0 0 0 0 0 0 0 5.2920 3.9978 3.9100 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3470 10.2058 0.1831 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3858 7.0403 0.2863 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9059 7.0858 0.1346 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2299 10.4618 -0.0072 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0054 13.4185 -0.0908 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1418 15.1591 1.7867 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8389 17.9064 -2.6800 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5999 15.6377 -2.4464 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9734 16.0884 0.2659 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2124 18.3571 0.0323 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 17.4426 -1.9028 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5005 20.2661 -1.9449 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6961 20.4188 -0.5326 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6370 18.9923 3.0549 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1910 18.1432 1.5929 H 0 0 0 0 0 0 0 0 0 0 0 0 11.7653 21.3978 1.4064 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4610 20.2745 -0.5692 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1506 22.5080 0.1332 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5267 21.1635 1.8831 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4844 1.6188 2.5232 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2202 0.0000 0.4252 H 0 0 0 0 0 0 0 0 0 0 0 0 9.9199 1.5347 -1.7648 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8854 4.6999 -1.8800 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3871 3.1579 3.2407 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1769 3.2190 4.6732 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5853 4.8678 4.7559 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 6 2 0 0 0 0 1 34 1 0 0 0 0 2 3 2 0 0 0 0 2 35 1 0 0 0 0 3 4 1 0 0 0 0 3 26 1 0 0 0 0 4 5 2 0 0 0 0 4 36 1 0 0 0 0 5 9 1 0 0 0 0 5 6 1 0 0 0 0 6 7 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 9 1 0 0 0 0 8 10 2 0 0 0 0 9 37 1 0 0 0 0 11 12 1 0 0 0 0 11 38 1 0 0 0 0 12 13 2 0 0 0 0 12 14 1 0 0 0 0 13 21 1 0 0 0 0 13 15 1 0 0 0 0 14 20 1 0 0 0 0 14 39 1 0 0 0 0 15 16 1 0 0 0 0 15 40 1 0 0 0 0 15 41 1 0 0 0 0 16 17 1 0 0 0 0 16 42 1 0 0 0 0 16 43 1 0 0 0 0 17 19 1 0 0 0 0 17 18 2 0 0 0 0 19 44 1 0 0 0 0 20 23 1 0 0 0 0 20 21 2 0 0 0 0 21 22 1 0 0 0 0 22 25 1 0 0 0 0 22 45 1 0 0 0 0 22 46 1 0 0 0 0 23 24 1 0 0 0 0 23 47 1 0 0 0 0 23 48 1 0 0 0 0 24 25 1 0 0 0 0 24 49 1 0 0 0 0 24 50 1 0 0 0 0 25 51 1 0 0 0 0 25 52 1 0 0 0 0 26 31 1 0 0 0 0 26 27 2 0 0 0 0 27 28 1 0 0 0 0 27 32 1 0 0 0 0 28 29 2 0 0 0 0 28 53 1 0 0 0 0 29 30 1 0 0 0 0 29 54 1 0 0 0 0 30 31 2 0 0 0 0 30 55 1 0 0 0 0 31 56 1 0 0 0 0 32 33 1 0 0 0 0 33 57 1 0 0 0 0 33 58 1 0 0 0 0 33 59 1 0 0 0 0 M END > (336) Indolin-2-one deriv. 9h > (336) PDGFR-beta > (336) 870 > (336) -1 > (336) P > (336) PDGFR-P334 $$$$ Pyrazine-Pyridine Biheteroaryl 56 csChFnd70/05150717532D 51 54 0 0 0 0 0 0 0 0999 V2000 1.0493 14.9411 -0.0846 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3562 12.7694 -0.3512 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6854 13.5681 -0.3824 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3738 15.7481 -0.1148 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0754 13.4765 -0.2033 N 0 0 0 0 0 0 0 0 0 0 0 0 3.6624 15.0439 -0.2629 N 0 0 0 0 0 0 0 0 0 0 0 0 5.1240 12.7741 -0.5479 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4600 13.5629 -0.5803 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8177 11.4028 -0.8481 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5381 10.5336 -0.8198 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1606 11.2245 -0.6671 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7402 12.8636 -0.7271 N 0 0 0 0 0 0 0 0 0 0 0 0 3.6754 18.0886 0.1190 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7918 19.4924 -0.5182 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8833 17.4813 0.8705 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1975 18.2716 0.9765 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3129 19.6669 0.3362 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1105 20.2781 -0.4082 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2581 22.0331 -1.2040 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.3440 17.2911 0.0099 N 0 0 3 0 0 0 0 0 0 0 0 0 8.0892 8.2704 -1.1168 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6334 8.9864 -0.9495 N 0 0 3 0 0 0 0 0 0 0 0 0 7.8822 6.5838 -1.2346 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4024 5.8359 -1.4093 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1985 4.1747 -1.5254 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0037 3.5080 -2.8979 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2103 3.2953 -0.2566 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0184 1.7724 -0.4168 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8231 1.1853 -1.8257 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8239 2.0550 -3.0082 N 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 15.5144 0.0411 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3730 11.5712 -0.4484 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4450 14.7613 -0.4845 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8909 10.8738 -0.9665 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1463 10.5795 -0.6409 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8535 19.9695 -1.0991 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7941 16.3920 1.3716 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1364 17.7996 1.5607 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3419 20.2828 0.4215 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3990 17.8136 0.0213 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6297 8.6827 -2.1219 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7794 8.5268 -0.1522 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7358 8.3865 -0.9289 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3416 6.1714 -0.2294 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1921 6.3274 -2.1992 H 0 0 0 0 0 0 0 0 0 0 0 0 9.9429 6.2483 -2.4144 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0925 6.0923 -0.4446 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9980 4.1845 -3.8917 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3657 3.7851 0.8304 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0218 1.0537 0.5471 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6728 0.0000 -1.9600 H 0 0 0 0 0 0 0 0 0 0 0 0 1 5 1 0 0 0 0 1 4 2 0 0 0 0 1 31 1 0 0 0 0 2 5 2 0 0 0 0 2 3 1 0 0 0 0 2 32 1 0 0 0 0 3 6 2 0 0 0 0 3 7 1 0 0 0 0 4 6 1 0 0 0 0 4 20 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 12 2 0 0 0 0 8 33 1 0 0 0 0 9 12 1 0 0 0 0 9 10 2 0 0 0 0 9 34 1 0 0 0 0 10 11 1 0 0 0 0 10 22 1 0 0 0 0 11 35 1 0 0 0 0 13 20 1 0 0 0 0 13 14 2 0 0 0 0 13 15 1 0 0 0 0 14 18 1 0 0 0 0 14 36 1 0 0 0 0 15 16 2 0 0 0 0 15 37 1 0 0 0 0 16 17 1 0 0 0 0 16 38 1 0 0 0 0 17 18 2 0 0 0 0 17 39 1 0 0 0 0 18 19 1 0 0 0 0 20 40 1 0 0 0 0 21 22 1 0 0 0 0 21 23 1 0 0 0 0 21 41 1 0 0 0 0 21 42 1 0 0 0 0 22 43 1 0 0 0 0 23 24 1 0 0 0 0 23 44 1 0 0 0 0 23 45 1 0 0 0 0 24 25 1 0 0 0 0 24 46 1 0 0 0 0 24 47 1 0 0 0 0 25 26 2 0 0 0 0 25 27 1 0 0 0 0 26 30 1 0 0 0 0 26 48 1 0 0 0 0 27 28 2 0 0 0 0 27 49 1 0 0 0 0 28 29 1 0 0 0 0 28 50 1 0 0 0 0 29 30 2 0 0 0 0 29 51 1 0 0 0 0 M END > (339) Pyrazine-Pyridine Biheteroaryl 56 > (339) PDGFR-beta > (339) 876 > (339) -1 > (339) P > (339) PDGFR-P337 $$$$ csChFnd70/05150717532D 60 63 0 0 0 0 0 0 0 0999 V2000 8.2802 15.3170 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3156 13.5192 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 8.3034 13.6063 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 9.8654 16.2093 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4162 15.2386 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9239 18.0410 0.0104 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0872 17.8054 -0.0216 C 0 0 0 0 0 0 0 0 0 0 0 0 14.4975 18.5158 -0.0319 O 0 0 0 0 0 0 0 0 0 0 0 0 12.9927 16.0619 -0.0296 N 0 0 3 0 0 0 0 0 0 0 0 0 14.5896 15.0341 -0.0497 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5029 18.8513 -0.0009 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6079 20.7692 0.0083 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6345 21.6851 -1.5515 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7320 23.4728 -1.5337 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8037 24.3554 0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7784 23.4553 1.5764 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6731 21.6678 1.5769 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6320 20.5410 3.5247 Cl 0 0 0 0 0 0 0 0 0 0 0 0 11.5461 20.5798 -3.5098 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.7891 12.7349 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7390 10.9457 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 8.0684 10.0426 -0.0156 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3762 8.0831 -0.0296 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6315 7.1398 -0.0187 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9391 5.1803 -0.0327 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7349 1.5006 -0.2204 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4935 2.4109 -0.3438 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0660 5.0401 -1.2904 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3074 4.1298 -1.1670 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5369 2.2660 -1.4886 N 0 0 0 0 0 0 0 0 0 0 0 0 0.8617 1.3603 -1.4781 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2640 4.2746 -0.0222 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0668 16.0154 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7410 18.7897 0.0253 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9729 14.7855 -1.3869 H 0 0 0 0 0 0 0 0 0 0 0 0 15.6164 15.7462 0.6099 H 0 0 0 0 0 0 0 0 0 0 0 0 14.3676 13.8058 0.6128 H 0 0 0 0 0 0 0 0 0 0 0 0 11.7526 24.1832 -2.7400 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8803 25.7534 0.0324 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8353 24.1519 2.7896 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8100 10.2869 -0.0398 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3481 10.3979 1.1470 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3266 10.4110 -1.1603 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0964 7.7277 -1.1921 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1181 7.7146 1.1151 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9111 7.4952 1.1439 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8896 7.5082 -1.1634 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6595 4.8250 -1.1953 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6811 4.8119 1.1120 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8963 0.1239 -0.4956 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2102 1.6631 1.0816 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3727 1.8707 0.6214 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0344 2.2185 -1.6350 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5907 4.8775 -2.5924 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9046 6.4167 -1.0153 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7666 4.3221 0.1242 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4281 4.6700 -2.1323 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2826 1.4558 -0.1928 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.9529 -2.4284 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0596 0.0000 -1.8056 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 33 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 34 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 35 1 0 0 0 0 10 36 1 0 0 0 0 10 37 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 38 1 0 0 0 0 15 16 1 0 0 0 0 15 39 1 0 0 0 0 16 17 2 0 0 0 0 16 40 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 41 1 0 0 0 0 22 23 1 0 0 0 0 22 42 1 0 0 0 0 22 43 1 0 0 0 0 23 24 1 0 0 0 0 23 44 1 0 0 0 0 23 45 1 0 0 0 0 24 25 1 0 0 0 0 24 46 1 0 0 0 0 24 47 1 0 0 0 0 25 32 1 0 0 0 0 25 48 1 0 0 0 0 25 49 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 50 1 0 0 0 0 26 51 1 0 0 0 0 27 32 1 0 0 0 0 27 52 1 0 0 0 0 27 53 1 0 0 0 0 28 32 1 0 0 0 0 28 29 1 0 0 0 0 28 54 1 0 0 0 0 28 55 1 0 0 0 0 29 30 1 0 0 0 0 29 56 1 0 0 0 0 29 57 1 0 0 0 0 30 31 1 0 0 0 0 31 58 1 0 0 0 0 31 59 1 0 0 0 0 31 60 1 0 0 0 0 M END > (341) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 32 > (341) PDGFR-beta > (341) 890 > (341) -1 > (341) P > (341) PDGFR-P339 $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7t csChFnd70/05150717532D 69 73 0 0 0 0 0 0 0 0999 V2000 10.0293 10.8246 3.0265 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1238 12.6969 0.9437 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5280 13.5057 0.7167 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3751 11.5668 2.8798 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1187 12.9431 1.6938 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9699 10.9586 3.8967 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3747 11.7207 3.7116 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1531 13.1452 2.4698 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7361 13.8287 2.2993 O 0 0 0 0 0 0 0 0 0 0 0 0 11.3214 11.4050 2.0712 N 0 0 0 0 0 0 0 0 0 0 0 0 6.5103 13.7025 1.5153 N 0 0 3 0 0 0 0 0 0 0 0 0 6.2719 15.1284 0.2777 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8814 11.1086 4.7599 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1444 11.2757 7.3478 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5386 11.8523 6.3770 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8071 9.7907 4.1312 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4171 9.2261 5.1149 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0886 9.9642 6.7200 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8621 13.4984 7.1672 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.2164 8.8638 2.1165 Cl 0 0 0 0 0 0 0 0 0 0 0 0 12.5400 13.2485 -0.0253 N 0 0 3 0 0 0 0 0 0 0 0 0 14.1155 12.3458 0.0721 C 0 0 0 0 0 0 0 0 0 0 0 0 17.2303 12.3429 0.0030 C 0 0 0 0 0 0 0 0 0 0 0 0 15.6728 9.6702 0.4215 C 0 0 0 0 0 0 0 0 0 0 0 0 14.1180 10.5598 0.3262 C 0 0 0 0 0 0 0 0 0 0 0 0 15.6767 13.2347 -0.0928 C 0 0 0 0 0 0 0 0 0 0 0 0 17.2318 10.5600 0.2636 C 0 0 0 0 0 0 0 0 0 0 0 0 18.7623 9.6828 0.3571 O 0 0 0 0 0 0 0 0 0 0 0 0 18.6674 7.8488 0.6273 C 0 0 0 0 0 0 0 0 0 0 0 0 20.5044 7.0933 0.6960 C 0 0 0 0 0 0 0 0 0 0 0 0 20.4027 5.1296 0.9854 C 0 0 0 0 0 0 0 0 0 0 0 0 24.9006 3.8911 -0.4900 C 0 0 0 0 0 0 0 0 0 0 0 0 24.0014 1.9113 1.7811 C 0 0 0 0 0 0 0 0 0 0 0 0 22.1371 2.5854 1.6308 C 0 0 0 0 0 0 0 0 0 0 0 0 23.0362 4.5653 -0.6403 C 0 0 0 0 0 0 0 0 0 0 0 0 22.1665 4.4042 1.0514 N 0 0 0 0 0 0 0 0 0 0 0 0 24.8711 2.0723 0.0894 N 0 0 0 0 0 0 0 0 0 0 0 0 26.6349 1.3469 0.1554 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2463 9.7753 3.9320 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3847 14.5548 -0.2038 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1539 9.9066 4.8065 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9029 14.6017 -0.9837 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2525 15.9930 0.7446 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4828 15.8513 0.1515 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8776 11.8501 8.5995 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5847 8.2062 4.6298 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 9.5178 7.4842 H 0 0 0 0 0 0 0 0 0 0 0 0 12.4383 14.2596 -0.7703 H 0 0 0 0 0 0 0 0 0 0 0 0 18.4446 13.0348 -0.1199 H 0 0 0 0 0 0 0 0 0 0 0 0 15.6753 8.2819 0.6244 H 0 0 0 0 0 0 0 0 0 0 0 0 12.9045 9.8669 0.4497 H 0 0 0 0 0 0 0 0 0 0 0 0 15.6757 14.6227 -0.2962 H 0 0 0 0 0 0 0 0 0 0 0 0 18.0028 7.5856 1.8495 H 0 0 0 0 0 0 0 0 0 0 0 0 17.9508 7.2511 -0.4376 H 0 0 0 0 0 0 0 0 0 0 0 0 21.1690 7.3565 -0.5262 H 0 0 0 0 0 0 0 0 0 0 0 0 21.2210 7.6909 1.7611 H 0 0 0 0 0 0 0 0 0 0 0 0 19.7381 4.8664 2.2077 H 0 0 0 0 0 0 0 0 0 0 0 0 19.6862 4.5320 -0.0796 H 0 0 0 0 0 0 0 0 0 0 0 0 25.5362 3.9744 -1.7525 H 0 0 0 0 0 0 0 0 0 0 0 0 25.6121 4.6749 0.4502 H 0 0 0 0 0 0 0 0 0 0 0 0 24.7026 2.6726 2.7472 H 0 0 0 0 0 0 0 0 0 0 0 0 23.9815 0.5512 2.1744 H 0 0 0 0 0 0 0 0 0 0 0 0 21.4256 1.8016 0.6905 H 0 0 0 0 0 0 0 0 0 0 0 0 21.5014 2.5022 2.8933 H 0 0 0 0 0 0 0 0 0 0 0 0 23.0561 5.9254 -1.0336 H 0 0 0 0 0 0 0 0 0 0 0 0 22.3350 3.8039 -1.6064 H 0 0 0 0 0 0 0 0 0 0 0 0 27.4211 2.0994 1.0612 H 0 0 0 0 0 0 0 0 0 0 0 0 26.5754 0.0000 0.5879 H 0 0 0 0 0 0 0 0 0 0 0 0 27.2169 1.4032 -1.1342 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 39 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 40 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 41 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 42 1 0 0 0 0 12 43 1 0 0 0 0 12 44 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 45 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 46 1 0 0 0 0 18 47 1 0 0 0 0 21 22 1 0 0 0 0 21 48 1 0 0 0 0 22 25 2 0 0 0 0 22 26 1 0 0 0 0 23 27 1 0 0 0 0 23 26 2 0 0 0 0 23 49 1 0 0 0 0 24 27 2 0 0 0 0 24 25 1 0 0 0 0 24 50 1 0 0 0 0 25 51 1 0 0 0 0 26 52 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 29 53 1 0 0 0 0 29 54 1 0 0 0 0 30 31 1 0 0 0 0 30 55 1 0 0 0 0 30 56 1 0 0 0 0 31 36 1 0 0 0 0 31 57 1 0 0 0 0 31 58 1 0 0 0 0 32 37 1 0 0 0 0 32 35 1 0 0 0 0 32 59 1 0 0 0 0 32 60 1 0 0 0 0 33 37 1 0 0 0 0 33 34 1 0 0 0 0 33 61 1 0 0 0 0 33 62 1 0 0 0 0 34 36 1 0 0 0 0 34 63 1 0 0 0 0 34 64 1 0 0 0 0 35 36 1 0 0 0 0 35 65 1 0 0 0 0 35 66 1 0 0 0 0 37 38 1 0 0 0 0 38 67 1 0 0 0 0 38 68 1 0 0 0 0 38 69 1 0 0 0 0 M END > (342) 1,6-naphthyridin-2(1H)-one deriv. 7t > (342) PDGFR-beta > (342) 900 > (342) -1 > (342) P > (342) PDGFR-P340 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 68 csChFnd70/05150717532D 73 77 0 0 0 0 0 0 0 0999 V2000 3.9763 15.9583 0.0581 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4836 13.3709 0.0154 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9987 14.2503 0.0446 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0122 14.1384 -0.0018 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5659 16.8485 0.0407 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1245 15.8705 0.0097 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6501 18.6675 0.0528 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7679 18.3798 0.0029 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2739 19.4354 0.0336 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6554 16.6757 -0.0079 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4404 21.3502 0.0443 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6977 24.0278 1.6144 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7514 24.9280 0.0645 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5428 22.2438 1.6131 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5029 22.2650 -1.5142 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6580 24.0489 -1.4954 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4749 21.1164 3.5596 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.3865 21.1638 -3.4736 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7447 10.6884 0.0224 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0389 8.7270 0.0036 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4213 11.5805 0.0032 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2880 7.7954 0.0237 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3913 19.1539 -0.0163 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8308 18.1641 -0.0456 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7067 16.5930 -0.0554 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8695 5.4293 -1.3018 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2014 3.4753 -1.2090 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2671 3.0252 -0.1922 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9352 4.9792 -0.2851 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5706 5.9122 0.0056 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5660 2.5422 -1.4997 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8486 0.6590 -1.5177 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4079 18.9161 -0.0644 N 0 0 3 0 0 0 0 0 0 0 0 0 14.9017 17.8937 0.0528 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3923 18.3702 -0.8376 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8673 17.3606 -0.7218 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8637 15.8752 0.2791 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3775 15.3925 1.1718 C 0 0 0 0 0 0 0 0 0 0 0 0 14.8979 16.4059 1.0649 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3757 13.9310 2.1554 O 0 0 0 0 0 0 0 0 0 0 0 0 17.9482 12.9531 2.2118 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7639 16.6583 0.0760 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4850 19.4436 0.0760 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7776 24.7213 2.8282 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8728 26.3230 0.0725 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7059 24.7587 -2.7013 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9983 11.0637 -1.1172 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0337 11.0469 1.1900 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7499 8.3686 -1.1638 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7853 8.3517 1.1434 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4876 10.9143 -0.0179 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5771 8.1538 1.1911 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5417 8.1707 -1.1161 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4902 20.4075 -0.0087 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0736 6.1245 -1.0494 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3912 5.7656 -2.5882 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1366 3.1083 -2.2027 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7131 3.1440 0.0658 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7453 2.6889 1.0941 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0630 2.3299 -0.4447 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4235 5.3104 -1.5600 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3462 0.7086 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3883 0.2518 -0.2769 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6177 0.0000 -1.7351 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7496 0.3279 -2.5547 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5073 20.1661 -0.1591 H 0 0 0 0 0 0 0 0 0 0 0 0 16.3984 19.5305 -1.6211 H 0 0 0 0 0 0 0 0 0 0 0 0 19.0252 17.7329 -1.4155 H 0 0 0 0 0 0 0 0 0 0 0 0 19.0184 15.0883 0.3667 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7422 16.0356 1.7631 H 0 0 0 0 0 0 0 0 0 0 0 0 17.7702 11.8224 3.0402 H 0 0 0 0 0 0 0 0 0 0 0 0 18.2880 12.5319 0.9064 H 0 0 0 0 0 0 0 0 0 0 0 0 18.9857 13.7593 2.7316 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 42 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 21 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 43 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 44 1 0 0 0 0 13 16 1 0 0 0 0 13 45 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 46 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 47 1 0 0 0 0 19 48 1 0 0 0 0 20 22 1 0 0 0 0 20 49 1 0 0 0 0 20 50 1 0 0 0 0 21 51 1 0 0 0 0 22 30 1 0 0 0 0 22 52 1 0 0 0 0 22 53 1 0 0 0 0 23 24 1 0 0 0 0 23 54 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 27 31 1 0 0 0 0 27 57 1 0 0 0 0 27 58 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 59 1 0 0 0 0 28 60 1 0 0 0 0 29 30 1 0 0 0 0 29 61 1 0 0 0 0 29 62 1 0 0 0 0 31 32 1 0 0 0 0 32 63 1 0 0 0 0 32 64 1 0 0 0 0 32 65 1 0 0 0 0 33 34 1 0 0 0 0 33 66 1 0 0 0 0 34 35 2 0 0 0 0 34 39 1 0 0 0 0 35 36 1 0 0 0 0 35 67 1 0 0 0 0 36 37 2 0 0 0 0 36 68 1 0 0 0 0 37 38 1 0 0 0 0 37 69 1 0 0 0 0 38 39 2 0 0 0 0 38 40 1 0 0 0 0 39 70 1 0 0 0 0 40 41 1 0 0 0 0 41 71 1 0 0 0 0 41 72 1 0 0 0 0 41 73 1 0 0 0 0 M END > (347) 6-arylpyrido[2,3-d]pyrimidine deriv. 68 > (347) PDGFR-beta > (347) 910 > (347) -1 > (347) P > (347) PDGFR-P345 $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 5 csChFnd70/05150717532D 34 36 0 0 0 0 0 0 0 0999 V2000 1.2021 4.9843 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6967 2.4256 -0.0161 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7723 5.8681 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3092 4.9061 -0.0181 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8306 7.6830 0.0114 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9649 7.4492 -0.0191 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3951 8.4858 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2251 3.2889 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2096 3.2027 -0.0263 N 0 0 0 0 0 0 0 0 0 0 0 0 7.3623 8.1531 -0.0282 O 0 0 0 0 0 0 0 0 0 0 0 0 5.8712 5.7217 -0.0281 N 0 0 3 0 0 0 0 0 0 0 0 0 4.4994 10.3859 0.0107 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6600 13.0477 1.5645 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5630 11.2763 1.5649 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5419 11.2925 -1.5350 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6390 13.0638 -1.5174 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6943 13.9392 0.0279 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5193 10.1601 3.4947 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.4736 10.1965 -3.4757 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6470 0.6529 -0.0252 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4536 4.7034 -0.0480 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9874 4.3589 -1.9078 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.6762 0.0329 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6585 8.4250 0.0262 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7088 13.7385 2.7665 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6725 13.7671 -2.7127 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7702 15.3242 0.0346 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5511 0.0604 -0.0178 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7082 0.0000 -0.0388 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4706 5.4087 0.6064 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2334 3.4861 0.6074 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1646 3.6011 -1.9226 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9702 3.6536 -2.5623 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2076 5.5762 -2.5633 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 23 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 20 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 11 1 0 0 0 0 5 7 2 0 0 0 0 5 24 1 0 0 0 0 6 11 1 0 0 0 0 6 7 1 0 0 0 0 6 10 2 0 0 0 0 7 12 1 0 0 0 0 11 21 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 25 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 26 1 0 0 0 0 17 27 1 0 0 0 0 20 28 1 0 0 0 0 20 29 1 0 0 0 0 21 22 1 0 0 0 0 21 30 1 0 0 0 0 21 31 1 0 0 0 0 22 32 1 0 0 0 0 22 33 1 0 0 0 0 22 34 1 0 0 0 0 M END > (352) pyrido[2,3-d]pyrimidin-7-one deriv. 5 > (352) PDGFR-beta > (352) 980 > (352) -1 > (352) P > (352) PDGFR-P350 $$$$ 3-substituted indolin-2-one 16i csChFnd70/05150717532D 55 58 0 0 0 0 0 0 0 0999 V2000 1.7813 10.8298 0.1583 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5844 9.2669 0.1311 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5747 10.8636 0.0818 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1606 11.6441 0.0958 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5298 13.3054 0.0342 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2182 13.3801 -0.0136 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7634 11.9328 0.0166 N 0 0 3 0 0 0 0 0 0 0 0 0 5.9898 14.5498 -0.0711 O 0 0 0 0 0 0 0 0 0 0 0 0 2.5067 14.5240 0.0232 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0563 16.0462 0.1488 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4250 17.3388 -0.5430 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3159 16.5239 0.9875 N 0 0 3 0 0 0 0 0 0 0 0 0 1.0256 17.3805 -1.5675 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4702 18.0691 0.8181 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8008 9.2450 0.2069 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2023 8.4584 0.1935 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7054 19.0445 1.5479 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3304 18.5943 -0.1107 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0823 20.2435 -0.5886 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0316 21.0413 0.5782 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7835 22.6905 0.1004 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3855 23.1778 -1.0551 O 0 0 0 0 0 0 0 0 0 0 0 0 0.8940 23.6181 0.9583 O 0 0 0 0 0 0 0 0 0 0 0 0 3.2185 6.7522 0.2454 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6148 5.9608 0.2391 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6261 4.3741 0.2880 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2489 3.5648 0.3432 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8565 4.3496 0.3492 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8376 5.9364 0.3075 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2639 2.0013 0.3907 O 0 0 0 0 0 0 0 0 0 0 0 0 1.8056 1.2419 0.4461 C 0 0 0 0 0 0 0 0 0 0 0 0 0.6981 11.4400 0.1737 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6646 8.6513 0.1211 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8480 11.6679 -0.0045 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2865 14.3104 -0.0815 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9806 15.8655 1.5970 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 17.5607 -0.8675 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1391 18.3189 -2.3926 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9256 16.2918 -2.1835 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7324 8.6111 0.2558 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6967 19.1067 0.7811 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2605 20.2001 1.7510 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0526 18.5321 2.6395 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1869 20.8373 -0.6313 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5469 20.2742 -1.7231 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9270 20.4475 0.6209 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5670 21.0105 1.7127 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7690 24.6664 0.6054 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6864 6.5897 0.1955 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7073 3.7603 0.2831 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7872 3.7166 0.3912 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7544 6.5463 0.3174 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9818 0.0000 0.4803 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1839 1.6046 1.4739 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1389 1.5418 -0.5738 H 0 0 0 0 0 0 0 0 0 0 0 0 1 15 1 0 0 0 0 1 4 2 0 0 0 0 1 32 1 0 0 0 0 2 16 1 0 0 0 0 2 3 2 0 0 0 0 2 33 1 0 0 0 0 3 7 1 0 0 0 0 3 4 1 0 0 0 0 4 5 1 0 0 0 0 5 6 1 0 0 0 0 5 9 2 0 0 0 0 6 7 1 0 0 0 0 6 8 2 0 0 0 0 7 34 1 0 0 0 0 9 10 1 0 0 0 0 9 35 1 0 0 0 0 10 11 2 0 0 0 0 10 12 1 0 0 0 0 11 18 1 0 0 0 0 11 13 1 0 0 0 0 12 14 1 0 0 0 0 12 36 1 0 0 0 0 13 37 1 0 0 0 0 13 38 1 0 0 0 0 13 39 1 0 0 0 0 14 18 2 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 40 1 0 0 0 0 16 24 1 0 0 0 0 17 41 1 0 0 0 0 17 42 1 0 0 0 0 17 43 1 0 0 0 0 18 19 1 0 0 0 0 19 20 1 0 0 0 0 19 44 1 0 0 0 0 19 45 1 0 0 0 0 20 21 1 0 0 0 0 20 46 1 0 0 0 0 20 47 1 0 0 0 0 21 23 1 0 0 0 0 21 22 2 0 0 0 0 23 48 1 0 0 0 0 24 29 2 0 0 0 0 24 25 1 0 0 0 0 25 26 2 0 0 0 0 25 49 1 0 0 0 0 26 27 1 0 0 0 0 26 50 1 0 0 0 0 27 28 2 0 0 0 0 27 30 1 0 0 0 0 28 29 1 0 0 0 0 28 51 1 0 0 0 0 29 52 1 0 0 0 0 30 31 1 0 0 0 0 31 53 1 0 0 0 0 31 54 1 0 0 0 0 31 55 1 0 0 0 0 M END > (356) 3-substituted indolin-2-one 16i > (356) PDGFR-beta > (356) 1000 > (356) -1 > (356) P > (356) PDGFR-P354 $$$$ tetrahydroindole deriv. 4d csChFnd70/05150717532D 39 42 0 0 0 0 0 0 0 0999 V2000 2.2351 4.0452 0.9543 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3246 2.5976 1.2564 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5860 1.8635 0.9817 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7389 2.5578 0.4166 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3990 4.7418 0.3842 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6641 4.0026 0.1106 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6555 6.2301 -0.0489 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1237 6.2509 -0.5703 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6538 4.9328 -0.4510 N 0 0 3 0 0 0 0 0 0 0 0 0 5.7518 7.2832 -1.0296 O 0 0 0 0 0 0 0 0 0 0 0 0 2.7172 7.3546 0.0216 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2341 8.7542 0.1372 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4328 9.9881 0.0622 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6972 10.5810 0.3978 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3665 11.1183 0.2281 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0195 12.6811 0.2303 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0040 11.4846 0.6089 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6534 13.0076 0.1529 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2787 13.4856 0.8751 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6281 9.1478 0.3520 N 0 0 3 0 0 0 0 0 0 0 0 0 1.0940 1.8446 1.8635 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.4842 2.1015 O 0 0 0 0 0 0 0 0 0 0 0 0 1.1829 0.4474 2.1541 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2637 4.6180 1.1589 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6550 0.7436 1.2156 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7070 1.9805 0.2095 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6097 4.6659 -0.7247 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5880 7.1617 -0.0118 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2996 10.0570 -0.0955 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8408 13.0419 -0.8540 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0710 12.8687 0.8652 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3074 11.4760 1.7251 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8718 11.0708 -0.0344 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5158 13.7119 0.4665 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5233 13.0457 -0.9957 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1336 14.6218 0.7142 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3402 13.2613 2.0081 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4256 8.5045 0.4507 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3490 0.0000 2.5510 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 5 2 0 0 0 0 1 24 1 0 0 0 0 2 3 2 0 0 0 0 2 21 1 0 0 0 0 3 4 1 0 0 0 0 3 25 1 0 0 0 0 4 6 2 0 0 0 0 4 26 1 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 9 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 9 1 0 0 0 0 8 10 2 0 0 0 0 9 27 1 0 0 0 0 11 12 1 0 0 0 0 11 28 1 0 0 0 0 12 13 2 0 0 0 0 12 20 1 0 0 0 0 13 15 1 0 0 0 0 13 29 1 0 0 0 0 14 20 1 0 0 0 0 14 17 1 0 0 0 0 14 15 2 0 0 0 0 15 16 1 0 0 0 0 16 19 1 0 0 0 0 16 30 1 0 0 0 0 16 31 1 0 0 0 0 17 18 1 0 0 0 0 17 32 1 0 0 0 0 17 33 1 0 0 0 0 18 19 1 0 0 0 0 18 34 1 0 0 0 0 18 35 1 0 0 0 0 19 36 1 0 0 0 0 19 37 1 0 0 0 0 20 38 1 0 0 0 0 21 23 1 0 0 0 0 21 22 2 0 0 0 0 23 39 1 0 0 0 0 M END > (366) Indolin-2-one deriv. 4d > (366) PDGFR-beta > (366) 1030 > (366) -1 > (366) P > (366) PDGFR-P364 $$$$ PD089828 analog 13 csChFnd70/05150717532D 48 50 0 0 0 0 0 0 0 0999 V2000 1.2015 4.9968 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6961 2.4337 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7763 5.8794 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3212 4.9109 -0.0184 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8590 7.6816 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4678 8.4431 0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2245 3.3045 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2104 3.1945 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8376 5.7093 -0.0280 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6350 0.6597 -0.0250 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6321 10.3406 0.0103 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4912 12.9546 -1.3820 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0777 11.2831 1.4278 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2338 13.0492 1.4299 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9387 13.8836 0.0288 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9485 7.3978 -0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5567 8.1654 -0.0302 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9835 7.1852 -0.0491 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8613 5.6284 -0.0568 O 0 0 0 0 0 0 0 0 0 0 0 0 5.3484 11.1880 -1.3952 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9581 10.1774 -2.9295 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5459 7.9308 -0.0595 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0968 6.8654 -0.0800 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0972 5.7400 -1.6912 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6859 8.0216 -0.0884 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1272 5.7216 1.5179 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.6899 0.0327 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7043 8.4503 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5352 0.0741 -0.0177 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6919 0.0000 -0.0387 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0455 13.6127 -2.4702 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5267 10.6329 2.5224 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8043 13.7808 2.5274 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0535 15.2661 0.0338 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6542 9.4075 -0.0240 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9079 10.0402 -3.8452 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0236 10.8511 -3.5386 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3838 8.9099 -2.5141 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6434 9.1729 -0.0533 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0755 6.5548 -2.8296 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2511 4.9472 -1.7066 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9651 4.9161 -1.6853 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6856 8.8234 1.0594 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8399 7.2289 -0.1036 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6643 8.8364 -1.2267 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9951 4.8979 1.5238 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2811 4.9290 1.5026 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1270 6.5234 2.6657 H 0 0 0 0 0 0 0 0 0 0 0 0 1 7 2 0 0 0 0 1 3 1 0 0 0 0 1 27 1 0 0 0 0 2 7 1 0 0 0 0 2 8 2 0 0 0 0 2 10 1 0 0 0 0 3 5 1 0 0 0 0 3 4 2 0 0 0 0 4 8 1 0 0 0 0 4 9 1 0 0 0 0 5 6 2 0 0 0 0 5 28 1 0 0 0 0 6 16 1 0 0 0 0 6 11 1 0 0 0 0 9 16 2 0 0 0 0 10 29 1 0 0 0 0 10 30 1 0 0 0 0 11 20 1 0 0 0 0 11 13 2 0 0 0 0 12 20 2 0 0 0 0 12 15 1 0 0 0 0 12 31 1 0 0 0 0 13 14 1 0 0 0 0 13 32 1 0 0 0 0 14 15 2 0 0 0 0 14 33 1 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 17 18 1 0 0 0 0 17 35 1 0 0 0 0 18 22 1 0 0 0 0 18 19 2 0 0 0 0 20 21 1 0 0 0 0 21 36 1 0 0 0 0 21 37 1 0 0 0 0 21 38 1 0 0 0 0 22 23 1 0 0 0 0 22 39 1 0 0 0 0 23 24 1 0 0 0 0 23 25 1 0 0 0 0 23 26 1 0 0 0 0 24 40 1 0 0 0 0 24 41 1 0 0 0 0 24 42 1 0 0 0 0 25 43 1 0 0 0 0 25 44 1 0 0 0 0 25 45 1 0 0 0 0 26 46 1 0 0 0 0 26 47 1 0 0 0 0 26 48 1 0 0 0 0 M END > (368) PD089828 analog 13 > (368) PDGFR-beta > (368) 1050 > (368) -1 > (368) P > (368) PDGFR-P366 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 21 csChFnd70/05150717532D 68 70 0 0 0 0 0 0 0 0999 V2000 7.3687 12.7401 0.5073 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1676 9.8501 0.4294 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9558 11.0821 0.4139 N 0 0 0 0 0 0 0 0 0 0 0 0 9.8418 10.1994 0.5378 N 0 0 0 0 0 0 0 0 0 0 0 0 9.1323 13.1923 0.6252 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3911 11.8454 0.6385 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6767 14.9300 0.7288 C 0 0 0 0 0 0 0 0 0 0 0 0 12.6192 13.8501 0.8470 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4429 15.2552 0.8407 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0768 12.2308 0.7486 N 0 0 0 0 0 0 0 0 0 0 0 0 12.0913 17.0644 0.9526 C 0 0 0 0 0 0 0 0 0 0 0 0 12.9151 19.5390 2.6632 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0952 19.6664 -0.4441 C 0 0 0 0 0 0 0 0 0 0 0 0 13.3035 20.4442 1.1613 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3105 17.8535 2.5677 C 0 0 0 0 0 0 0 0 0 0 0 0 12.4918 17.9815 -0.5568 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7804 16.6182 4.6226 Br 0 0 0 0 0 0 0 0 0 0 0 0 12.2096 16.9200 -2.7528 Br 0 0 0 0 0 0 0 0 0 0 0 0 7.6516 8.1344 0.3284 N 0 0 3 0 0 0 0 0 0 0 0 0 5.8030 7.7027 0.2072 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5883 5.7300 0.1122 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6577 5.2792 -0.0143 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4517 3.3851 -0.1056 N 0 0 0 0 0 0 0 0 0 0 0 0 4.0051 2.5580 1.5217 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2744 0.6133 1.2180 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6542 2.9129 -0.5355 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3364 3.2124 -2.4736 C 0 0 0 0 0 0 0 0 0 0 0 0 14.3864 14.1815 0.9588 N 0 0 3 0 0 0 0 0 0 0 0 0 15.5268 12.8542 0.9657 C 0 0 0 0 0 0 0 0 0 0 0 0 15.0071 11.3666 0.8740 O 0 0 0 0 0 0 0 0 0 0 0 0 17.2436 13.1762 1.0742 N 0 0 3 0 0 0 0 0 0 0 0 0 18.4833 11.7335 1.0817 C 0 0 0 0 0 0 0 0 0 0 0 0 18.2960 10.6906 -0.5987 C 0 0 0 0 0 0 0 0 0 0 0 0 20.3318 12.4493 1.2142 C 0 0 0 0 0 0 0 0 0 0 0 0 18.1170 10.5537 2.6376 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3746 13.7290 0.4880 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7475 15.9801 0.7209 H 0 0 0 0 0 0 0 0 0 0 0 0 13.0853 20.1515 3.9132 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4058 20.3779 -1.6119 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7757 21.7621 1.2428 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5135 7.2159 0.3376 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1275 8.1962 1.3488 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2558 8.2935 -0.9567 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2638 5.2365 -1.0294 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1355 5.1392 1.2761 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9822 5.7728 1.1273 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1106 5.8699 -1.1782 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2194 3.1401 1.9574 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0097 2.7478 2.5097 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1378 0.4236 0.1126 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8506 0.0309 2.3720 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0267 0.0000 0.9527 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4383 1.5486 -0.2274 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7631 3.7136 0.2180 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.8713 -2.7907 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5618 4.5749 -2.7835 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2212 2.4046 -3.2272 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8010 15.3686 1.0319 H 0 0 0 0 0 0 0 0 0 0 0 0 17.6583 14.3633 1.1473 H 0 0 0 0 0 0 0 0 0 0 0 0 18.5570 11.5311 -1.7072 H 0 0 0 0 0 0 0 0 0 0 0 0 19.2184 9.6171 -0.5931 H 0 0 0 0 0 0 0 0 0 0 0 0 16.9790 10.1805 -0.6931 H 0 0 0 0 0 0 0 0 0 0 0 0 20.4653 13.1923 2.4115 H 0 0 0 0 0 0 0 0 0 0 0 0 21.2541 11.3759 1.2198 H 0 0 0 0 0 0 0 0 0 0 0 0 20.5927 13.2898 0.1058 H 0 0 0 0 0 0 0 0 0 0 0 0 16.8001 10.0437 2.5432 H 0 0 0 0 0 0 0 0 0 0 0 0 19.0393 9.4803 2.6432 H 0 0 0 0 0 0 0 0 0 0 0 0 18.2505 11.2967 3.8348 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 36 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 19 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 37 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 28 1 0 0 0 0 9 11 1 0 0 0 0 11 15 2 0 0 0 0 11 16 1 0 0 0 0 12 15 1 0 0 0 0 12 14 2 0 0 0 0 12 38 1 0 0 0 0 13 16 2 0 0 0 0 13 14 1 0 0 0 0 13 39 1 0 0 0 0 14 40 1 0 0 0 0 15 17 1 0 0 0 0 16 18 1 0 0 0 0 19 20 1 0 0 0 0 19 41 1 0 0 0 0 20 21 1 0 0 0 0 20 42 1 0 0 0 0 20 43 1 0 0 0 0 21 22 1 0 0 0 0 21 44 1 0 0 0 0 21 45 1 0 0 0 0 22 23 1 0 0 0 0 22 46 1 0 0 0 0 22 47 1 0 0 0 0 23 24 1 0 0 0 0 23 26 1 0 0 0 0 24 25 1 0 0 0 0 24 48 1 0 0 0 0 24 49 1 0 0 0 0 25 50 1 0 0 0 0 25 51 1 0 0 0 0 25 52 1 0 0 0 0 26 27 1 0 0 0 0 26 53 1 0 0 0 0 26 54 1 0 0 0 0 27 55 1 0 0 0 0 27 56 1 0 0 0 0 27 57 1 0 0 0 0 28 29 1 0 0 0 0 28 58 1 0 0 0 0 29 31 1 0 0 0 0 29 30 2 0 0 0 0 31 32 1 0 0 0 0 31 59 1 0 0 0 0 32 33 1 0 0 0 0 32 34 1 0 0 0 0 32 35 1 0 0 0 0 33 60 1 0 0 0 0 33 61 1 0 0 0 0 33 62 1 0 0 0 0 34 63 1 0 0 0 0 34 64 1 0 0 0 0 34 65 1 0 0 0 0 35 66 1 0 0 0 0 35 67 1 0 0 0 0 35 68 1 0 0 0 0 M END > (370) 6-arylpyrido[2,3-d]pyrimidine deriv. 21 > (370) PDGFR-beta > (370) 1100 > (370) -1 > (370) P > (370) PDGFR-P368 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 75 csChFnd70/05150717532D 81 84 0 0 0 0 0 0 0 0999 V2000 6.6113 15.0573 2.3554 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2051 12.5606 1.6773 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6787 13.3712 1.9592 N 0 0 0 0 0 0 0 0 0 0 0 0 9.7329 13.3783 1.7740 N 0 0 0 0 0 0 0 0 0 0 0 0 8.1976 15.9984 2.4772 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8014 15.0933 2.1686 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2352 17.7984 2.8928 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4000 17.6362 2.6609 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8593 18.6204 2.9840 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3305 15.9484 2.2733 N 0 0 0 0 0 0 0 0 0 0 0 0 9.9777 20.5182 3.4167 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2377 22.8272 5.5586 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1981 24.0644 4.2253 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1280 21.0570 5.1642 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9468 21.7721 2.0776 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0575 23.5383 2.4894 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1764 19.5062 6.8395 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.7703 21.1143 -0.1018 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.1887 10.7899 1.2665 N 0 0 3 0 0 0 0 0 0 0 0 0 6.5142 9.8437 1.1490 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8635 7.9180 0.6799 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0226 18.4640 2.7529 N 0 0 3 0 0 0 0 0 0 0 0 0 14.5061 17.5429 2.4473 C 0 0 0 0 0 0 0 0 0 0 0 0 16.0834 18.3474 2.5366 N 0 0 3 0 0 0 0 0 0 0 0 0 17.6959 17.3461 2.2045 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1147 6.9296 0.5570 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4641 5.0040 0.0879 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7850 4.0551 -0.0300 N 0 0 0 0 0 0 0 0 0 0 0 0 2.7254 4.7038 -1.5099 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8204 4.0939 -1.2890 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0747 2.1497 -0.1686 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5632 1.4122 1.6390 C 0 0 0 0 0 0 0 0 0 0 0 0 14.3872 15.3507 1.9457 S 0 0 0 0 0 0 0 0 0 0 0 0 19.2897 18.5611 2.3881 C 0 0 0 0 0 0 0 0 0 0 0 0 20.9738 17.5154 2.0413 C 0 0 0 0 0 0 0 0 0 0 0 0 24.1520 17.6702 2.2033 C 0 0 0 0 0 0 0 0 0 0 0 0 22.3746 19.7578 3.8192 C 0 0 0 0 0 0 0 0 0 0 0 0 23.9519 21.0062 3.9102 C 0 0 0 0 0 0 0 0 0 0 0 0 25.7117 18.9397 2.3105 C 0 0 0 0 0 0 0 0 0 0 0 0 22.5041 18.6820 2.2177 N 0 0 0 0 0 0 0 0 0 0 0 0 25.5418 20.0023 3.8534 O 0 0 0 0 0 0 0 0 0 0 0 0 5.3650 15.7025 2.5757 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0351 18.5193 3.1334 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3543 23.2460 6.9111 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2848 25.4468 4.5406 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0336 24.5103 1.4538 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2859 10.1737 1.0562 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8366 9.9129 2.4105 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6973 10.4422 0.1342 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5413 7.8488 -0.5816 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6806 7.3195 1.6947 H 0 0 0 0 0 0 0 0 0 0 0 0 13.0900 19.7060 3.0371 H 0 0 0 0 0 0 0 0 0 0 0 0 16.1507 19.5894 2.8209 H 0 0 0 0 0 0 0 0 0 0 0 0 17.7985 16.2766 3.1538 H 0 0 0 0 0 0 0 0 0 0 0 0 17.6577 16.8053 0.8773 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4370 6.9988 1.8186 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2978 7.5281 -0.4577 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1417 4.9348 -1.1737 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2810 4.4055 1.1028 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7684 6.1366 -1.5364 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2534 4.1869 -2.7385 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7540 2.6696 -1.4395 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3497 4.4590 0.0151 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 4.7184 -2.2853 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8759 1.5167 -0.6350 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1406 1.8944 -1.0929 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7566 2.0522 2.1097 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4932 1.6589 2.5608 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7877 0.0000 1.5342 H 0 0 0 0 0 0 0 0 0 0 0 0 19.1872 19.6308 1.4390 H 0 0 0 0 0 0 0 0 0 0 0 0 19.3279 19.1021 3.7153 H 0 0 0 0 0 0 0 0 0 0 0 0 21.0763 16.4459 2.9906 H 0 0 0 0 0 0 0 0 0 0 0 0 20.9357 16.9746 0.7141 H 0 0 0 0 0 0 0 0 0 0 0 0 24.2363 16.9096 0.9908 H 0 0 0 0 0 0 0 0 0 0 0 0 24.1788 16.7828 3.3290 H 0 0 0 0 0 0 0 0 0 0 0 0 22.3728 18.9038 4.9708 H 0 0 0 0 0 0 0 0 0 0 0 0 21.1613 20.5210 3.7865 H 0 0 0 0 0 0 0 0 0 0 0 0 23.9144 21.9071 2.7955 H 0 0 0 0 0 0 0 0 0 0 0 0 23.9012 21.7536 5.1327 H 0 0 0 0 0 0 0 0 0 0 0 0 26.9335 18.1924 2.3759 H 0 0 0 0 0 0 0 0 0 0 0 0 25.7254 19.7803 1.1492 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 42 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 19 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 43 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 22 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 44 1 0 0 0 0 13 16 1 0 0 0 0 13 45 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 46 1 0 0 0 0 19 20 1 0 0 0 0 19 47 1 0 0 0 0 20 21 1 0 0 0 0 20 48 1 0 0 0 0 20 49 1 0 0 0 0 21 26 1 0 0 0 0 21 50 1 0 0 0 0 21 51 1 0 0 0 0 22 23 1 0 0 0 0 22 52 1 0 0 0 0 23 24 1 0 0 0 0 23 33 2 0 0 0 0 24 25 1 0 0 0 0 24 53 1 0 0 0 0 25 34 1 0 0 0 0 25 54 1 0 0 0 0 25 55 1 0 0 0 0 26 27 1 0 0 0 0 26 56 1 0 0 0 0 26 57 1 0 0 0 0 27 28 1 0 0 0 0 27 58 1 0 0 0 0 27 59 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 29 60 1 0 0 0 0 29 61 1 0 0 0 0 30 62 1 0 0 0 0 30 63 1 0 0 0 0 30 64 1 0 0 0 0 31 32 1 0 0 0 0 31 65 1 0 0 0 0 31 66 1 0 0 0 0 32 67 1 0 0 0 0 32 68 1 0 0 0 0 32 69 1 0 0 0 0 34 35 1 0 0 0 0 34 70 1 0 0 0 0 34 71 1 0 0 0 0 35 40 1 0 0 0 0 35 72 1 0 0 0 0 35 73 1 0 0 0 0 36 40 1 0 0 0 0 36 39 1 0 0 0 0 36 74 1 0 0 0 0 36 75 1 0 0 0 0 37 40 1 0 0 0 0 37 38 1 0 0 0 0 37 76 1 0 0 0 0 37 77 1 0 0 0 0 38 41 1 0 0 0 0 38 78 1 0 0 0 0 38 79 1 0 0 0 0 39 41 1 0 0 0 0 39 80 1 0 0 0 0 39 81 1 0 0 0 0 M END > (374) 6-arylpyrido[2,3-d]pyrimidine deriv. 75 > (374) PDGFR-beta > (374) 1100 > (374) -1 > (374) P > (374) PDGFR-P372 $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 16 csChFnd70/05150717532D 38 40 0 0 0 0 0 0 0 0999 V2000 1.2133 5.0305 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7217 2.4481 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7980 5.9225 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3491 4.9515 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8568 7.7542 0.0115 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0201 7.5182 -0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4358 8.5644 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2365 3.3194 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2486 3.2324 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4305 8.2286 -0.0285 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9256 5.7747 -0.0284 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5411 10.4821 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7031 13.1686 1.5790 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6052 11.3808 1.5794 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5840 11.3971 -1.5492 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6820 13.1848 -1.5314 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7377 14.0683 0.0281 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5612 10.2542 3.5271 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5150 10.2909 -3.5079 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6716 0.6590 -0.0254 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5226 4.7469 -0.0485 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0614 4.3992 -1.9255 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7292 3.3258 -1.9465 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2324 3.0011 -3.6995 O 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.7288 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6739 8.5031 0.0264 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7524 13.8658 2.7921 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7158 13.8946 -2.7378 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8144 15.4662 0.0349 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5655 0.0609 -0.0180 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7425 0.0000 -0.0392 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5491 5.4588 0.6120 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3004 3.5184 0.6130 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0348 3.6874 -2.5860 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2836 5.6278 -2.5871 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7558 4.0376 -1.2860 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5070 2.0973 -1.2848 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2824 2.3253 -3.8118 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 25 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 20 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 11 1 0 0 0 0 5 7 2 0 0 0 0 5 26 1 0 0 0 0 6 11 1 0 0 0 0 6 7 1 0 0 0 0 6 10 2 0 0 0 0 7 12 1 0 0 0 0 11 21 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 27 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 28 1 0 0 0 0 17 29 1 0 0 0 0 20 30 1 0 0 0 0 20 31 1 0 0 0 0 21 22 1 0 0 0 0 21 32 1 0 0 0 0 21 33 1 0 0 0 0 22 23 1 0 0 0 0 22 34 1 0 0 0 0 22 35 1 0 0 0 0 23 24 1 0 0 0 0 23 36 1 0 0 0 0 23 37 1 0 0 0 0 24 38 1 0 0 0 0 M END > (375) pyrido[2,3-d]pyrimidin-7-one deriv. 16 > (375) PDGFR-beta > (375) 1100 > (375) -1 > (375) P > (375) PDGFR-P373 $$$$ 1,6-naphthyridin-2(1H)-one deriv. 8f csChFnd70/05150717532D 55 57 0 0 0 0 0 0 0 0999 V2000 1.2336 15.0267 1.7044 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7563 12.4634 1.2948 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3519 13.2943 1.4376 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7839 15.9672 1.8650 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3844 15.0772 1.7280 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7658 17.7833 2.1591 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3114 18.6519 2.3067 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9481 17.6896 2.1581 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3283 18.4554 2.2897 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2736 13.3391 1.4301 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9331 15.9600 1.8786 N 0 0 3 0 0 0 0 0 0 0 0 0 4.3293 20.5533 2.6142 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3474 22.9765 4.5861 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3308 21.2024 4.3085 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3526 21.7031 1.2108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3691 23.4742 1.5064 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3635 24.1093 3.1892 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3106 19.7831 6.0634 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.3612 20.9088 -0.9021 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.7088 10.6838 1.0043 N 0 0 3 0 0 0 0 0 0 0 0 0 4.3328 9.7000 0.8520 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9181 7.7801 0.5368 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6141 6.7527 0.3780 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1993 4.8328 0.0628 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8277 3.8463 -0.0898 N 0 0 0 0 0 0 0 0 0 0 0 0 6.4921 1.9660 -0.0844 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0811 1.3712 1.7688 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7978 4.3639 -1.6517 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6739 3.7174 -1.5118 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 15.6887 1.8122 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5481 12.5672 1.3256 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5482 18.4748 2.2654 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0228 15.3325 1.7822 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3480 23.4805 5.8967 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3871 24.3655 0.4214 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3765 25.4954 3.4133 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6004 10.0908 0.9021 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0905 10.2042 -0.2344 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0790 9.8317 2.0498 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1604 7.2760 1.6233 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1719 7.6484 -0.6608 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3717 7.2569 -0.7085 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3602 6.8844 1.5756 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4416 4.3287 1.1493 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4531 4.7011 -1.1350 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3893 1.6805 -0.9277 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6385 1.2802 -0.5575 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7229 0.0000 1.7565 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2233 1.5536 2.5878 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0043 2.1360 2.2827 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1866 3.7960 -2.7973 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7921 5.7767 -1.7648 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4245 4.2040 -2.6110 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2466 4.1875 -0.3036 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6871 2.3003 -1.5209 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 30 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 20 1 0 0 0 0 3 5 2 0 0 0 0 3 31 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 32 1 0 0 0 0 7 8 1 0 0 0 0 7 12 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 33 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 34 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 35 1 0 0 0 0 17 36 1 0 0 0 0 20 21 1 0 0 0 0 20 37 1 0 0 0 0 21 22 1 0 0 0 0 21 38 1 0 0 0 0 21 39 1 0 0 0 0 22 23 1 0 0 0 0 22 40 1 0 0 0 0 22 41 1 0 0 0 0 23 24 1 0 0 0 0 23 42 1 0 0 0 0 23 43 1 0 0 0 0 24 25 1 0 0 0 0 24 44 1 0 0 0 0 24 45 1 0 0 0 0 25 26 1 0 0 0 0 25 28 1 0 0 0 0 26 27 1 0 0 0 0 26 46 1 0 0 0 0 26 47 1 0 0 0 0 27 48 1 0 0 0 0 27 49 1 0 0 0 0 27 50 1 0 0 0 0 28 29 1 0 0 0 0 28 51 1 0 0 0 0 28 52 1 0 0 0 0 29 53 1 0 0 0 0 29 54 1 0 0 0 0 29 55 1 0 0 0 0 M END > (376) 1,6-naphthyridin-2(1H)-one deriv. 8f > (376) PDGFR-beta > (376) 1100 > (376) -1 > (376) P > (376) PDGFR-P374 $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7i csChFnd70/05150717532D 61 64 0 0 0 0 0 0 0 0999 V2000 1.2234 16.3018 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7163 13.6988 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3154 14.5240 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7784 17.2379 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3653 16.3246 -0.0179 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7781 19.0725 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3277 19.9358 -0.0006 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9499 18.9492 -0.0214 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3335 19.7106 -0.0303 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2466 14.5966 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9180 17.2025 -0.0285 N 0 0 3 0 0 0 0 0 0 0 0 0 7.5497 16.2307 -0.0487 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3643 21.8562 0.0072 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4309 24.5478 1.5737 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3970 22.7577 1.5754 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3738 22.7711 -1.5534 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4078 24.5612 -1.5369 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4333 25.4471 0.0222 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3940 21.6315 3.5239 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.3435 21.6616 -3.5112 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6514 11.9016 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2609 10.8933 -0.0467 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8285 8.9575 -0.0537 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5093 7.9047 -0.0755 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0768 5.9689 -0.0825 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3529 4.2227 -1.6671 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0601 2.1190 0.2694 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3422 3.1092 0.1983 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6350 5.2129 -1.7382 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6906 4.9579 -0.1033 N 0 0 0 0 0 0 0 0 0 0 0 0 9.0046 2.3741 -1.3654 N 0 0 0 0 0 0 0 0 0 0 0 0 10.6184 1.3632 -1.3863 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.9823 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5009 13.7790 -0.0420 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5710 19.7816 0.0257 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9416 15.9959 -1.3860 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5512 16.9777 0.6114 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3703 14.9952 0.6133 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4557 25.2472 2.7864 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4152 25.2708 -2.7438 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4598 26.8470 0.0279 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5405 11.3124 -0.0188 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0029 11.2145 -1.2057 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0245 11.2012 1.1017 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0864 8.6365 1.1053 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0649 8.6496 -1.2022 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2512 8.2257 -1.2345 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2729 8.2126 1.0730 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3348 5.6477 1.0766 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3132 5.6610 -1.2310 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0385 4.3794 -2.8927 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1467 4.7308 -0.6141 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8393 2.6032 1.3444 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8033 0.7421 0.4556 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5484 2.6011 -0.8546 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6567 2.9526 1.4240 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8919 6.5900 -1.9243 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8559 4.7288 -2.8131 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4817 1.8331 -0.3710 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3232 0.0000 -1.1599 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2477 1.5064 -2.6434 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 33 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 34 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 35 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 36 1 0 0 0 0 12 37 1 0 0 0 0 12 38 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 39 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 40 1 0 0 0 0 18 41 1 0 0 0 0 21 22 1 0 0 0 0 21 42 1 0 0 0 0 22 23 1 0 0 0 0 22 43 1 0 0 0 0 22 44 1 0 0 0 0 23 24 1 0 0 0 0 23 45 1 0 0 0 0 23 46 1 0 0 0 0 24 25 1 0 0 0 0 24 47 1 0 0 0 0 24 48 1 0 0 0 0 25 30 1 0 0 0 0 25 49 1 0 0 0 0 25 50 1 0 0 0 0 26 31 1 0 0 0 0 26 29 1 0 0 0 0 26 51 1 0 0 0 0 26 52 1 0 0 0 0 27 31 1 0 0 0 0 27 28 1 0 0 0 0 27 53 1 0 0 0 0 27 54 1 0 0 0 0 28 30 1 0 0 0 0 28 55 1 0 0 0 0 28 56 1 0 0 0 0 29 30 1 0 0 0 0 29 57 1 0 0 0 0 29 58 1 0 0 0 0 31 32 1 0 0 0 0 32 59 1 0 0 0 0 32 60 1 0 0 0 0 32 61 1 0 0 0 0 M END > (377) 1,6-naphthyridin-2(1H)-one deriv. 7i > (377) PDGFR-beta > (377) 1100 > (377) -1 > (377) P > (377) PDGFR-P375 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 30 csChFnd70/05150717532D 65 67 0 0 0 0 0 0 0 0999 V2000 4.9429 13.4903 -0.8202 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4362 10.8783 -0.6069 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9493 11.7744 -0.6889 N 0 0 0 0 0 0 0 0 0 0 0 0 7.9836 11.6355 -0.6508 N 0 0 0 0 0 0 0 0 0 0 0 0 6.5522 14.3701 -0.8728 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1131 13.3737 -0.7826 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6543 16.1961 -1.0121 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7921 15.8793 -0.9600 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2972 16.9528 -1.0556 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6627 14.1690 -0.8298 N 0 0 0 0 0 0 0 0 0 0 0 0 8.4833 18.8742 -1.2021 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7304 21.6924 0.1538 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8307 22.4645 -1.4759 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5570 19.9029 0.2991 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5927 19.6601 -2.8417 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7659 21.4508 -2.9694 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4304 18.9364 2.3457 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.5124 18.3900 -4.7176 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.3564 9.0806 -0.4697 N 0 0 3 0 0 0 0 0 0 0 0 0 4.6591 8.1998 -0.4171 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9369 6.2273 -0.2631 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4346 16.6422 -1.0040 N 0 0 3 0 0 0 0 0 0 0 0 0 12.8753 15.6355 -0.9140 C 0 0 0 0 0 0 0 0 0 0 0 0 12.7356 14.0588 -0.7943 O 0 0 0 0 0 0 0 0 0 0 0 0 14.4709 16.3768 -0.9569 N 0 0 3 0 0 0 0 0 0 0 0 0 16.5044 14.6238 -2.6863 C 0 0 0 0 0 0 0 0 0 0 0 0 16.0369 15.2824 -0.8589 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1643 5.3075 -0.2081 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7775 2.5131 0.3059 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2802 2.7871 2.2215 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4310 3.4136 -0.0605 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2611 2.7109 -1.6406 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9812 0.8868 -1.2596 C 0 0 0 0 0 0 0 0 0 0 0 0 17.5554 16.3564 -0.1295 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7284 14.2036 -0.8914 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4882 16.9859 -1.0835 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7881 22.4903 1.3152 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9662 23.8640 -1.5826 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8504 22.0609 -4.2381 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4242 8.4021 -0.4081 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9184 8.6636 0.7064 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9389 8.4858 -1.6110 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6776 5.7635 -1.3865 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6571 5.9413 0.9308 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5462 17.9004 -1.0996 H 0 0 0 0 0 0 0 0 0 0 0 0 14.5824 17.6348 -1.0525 H 0 0 0 0 0 0 0 0 0 0 0 0 17.6694 13.8096 -2.6135 H 0 0 0 0 0 0 0 0 0 0 0 0 15.4225 13.8586 -3.2060 H 0 0 0 0 0 0 0 0 0 0 0 0 16.7540 15.7340 -3.5413 H 0 0 0 0 0 0 0 0 0 0 0 0 15.7872 14.1722 -0.0040 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4237 5.7713 0.9152 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4442 5.5935 -1.4022 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9283 1.1213 0.0494 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7540 3.0414 -0.5301 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.2150 2.4657 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2471 2.1603 3.0570 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2392 4.1809 2.5063 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2992 2.6323 -2.6868 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3256 3.5678 -2.0383 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8508 0.9455 -0.1344 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9034 0.0000 -0.9804 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7022 0.4152 -2.3925 H 0 0 0 0 0 0 0 0 0 0 0 0 17.2224 16.8257 1.1722 H 0 0 0 0 0 0 0 0 0 0 0 0 18.7205 15.5423 -0.0568 H 0 0 0 0 0 0 0 0 0 0 0 0 17.8051 17.4666 -0.9846 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 35 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 19 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 36 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 22 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 37 1 0 0 0 0 13 16 1 0 0 0 0 13 38 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 39 1 0 0 0 0 19 20 1 0 0 0 0 19 40 1 0 0 0 0 20 21 1 0 0 0 0 20 41 1 0 0 0 0 20 42 1 0 0 0 0 21 28 1 0 0 0 0 21 43 1 0 0 0 0 21 44 1 0 0 0 0 22 23 1 0 0 0 0 22 45 1 0 0 0 0 23 25 1 0 0 0 0 23 24 2 0 0 0 0 25 27 1 0 0 0 0 25 46 1 0 0 0 0 26 27 1 0 0 0 0 26 47 1 0 0 0 0 26 48 1 0 0 0 0 26 49 1 0 0 0 0 27 34 1 0 0 0 0 27 50 1 0 0 0 0 28 31 1 0 0 0 0 28 51 1 0 0 0 0 28 52 1 0 0 0 0 29 31 1 0 0 0 0 29 30 1 0 0 0 0 29 53 1 0 0 0 0 29 54 1 0 0 0 0 30 55 1 0 0 0 0 30 56 1 0 0 0 0 30 57 1 0 0 0 0 31 32 1 0 0 0 0 32 33 1 0 0 0 0 32 58 1 0 0 0 0 32 59 1 0 0 0 0 33 60 1 0 0 0 0 33 61 1 0 0 0 0 33 62 1 0 0 0 0 34 63 1 0 0 0 0 34 64 1 0 0 0 0 34 65 1 0 0 0 0 M END > (378) 6-arylpyrido[2,3-d]pyrimidine deriv. 30 > (378) PDGFR-beta > (378) 1100 > (378) -1 > (378) P > (378) PDGFR-P376 $$$$ Structure136 csChFnd70/05150717532D 45 47 0 0 0 0 0 0 0 0999 V2000 2.5954 9.5776 0.0119 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6187 7.8678 0.0026 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0568 6.9716 -0.0154 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5794 7.7712 -0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6016 9.5947 -0.0167 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0504 6.8927 -0.0435 N 0 0 0 0 0 0 0 0 0 0 0 0 8.5496 7.6779 -0.0530 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6707 9.4859 -0.0450 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0425 6.7048 -0.0697 N 0 0 3 0 0 0 0 0 0 0 0 0 9.9490 4.9762 -0.0776 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3991 4.0310 -0.0937 N 0 0 3 0 0 0 0 0 0 0 0 0 8.5565 4.2697 -0.0700 O 0 0 0 0 0 0 0 0 0 0 0 0 1.0726 6.9958 0.0127 N 0 0 0 0 0 0 0 0 0 0 0 0 10.3757 10.3339 -0.0548 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1940 10.7268 1.4898 C 0 0 0 0 0 0 0 0 0 0 0 0 12.7827 11.5165 1.4719 C 0 0 0 0 0 0 0 0 0 0 0 0 13.5618 11.9180 -0.0733 C 0 0 0 0 0 0 0 0 0 0 0 0 12.7571 11.5318 -1.6094 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1716 10.7355 -1.6089 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0278 10.4790 0.0032 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1825 10.4627 -0.0284 C 0 0 0 0 0 0 0 0 0 0 0 0 11.2975 2.1520 -0.1024 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3243 1.5561 -1.7022 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1120 1.3980 -0.1205 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3497 1.5400 1.5068 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1640 10.2512 -3.5382 Cl 0 0 0 0 0 0 0 0 0 0 0 0 10.2174 10.2251 3.4306 Cl 0 0 0 0 0 0 0 0 0 0 0 0 11.1535 7.2685 -0.0757 H 0 0 0 0 0 0 0 0 0 0 0 0 12.5101 4.5947 -0.0998 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0600 5.7501 0.0066 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 7.6296 0.0259 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4176 11.8213 2.6670 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8036 12.5362 -0.0805 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3720 11.8490 -2.8117 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9934 11.8657 0.0109 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2370 11.8489 -0.0218 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9994 1.9920 -2.8486 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2486 0.1581 -1.7085 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0315 2.0933 -1.6893 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8053 1.8226 1.0193 H 0 0 0 0 0 0 0 0 0 0 0 0 13.0365 0.0000 -0.1269 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7872 1.8340 -1.2668 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0571 2.0773 1.5197 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2741 0.1421 1.5003 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0430 1.9646 2.6465 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 20 2 0 0 0 0 2 3 2 0 0 0 0 2 13 1 0 0 0 0 3 4 1 0 0 0 0 4 6 2 0 0 0 0 4 5 1 0 0 0 0 5 20 1 0 0 0 0 5 21 2 0 0 0 0 6 7 1 0 0 0 0 7 8 2 0 0 0 0 7 9 1 0 0 0 0 8 14 1 0 0 0 0 8 21 1 0 0 0 0 9 10 1 0 0 0 0 9 28 1 0 0 0 0 10 11 1 0 0 0 0 10 12 2 0 0 0 0 11 22 1 0 0 0 0 11 29 1 0 0 0 0 13 30 1 0 0 0 0 13 31 1 0 0 0 0 14 15 2 0 0 0 0 14 19 1 0 0 0 0 15 16 1 0 0 0 0 15 27 1 0 0 0 0 16 17 2 0 0 0 0 16 32 1 0 0 0 0 17 18 1 0 0 0 0 17 33 1 0 0 0 0 18 19 2 0 0 0 0 18 34 1 0 0 0 0 19 26 1 0 0 0 0 20 35 1 0 0 0 0 21 36 1 0 0 0 0 22 23 1 0 0 0 0 22 24 1 0 0 0 0 22 25 1 0 0 0 0 23 37 1 0 0 0 0 23 38 1 0 0 0 0 23 39 1 0 0 0 0 24 40 1 0 0 0 0 24 41 1 0 0 0 0 24 42 1 0 0 0 0 25 43 1 0 0 0 0 25 44 1 0 0 0 0 25 45 1 0 0 0 0 M END > (381) 9240345-4b > (381) PDGFR-beta > (381) 1110 > (381) -1 > (381) P > (381) PDGFR-P379 $$$$ csChFnd70/05150717532D 44 47 0 0 0 0 0 0 0 0999 V2000 5.7137 8.3926 0.0167 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5988 6.6823 -0.0028 N 0 0 0 0 0 0 0 0 0 0 0 0 5.7351 6.7666 0.0014 N 0 0 0 0 0 0 0 0 0 0 0 0 7.2213 9.2403 0.0229 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6952 8.3167 0.0124 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2776 10.9812 0.0387 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2848 10.7559 0.0329 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6259 11.4307 0.0381 O 0 0 0 0 0 0 0 0 0 0 0 0 10.1942 9.0987 0.0174 N 0 0 3 0 0 0 0 0 0 0 0 0 8.7791 11.7510 0.0435 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8798 13.5740 0.0594 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9184 14.4496 -1.4202 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0115 16.1490 -1.3968 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0667 16.9831 0.0890 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0295 16.1224 1.5601 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9292 14.4233 1.5539 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8730 13.3459 3.4015 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.8500 13.4053 -3.2861 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.1472 5.9375 -0.0081 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0987 4.2354 -0.0248 N 0 0 3 0 0 0 0 0 0 0 0 0 5.5902 3.4152 0.1147 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3313 1.9465 -0.7259 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3492 4.0632 1.0999 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8606 3.2494 1.2354 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7121 8.1209 0.0064 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8397 1.1391 -0.5849 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6046 1.7910 0.3918 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9788 0.9062 0.5431 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5605 9.0571 0.0188 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1533 11.6935 0.0463 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0420 16.8283 -2.5410 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1396 18.3119 0.1006 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0734 16.7808 2.7159 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1115 3.6096 -0.1331 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2952 1.4370 -1.4891 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5485 5.2020 1.7593 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8936 3.7552 1.9974 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0867 7.8899 -1.2628 H 0 0 0 0 0 0 0 0 0 0 0 0 12.6834 8.7946 0.6444 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4954 6.9506 0.6293 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6358 0.0000 -1.2425 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0314 0.0461 1.5735 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.8011 0.7563 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7290 0.2312 -0.5912 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 29 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 30 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 25 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 31 1 0 0 0 0 14 15 1 0 0 0 0 14 32 1 0 0 0 0 15 16 2 0 0 0 0 15 33 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 34 1 0 0 0 0 21 22 1 0 0 0 0 21 23 2 0 0 0 0 22 26 2 0 0 0 0 22 35 1 0 0 0 0 23 24 1 0 0 0 0 23 36 1 0 0 0 0 24 27 2 0 0 0 0 24 37 1 0 0 0 0 25 38 1 0 0 0 0 25 39 1 0 0 0 0 25 40 1 0 0 0 0 26 27 1 0 0 0 0 26 41 1 0 0 0 0 27 28 1 0 0 0 0 28 42 1 0 0 0 0 28 43 1 0 0 0 0 28 44 1 0 0 0 0 M END > (385) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 46 > (385) PDGFR-beta > (385) 1200 > (385) -1 > (385) P > (385) PDGFR-P383 $$$$ 1,6-naphthyridin 28 csChFnd70/05150717532D 72 75 0 0 0 0 0 0 0 0999 V2000 1.2227 16.2720 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7133 13.6628 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3127 14.4672 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7814 17.2064 0.0021 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3766 16.2856 -0.0180 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8075 19.0291 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9353 18.8469 -0.0203 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4041 19.8494 -0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2458 14.5696 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8819 17.1413 -0.0284 N 0 0 0 0 0 0 0 0 0 0 0 0 4.5049 21.7688 0.0076 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6372 24.5191 -1.1626 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5380 22.7329 -1.1761 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5616 22.6166 1.2037 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6505 24.4034 1.2049 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6932 25.3531 0.0228 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6343 11.8626 -0.0258 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2358 10.8421 -0.0464 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7883 8.9097 -0.0533 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4609 7.8439 -0.0749 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6900 5.5938 1.2125 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2064 3.6732 1.0939 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1028 3.0061 0.0882 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5864 4.9267 0.2068 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0313 5.9886 -0.0815 N 0 0 0 0 0 0 0 0 0 0 0 0 4.7615 2.6113 1.3822 N 0 0 0 0 0 0 0 0 0 0 0 0 4.3319 0.7560 1.3755 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5318 19.6780 -0.0316 N 0 0 3 0 0 0 0 0 0 0 0 0 9.0052 18.7393 -0.0507 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9364 17.1648 -0.0579 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5549 19.5461 -0.0617 N 0 0 3 0 0 0 0 0 0 0 0 0 12.1565 18.5257 -0.0823 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1960 17.3899 -1.7079 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7189 19.7475 -0.0914 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2275 17.3737 1.5307 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.9537 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4913 13.7117 -0.0419 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6177 19.7671 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8885 25.2674 -2.0791 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7131 22.0832 -2.1022 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3089 21.8765 2.1278 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4687 25.0615 2.1311 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7663 26.7512 0.0289 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5189 11.2822 -0.0187 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9803 11.1572 -1.2053 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0017 11.1440 1.1019 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0439 8.5946 1.1056 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0224 8.6077 -1.2017 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2054 8.1590 -1.2339 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2268 8.1459 1.0735 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5459 6.3844 0.9619 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1848 5.8764 2.5056 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2388 3.3691 2.0777 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6788 3.3983 -0.1878 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6081 2.7235 -1.2048 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2469 2.2155 0.3389 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1141 5.2016 1.4885 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5540 5.2308 -0.7770 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7702 0.4071 0.1269 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5059 0.0000 1.5917 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4010 0.4846 2.4033 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5866 20.9343 -0.0259 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6099 20.8023 -0.0559 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1454 18.2107 -2.8572 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3876 16.6308 -1.7234 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0829 16.5195 -1.7016 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6908 20.5567 1.0666 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9105 18.9884 -0.1068 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6684 20.5682 -1.2406 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1144 16.5033 1.5372 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4191 16.6146 1.5153 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1993 18.1828 2.6889 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 36 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 17 1 0 0 0 0 3 5 2 0 0 0 0 3 37 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 38 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 28 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 39 1 0 0 0 0 13 40 1 0 0 0 0 14 15 1 0 0 0 0 14 41 1 0 0 0 0 15 16 2 0 0 0 0 15 42 1 0 0 0 0 16 43 1 0 0 0 0 17 18 1 0 0 0 0 17 44 1 0 0 0 0 18 19 1 0 0 0 0 18 45 1 0 0 0 0 18 46 1 0 0 0 0 19 20 1 0 0 0 0 19 47 1 0 0 0 0 19 48 1 0 0 0 0 20 25 1 0 0 0 0 20 49 1 0 0 0 0 20 50 1 0 0 0 0 21 25 1 0 0 0 0 21 22 1 0 0 0 0 21 51 1 0 0 0 0 21 52 1 0 0 0 0 22 26 1 0 0 0 0 22 53 1 0 0 0 0 22 54 1 0 0 0 0 23 26 1 0 0 0 0 23 24 1 0 0 0 0 23 55 1 0 0 0 0 23 56 1 0 0 0 0 24 25 1 0 0 0 0 24 57 1 0 0 0 0 24 58 1 0 0 0 0 26 27 1 0 0 0 0 27 59 1 0 0 0 0 27 60 1 0 0 0 0 27 61 1 0 0 0 0 28 29 1 0 0 0 0 28 62 1 0 0 0 0 29 30 2 0 0 0 0 29 31 1 0 0 0 0 31 32 1 0 0 0 0 31 63 1 0 0 0 0 32 33 1 0 0 0 0 32 34 1 0 0 0 0 32 35 1 0 0 0 0 33 64 1 0 0 0 0 33 65 1 0 0 0 0 33 66 1 0 0 0 0 34 67 1 0 0 0 0 34 68 1 0 0 0 0 34 69 1 0 0 0 0 35 70 1 0 0 0 0 35 71 1 0 0 0 0 35 72 1 0 0 0 0 M END > (387) 1,6-naphthyridine 28 > (387) PDGFR-beta > (387) 1200 > (387) -1 > (387) P > (387) PDGFR-P385 $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 6 csChFnd70/05150717532D 37 39 0 0 0 0 0 0 0 0999 V2000 1.2133 5.0305 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7217 2.4481 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7980 5.9225 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3491 4.9515 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8568 7.7542 0.0115 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0201 7.5182 -0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4358 8.5644 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2365 3.3194 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2486 3.2324 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4305 8.2286 -0.0285 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9256 5.7747 -0.0284 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5411 10.4821 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7031 13.1686 1.5790 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6052 11.3808 1.5794 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5840 11.3971 -1.5492 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6820 13.1848 -1.5314 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7377 14.0683 0.0281 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5612 10.2542 3.5271 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5150 10.2909 -3.5079 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6716 0.6590 -0.0254 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5226 4.7469 -0.0485 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0614 4.3992 -1.9255 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7292 3.3258 -1.9465 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.7288 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6739 8.5031 0.0264 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7524 13.8658 2.7921 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7158 13.8946 -2.7378 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8144 15.4662 0.0349 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5655 0.0609 -0.0180 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7425 0.0000 -0.0392 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5491 5.4588 0.6120 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3004 3.5184 0.6130 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0348 3.6874 -2.5860 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2836 5.6278 -2.5871 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1131 3.0781 -3.2836 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7558 4.0376 -1.2860 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5070 2.0973 -1.2848 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 24 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 20 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 11 1 0 0 0 0 5 7 2 0 0 0 0 5 25 1 0 0 0 0 6 11 1 0 0 0 0 6 7 1 0 0 0 0 6 10 2 0 0 0 0 7 12 1 0 0 0 0 11 21 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 26 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 27 1 0 0 0 0 17 28 1 0 0 0 0 20 29 1 0 0 0 0 20 30 1 0 0 0 0 21 22 1 0 0 0 0 21 31 1 0 0 0 0 21 32 1 0 0 0 0 22 23 1 0 0 0 0 22 33 1 0 0 0 0 22 34 1 0 0 0 0 23 35 1 0 0 0 0 23 36 1 0 0 0 0 23 37 1 0 0 0 0 M END > (390) pyrido[2,3-d]pyrimidin-7-one deriv. 6 > (390) PDGFR-beta > (390) 1200 > (390) -1 > (390) P > (390) PDGFR-P388 $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 13 csChFnd70/05150717532D 40 43 0 0 0 0 0 0 0 0999 V2000 1.2132 5.0301 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7216 2.4479 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7978 5.9221 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3488 4.9512 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8566 7.7537 0.0115 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0197 7.5177 -0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4355 8.5639 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2364 3.3192 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2484 3.2322 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4300 8.2281 -0.0285 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9252 5.7743 -0.0284 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5408 10.4815 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7028 13.1678 1.5789 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6049 11.3801 1.5793 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5837 11.3964 -1.5491 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6817 13.1840 -1.5313 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7374 14.0674 0.0281 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5609 10.2536 3.5268 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5147 10.2903 -3.5077 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6714 0.6589 -0.0254 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5221 4.7466 -0.0485 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0527 4.4042 -1.8971 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1383 5.5413 -2.7685 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4730 2.9407 -2.7646 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9869 2.6696 -4.4594 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5971 5.1844 -4.4630 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0156 3.7827 -5.2499 N 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.7285 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6738 8.5025 0.0264 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7521 13.8649 2.7920 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7155 13.8937 -2.7376 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8141 15.4652 0.0349 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5654 0.0609 -0.0180 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7423 0.0000 -0.0391 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5486 5.4584 0.6120 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3000 3.5181 0.6130 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6188 6.6914 -2.1311 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6311 2.0239 -2.1239 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5409 1.5329 -5.1441 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4418 6.0639 -5.1510 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 28 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 20 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 11 1 0 0 0 0 5 7 2 0 0 0 0 5 29 1 0 0 0 0 6 11 1 0 0 0 0 6 7 1 0 0 0 0 6 10 2 0 0 0 0 7 12 1 0 0 0 0 11 21 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 30 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 31 1 0 0 0 0 17 32 1 0 0 0 0 20 33 1 0 0 0 0 20 34 1 0 0 0 0 21 22 1 0 0 0 0 21 35 1 0 0 0 0 21 36 1 0 0 0 0 22 23 2 0 0 0 0 22 24 1 0 0 0 0 23 26 1 0 0 0 0 23 37 1 0 0 0 0 24 25 2 0 0 0 0 24 38 1 0 0 0 0 25 27 1 0 0 0 0 25 39 1 0 0 0 0 26 27 2 0 0 0 0 26 40 1 0 0 0 0 M END > (391) pyrido[2,3-d]pyrimidin-7-one deriv. 13 > (391) PDGFR-beta > (391) 1200 > (391) -1 > (391) P > (391) PDGFR-P389 $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 7 csChFnd70/05150717532D 40 42 0 0 0 0 0 0 0 0999 V2000 1.2133 5.0305 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7217 2.4481 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7980 5.9225 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3491 4.9515 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8568 7.7542 0.0115 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0201 7.5182 -0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4358 8.5644 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2365 3.3194 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2486 3.2324 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4305 8.2286 -0.0285 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9256 5.7747 -0.0284 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5411 10.4821 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7031 13.1686 1.5790 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6052 11.3808 1.5794 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5840 11.3971 -1.5492 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6820 13.1848 -1.5314 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7377 14.0683 0.0281 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5612 10.2542 3.5271 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5150 10.2909 -3.5079 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6716 0.6590 -0.0254 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5226 4.7469 -0.0485 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0614 4.3992 -1.9255 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7292 3.3258 -1.9465 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2680 2.9780 -3.8234 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.7288 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6739 8.5031 0.0264 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7524 13.8658 2.7921 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7158 13.8946 -2.7378 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8144 15.4662 0.0349 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5655 0.0609 -0.0180 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7425 0.0000 -0.0392 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5491 5.4588 0.6120 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3004 3.5184 0.6130 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0348 3.6874 -2.5860 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2836 5.6278 -2.5871 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7558 4.0376 -1.2860 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5070 2.0973 -1.2848 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2415 2.2663 -4.4840 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4902 4.2067 -4.4851 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4562 2.2134 -3.8385 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 25 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 20 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 11 1 0 0 0 0 5 7 2 0 0 0 0 5 26 1 0 0 0 0 6 11 1 0 0 0 0 6 7 1 0 0 0 0 6 10 2 0 0 0 0 7 12 1 0 0 0 0 11 21 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 27 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 28 1 0 0 0 0 17 29 1 0 0 0 0 20 30 1 0 0 0 0 20 31 1 0 0 0 0 21 22 1 0 0 0 0 21 32 1 0 0 0 0 21 33 1 0 0 0 0 22 23 1 0 0 0 0 22 34 1 0 0 0 0 22 35 1 0 0 0 0 23 24 1 0 0 0 0 23 36 1 0 0 0 0 23 37 1 0 0 0 0 24 38 1 0 0 0 0 24 39 1 0 0 0 0 24 40 1 0 0 0 0 M END > (392) pyrido[2,3-d]pyrimidin-7-one deriv. 7 > (392) PDGFR-beta > (392) 1200 > (392) -1 > (392) P > (392) PDGFR-P390 $$$$ 3-substituted indolin-2-one 16c csChFnd70/05150717532D 44 46 0 0 0 0 0 0 0 0999 V2000 2.3699 4.6173 -0.1495 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7644 3.1785 -1.7437 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8053 4.7667 -1.5088 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5947 5.4802 -0.7051 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9720 7.1435 -0.6486 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4482 7.2853 -1.4640 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8738 5.8732 -1.9356 N 0 0 3 0 0 0 0 0 0 0 0 0 6.1620 8.4756 -1.6760 O 0 0 0 0 0 0 0 0 0 0 0 0 3.1202 8.3086 0.0242 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7386 9.8076 0.1350 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9204 11.1773 0.0466 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2669 10.1802 0.3578 N 0 0 3 0 0 0 0 0 0 0 0 0 1.2071 11.3433 -0.1849 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3993 11.7377 0.4003 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3432 3.0269 -0.3928 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5511 2.3190 -1.1940 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8794 12.6188 0.6240 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9835 12.3735 0.2129 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6214 14.0721 0.1917 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2723 14.6192 1.8313 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9102 16.3177 1.8102 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9292 17.0188 0.6070 O 0 0 0 0 0 0 0 0 0 0 0 0 2.5664 17.0518 3.1278 O 0 0 0 0 0 0 0 0 0 0 0 0 1.0471 2.0960 0.1929 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.7131 0.8886 O 0 0 0 0 0 0 0 0 0 0 0 0 1.0241 0.5613 -0.0433 O 0 0 0 0 0 0 0 0 0 0 0 0 1.4446 5.1712 0.4721 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6899 2.6197 -2.3606 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8117 5.6559 -2.5040 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9806 8.0713 0.4655 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1071 9.4508 0.4664 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6335 11.3627 0.9326 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9689 12.4145 -0.7964 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7795 10.3728 -0.8582 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5300 1.0888 -1.3824 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4031 12.8484 -0.4945 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6359 13.7063 1.2037 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6697 11.9385 1.3246 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6081 14.7051 -0.2598 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6213 14.2780 -0.5402 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2856 13.9861 2.2828 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2724 14.4134 2.5633 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3422 18.1413 3.0564 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1509 0.0000 0.3620 H 0 0 0 0 0 0 0 0 0 0 0 0 1 15 1 0 0 0 0 1 4 2 0 0 0 0 1 27 1 0 0 0 0 2 16 1 0 0 0 0 2 3 2 0 0 0 0 2 28 1 0 0 0 0 3 7 1 0 0 0 0 3 4 1 0 0 0 0 4 5 1 0 0 0 0 5 6 1 0 0 0 0 5 9 2 0 0 0 0 6 7 1 0 0 0 0 6 8 2 0 0 0 0 7 29 1 0 0 0 0 9 10 1 0 0 0 0 9 30 1 0 0 0 0 10 11 2 0 0 0 0 10 12 1 0 0 0 0 11 18 1 0 0 0 0 11 13 1 0 0 0 0 12 14 1 0 0 0 0 12 31 1 0 0 0 0 13 32 1 0 0 0 0 13 33 1 0 0 0 0 13 34 1 0 0 0 0 14 18 2 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 24 1 0 0 0 0 16 35 1 0 0 0 0 17 36 1 0 0 0 0 17 37 1 0 0 0 0 17 38 1 0 0 0 0 18 19 1 0 0 0 0 19 20 1 0 0 0 0 19 39 1 0 0 0 0 19 40 1 0 0 0 0 20 21 1 0 0 0 0 20 41 1 0 0 0 0 20 42 1 0 0 0 0 21 23 1 0 0 0 0 21 22 2 0 0 0 0 23 43 1 0 0 0 0 24 26 1 0 0 0 0 24 25 2 0 0 0 0 26 44 1 0 0 0 0 M END > (396) 3-substituted indolin-2-one 16c > (396) PDGFR-beta > (396) 1210 > (396) -1 > (396) P > (396) PDGFR-P394 $$$$ PD0173956 csChFnd70/05150717532D 41 44 0 0 0 0 0 0 0 0999 V2000 3.5539 14.4150 -0.7349 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1245 17.1532 -0.8061 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1345 15.3429 -0.6781 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9729 15.3239 -0.9278 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9812 17.1343 -1.0542 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5522 18.0467 -0.9900 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1091 14.2241 -0.4465 Cl 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 14.1812 -1.0092 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.4501 4.4855 1.3050 N 0 0 3 0 0 0 0 0 0 0 0 0 3.4795 3.6356 2.9355 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4352 3.5218 5.9364 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5389 1.9541 6.1602 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6186 1.2229 4.7710 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5872 2.0598 3.1608 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4074 4.3631 4.3284 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5548 12.4728 -0.5991 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4289 11.6752 1.0087 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6824 11.3889 -2.1842 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7887 12.0877 -3.6204 O 0 0 0 0 0 0 0 0 0 0 0 0 3.6834 9.6231 -2.0620 N 0 0 3 0 0 0 0 0 0 0 0 0 3.8196 8.5575 -3.6595 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4445 6.2992 1.2267 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5653 8.8122 -0.4559 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4334 9.8197 1.0964 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3075 8.9391 2.7111 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3180 7.2048 2.7140 N 0 0 0 0 0 0 0 0 0 0 0 0 3.5657 7.0715 -0.3280 N 0 0 0 0 0 0 0 0 0 0 0 0 3.5679 1.1333 7.7341 F 0 0 0 0 0 0 0 0 0 0 0 0 6.3469 17.8730 -0.7623 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7585 17.8393 -1.2039 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5515 19.4624 -1.0899 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4335 3.8009 0.2298 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1518 4.0901 7.0217 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9203 0.0000 4.9484 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8688 1.4892 2.0779 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1072 5.5855 4.1543 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3284 12.4520 2.1922 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5071 8.2798 -4.1615 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5674 9.2740 -4.6491 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4853 7.3259 -3.3568 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2046 9.6652 3.9263 H 0 0 0 0 0 0 0 0 0 0 0 0 1 16 1 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 2 3 1 0 0 0 0 2 6 2 0 0 0 0 2 29 1 0 0 0 0 3 7 1 0 0 0 0 4 5 2 0 0 0 0 4 8 1 0 0 0 0 5 6 1 0 0 0 0 5 30 1 0 0 0 0 6 31 1 0 0 0 0 9 22 1 0 0 0 0 9 10 1 0 0 0 0 9 32 1 0 0 0 0 10 14 2 0 0 0 0 10 15 1 0 0 0 0 11 12 1 0 0 0 0 11 15 2 0 0 0 0 11 33 1 0 0 0 0 12 13 2 0 0 0 0 12 28 1 0 0 0 0 13 14 1 0 0 0 0 13 34 1 0 0 0 0 14 35 1 0 0 0 0 15 36 1 0 0 0 0 16 18 1 0 0 0 0 16 17 2 0 0 0 0 17 24 1 0 0 0 0 17 37 1 0 0 0 0 18 20 1 0 0 0 0 18 19 2 0 0 0 0 20 23 1 0 0 0 0 20 21 1 0 0 0 0 21 38 1 0 0 0 0 21 39 1 0 0 0 0 21 40 1 0 0 0 0 22 26 2 0 0 0 0 22 27 1 0 0 0 0 23 27 2 0 0 0 0 23 24 1 0 0 0 0 24 25 2 0 0 0 0 25 26 1 0 0 0 0 25 41 1 0 0 0 0 M END > (399) PD173956 > (399) PDGFR-beta > (399) 1250 > (399) -1 > (399) P > (399) PDGFR-P397 $$$$ SU11248 analog 12i csChFnd70/05150717532D 48 51 0 0 0 0 0 0 0 0999 V2000 2.9298 3.8254 -0.1628 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9007 2.1103 -0.4264 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1967 1.3403 -1.2964 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5252 2.2710 -1.9063 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2636 4.7720 -0.7738 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5759 3.9967 -1.6526 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2774 6.7435 -1.6076 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6727 6.5832 -0.7125 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7434 5.2064 -2.1231 N 0 0 3 0 0 0 0 0 0 0 0 0 7.0513 8.0419 -1.8391 O 0 0 0 0 0 0 0 0 0 0 0 0 3.7465 7.8486 0.0255 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4186 9.4843 0.1456 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2537 11.5618 0.4375 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6885 12.2844 0.2309 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5212 10.9643 0.0483 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0860 9.8844 0.3883 N 0 0 3 0 0 0 0 0 0 0 0 0 1.6544 11.1365 -0.2047 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8778 12.5006 0.6821 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3102 14.0957 0.2066 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3359 14.8634 -1.1126 O 0 0 0 0 0 0 0 0 0 0 0 0 3.9356 14.9010 1.6467 N 0 0 3 0 0 0 0 0 0 0 0 0 1.6088 1.1839 0.1644 F 0 0 0 0 0 0 0 0 0 0 0 0 3.5595 16.7011 1.6228 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1851 17.2906 3.3810 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4579 17.8737 4.4151 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5587 17.2694 4.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2634 17.8196 5.6190 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0670 18.4039 6.0201 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5061 18.3601 6.5696 N 0 0 0 0 0 0 0 0 0 0 0 0 1.9187 4.4282 0.5097 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1668 0.0000 -1.4984 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5276 1.6569 -2.5817 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7631 4.9708 -2.7457 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5079 7.5873 0.5109 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9938 9.0813 0.5056 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0291 11.1564 1.0122 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3902 12.3014 -0.8723 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1936 10.0765 -0.9370 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4509 12.7458 -0.5360 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6278 13.6874 1.3157 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7297 11.7476 1.4436 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9150 14.2887 2.6991 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6377 17.3857 1.1321 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4722 16.9293 0.8240 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7386 17.9126 3.9721 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5355 16.8290 3.2276 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 17.8070 6.1110 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0512 18.8595 6.8336 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 5 2 0 0 0 0 1 30 1 0 0 0 0 2 3 2 0 0 0 0 2 22 1 0 0 0 0 3 4 1 0 0 0 0 3 31 1 0 0 0 0 4 6 2 0 0 0 0 4 32 1 0 0 0 0 5 8 1 0 0 0 0 5 6 1 0 0 0 0 6 9 1 0 0 0 0 7 9 1 0 0 0 0 7 8 1 0 0 0 0 7 10 2 0 0 0 0 8 11 2 0 0 0 0 9 33 1 0 0 0 0 11 12 1 0 0 0 0 11 34 1 0 0 0 0 12 15 2 0 0 0 0 12 16 1 0 0 0 0 13 16 1 0 0 0 0 13 14 2 0 0 0 0 13 18 1 0 0 0 0 14 15 1 0 0 0 0 14 19 1 0 0 0 0 15 17 1 0 0 0 0 16 35 1 0 0 0 0 17 36 1 0 0 0 0 17 37 1 0 0 0 0 17 38 1 0 0 0 0 18 39 1 0 0 0 0 18 40 1 0 0 0 0 18 41 1 0 0 0 0 19 20 2 0 0 0 0 19 21 1 0 0 0 0 21 23 1 0 0 0 0 21 42 1 0 0 0 0 23 24 1 0 0 0 0 23 43 1 0 0 0 0 23 44 1 0 0 0 0 24 25 2 0 0 0 0 24 26 1 0 0 0 0 25 28 1 0 0 0 0 25 45 1 0 0 0 0 26 27 2 0 0 0 0 26 46 1 0 0 0 0 27 29 1 0 0 0 0 27 47 1 0 0 0 0 28 29 2 0 0 0 0 28 48 1 0 0 0 0 M END > (5) SU11248 analog 12i > (5) PDGFR-beta > (5) 1 > (5) -1 > (5) P > (5) PDGFR-P3 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 29 csChFnd70/05150717532D 62 64 0 0 0 0 0 0 0 0999 V2000 4.3571 13.4370 0.0670 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9475 10.8966 -0.0323 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4337 11.7292 0.0006 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4536 11.7125 -0.0014 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9198 14.3773 0.1026 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5112 13.4481 0.0658 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9465 16.1993 0.1727 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0766 16.0099 0.1632 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5477 17.0186 0.2030 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0180 14.3020 0.0976 N 0 0 0 0 0 0 0 0 0 0 0 0 7.6537 18.9389 0.2761 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8035 21.5759 1.9348 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8520 22.5272 0.4127 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7048 19.7865 1.8755 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7106 19.9053 -1.2543 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8094 21.6941 -1.1775 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6434 18.5949 3.7873 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.6580 18.8619 -3.2512 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.9418 9.1038 -0.1011 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2917 8.1589 -0.1363 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6484 6.2064 -0.2116 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6771 16.8355 0.1938 N 0 0 3 0 0 0 0 0 0 0 0 0 12.1494 15.8910 0.1564 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0751 14.3157 0.0959 O 0 0 0 0 0 0 0 0 0 0 0 0 13.7042 16.6929 0.1863 N 0 0 3 0 0 0 0 0 0 0 0 0 16.8734 16.8837 0.1914 C 0 0 0 0 0 0 0 0 0 0 0 0 15.3046 15.6663 0.1456 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9251 5.2194 -0.2483 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1025 2.7402 1.2838 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9055 0.9494 0.9782 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2675 3.3448 -0.3206 N 0 0 0 0 0 0 0 0 0 0 0 0 1.6653 2.3701 -0.6663 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1941 2.5314 -2.5891 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1214 14.0990 0.0875 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7557 16.9389 0.2013 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8435 22.2337 3.1724 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9292 23.9262 0.4659 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8529 22.4439 -2.3614 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0303 8.4712 -0.1262 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5516 8.4584 1.0318 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5500 8.5472 -1.2772 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3885 5.9068 -1.3798 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3901 5.8181 0.9291 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7363 18.0924 0.2421 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7634 17.9498 0.2345 H 0 0 0 0 0 0 0 0 0 0 0 0 16.8361 17.7437 -0.9317 H 0 0 0 0 0 0 0 0 0 0 0 0 16.8377 17.6549 1.3772 H 0 0 0 0 0 0 0 0 0 0 0 0 18.0642 16.1199 0.1612 H 0 0 0 0 0 0 0 0 0 0 0 0 15.3420 14.8064 1.2689 H 0 0 0 0 0 0 0 0 0 0 0 0 15.3405 14.8952 -1.0402 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1850 5.5190 0.9199 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1834 5.6077 -1.3892 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1370 2.6546 2.3147 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1157 3.6531 1.6613 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6720 0.5772 2.1077 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8765 0.0000 0.7728 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7397 0.9952 -0.1638 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8630 1.0070 -0.3418 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6144 2.8951 0.1224 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0058 3.8952 -2.9159 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2408 1.9975 -3.3776 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.8162 -2.8437 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 34 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 19 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 35 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 22 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 36 1 0 0 0 0 13 16 1 0 0 0 0 13 37 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 38 1 0 0 0 0 19 20 1 0 0 0 0 19 39 1 0 0 0 0 20 21 1 0 0 0 0 20 40 1 0 0 0 0 20 41 1 0 0 0 0 21 28 1 0 0 0 0 21 42 1 0 0 0 0 21 43 1 0 0 0 0 22 23 1 0 0 0 0 22 44 1 0 0 0 0 23 25 1 0 0 0 0 23 24 2 0 0 0 0 25 27 1 0 0 0 0 25 45 1 0 0 0 0 26 27 1 0 0 0 0 26 46 1 0 0 0 0 26 47 1 0 0 0 0 26 48 1 0 0 0 0 27 49 1 0 0 0 0 27 50 1 0 0 0 0 28 31 1 0 0 0 0 28 51 1 0 0 0 0 28 52 1 0 0 0 0 29 31 1 0 0 0 0 29 30 1 0 0 0 0 29 53 1 0 0 0 0 29 54 1 0 0 0 0 30 55 1 0 0 0 0 30 56 1 0 0 0 0 30 57 1 0 0 0 0 31 32 1 0 0 0 0 32 33 1 0 0 0 0 32 58 1 0 0 0 0 32 59 1 0 0 0 0 33 60 1 0 0 0 0 33 61 1 0 0 0 0 33 62 1 0 0 0 0 M END > (403) 6-arylpyrido[2,3-d]pyrimidine deriv. 29 > (403) PDGFR-beta > (403) 1300 > (403) -1 > (403) P > (403) PDGFR-P401 $$$$ Structure127 csChFnd70/05150717532D 59 61 0 0 0 0 0 0 0 0999 V2000 1.1700 14.9241 0.0120 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6305 15.8427 0.0030 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1792 15.1167 -0.0163 N 0 0 0 0 0 0 0 0 0 0 0 0 4.3378 13.3887 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8055 12.3690 -0.0174 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1932 13.2159 0.0026 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8894 12.6245 -0.0461 N 0 0 0 0 0 0 0 0 0 0 0 0 6.0470 10.9242 -0.0563 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5817 9.8291 -0.0473 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9382 10.5532 -0.0289 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7992 7.9194 -0.0585 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9149 6.9008 1.1426 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1211 5.1167 1.1289 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2065 4.3444 -0.0789 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0889 5.3547 -1.2766 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8828 7.1389 -1.2746 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6902 10.1938 -0.0753 N 0 0 3 0 0 0 0 0 0 0 0 0 9.1028 11.2216 -0.0840 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6992 10.5120 -0.1027 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9373 12.7886 -0.0751 O 0 0 0 0 0 0 0 0 0 0 0 0 2.5203 17.6307 0.0137 N 0 0 0 0 0 0 0 0 0 0 0 0 12.2349 11.6291 -0.1120 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2350 12.7665 1.5127 C 0 0 0 0 0 0 0 0 0 0 0 0 13.8693 10.5061 -0.1330 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2040 12.7818 -1.7257 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1511 4.5930 -2.4577 O 0 0 0 0 0 0 0 0 0 0 0 0 3.2594 4.1224 2.3003 O 0 0 0 0 0 0 0 0 0 0 0 0 3.5323 2.2923 2.2122 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2969 2.7477 -2.3907 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4629 1.3959 3.6215 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5392 2.1309 -3.8083 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 12.4838 0.0105 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7943 9.7462 -0.0218 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0700 7.5013 2.0836 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3653 2.9535 -0.0867 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5701 7.9247 -2.2073 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8223 8.9434 -0.0824 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8314 9.2616 -0.1098 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3947 18.1911 0.0275 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5685 18.3251 0.0074 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2569 11.9454 2.6624 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3775 13.5977 1.5057 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0705 13.5666 1.5276 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8693 9.6959 -1.2904 H 0 0 0 0 0 0 0 0 0 0 0 0 15.0118 11.3373 -0.1400 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8913 9.6850 1.0166 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0396 13.5818 -1.7109 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3465 13.6129 -1.7327 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2039 11.9715 -2.8833 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1319 1.8171 0.9433 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9026 2.0104 2.4097 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7952 2.3602 -1.1266 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0250 2.1670 -2.5938 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0926 1.6779 3.4238 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6709 0.0000 3.5542 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8633 1.8711 4.8904 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0411 2.5184 -5.0724 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8112 2.7115 -3.6052 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6506 0.7233 -3.7572 H 0 0 0 0 0 0 0 0 0 0 0 0 1 6 1 0 0 0 0 1 2 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 4 2 0 0 0 0 4 7 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 5 6 2 0 0 0 0 6 32 1 0 0 0 0 7 8 2 0 0 0 0 8 9 1 0 0 0 0 8 17 1 0 0 0 0 9 11 1 0 0 0 0 9 10 2 0 0 0 0 10 33 1 0 0 0 0 11 12 2 0 0 0 0 11 16 1 0 0 0 0 12 13 1 0 0 0 0 12 34 1 0 0 0 0 13 14 2 0 0 0 0 13 27 1 0 0 0 0 14 15 1 0 0 0 0 14 35 1 0 0 0 0 15 16 2 0 0 0 0 15 26 1 0 0 0 0 16 36 1 0 0 0 0 17 18 1 0 0 0 0 17 37 1 0 0 0 0 18 19 1 0 0 0 0 18 20 2 0 0 0 0 19 22 1 0 0 0 0 19 38 1 0 0 0 0 21 39 1 0 0 0 0 21 40 1 0 0 0 0 22 23 1 0 0 0 0 22 24 1 0 0 0 0 22 25 1 0 0 0 0 23 41 1 0 0 0 0 23 42 1 0 0 0 0 23 43 1 0 0 0 0 24 44 1 0 0 0 0 24 45 1 0 0 0 0 24 46 1 0 0 0 0 25 47 1 0 0 0 0 25 48 1 0 0 0 0 25 49 1 0 0 0 0 26 29 1 0 0 0 0 27 28 1 0 0 0 0 28 30 1 0 0 0 0 28 50 1 0 0 0 0 28 51 1 0 0 0 0 29 31 1 0 0 0 0 29 52 1 0 0 0 0 29 53 1 0 0 0 0 30 54 1 0 0 0 0 30 55 1 0 0 0 0 30 56 1 0 0 0 0 31 57 1 0 0 0 0 31 58 1 0 0 0 0 31 59 1 0 0 0 0 M END > (410) 17964795-16 > (410) PDGFR-beta > (410) 1300 > (410) -1 > (410) P > (410) PDGFR-P408 $$$$ Structure133 csChFnd70/05150717532D 53 55 0 0 0 0 0 0 0 0999 V2000 1.1594 13.1502 0.0119 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6067 14.0605 0.0029 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1414 13.3410 -0.0162 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2985 11.6287 -0.0268 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7801 10.6183 -0.0172 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1824 11.4574 0.0026 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8361 10.8714 -0.0457 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9923 9.1865 -0.0557 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5403 8.1014 -0.0469 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9116 8.8189 -0.0286 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7558 6.2089 -0.0579 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8795 5.1995 1.1323 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0837 3.4316 1.1187 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1594 2.6663 -0.0782 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0338 3.6675 -1.2650 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8295 5.4355 -1.2631 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6205 8.4627 -0.0746 N 0 0 3 0 0 0 0 0 0 0 0 0 9.0204 9.4812 -0.0832 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6023 8.7781 -0.1017 N 0 0 3 0 0 0 0 0 0 0 0 0 8.8564 11.0341 -0.0744 O 0 0 0 0 0 0 0 0 0 0 0 0 2.4975 15.8323 0.0136 N 0 0 0 0 0 0 0 0 0 0 0 0 12.1241 9.8851 -0.1110 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1242 11.0121 1.4990 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7437 8.7722 -0.1318 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0935 11.0272 -1.7101 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0863 2.9127 -2.4354 O 0 0 0 0 0 0 0 0 0 0 0 0 3.2299 2.4462 2.2795 O 0 0 0 0 0 0 0 0 0 0 0 0 3.5003 0.6328 2.1922 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2308 1.0840 -2.3690 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 10.7319 0.0104 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7780 8.0192 -0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0422 5.7946 2.0647 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3167 1.2880 -0.0859 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5106 6.2141 -2.1873 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7514 7.2236 -0.0817 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7333 7.5390 -0.1088 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3821 16.3876 0.0272 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5362 16.5204 0.0073 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1459 10.1985 2.6383 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2564 11.8358 1.4921 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9703 11.8050 1.5138 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7437 7.9693 -1.2787 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8759 9.5959 -0.1387 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7656 7.9585 1.0074 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9396 11.8201 -1.6954 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2257 11.8509 -1.7170 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0934 10.2243 -2.8572 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1035 0.1618 0.9347 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8582 0.3534 2.3879 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7453 0.0000 3.1870 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9705 0.5086 -2.5703 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1079 0.6486 -3.3698 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7246 0.7001 -1.1164 H 0 0 0 0 0 0 0 0 0 0 0 0 1 6 1 0 0 0 0 1 2 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 4 2 0 0 0 0 4 7 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 5 6 2 0 0 0 0 6 30 1 0 0 0 0 7 8 2 0 0 0 0 8 9 1 0 0 0 0 8 17 1 0 0 0 0 9 11 1 0 0 0 0 9 10 2 0 0 0 0 10 31 1 0 0 0 0 11 12 2 0 0 0 0 11 16 1 0 0 0 0 12 13 1 0 0 0 0 12 32 1 0 0 0 0 13 14 2 0 0 0 0 13 27 1 0 0 0 0 14 15 1 0 0 0 0 14 33 1 0 0 0 0 15 16 2 0 0 0 0 15 26 1 0 0 0 0 16 34 1 0 0 0 0 17 18 1 0 0 0 0 17 35 1 0 0 0 0 18 19 1 0 0 0 0 18 20 2 0 0 0 0 19 22 1 0 0 0 0 19 36 1 0 0 0 0 21 37 1 0 0 0 0 21 38 1 0 0 0 0 22 23 1 0 0 0 0 22 24 1 0 0 0 0 22 25 1 0 0 0 0 23 39 1 0 0 0 0 23 40 1 0 0 0 0 23 41 1 0 0 0 0 24 42 1 0 0 0 0 24 43 1 0 0 0 0 24 44 1 0 0 0 0 25 45 1 0 0 0 0 25 46 1 0 0 0 0 25 47 1 0 0 0 0 26 29 1 0 0 0 0 27 28 1 0 0 0 0 28 48 1 0 0 0 0 28 49 1 0 0 0 0 28 50 1 0 0 0 0 29 51 1 0 0 0 0 29 52 1 0 0 0 0 29 53 1 0 0 0 0 M END > (411) 17964795-17 > (411) PDGFR-beta > (411) 1300 > (411) -1 > (411) P > (411) PDGFR-P409 $$$$ Structure140 csChFnd70/05150717532D 39 41 0 0 0 0 0 0 0 0999 V2000 2.3271 8.5873 0.0107 N 0 0 0 0 0 0 0 0 0 0 0 0 2.3479 7.0543 0.0023 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6373 6.2507 -0.0138 N 0 0 0 0 0 0 0 0 0 0 0 0 5.0025 6.9677 -0.0230 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0224 8.6026 -0.0150 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3214 6.1800 -0.0390 N 0 0 0 0 0 0 0 0 0 0 0 0 7.6656 6.8840 -0.0476 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7742 8.5051 -0.0403 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0041 6.0115 -0.0625 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9202 4.4617 -0.0696 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2204 3.6142 -0.0841 N 0 0 3 0 0 0 0 0 0 0 0 0 7.6718 3.8282 -0.0628 O 0 0 0 0 0 0 0 0 0 0 0 0 0.9617 6.2725 0.0114 N 0 0 0 0 0 0 0 0 0 0 0 0 9.3028 9.2654 -0.0492 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0365 9.6176 1.3357 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4609 10.3256 1.3197 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1595 10.6856 -0.0657 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4380 10.3394 -1.4430 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0165 9.6255 -1.4425 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6113 9.3955 0.0029 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4398 9.3809 -0.0255 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1130 9.1912 -3.1723 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.1609 9.1678 3.0758 Cl 0 0 0 0 0 0 0 0 0 0 0 0 11.7562 1.2534 -0.1080 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1293 1.9295 -0.0918 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0002 6.5169 -0.0678 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2165 4.1196 -0.0895 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9504 5.1555 0.0059 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 6.8407 0.0233 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0302 10.5989 2.3912 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2729 11.2399 -0.0722 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9893 10.6238 -2.5210 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5805 10.6388 0.0098 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4887 10.6237 -0.0196 H 0 0 0 0 0 0 0 0 0 0 0 0 12.3616 1.6444 -1.1358 H 0 0 0 0 0 0 0 0 0 0 0 0 12.3778 1.6341 0.9139 H 0 0 0 0 0 0 0 0 0 0 0 0 11.6885 0.0000 -0.1138 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5239 1.5387 0.9360 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5077 1.5488 -1.1137 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 20 2 0 0 0 0 2 3 2 0 0 0 0 2 13 1 0 0 0 0 3 4 1 0 0 0 0 4 6 2 0 0 0 0 4 5 1 0 0 0 0 5 20 1 0 0 0 0 5 21 2 0 0 0 0 6 7 1 0 0 0 0 7 8 2 0 0 0 0 7 9 1 0 0 0 0 8 14 1 0 0 0 0 8 21 1 0 0 0 0 9 10 1 0 0 0 0 9 26 1 0 0 0 0 10 11 1 0 0 0 0 10 12 2 0 0 0 0 11 25 1 0 0 0 0 11 27 1 0 0 0 0 13 28 1 0 0 0 0 13 29 1 0 0 0 0 14 15 2 0 0 0 0 14 19 1 0 0 0 0 15 16 1 0 0 0 0 15 23 1 0 0 0 0 16 17 2 0 0 0 0 16 30 1 0 0 0 0 17 18 1 0 0 0 0 17 31 1 0 0 0 0 18 19 2 0 0 0 0 18 32 1 0 0 0 0 19 22 1 0 0 0 0 20 33 1 0 0 0 0 21 34 1 0 0 0 0 24 25 1 0 0 0 0 24 35 1 0 0 0 0 24 36 1 0 0 0 0 24 37 1 0 0 0 0 25 38 1 0 0 0 0 25 39 1 0 0 0 0 M END > (413) 9240345-4f > (413) PDGFR-beta > (413) 1300 > (413) -1 > (413) P > (413) PDGFR-P411 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 19 csChFnd70/05150717532D 45 47 0 0 0 0 0 0 0 0999 V2000 1.2016 4.9968 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6958 2.4336 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2246 3.3042 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2104 3.1947 -0.0265 N 0 0 0 0 0 0 0 0 0 0 0 0 2.7759 5.8791 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3210 4.9105 -0.0184 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8586 7.6814 0.0099 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9481 7.3973 -0.0217 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4674 8.4428 -0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8374 5.7089 -0.0292 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6317 10.3400 0.0054 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8770 12.9959 1.5563 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8549 13.0098 -1.5250 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9385 13.8845 0.0191 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7242 11.2287 1.5580 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7018 11.2427 -1.5403 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6346 0.6597 -0.0245 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6395 10.0164 3.6610 Br 0 0 0 0 0 0 0 0 0 0 0 0 4.5884 10.0492 -3.6527 Br 0 0 0 0 0 0 0 0 0 0 0 0 7.5563 8.1649 -0.0334 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9831 7.1847 -0.0523 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8609 5.6281 -0.0590 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5453 7.9305 -0.0638 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0962 6.8651 -0.0843 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0959 5.7387 -1.6947 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6852 8.0214 -0.0939 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1272 5.7224 1.5143 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.6899 0.0214 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7041 8.4500 0.0245 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9492 13.6855 2.7578 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9092 13.7102 -2.7211 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0582 15.2664 0.0245 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5349 0.0741 -0.0167 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6915 0.0000 -0.0381 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6538 9.4070 -0.0281 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6428 9.1725 -0.0584 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0738 6.5527 -2.8335 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2498 4.9460 -1.7098 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9639 4.9149 -1.6877 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6854 8.8238 1.0534 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8391 7.2287 -0.1092 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6630 8.8354 -1.2328 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9953 4.8987 1.5211 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2812 4.9298 1.4991 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1274 6.5249 2.6616 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 28 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 17 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 29 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 20 1 0 0 0 0 9 11 1 0 0 0 0 11 15 2 0 0 0 0 11 16 1 0 0 0 0 12 15 1 0 0 0 0 12 14 2 0 0 0 0 12 30 1 0 0 0 0 13 16 2 0 0 0 0 13 14 1 0 0 0 0 13 31 1 0 0 0 0 14 32 1 0 0 0 0 15 18 1 0 0 0 0 16 19 1 0 0 0 0 17 33 1 0 0 0 0 17 34 1 0 0 0 0 20 21 1 0 0 0 0 20 35 1 0 0 0 0 21 23 1 0 0 0 0 21 22 2 0 0 0 0 23 24 1 0 0 0 0 23 36 1 0 0 0 0 24 25 1 0 0 0 0 24 26 1 0 0 0 0 24 27 1 0 0 0 0 25 37 1 0 0 0 0 25 38 1 0 0 0 0 25 39 1 0 0 0 0 26 40 1 0 0 0 0 26 41 1 0 0 0 0 26 42 1 0 0 0 0 27 43 1 0 0 0 0 27 44 1 0 0 0 0 27 45 1 0 0 0 0 M END > (419) PD089828 analog 8 > (419) PDGFR-beta > (419) 1400 > (419) -1 > (419) P > (419) PDGFR-P417 $$$$ 1,6-naphthyridin-2(1H)-one deriv. 8h csChFnd70/05150717532D 55 58 0 0 0 0 0 0 0 0999 V2000 1.2235 16.2414 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7163 13.6384 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3155 14.4636 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7784 17.1776 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3654 16.2642 -0.0179 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7782 19.0122 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3278 19.8756 -0.0006 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9501 18.8889 -0.0214 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3337 19.6503 -0.0303 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2467 14.5362 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9182 17.1422 -0.0285 N 0 0 3 0 0 0 0 0 0 0 0 0 4.3644 21.7960 0.0072 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4310 24.4877 1.5738 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3971 22.6976 1.5755 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3739 22.7109 -1.5534 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4080 24.5011 -1.5369 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4334 25.3871 0.0222 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3941 21.5713 3.5240 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.3437 21.6014 -3.5113 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6515 11.8411 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2611 10.8329 -0.0467 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8286 8.8970 -0.0537 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5094 7.8441 -0.0755 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7559 5.5801 1.2119 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2872 3.6556 1.0932 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1889 3.0110 0.0874 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6576 4.9354 0.2061 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0942 5.9854 -0.0822 N 0 0 0 0 0 0 0 0 0 0 0 0 4.8507 2.6058 1.3814 N 0 0 0 0 0 0 0 0 0 0 0 0 4.4354 0.7470 1.3748 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.9220 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5010 13.7187 -0.0420 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5711 19.7214 0.0257 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9986 16.4988 -0.0419 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4558 25.1872 2.7865 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4154 25.2107 -2.7438 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4599 26.7870 0.0279 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5406 11.2519 -0.0188 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0031 11.1540 -1.2057 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0247 11.1408 1.1017 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0865 8.5760 1.1054 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0650 8.5891 -1.2022 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2514 8.1651 -1.2345 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2731 8.1520 1.0731 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6056 6.3619 0.9613 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2485 5.8664 2.5051 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3220 3.3440 2.0771 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7616 3.3766 -0.1886 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6964 2.7247 -1.2058 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3391 2.2293 0.3378 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1832 5.2144 1.4878 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6229 5.2472 -0.7777 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8763 0.3937 0.1259 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6154 0.0000 1.5908 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5065 0.4682 2.4025 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 31 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 20 1 0 0 0 0 3 5 2 0 0 0 0 3 32 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 33 1 0 0 0 0 7 8 1 0 0 0 0 7 12 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 34 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 35 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 36 1 0 0 0 0 17 37 1 0 0 0 0 20 21 1 0 0 0 0 20 38 1 0 0 0 0 21 22 1 0 0 0 0 21 39 1 0 0 0 0 21 40 1 0 0 0 0 22 23 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 28 1 0 0 0 0 23 43 1 0 0 0 0 23 44 1 0 0 0 0 24 28 1 0 0 0 0 24 25 1 0 0 0 0 24 45 1 0 0 0 0 24 46 1 0 0 0 0 25 29 1 0 0 0 0 25 47 1 0 0 0 0 25 48 1 0 0 0 0 26 29 1 0 0 0 0 26 27 1 0 0 0 0 26 49 1 0 0 0 0 26 50 1 0 0 0 0 27 28 1 0 0 0 0 27 51 1 0 0 0 0 27 52 1 0 0 0 0 29 30 1 0 0 0 0 30 53 1 0 0 0 0 30 54 1 0 0 0 0 30 55 1 0 0 0 0 M END > (422) 1,6-naphthyridin-2(1H)-one deriv. 8h > (422) PDGFR-beta > (422) 1400 > (422) -1 > (422) P > (422) PDGFR-P420 $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7n csChFnd70/05150717532D 42 45 0 0 0 0 0 0 0 0999 V2000 3.9745 7.6514 0.8017 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1621 5.4837 0.1715 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4864 6.2043 -0.0869 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2642 8.4649 0.5658 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5535 7.7215 0.1095 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2905 10.0098 0.7768 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5744 10.7619 0.5332 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8916 9.9573 0.0606 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0379 10.6210 -0.1579 O 0 0 0 0 0 0 0 0 0 0 0 0 3.9689 6.2161 0.6000 N 0 0 0 0 0 0 0 0 0 0 0 0 7.8403 8.4859 -0.1331 N 0 0 3 0 0 0 0 0 0 0 0 0 9.1654 7.6938 -0.6054 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6320 12.3797 0.7454 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0574 14.4750 2.3075 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0053 12.9658 2.1172 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3192 13.3240 -0.4274 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3753 14.8311 -0.2223 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7405 15.4049 1.1419 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4028 11.8005 3.5816 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.8612 12.6060 -2.1406 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.0827 3.9684 -0.0219 N 0 0 3 0 0 0 0 0 0 0 0 0 3.7282 3.2460 0.1033 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3279 1.1080 0.7756 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0467 1.8158 0.3513 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1032 3.2344 -0.2024 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4399 3.9515 -0.3277 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6681 1.8186 0.6533 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9816 8.2041 1.1556 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4484 5.5962 -0.4351 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3099 10.5874 1.1252 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1992 7.6498 -1.8054 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1401 8.2654 -0.1981 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1427 6.5768 -0.1644 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3459 14.9301 3.3688 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1339 15.5632 -1.1291 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7824 16.5843 1.2966 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9673 3.4109 -0.2441 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2798 0.0000 1.2077 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.2574 0.4477 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1006 3.7839 -0.5332 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4833 5.0596 -0.7601 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6684 1.2650 0.9844 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 28 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 29 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 30 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 31 1 0 0 0 0 12 32 1 0 0 0 0 12 33 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 34 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 35 1 0 0 0 0 18 36 1 0 0 0 0 21 22 1 0 0 0 0 21 37 1 0 0 0 0 22 26 2 0 0 0 0 22 27 1 0 0 0 0 23 24 1 0 0 0 0 23 27 2 0 0 0 0 23 38 1 0 0 0 0 24 25 2 0 0 0 0 24 39 1 0 0 0 0 25 26 1 0 0 0 0 25 40 1 0 0 0 0 26 41 1 0 0 0 0 27 42 1 0 0 0 0 M END > (423) 1,6-naphthyridin-2(1H)-one deriv. 7n > (423) PDGFR-beta > (423) 1400 > (423) -1 > (423) P > (423) PDGFR-P421 $$$$ 3-substituted indolin-2-one 11g csChFnd70/05150717532D 52 55 0 0 0 0 0 0 0 0999 V2000 2.1414 9.5036 0.1766 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2721 7.7583 0.1455 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2612 9.5415 0.0912 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6817 10.4131 0.1068 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0939 12.2684 0.0381 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9797 12.3520 -0.0154 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5886 10.7358 0.0181 N 0 0 3 0 0 0 0 0 0 0 0 0 6.8411 13.6585 -0.0798 O 0 0 0 0 0 0 0 0 0 0 0 0 2.9514 13.6294 0.0264 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5650 15.3295 0.1665 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8597 16.7730 -0.6059 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9719 15.8630 1.1028 N 0 0 3 0 0 0 0 0 0 0 0 0 1.2963 16.8195 -1.7494 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1441 17.5886 0.9138 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8708 18.1753 -0.1233 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1632 7.7338 0.2310 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7285 6.8552 0.2158 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5935 20.0171 -0.6568 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2952 20.8625 0.5550 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0178 22.7043 0.0213 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7806 23.2815 -1.2026 O 0 0 0 0 0 0 0 0 0 0 0 0 0.9236 23.7035 0.9059 O 0 0 0 0 0 0 0 0 0 0 0 0 3.7468 4.9502 0.2745 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8189 2.2954 1.5694 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7818 1.3879 0.3829 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7311 2.2493 -0.8505 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7185 4.0230 -0.9104 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7944 4.0757 1.5244 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8492 4.9690 2.6901 O 0 0 0 0 0 0 0 0 0 0 0 0 0.9093 3.9894 3.9283 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9317 10.1850 0.1940 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4786 7.0710 0.1333 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8000 10.4401 -0.0046 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5884 13.3907 -0.0902 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7144 15.1277 1.7836 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1512 17.0210 -0.9671 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4227 17.8676 -2.6710 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1842 15.6037 -2.4371 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1325 18.3696 1.4982 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9700 7.0258 0.2857 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8103 20.7096 -0.5946 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1015 20.0544 -1.9685 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0784 20.1699 0.4927 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7872 20.8252 1.8665 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7882 24.8759 0.5150 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0848 1.6158 2.5324 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7977 0.0000 0.4222 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4801 1.5314 -1.7730 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4607 4.6910 -1.8751 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.1518 3.2687 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7992 3.2117 4.6815 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2123 4.8577 4.7792 H 0 0 0 0 0 0 0 0 0 0 0 0 1 16 1 0 0 0 0 1 4 2 0 0 0 0 1 31 1 0 0 0 0 2 17 1 0 0 0 0 2 3 2 0 0 0 0 2 32 1 0 0 0 0 3 7 1 0 0 0 0 3 4 1 0 0 0 0 4 5 1 0 0 0 0 5 6 1 0 0 0 0 5 9 2 0 0 0 0 6 7 1 0 0 0 0 6 8 2 0 0 0 0 7 33 1 0 0 0 0 9 10 1 0 0 0 0 9 34 1 0 0 0 0 10 11 2 0 0 0 0 10 12 1 0 0 0 0 11 15 1 0 0 0 0 11 13 1 0 0 0 0 12 14 1 0 0 0 0 12 35 1 0 0 0 0 13 36 1 0 0 0 0 13 37 1 0 0 0 0 13 38 1 0 0 0 0 14 15 2 0 0 0 0 14 39 1 0 0 0 0 15 18 1 0 0 0 0 16 17 2 0 0 0 0 16 40 1 0 0 0 0 17 23 1 0 0 0 0 18 19 1 0 0 0 0 18 41 1 0 0 0 0 18 42 1 0 0 0 0 19 20 1 0 0 0 0 19 43 1 0 0 0 0 19 44 1 0 0 0 0 20 22 1 0 0 0 0 20 21 2 0 0 0 0 22 45 1 0 0 0 0 23 27 2 0 0 0 0 23 28 1 0 0 0 0 24 28 2 0 0 0 0 24 25 1 0 0 0 0 24 46 1 0 0 0 0 25 26 2 0 0 0 0 25 47 1 0 0 0 0 26 27 1 0 0 0 0 26 48 1 0 0 0 0 27 49 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 30 50 1 0 0 0 0 30 51 1 0 0 0 0 30 52 1 0 0 0 0 M END > (425) 3-substituted indolin-2-one 11g > (425) PDGFR-beta > (425) 1420 > (425) -1 > (425) P > (425) PDGFR-P423 $$$$ PD0180970 csChFnd70/05150717532D 44 47 0 0 0 0 0 0 0 0999 V2000 3.5238 14.9984 0.7708 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0555 17.7099 1.1021 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0832 15.9157 0.9579 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9464 15.9022 0.7235 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9370 17.6964 0.8689 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4867 18.5973 1.0611 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0532 14.8042 1.0105 Cl 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 14.7741 0.4817 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.5438 13.0737 0.6149 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4355 12.0513 2.0733 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6716 12.2479 -1.1012 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7625 13.1479 -2.4060 O 0 0 0 0 0 0 0 0 0 0 0 0 3.6898 10.4983 -1.2439 N 0 0 3 0 0 0 0 0 0 0 0 0 3.8265 9.6925 -2.9694 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5319 4.9575 1.2943 N 0 0 3 0 0 0 0 0 0 0 0 0 3.5731 3.8819 2.7665 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7032 2.2943 2.7538 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7460 1.2345 4.2078 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6551 1.7539 5.6783 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5226 3.3361 5.6941 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4899 4.3966 4.2395 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5096 3.8983 7.2964 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6949 0.7153 7.0997 F 0 0 0 0 0 0 0 0 0 0 0 0 3.4576 10.2189 1.8831 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5893 9.4633 0.2109 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3512 9.1136 3.3364 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5094 6.7476 1.4876 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6067 7.7372 0.0773 N 0 0 0 0 0 0 0 0 0 0 0 0 3.3789 7.4131 3.0812 N 0 0 0 0 0 0 0 0 0 0 0 0 6.2613 18.4214 1.2476 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7170 18.3976 0.8320 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4722 20.0004 1.1743 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3350 12.6358 3.3498 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5249 9.4811 -3.4978 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5560 10.5497 -3.8361 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5005 8.4467 -2.8582 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5192 4.4464 0.1381 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9933 1.8892 1.6077 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0698 0.0000 4.1986 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1719 5.6279 4.2501 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8497 3.4341 7.2143 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5040 5.3162 7.3828 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8888 3.3510 8.4512 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2492 9.6437 4.6365 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 2 3 1 0 0 0 0 2 6 2 0 0 0 0 2 30 1 0 0 0 0 3 7 1 0 0 0 0 4 5 2 0 0 0 0 4 8 1 0 0 0 0 5 6 1 0 0 0 0 5 31 1 0 0 0 0 6 32 1 0 0 0 0 9 11 1 0 0 0 0 9 10 2 0 0 0 0 10 24 1 0 0 0 0 10 33 1 0 0 0 0 11 13 1 0 0 0 0 11 12 2 0 0 0 0 13 25 1 0 0 0 0 13 14 1 0 0 0 0 14 34 1 0 0 0 0 14 35 1 0 0 0 0 14 36 1 0 0 0 0 15 16 1 0 0 0 0 15 27 1 0 0 0 0 15 37 1 0 0 0 0 16 17 1 0 0 0 0 16 21 2 0 0 0 0 17 18 2 0 0 0 0 17 38 1 0 0 0 0 18 19 1 0 0 0 0 18 39 1 0 0 0 0 19 20 2 0 0 0 0 19 23 1 0 0 0 0 20 21 1 0 0 0 0 20 22 1 0 0 0 0 21 40 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 22 43 1 0 0 0 0 24 26 1 0 0 0 0 24 25 2 0 0 0 0 25 28 1 0 0 0 0 26 29 2 0 0 0 0 26 44 1 0 0 0 0 27 29 1 0 0 0 0 27 28 2 0 0 0 0 M END > (426) PD180970 > (426) PDGFR-beta > (426) 1430 > (426) -1 > (426) P > (426) PDGFR-P424 $$$$ PD089828 analog 18 csChFnd70/05150717532D 54 56 0 0 0 0 0 0 0 0999 V2000 1.2016 4.9972 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6963 2.4339 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7765 5.8798 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3215 4.9112 -0.0184 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8592 7.6822 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4682 8.4437 0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2246 3.3047 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2108 3.1948 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8381 5.7097 -0.0273 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6352 0.6598 -0.0244 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6325 10.3413 0.0103 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8776 12.9936 1.5650 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6879 11.2467 -1.5337 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8408 13.0129 -1.5166 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9489 7.3983 -0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5572 8.1660 -0.0294 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9843 7.1856 -0.0470 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8620 5.6288 -0.0541 O 0 0 0 0 0 0 0 0 0 0 0 0 4.7247 11.2274 1.5636 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5467 7.9314 -0.0567 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0978 6.8659 -0.0758 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0992 5.7397 -1.6865 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6870 8.0223 -0.0835 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1272 5.7227 1.5229 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6570 10.2586 3.2383 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9392 13.8846 0.0288 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1064 15.8133 0.0388 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5814 10.2988 -3.2181 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.6903 0.0327 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7044 8.4509 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5353 0.0741 -0.0167 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6923 0.0000 -0.0382 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9491 13.6814 2.7676 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8844 13.7156 -2.7119 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6547 9.4082 -0.0238 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6442 9.1736 -0.0510 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0783 6.5540 -2.8253 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2532 4.9468 -1.7007 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9670 4.9159 -1.6810 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6860 8.8245 1.0640 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8410 7.2294 -0.0976 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6661 8.8366 -1.2223 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9949 4.8989 1.5284 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2811 4.9300 1.5086 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1261 6.5251 2.6704 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9557 9.9107 3.6291 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0743 11.0669 4.2219 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8919 9.0973 3.0751 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4617 16.1644 0.0280 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4782 16.3420 -1.0954 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4999 16.3283 1.1911 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2406 10.1836 -3.6049 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2906 11.0055 -4.1970 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1360 9.0215 -3.0708 H 0 0 0 0 0 0 0 0 0 0 0 0 1 7 2 0 0 0 0 1 3 1 0 0 0 0 1 29 1 0 0 0 0 2 7 1 0 0 0 0 2 8 2 0 0 0 0 2 10 1 0 0 0 0 3 5 1 0 0 0 0 3 4 2 0 0 0 0 4 8 1 0 0 0 0 4 9 1 0 0 0 0 5 6 2 0 0 0 0 5 30 1 0 0 0 0 6 15 1 0 0 0 0 6 11 1 0 0 0 0 9 15 2 0 0 0 0 10 31 1 0 0 0 0 10 32 1 0 0 0 0 11 19 1 0 0 0 0 11 13 2 0 0 0 0 12 19 2 0 0 0 0 12 26 1 0 0 0 0 12 33 1 0 0 0 0 13 14 1 0 0 0 0 13 28 1 0 0 0 0 14 26 2 0 0 0 0 14 34 1 0 0 0 0 15 16 1 0 0 0 0 16 17 1 0 0 0 0 16 35 1 0 0 0 0 17 20 1 0 0 0 0 17 18 2 0 0 0 0 19 25 1 0 0 0 0 20 21 1 0 0 0 0 20 36 1 0 0 0 0 21 22 1 0 0 0 0 21 23 1 0 0 0 0 21 24 1 0 0 0 0 22 37 1 0 0 0 0 22 38 1 0 0 0 0 22 39 1 0 0 0 0 23 40 1 0 0 0 0 23 41 1 0 0 0 0 23 42 1 0 0 0 0 24 43 1 0 0 0 0 24 44 1 0 0 0 0 24 45 1 0 0 0 0 25 46 1 0 0 0 0 25 47 1 0 0 0 0 25 48 1 0 0 0 0 26 27 1 0 0 0 0 27 49 1 0 0 0 0 27 50 1 0 0 0 0 27 51 1 0 0 0 0 28 52 1 0 0 0 0 28 53 1 0 0 0 0 28 54 1 0 0 0 0 M END > (428) PD089828 analog 18 > (428) PDGFR-beta > (428) 1470 > (428) -1 > (428) P > (428) PDGFR-P426 $$$$ csChFnd70/05150717532D 48 51 0 0 0 0 0 0 0 0999 V2000 5.9769 9.7712 0.0166 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8584 8.0633 -0.0029 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9983 8.1474 0.0012 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4824 10.6177 0.0228 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9544 9.6954 0.0123 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5387 12.3564 0.0384 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5419 12.1315 0.0321 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8811 12.8055 0.0364 O 0 0 0 0 0 0 0 0 0 0 0 0 10.4516 10.4764 0.0172 N 0 0 3 0 0 0 0 0 0 0 0 0 9.0382 13.1251 0.0433 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1385 14.9457 0.0591 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1770 15.8202 -1.4186 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2701 17.5174 -1.3953 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3251 18.3502 0.0885 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2874 17.4908 1.5576 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1879 15.7938 1.5516 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1316 14.7181 3.3967 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.1088 14.7771 -3.2820 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4086 7.3193 -0.0082 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3603 5.6199 -0.0241 N 0 0 3 0 0 0 0 0 0 0 0 0 5.8513 4.7995 0.1159 C 0 0 0 0 0 0 0 0 0 0 0 0 11.9674 9.5001 0.0069 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1060 2.5245 -0.5847 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5943 3.3328 -0.7234 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6137 5.4480 1.0997 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1256 4.6381 1.2371 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7795 5.3457 2.2988 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8674 3.1770 0.3928 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4018 2.3805 0.5285 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2231 0.8789 -0.3693 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8252 10.4347 0.0187 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4159 13.0676 0.0460 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3003 18.1955 -2.5379 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3983 19.6773 0.1000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3311 18.1484 2.7119 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3718 4.9951 -0.1323 H 0 0 0 0 0 0 0 0 0 0 0 0 12.3417 9.2689 -1.2604 H 0 0 0 0 0 0 0 0 0 0 0 0 12.9372 10.1732 0.6440 H 0 0 0 0 0 0 0 0 0 0 0 0 11.7509 8.3316 0.6294 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9038 1.3870 -1.2421 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5581 2.8249 -1.4849 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8148 6.5855 1.7575 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8947 4.8656 3.5461 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8851 6.6828 2.3228 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5849 5.0005 1.7954 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3827 1.1195 -1.6795 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1502 0.0000 0.0401 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.3717 -0.1536 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 31 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 32 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 33 1 0 0 0 0 14 15 1 0 0 0 0 14 34 1 0 0 0 0 15 16 2 0 0 0 0 15 35 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 36 1 0 0 0 0 21 24 1 0 0 0 0 21 25 2 0 0 0 0 22 37 1 0 0 0 0 22 38 1 0 0 0 0 22 39 1 0 0 0 0 23 28 1 0 0 0 0 23 24 2 0 0 0 0 23 40 1 0 0 0 0 24 41 1 0 0 0 0 25 26 1 0 0 0 0 25 42 1 0 0 0 0 26 28 2 0 0 0 0 26 27 1 0 0 0 0 27 43 1 0 0 0 0 27 44 1 0 0 0 0 27 45 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 30 46 1 0 0 0 0 30 47 1 0 0 0 0 30 48 1 0 0 0 0 M END > (431) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 53 > (431) PDGFR-beta > (431) 1500 > (431) -1 > (431) P > (431) PDGFR-P429 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 63 csChFnd70/05150717532D 69 73 0 0 0 0 0 0 0 0999 V2000 3.9016 15.6743 1.3910 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3606 13.1379 1.6141 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9176 14.0194 1.6427 N 0 0 0 0 0 0 0 0 0 0 0 0 6.8520 13.8506 1.3359 N 0 0 0 0 0 0 0 0 0 0 0 0 5.4529 16.5046 1.0881 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9674 15.5260 1.0663 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5410 18.2647 0.8079 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5766 17.9233 0.5156 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1252 18.9758 0.5189 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4611 16.2752 0.7816 N 0 0 0 0 0 0 0 0 0 0 0 0 7.2939 20.8270 0.2151 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7010 23.6561 1.2852 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6102 24.2857 -0.3528 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5441 21.9328 1.5768 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2102 21.4690 -1.4343 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3688 23.1949 -1.7090 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6577 21.1453 3.6336 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.9081 20.1020 -3.1383 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.6579 10.5748 2.2009 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9378 8.6692 2.4616 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2938 11.4050 1.8876 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2293 7.8022 2.7886 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1602 18.6404 0.2257 N 0 0 3 0 0 0 0 0 0 0 0 0 11.5587 17.6529 0.2185 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4326 16.1336 0.4660 O 0 0 0 0 0 0 0 0 0 0 0 0 3.6402 5.2795 1.7349 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9674 3.3977 2.0985 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2001 3.1720 3.4199 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8730 5.0537 3.0563 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4980 5.9724 3.0389 N 0 0 0 0 0 0 0 0 0 0 0 0 2.3423 2.4790 2.1159 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6111 0.6493 2.3662 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0971 18.3495 -0.0631 N 0 0 3 0 0 0 0 0 0 0 0 0 14.5614 17.3474 0.0518 C 0 0 0 0 0 0 0 0 0 0 0 0 14.5230 15.6632 -0.4722 C 0 0 0 0 0 0 0 0 0 0 0 0 15.9698 14.6774 -0.3580 C 0 0 0 0 0 0 0 0 0 0 0 0 17.4566 15.3662 0.2778 C 0 0 0 0 0 0 0 0 0 0 0 0 17.4984 17.0436 0.8013 C 0 0 0 0 0 0 0 0 0 0 0 0 16.0572 18.0373 0.6831 C 0 0 0 0 0 0 0 0 0 0 0 0 19.4352 14.0125 0.4322 Br 0 0 0 0 0 0 0 0 0 0 0 0 2.7226 16.3756 1.4115 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4090 19.0397 0.8171 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8952 24.5137 2.3383 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7330 25.6340 -0.5742 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3038 23.6937 -2.9855 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8235 10.7743 1.1140 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0756 11.1152 3.3351 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5200 8.1288 1.3274 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7722 8.4696 3.5485 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3300 10.7384 1.8722 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6471 8.3426 3.9229 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3948 8.0016 1.7018 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2608 19.8526 0.0283 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8403 5.9698 1.7578 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0533 5.4139 0.4879 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7848 2.8719 1.1122 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5859 3.2660 3.3304 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7871 3.0376 4.6668 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.4816 3.3971 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2546 5.1855 1.8245 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0556 5.5795 4.0427 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2535 0.4383 3.5745 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3881 0.0000 2.3739 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3912 0.1522 1.3358 H 0 0 0 0 0 0 0 0 0 0 0 0 13.1897 19.5454 -0.3454 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3626 15.1249 -0.9681 H 0 0 0 0 0 0 0 0 0 0 0 0 15.9404 13.3676 -0.7649 H 0 0 0 0 0 0 0 0 0 0 0 0 18.6605 17.5781 1.2975 H 0 0 0 0 0 0 0 0 0 0 0 0 16.0921 19.3483 1.0863 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 41 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 21 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 42 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 43 1 0 0 0 0 13 16 1 0 0 0 0 13 44 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 45 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 46 1 0 0 0 0 19 47 1 0 0 0 0 20 22 1 0 0 0 0 20 48 1 0 0 0 0 20 49 1 0 0 0 0 21 50 1 0 0 0 0 22 30 1 0 0 0 0 22 51 1 0 0 0 0 22 52 1 0 0 0 0 23 24 1 0 0 0 0 23 53 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 54 1 0 0 0 0 26 55 1 0 0 0 0 27 31 1 0 0 0 0 27 56 1 0 0 0 0 27 57 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 58 1 0 0 0 0 28 59 1 0 0 0 0 29 30 1 0 0 0 0 29 60 1 0 0 0 0 29 61 1 0 0 0 0 31 32 1 0 0 0 0 32 62 1 0 0 0 0 32 63 1 0 0 0 0 32 64 1 0 0 0 0 33 34 1 0 0 0 0 33 65 1 0 0 0 0 34 35 2 0 0 0 0 34 39 1 0 0 0 0 35 36 1 0 0 0 0 35 66 1 0 0 0 0 36 37 2 0 0 0 0 36 67 1 0 0 0 0 37 38 1 0 0 0 0 37 40 1 0 0 0 0 38 39 2 0 0 0 0 38 68 1 0 0 0 0 39 69 1 0 0 0 0 M END > (432) 6-arylpyrido[2,3-d]pyrimidine deriv. 63 > (432) PDGFR-beta > (432) 1500 > (432) -1 > (432) P > (432) PDGFR-P430 $$$$ 3-substituted indolin-2-one 16d csChFnd70/05150717532D 46 48 0 0 0 0 0 0 0 0999 V2000 3.6120 4.2541 -0.1497 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0238 2.8097 -1.7564 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0714 4.4113 -1.5238 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8513 5.1318 -0.7128 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2316 6.8115 -0.6563 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7227 6.9581 -1.4807 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1546 5.5318 -1.9582 N 0 0 3 0 0 0 0 0 0 0 0 0 7.4419 8.1622 -1.6949 O 0 0 0 0 0 0 0 0 0 0 0 0 4.3698 7.9878 0.0245 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9931 9.5030 0.1363 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1648 10.8860 0.0469 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5368 9.8813 0.3615 N 0 0 3 0 0 0 0 0 0 0 0 0 2.4336 11.0520 -0.1877 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6688 11.4552 0.4054 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5856 2.6650 -0.3922 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7887 1.9491 -1.1924 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1632 12.3470 0.6319 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2375 12.0960 0.2160 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8697 13.8118 0.1951 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5154 14.3636 1.8519 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1475 16.0794 1.8308 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1667 16.7883 0.6155 O 0 0 0 0 0 0 0 0 0 0 0 0 3.7986 16.8203 3.1623 O 0 0 0 0 0 0 0 0 0 0 0 0 2.5854 0.0000 0.4817 O 0 0 0 0 0 0 0 0 0 0 0 0 1.3601 2.4059 1.5690 O 0 0 0 0 0 0 0 0 0 0 0 0 2.0190 1.5462 0.3179 S 0 0 0 0 0 0 0 0 0 0 0 0 0.6809 1.4919 -1.0697 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6768 4.8126 0.4791 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9549 2.2380 -2.3794 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1023 5.3124 -2.5325 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2190 7.7467 0.4708 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3866 9.1452 0.4709 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8534 11.0706 0.9411 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1922 12.1343 -0.8055 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0029 10.0711 -0.8686 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7604 0.7054 -1.3773 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6920 12.5804 -0.4982 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9159 13.4452 1.2183 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9627 11.6602 1.3393 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8662 14.4527 -0.2604 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8593 14.0189 -0.5449 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5189 13.7228 2.3072 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5258 14.1564 2.5918 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5710 17.9208 3.0905 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.5954 -1.1630 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5782 2.3565 -1.7894 H 0 0 0 0 0 0 0 0 0 0 0 0 1 15 1 0 0 0 0 1 4 2 0 0 0 0 1 28 1 0 0 0 0 2 16 1 0 0 0 0 2 3 2 0 0 0 0 2 29 1 0 0 0 0 3 7 1 0 0 0 0 3 4 1 0 0 0 0 4 5 1 0 0 0 0 5 6 1 0 0 0 0 5 9 2 0 0 0 0 6 7 1 0 0 0 0 6 8 2 0 0 0 0 7 30 1 0 0 0 0 9 10 1 0 0 0 0 9 31 1 0 0 0 0 10 11 2 0 0 0 0 10 12 1 0 0 0 0 11 18 1 0 0 0 0 11 13 1 0 0 0 0 12 14 1 0 0 0 0 12 32 1 0 0 0 0 13 33 1 0 0 0 0 13 34 1 0 0 0 0 13 35 1 0 0 0 0 14 18 2 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 26 1 0 0 0 0 16 36 1 0 0 0 0 17 37 1 0 0 0 0 17 38 1 0 0 0 0 17 39 1 0 0 0 0 18 19 1 0 0 0 0 19 20 1 0 0 0 0 19 40 1 0 0 0 0 19 41 1 0 0 0 0 20 21 1 0 0 0 0 20 42 1 0 0 0 0 20 43 1 0 0 0 0 21 23 1 0 0 0 0 21 22 2 0 0 0 0 23 44 1 0 0 0 0 24 26 2 0 0 0 0 25 26 2 0 0 0 0 26 27 1 0 0 0 0 27 45 1 0 0 0 0 27 46 1 0 0 0 0 M END > (439) 3-substituted indolin-2-one 16d > (439) PDGFR-beta > (439) 1530 > (439) -1 > (439) P > (439) PDGFR-P437 $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 8 csChFnd70/05150717532D 40 42 0 0 0 0 0 0 0 0999 V2000 1.2132 5.0301 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7216 2.4479 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7978 5.9221 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3488 4.9512 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8566 7.7537 0.0115 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0197 7.5177 -0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4355 8.5639 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2364 3.3192 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2484 3.2322 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4300 8.2281 -0.0285 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9252 5.7743 -0.0284 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5408 10.4815 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7028 13.1678 1.5789 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6049 11.3801 1.5793 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5837 11.3964 -1.5491 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6817 13.1840 -1.5313 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7374 14.0674 0.0281 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5609 10.2536 3.5268 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5147 10.2903 -3.5077 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6714 0.6589 -0.0254 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5221 4.7466 -0.0485 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0609 4.3990 -1.9254 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5287 6.1127 -2.8073 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6347 3.1923 -1.9486 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.7285 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6738 8.5025 0.0264 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7521 13.8649 2.7920 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7155 13.8937 -2.7376 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8141 15.4652 0.0349 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5654 0.0609 -0.0180 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7423 0.0000 -0.0391 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5486 5.4584 0.6120 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3000 3.5181 0.6130 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9901 3.7900 -2.6176 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9126 5.8650 -4.1443 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4074 6.9724 -2.7907 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5993 6.7217 -2.1150 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3015 1.9713 -1.3203 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0186 2.9445 -3.2857 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7055 3.8013 -1.2564 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 25 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 20 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 11 1 0 0 0 0 5 7 2 0 0 0 0 5 26 1 0 0 0 0 6 11 1 0 0 0 0 6 7 1 0 0 0 0 6 10 2 0 0 0 0 7 12 1 0 0 0 0 11 21 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 27 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 28 1 0 0 0 0 17 29 1 0 0 0 0 20 30 1 0 0 0 0 20 31 1 0 0 0 0 21 22 1 0 0 0 0 21 32 1 0 0 0 0 21 33 1 0 0 0 0 22 23 1 0 0 0 0 22 24 1 0 0 0 0 22 34 1 0 0 0 0 23 35 1 0 0 0 0 23 36 1 0 0 0 0 23 37 1 0 0 0 0 24 38 1 0 0 0 0 24 39 1 0 0 0 0 24 40 1 0 0 0 0 M END > (442) pyrido[2,3-d]pyrimidin-7-one deriv. 8 > (442) PDGFR-beta > (442) 1600 > (442) -1 > (442) P > (442) PDGFR-P440 $$$$ PD0173955 csChFnd70/05150717532D 45 48 0 0 0 0 0 0 0 0999 V2000 3.5704 17.0561 -0.7083 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1473 19.8082 -0.7717 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1582 17.9888 -0.6487 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9817 17.9690 -0.8991 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9892 19.7885 -1.0209 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5671 20.7057 -0.9538 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1427 16.8650 -0.4195 Cl 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.8204 -0.9843 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.4652 7.0731 1.3112 N 0 0 3 0 0 0 0 0 0 0 0 0 3.4938 6.2150 2.9451 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4570 6.0949 5.9632 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5591 4.5234 6.1905 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6285 3.7855 4.7912 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5967 4.6334 3.1659 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4273 6.9419 4.3481 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5724 15.1043 -0.5776 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4463 14.2981 1.0354 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7009 14.0199 -2.1735 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8073 14.7264 -3.6144 O 0 0 0 0 0 0 0 0 0 0 0 0 3.7027 12.2455 -2.0560 N 0 0 3 0 0 0 0 0 0 0 0 0 3.8404 11.1797 -3.6643 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4610 8.8961 1.2381 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5838 11.4260 -0.4448 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4509 12.4335 1.1178 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3241 11.5439 2.7376 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3340 9.8013 2.7350 N 0 0 0 0 0 0 0 0 0 0 0 0 3.5843 9.6765 -0.3215 N 0 0 0 0 0 0 0 0 0 0 0 0 1.9220 1.2375 7.3727 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4841 1.7810 5.0815 S 0 0 0 0 0 0 0 0 0 0 0 0 6.3752 20.5317 -0.7258 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7604 20.4967 -1.1690 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5658 22.1284 -1.0499 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4483 6.3888 0.2287 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1787 6.6657 7.0526 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5849 3.8646 7.4548 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8747 4.0632 2.0763 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1308 8.1700 4.1751 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3455 15.0749 2.2269 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5220 10.9017 -4.1698 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5920 11.9027 -4.6560 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5097 9.9416 -3.3635 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2208 12.2696 3.9607 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4209 2.2883 8.2192 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2674 0.0000 7.7058 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3407 1.0981 7.5699 H 0 0 0 0 0 0 0 0 0 0 0 0 1 16 1 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 2 3 1 0 0 0 0 2 6 2 0 0 0 0 2 30 1 0 0 0 0 3 7 1 0 0 0 0 4 5 2 0 0 0 0 4 8 1 0 0 0 0 5 6 1 0 0 0 0 5 31 1 0 0 0 0 6 32 1 0 0 0 0 9 22 1 0 0 0 0 9 10 1 0 0 0 0 9 33 1 0 0 0 0 10 14 2 0 0 0 0 10 15 1 0 0 0 0 11 12 1 0 0 0 0 11 15 2 0 0 0 0 11 34 1 0 0 0 0 12 13 2 0 0 0 0 12 35 1 0 0 0 0 13 14 1 0 0 0 0 13 29 1 0 0 0 0 14 36 1 0 0 0 0 15 37 1 0 0 0 0 16 18 1 0 0 0 0 16 17 2 0 0 0 0 17 24 1 0 0 0 0 17 38 1 0 0 0 0 18 20 1 0 0 0 0 18 19 2 0 0 0 0 20 23 1 0 0 0 0 20 21 1 0 0 0 0 21 39 1 0 0 0 0 21 40 1 0 0 0 0 21 41 1 0 0 0 0 22 26 2 0 0 0 0 22 27 1 0 0 0 0 23 27 2 0 0 0 0 23 24 1 0 0 0 0 24 25 2 0 0 0 0 25 26 1 0 0 0 0 25 42 1 0 0 0 0 28 29 1 0 0 0 0 28 43 1 0 0 0 0 28 44 1 0 0 0 0 28 45 1 0 0 0 0 M END > (446) PD173955 > (446) PDGFR-beta > (446) 1660 > (446) -1 > (446) P > (446) PDGFR-P444 $$$$ PD089828 analog 10 csChFnd70/05150717532D 45 47 0 0 0 0 0 0 0 0999 V2000 1.2015 4.9970 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6960 2.4338 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7763 5.8795 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3209 4.9110 -0.0184 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8588 7.6819 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4675 8.4434 0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2245 3.3046 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2103 3.1947 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8374 5.7095 -0.0280 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6350 0.6596 -0.0244 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6318 10.3405 0.0103 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8836 12.9968 1.5649 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6873 11.2476 -1.5351 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8399 13.0166 -1.5165 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9377 13.8876 0.0288 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9484 7.3978 -0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5568 8.1654 -0.0307 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9836 7.1852 -0.0502 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8613 5.6286 -0.0579 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5459 7.9308 -0.0613 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0964 5.7400 -1.6936 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6858 8.0215 -0.0913 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0968 6.8654 -0.0825 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1278 5.7217 1.5154 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7243 11.2282 1.5651 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6642 10.3606 3.0668 F 0 0 0 0 0 0 0 0 0 0 0 0 4.5925 10.3987 -3.0456 F 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.6901 0.0327 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7041 8.4504 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5352 0.0741 -0.0167 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6918 0.0000 -0.0381 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9556 13.6853 2.7670 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8834 13.7201 -2.7113 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0623 15.2692 0.0360 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6543 9.4076 -0.0245 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6434 9.1729 -0.0551 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0745 6.5548 -2.8319 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2504 4.9473 -1.7094 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9644 4.9163 -1.6873 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6861 8.8233 1.0565 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8398 7.2289 -0.1071 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6639 8.8364 -1.2296 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9956 4.8979 1.5217 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2816 4.9289 1.4996 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1280 6.5233 2.6632 H 0 0 0 0 0 0 0 0 0 0 0 0 1 7 2 0 0 0 0 1 3 1 0 0 0 0 1 28 1 0 0 0 0 2 7 1 0 0 0 0 2 8 2 0 0 0 0 2 10 1 0 0 0 0 3 5 1 0 0 0 0 3 4 2 0 0 0 0 4 8 1 0 0 0 0 4 9 1 0 0 0 0 5 6 2 0 0 0 0 5 29 1 0 0 0 0 6 16 1 0 0 0 0 6 11 1 0 0 0 0 9 16 2 0 0 0 0 10 30 1 0 0 0 0 10 31 1 0 0 0 0 11 25 1 0 0 0 0 11 13 2 0 0 0 0 12 25 2 0 0 0 0 12 15 1 0 0 0 0 12 32 1 0 0 0 0 13 14 1 0 0 0 0 13 27 1 0 0 0 0 14 15 2 0 0 0 0 14 33 1 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 17 18 1 0 0 0 0 17 35 1 0 0 0 0 18 20 1 0 0 0 0 18 19 2 0 0 0 0 20 23 1 0 0 0 0 20 36 1 0 0 0 0 21 23 1 0 0 0 0 21 37 1 0 0 0 0 21 38 1 0 0 0 0 21 39 1 0 0 0 0 22 23 1 0 0 0 0 22 40 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 24 1 0 0 0 0 24 43 1 0 0 0 0 24 44 1 0 0 0 0 24 45 1 0 0 0 0 25 26 1 0 0 0 0 M END > (447) PD089828 analog 10 > (447) PDGFR-beta > (447) 1670 > (447) -1 > (447) P > (447) PDGFR-P445 $$$$ csChFnd70/05150717532D 49 52 0 0 0 0 0 0 0 0999 V2000 6.4416 10.5826 0.0155 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3247 8.8735 -0.0033 N 0 0 0 0 0 0 0 0 0 0 0 0 6.4629 8.9577 0.0006 N 0 0 0 0 0 0 0 0 0 0 0 0 7.9480 11.4296 0.0217 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4209 10.5067 0.0116 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0043 13.1695 0.0369 C 0 0 0 0 0 0 0 0 0 0 0 0 11.0094 12.9444 0.0337 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3496 13.6186 0.0399 O 0 0 0 0 0 0 0 0 0 0 0 0 10.9189 11.2881 0.0176 N 0 0 3 0 0 0 0 0 0 0 0 0 9.5048 13.9388 0.0417 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6052 15.7604 0.0573 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6439 16.6352 -1.4214 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7378 18.3333 -1.3984 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7933 19.1671 0.0862 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7554 18.3073 1.5564 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6545 16.6093 1.5506 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5975 15.5332 3.3970 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.5751 15.5912 -3.2858 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.8741 8.1292 -0.0086 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8257 6.4282 -0.0241 N 0 0 3 0 0 0 0 0 0 0 0 0 6.3183 5.6086 0.1158 C 0 0 0 0 0 0 0 0 0 0 0 0 12.4357 10.3112 0.0069 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0611 4.1415 -0.7239 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0799 6.2576 1.1002 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5855 5.4437 1.2388 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3272 3.9815 0.3944 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3712 6.0816 2.1978 O 0 0 0 0 0 0 0 0 0 0 0 0 0.8612 5.1814 2.2791 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5659 3.3291 -0.5840 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3116 1.8967 -1.4112 O 0 0 0 0 0 0 0 0 0 0 0 0 2.7396 1.1298 -1.2163 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2891 11.2466 0.0175 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8808 13.8812 0.0443 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7682 19.0119 -2.5420 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8671 20.4950 0.0974 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7991 18.9656 2.7113 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8378 5.8029 -0.1321 H 0 0 0 0 0 0 0 0 0 0 0 0 12.8107 10.0809 -1.2612 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4060 10.9842 0.6452 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2189 9.1415 0.6288 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0253 3.6335 -1.4862 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2809 7.3959 1.7581 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1629 3.3479 0.5033 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.8238 3.0837 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3337 5.0803 1.0489 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0981 3.9533 2.7666 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7000 0.0000 -1.9403 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5415 0.8384 0.0791 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7783 1.9660 -1.6389 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 32 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 33 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 34 1 0 0 0 0 14 15 1 0 0 0 0 14 35 1 0 0 0 0 15 16 2 0 0 0 0 15 36 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 37 1 0 0 0 0 21 23 1 0 0 0 0 21 24 2 0 0 0 0 22 38 1 0 0 0 0 22 39 1 0 0 0 0 22 40 1 0 0 0 0 23 29 2 0 0 0 0 23 41 1 0 0 0 0 24 25 1 0 0 0 0 24 42 1 0 0 0 0 25 26 2 0 0 0 0 25 27 1 0 0 0 0 26 29 1 0 0 0 0 26 43 1 0 0 0 0 27 28 1 0 0 0 0 28 44 1 0 0 0 0 28 45 1 0 0 0 0 28 46 1 0 0 0 0 29 30 1 0 0 0 0 30 31 1 0 0 0 0 31 47 1 0 0 0 0 31 48 1 0 0 0 0 31 49 1 0 0 0 0 M END > (448) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 54 > (448) PDGFR-beta > (448) 1700 > (448) -1 > (448) P > (448) PDGFR-P446 $$$$ csChFnd70/05150717532D 50 53 0 0 0 0 0 0 0 0999 V2000 9.4017 8.4202 0.0156 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2933 6.7061 -0.0033 N 0 0 0 0 0 0 0 0 0 0 0 0 9.4231 6.7906 0.0006 N 0 0 0 0 0 0 0 0 0 0 0 0 10.9125 9.2698 0.0217 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3898 8.3441 0.0116 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9690 11.0148 0.0370 C 0 0 0 0 0 0 0 0 0 0 0 0 13.9830 10.7890 0.0316 C 0 0 0 0 0 0 0 0 0 0 0 0 15.3271 11.4653 0.0363 O 0 0 0 0 0 0 0 0 0 0 0 0 13.8924 9.1279 0.0166 N 0 0 3 0 0 0 0 0 0 0 0 0 12.4739 11.7863 0.0420 C 0 0 0 0 0 0 0 0 0 0 0 0 12.5747 13.6134 0.0585 C 0 0 0 0 0 0 0 0 0 0 0 0 12.6129 14.4917 -1.4239 C 0 0 0 0 0 0 0 0 0 0 0 0 12.7064 16.1948 -1.3998 C 0 0 0 0 0 0 0 0 0 0 0 0 12.7620 17.0301 0.0897 C 0 0 0 0 0 0 0 0 0 0 0 0 12.7250 16.1668 1.5637 C 0 0 0 0 0 0 0 0 0 0 0 0 12.6246 14.4639 1.5569 C 0 0 0 0 0 0 0 0 0 0 0 0 12.5688 13.3834 3.4082 Cl 0 0 0 0 0 0 0 0 0 0 0 0 12.5440 13.4458 -3.2946 Cl 0 0 0 0 0 0 0 0 0 0 0 0 10.8384 5.9595 -0.0086 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7899 4.2537 -0.0248 N 0 0 3 0 0 0 0 0 0 0 0 0 9.2776 3.4313 0.1151 C 0 0 0 0 0 0 0 0 0 0 0 0 15.4135 8.1480 0.0058 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0199 1.9582 -0.7290 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0376 4.0812 1.1008 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5307 3.2558 1.2360 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2822 1.7807 0.3775 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5271 1.1408 -0.5955 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2004 3.9434 2.2790 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4193 5.2266 3.0247 O 0 0 0 0 0 0 0 0 0 0 0 0 3.7446 3.1471 2.4028 O 0 0 0 0 0 0 0 0 0 0 0 0 2.4944 3.8942 3.4493 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9386 2.8215 3.4360 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2458 9.0862 0.0175 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8422 11.7286 0.0445 H 0 0 0 0 0 0 0 0 0 0 0 0 12.7365 16.8760 -2.5463 H 0 0 0 0 0 0 0 0 0 0 0 0 12.8349 18.3619 0.1018 H 0 0 0 0 0 0 0 0 0 0 0 0 12.7694 16.8263 2.7224 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8051 3.6264 -0.1332 H 0 0 0 0 0 0 0 0 0 0 0 0 15.7891 7.9162 -1.2660 H 0 0 0 0 0 0 0 0 0 0 0 0 16.3869 8.8235 0.6452 H 0 0 0 0 0 0 0 0 0 0 0 0 15.1963 6.9753 0.6304 H 0 0 0 0 0 0 0 0 0 0 0 0 9.9895 1.4511 -1.4921 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2374 5.2224 1.7622 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1177 1.1379 0.4788 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3323 0.0000 -1.2590 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9620 3.9909 4.7081 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1965 5.1226 2.9855 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.3824 4.2215 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4710 2.7248 2.1772 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2365 1.5931 3.8997 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 33 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 34 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 35 1 0 0 0 0 14 15 1 0 0 0 0 14 36 1 0 0 0 0 15 16 2 0 0 0 0 15 37 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 38 1 0 0 0 0 21 23 1 0 0 0 0 21 24 2 0 0 0 0 22 39 1 0 0 0 0 22 40 1 0 0 0 0 22 41 1 0 0 0 0 23 27 2 0 0 0 0 23 42 1 0 0 0 0 24 25 1 0 0 0 0 24 43 1 0 0 0 0 25 26 2 0 0 0 0 25 28 1 0 0 0 0 26 27 1 0 0 0 0 26 44 1 0 0 0 0 27 45 1 0 0 0 0 28 30 1 0 0 0 0 28 29 2 0 0 0 0 30 31 1 0 0 0 0 31 32 1 0 0 0 0 31 46 1 0 0 0 0 31 47 1 0 0 0 0 32 48 1 0 0 0 0 32 49 1 0 0 0 0 32 50 1 0 0 0 0 M END > (449) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 55 > (449) PDGFR-beta > (449) 1700 > (449) -1 > (449) P > (449) PDGFR-P447 $$$$ Pyrazine-Pyridine Biheteroaryl 57 csChFnd70/05150717532D 49 52 0 0 0 0 0 0 0 0999 V2000 1.0493 13.9815 -0.0846 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3562 11.8097 -0.3512 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6854 12.6085 -0.3824 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3738 14.7885 -0.1148 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0754 12.5169 -0.2033 N 0 0 0 0 0 0 0 0 0 0 0 0 3.6624 14.0842 -0.2629 N 0 0 0 0 0 0 0 0 0 0 0 0 5.1240 11.8144 -0.5479 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4600 12.6033 -0.5803 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8177 10.4431 -0.8481 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5381 9.5740 -0.8198 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1606 10.2649 -0.6671 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7402 11.9039 -0.7271 N 0 0 0 0 0 0 0 0 0 0 0 0 3.6754 17.1290 0.1190 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7918 18.5328 -0.5182 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8833 16.5217 0.8705 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1975 17.3120 0.9765 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3129 18.7072 0.3362 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1105 19.3184 -0.4082 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2581 21.0735 -1.2040 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.3440 16.3315 0.0099 N 0 0 3 0 0 0 0 0 0 0 0 0 8.0892 7.3107 -1.1168 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6334 8.0268 -0.9495 N 0 0 3 0 0 0 0 0 0 0 0 0 7.8822 5.6242 -1.2346 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4024 4.8763 -1.4093 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7115 2.3840 -2.6310 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2991 0.9685 -2.3217 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5128 0.9813 -0.9778 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2042 3.2614 -1.5221 N 0 0 3 0 0 0 0 0 0 0 0 0 8.4552 2.3552 -0.4974 N 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 14.5548 0.0411 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3730 10.6116 -0.4484 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4450 13.8017 -0.4845 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8909 9.9142 -0.9665 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1463 9.6199 -0.6409 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8535 19.0098 -1.0991 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7941 15.4324 1.3716 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1364 16.8400 1.5607 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3419 19.3232 0.4215 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3990 16.8540 0.0213 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6297 7.7231 -2.1219 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7794 7.5671 -0.1522 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7358 7.4269 -0.9289 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3416 5.2118 -0.2294 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1921 5.3678 -2.1992 H 0 0 0 0 0 0 0 0 0 0 0 0 9.9429 5.2886 -2.4144 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0925 5.1327 -0.4446 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3388 2.7460 -3.5907 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5354 0.0000 -2.9939 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0354 0.0228 -0.4312 H 0 0 0 0 0 0 0 0 0 0 0 0 1 5 1 0 0 0 0 1 4 2 0 0 0 0 1 30 1 0 0 0 0 2 5 2 0 0 0 0 2 3 1 0 0 0 0 2 31 1 0 0 0 0 3 6 2 0 0 0 0 3 7 1 0 0 0 0 4 6 1 0 0 0 0 4 20 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 12 2 0 0 0 0 8 32 1 0 0 0 0 9 12 1 0 0 0 0 9 10 2 0 0 0 0 9 33 1 0 0 0 0 10 11 1 0 0 0 0 10 22 1 0 0 0 0 11 34 1 0 0 0 0 13 20 1 0 0 0 0 13 14 2 0 0 0 0 13 15 1 0 0 0 0 14 18 1 0 0 0 0 14 35 1 0 0 0 0 15 16 2 0 0 0 0 15 36 1 0 0 0 0 16 17 1 0 0 0 0 16 37 1 0 0 0 0 17 18 2 0 0 0 0 17 38 1 0 0 0 0 18 19 1 0 0 0 0 20 39 1 0 0 0 0 21 22 1 0 0 0 0 21 23 1 0 0 0 0 21 40 1 0 0 0 0 21 41 1 0 0 0 0 22 42 1 0 0 0 0 23 24 1 0 0 0 0 23 43 1 0 0 0 0 23 44 1 0 0 0 0 24 28 1 0 0 0 0 24 45 1 0 0 0 0 24 46 1 0 0 0 0 25 28 1 0 0 0 0 25 26 2 0 0 0 0 25 47 1 0 0 0 0 26 27 1 0 0 0 0 26 48 1 0 0 0 0 27 29 2 0 0 0 0 27 49 1 0 0 0 0 28 29 1 0 0 0 0 M END > (451) Pyrazine-Pyridine Biheteroaryl 57 > (451) PDGFR-beta > (451) 1700 > (451) -1 > (451) P > (451) PDGFR-P449 $$$$ Structure358 csChFnd70/05150717532D 26 28 0 0 0 0 0 0 0 0999 V2000 1.0168 7.5629 0.0103 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0370 6.0701 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3258 5.3357 -0.0141 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6121 6.0932 -0.0223 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5976 7.6054 -0.0140 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2819 8.3324 0.0025 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0457 5.6972 -0.0385 N 0 0 3 0 0 0 0 0 0 0 0 0 5.8376 6.9305 -0.0397 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9908 8.0454 -0.0254 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5847 4.2874 -0.0507 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6182 3.8913 -1.0538 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1483 2.5035 -1.0653 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6481 1.5050 -0.0750 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6151 1.9001 0.9273 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0894 3.2896 0.9445 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1701 0.1386 -0.0870 O 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 8.1255 0.0182 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0362 5.4794 0.0089 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3341 4.1738 -0.0200 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2578 9.4941 0.0089 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9986 6.9764 -0.0509 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0070 4.6684 -1.8253 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9522 2.1952 -1.8457 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2255 1.1221 1.6976 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2854 3.5972 1.7250 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0073 0.0000 0.5149 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 2 0 0 0 0 1 6 1 0 0 0 0 1 17 1 0 0 0 0 2 3 1 0 0 0 0 2 18 1 0 0 0 0 3 4 2 0 0 0 0 3 19 1 0 0 0 0 4 5 1 0 0 0 0 4 7 1 0 0 0 0 5 6 2 0 0 0 0 5 9 1 0 0 0 0 6 20 1 0 0 0 0 7 8 1 0 0 0 0 7 10 1 0 0 0 0 8 9 2 0 0 0 0 8 21 1 0 0 0 0 10 11 2 0 0 0 0 10 15 1 0 0 0 0 11 12 1 0 0 0 0 11 22 1 0 0 0 0 12 13 2 0 0 0 0 12 23 1 0 0 0 0 13 14 1 0 0 0 0 13 16 1 0 0 0 0 14 15 2 0 0 0 0 14 24 1 0 0 0 0 15 25 1 0 0 0 0 16 26 1 0 0 0 0 M END > (453) 16230017 -67 > (453) PDGFR-beta > (453) 1778 > (453) -1 > (453) P > (453) PDGFR-P451 $$$$ csChFnd70/05150717532D 45 48 0 0 0 0 0 0 0 0999 V2000 3.7591 8.5419 0.1916 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2347 7.0485 -0.2863 N 0 0 0 0 0 0 0 0 0 0 0 0 3.7795 7.1213 0.1962 N 0 0 0 0 0 0 0 0 0 0 0 0 5.0504 9.2828 -0.0669 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3151 8.4764 -0.3107 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0963 10.8040 -0.0856 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6746 10.6081 -0.5915 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8233 11.1981 -0.8210 O 0 0 0 0 0 0 0 0 0 0 0 0 7.5991 9.1601 -0.5678 N 0 0 3 0 0 0 0 0 0 0 0 0 6.3824 11.4769 -0.3430 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4661 13.0697 -0.3697 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2486 13.8153 -1.6559 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3276 15.3002 -1.6732 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6217 16.0482 -0.4193 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8384 15.3157 0.8592 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7567 13.8312 0.8925 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0215 12.9143 2.4997 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.8801 12.8785 -3.2307 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.9912 6.3972 -0.0378 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9518 4.9106 -0.0216 N 0 0 3 0 0 0 0 0 0 0 0 0 3.6316 4.1927 0.1004 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2743 2.0885 0.7569 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9016 8.3064 -0.8188 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0672 4.1596 -0.1994 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0195 2.7730 0.3406 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3687 4.8705 -0.3204 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5834 2.7935 0.6391 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8183 2.1214 1.0477 O 0 0 0 0 0 0 0 0 0 0 0 0 4.6866 0.6876 1.5899 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7687 9.1220 0.3780 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1315 11.4259 0.1000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1599 15.8785 -2.6679 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6827 17.2093 -0.4387 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0680 15.9060 1.8344 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8387 4.3640 -0.0947 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2332 1.0055 1.1787 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0108 8.0877 -1.9667 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8393 8.9038 -0.4435 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8235 7.2923 -0.2332 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0843 4.6900 -0.5233 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.2214 0.4329 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4028 5.9537 -0.7423 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7489 0.2783 1.8757 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9997 0.6906 2.5414 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2112 0.0000 0.7663 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 30 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 31 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 23 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 32 1 0 0 0 0 14 15 1 0 0 0 0 14 33 1 0 0 0 0 15 16 2 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 35 1 0 0 0 0 21 26 1 0 0 0 0 21 27 2 0 0 0 0 22 25 2 0 0 0 0 22 27 1 0 0 0 0 22 36 1 0 0 0 0 23 37 1 0 0 0 0 23 38 1 0 0 0 0 23 39 1 0 0 0 0 24 25 1 0 0 0 0 24 26 2 0 0 0 0 24 40 1 0 0 0 0 25 41 1 0 0 0 0 26 42 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 43 1 0 0 0 0 29 44 1 0 0 0 0 29 45 1 0 0 0 0 M END > (455) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 47 > (455) PDGFR-beta > (455) 1800 > (455) -1 > (455) P > (455) PDGFR-P453 $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 14 csChFnd70/05150717532D 45 47 0 0 0 0 0 0 0 0999 V2000 1.2134 5.0308 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7219 2.4482 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7981 5.9229 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3494 4.9518 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8570 7.7547 0.0115 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0205 7.5187 -0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4361 8.5650 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2365 3.3196 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2489 3.2326 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4310 8.2292 -0.0285 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9260 5.7751 -0.0284 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5414 10.4828 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7034 13.1695 1.5791 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6056 11.3816 1.5795 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5843 11.3979 -1.5493 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6823 13.1857 -1.5315 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7381 14.0693 0.0281 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5615 10.2549 3.5273 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5153 10.2916 -3.5081 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6717 0.6590 -0.0254 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5231 4.7473 -0.0485 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0620 4.3995 -1.9256 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7299 3.3261 -1.9466 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2472 2.9921 -3.7489 N 0 0 0 0 0 0 0 0 0 0 0 0 11.9932 2.2356 -3.8287 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9788 1.8757 -4.6273 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.7292 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6740 8.5036 0.0264 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7527 13.8668 2.7923 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7161 13.8955 -2.7380 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8147 15.4673 0.0349 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5656 0.0609 -0.0180 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7428 0.0000 -0.0392 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5497 5.4592 0.6121 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3009 3.5186 0.6131 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0353 3.6877 -2.5862 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2842 5.6282 -2.5872 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7565 4.0378 -1.2861 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5076 2.0974 -1.2849 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0101 1.0140 -3.1186 H 0 0 0 0 0 0 0 0 0 0 0 0 12.3438 2.0015 -5.1775 H 0 0 0 0 0 0 0 0 0 0 0 0 12.9211 3.1302 -3.2493 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7153 2.5085 -4.6285 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3933 1.6491 -5.9592 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8865 0.6410 -3.9462 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 27 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 20 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 11 1 0 0 0 0 5 7 2 0 0 0 0 5 28 1 0 0 0 0 6 11 1 0 0 0 0 6 7 1 0 0 0 0 6 10 2 0 0 0 0 7 12 1 0 0 0 0 11 21 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 29 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 30 1 0 0 0 0 17 31 1 0 0 0 0 20 32 1 0 0 0 0 20 33 1 0 0 0 0 21 22 1 0 0 0 0 21 34 1 0 0 0 0 21 35 1 0 0 0 0 22 23 1 0 0 0 0 22 36 1 0 0 0 0 22 37 1 0 0 0 0 23 24 1 0 0 0 0 23 38 1 0 0 0 0 23 39 1 0 0 0 0 24 25 1 0 0 0 0 24 26 1 0 0 0 0 25 40 1 0 0 0 0 25 41 1 0 0 0 0 25 42 1 0 0 0 0 26 43 1 0 0 0 0 26 44 1 0 0 0 0 26 45 1 0 0 0 0 M END > (456) pyrido[2,3-d]pyrimidin-7-one deriv. 14 > (456) PDGFR-beta > (456) 1800 > (456) -1 > (456) P > (456) PDGFR-P454 $$$$ 1,6-naphthyridine-2,7-diamine deriv. 11 csChFnd70/05150717532D 46 48 0 0 0 0 0 0 0 0999 V2000 2.7233 7.7429 0.0126 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8266 7.6490 -0.0176 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2820 8.5997 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3533 5.0693 -0.0173 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7479 5.9369 0.0026 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2301 4.9681 0.0113 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7790 2.4252 -0.0171 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3407 3.2664 -0.0270 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3003 3.2826 0.0015 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8207 5.9583 -0.0272 N 0 0 0 0 0 0 0 0 0 0 0 0 2.7509 0.6399 -0.0271 N 0 0 0 0 0 0 0 0 0 0 0 0 4.3289 10.5033 0.0114 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4087 13.1686 1.5649 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3723 13.1843 -1.5165 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4154 14.0607 0.0285 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3292 11.4106 -1.5337 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3657 11.3948 1.5651 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2759 10.3131 -3.4739 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.3565 10.2776 3.4949 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.3850 8.5163 -0.0284 N 0 0 3 0 0 0 0 0 0 0 0 0 8.8702 7.6274 -0.0486 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8455 6.0659 -0.0571 O 0 0 0 0 0 0 0 0 0 0 0 0 10.3829 8.4692 -0.0591 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0674 6.3806 -1.6928 C 0 0 0 0 0 0 0 0 0 0 0 0 13.5110 8.7561 -0.0891 C 0 0 0 0 0 0 0 0 0 0 0 0 11.9974 7.5028 -0.0809 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0999 6.3623 1.5162 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5247 8.4411 0.0334 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.6092 0.0265 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5291 2.5510 -0.0434 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6622 0.0339 -0.0203 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8199 0.0000 -0.0407 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4375 13.8604 2.7670 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3725 13.8883 -2.7118 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4486 15.4474 0.0352 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4046 9.7622 -0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4026 9.7150 -0.0521 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9943 7.1931 -2.8306 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2686 5.6616 -1.7090 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9889 5.4877 -1.6869 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4612 9.5556 1.0592 H 0 0 0 0 0 0 0 0 0 0 0 0 14.7123 8.0371 -0.1055 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4380 9.5687 -1.2269 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0214 5.4694 1.5221 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3011 5.6434 1.5000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0501 7.1617 2.6645 H 0 0 0 0 0 0 0 0 0 0 0 0 1 5 1 0 0 0 0 1 3 2 0 0 0 0 1 28 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 20 1 0 0 0 0 3 12 1 0 0 0 0 4 10 1 0 0 0 0 4 8 2 0 0 0 0 4 5 1 0 0 0 0 5 6 2 0 0 0 0 6 9 1 0 0 0 0 6 29 1 0 0 0 0 7 9 2 0 0 0 0 7 8 1 0 0 0 0 7 11 1 0 0 0 0 8 30 1 0 0 0 0 11 31 1 0 0 0 0 11 32 1 0 0 0 0 12 17 1 0 0 0 0 12 16 2 0 0 0 0 13 17 2 0 0 0 0 13 15 1 0 0 0 0 13 33 1 0 0 0 0 14 16 1 0 0 0 0 14 15 2 0 0 0 0 14 34 1 0 0 0 0 15 35 1 0 0 0 0 16 18 1 0 0 0 0 17 19 1 0 0 0 0 20 21 1 0 0 0 0 20 36 1 0 0 0 0 21 22 2 0 0 0 0 21 23 1 0 0 0 0 23 26 1 0 0 0 0 23 37 1 0 0 0 0 24 26 1 0 0 0 0 24 38 1 0 0 0 0 24 39 1 0 0 0 0 24 40 1 0 0 0 0 25 26 1 0 0 0 0 25 41 1 0 0 0 0 25 42 1 0 0 0 0 25 43 1 0 0 0 0 26 27 1 0 0 0 0 27 44 1 0 0 0 0 27 45 1 0 0 0 0 27 46 1 0 0 0 0 M END > (457) 1,6-naphthyridine deriv. 11 > (457) PDGFR-beta > (457) 1800 > (457) -1 > (457) P > (457) PDGFR-P455 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 62 csChFnd70/05150717532D 69 73 0 0 0 0 0 0 0 0999 V2000 3.9016 15.6744 1.3909 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3606 13.1380 1.6140 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9176 14.0195 1.6426 N 0 0 0 0 0 0 0 0 0 0 0 0 6.8520 13.8507 1.3359 N 0 0 0 0 0 0 0 0 0 0 0 0 5.4529 16.5047 1.0881 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9674 15.5262 1.0662 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5410 18.2647 0.8079 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5766 17.9235 0.5156 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1252 18.9759 0.5189 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4611 16.2753 0.7816 N 0 0 0 0 0 0 0 0 0 0 0 0 7.2939 20.8271 0.2151 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7010 23.6562 1.2852 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6102 24.2858 -0.3528 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5441 21.9330 1.5768 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2102 21.4691 -1.4343 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3688 23.1951 -1.7090 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6577 21.1455 3.6335 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.9081 20.1021 -3.1383 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.6579 10.5748 2.2006 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9378 8.6693 2.4613 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2938 11.4051 1.8875 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2293 7.8021 2.7884 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1602 18.6406 0.2257 N 0 0 3 0 0 0 0 0 0 0 0 0 11.5587 17.6530 0.2185 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4326 16.1338 0.4660 O 0 0 0 0 0 0 0 0 0 0 0 0 3.6402 5.2796 1.7347 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9674 3.3978 2.0982 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2001 3.1721 3.4197 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8730 5.0539 3.0561 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4980 5.9726 3.0387 N 0 0 0 0 0 0 0 0 0 0 0 0 2.3423 2.4791 2.1156 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6111 0.6494 2.3659 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0971 18.3497 -0.0631 N 0 0 3 0 0 0 0 0 0 0 0 0 14.5616 17.3473 0.0518 C 0 0 0 0 0 0 0 0 0 0 0 0 14.5231 15.6634 -0.4722 C 0 0 0 0 0 0 0 0 0 0 0 0 15.9698 14.6773 -0.3580 C 0 0 0 0 0 0 0 0 0 0 0 0 17.4570 15.3662 0.2778 C 0 0 0 0 0 0 0 0 0 0 0 0 17.4985 17.0439 0.8013 C 0 0 0 0 0 0 0 0 0 0 0 0 16.0573 18.0374 0.6832 C 0 0 0 0 0 0 0 0 0 0 0 0 19.2732 14.1234 0.4196 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.7226 16.3758 1.4115 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4090 19.0397 0.8171 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8952 24.5138 2.3383 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7330 25.6341 -0.5741 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3039 23.6938 -2.9855 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8235 10.7744 1.1138 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0756 11.1152 3.3349 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5200 8.1289 1.3271 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7722 8.4697 3.5482 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3300 10.7385 1.8721 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6470 8.3426 3.9226 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3948 8.0017 1.7015 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2608 19.8528 0.0283 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8403 5.9699 1.7577 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0533 5.4139 0.4878 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7848 2.8720 1.1119 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5859 3.2660 3.3301 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7871 3.0377 4.6665 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.4816 3.3967 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2546 5.1856 1.8242 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0556 5.5795 4.0424 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2534 0.4383 3.5743 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3881 0.0000 2.3737 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3912 0.1523 1.3355 H 0 0 0 0 0 0 0 0 0 0 0 0 13.1897 19.5456 -0.3454 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3626 15.1250 -0.9681 H 0 0 0 0 0 0 0 0 0 0 0 0 15.9404 13.3675 -0.7650 H 0 0 0 0 0 0 0 0 0 0 0 0 18.6607 17.5783 1.2975 H 0 0 0 0 0 0 0 0 0 0 0 0 16.0921 19.3483 1.0863 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 41 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 21 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 42 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 43 1 0 0 0 0 13 16 1 0 0 0 0 13 44 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 45 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 46 1 0 0 0 0 19 47 1 0 0 0 0 20 22 1 0 0 0 0 20 48 1 0 0 0 0 20 49 1 0 0 0 0 21 50 1 0 0 0 0 22 30 1 0 0 0 0 22 51 1 0 0 0 0 22 52 1 0 0 0 0 23 24 1 0 0 0 0 23 53 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 54 1 0 0 0 0 26 55 1 0 0 0 0 27 31 1 0 0 0 0 27 56 1 0 0 0 0 27 57 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 58 1 0 0 0 0 28 59 1 0 0 0 0 29 30 1 0 0 0 0 29 60 1 0 0 0 0 29 61 1 0 0 0 0 31 32 1 0 0 0 0 32 62 1 0 0 0 0 32 63 1 0 0 0 0 32 64 1 0 0 0 0 33 34 1 0 0 0 0 33 65 1 0 0 0 0 34 35 2 0 0 0 0 34 39 1 0 0 0 0 35 36 1 0 0 0 0 35 66 1 0 0 0 0 36 37 2 0 0 0 0 36 67 1 0 0 0 0 37 38 1 0 0 0 0 37 40 1 0 0 0 0 38 39 2 0 0 0 0 38 68 1 0 0 0 0 39 69 1 0 0 0 0 M END > (458) 6-arylpyrido[2,3-d]pyrimidine deriv. 62 > (458) PDGFR-beta > (458) 1800 > (458) -1 > (458) P > (458) PDGFR-P456 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 82 csChFnd70/05150717532D 71 74 0 0 0 0 0 0 0 0999 V2000 5.3899 15.6407 0.5468 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5970 12.9151 0.7205 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2242 13.9527 0.7025 N 0 0 0 0 0 0 0 0 0 0 0 0 8.1943 13.4976 0.5856 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0610 16.3373 0.3981 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4960 15.1940 0.4219 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3442 18.1227 0.2271 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3985 17.4824 0.1214 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0358 18.6950 0.0876 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0996 15.8134 0.2830 N 0 0 0 0 0 0 0 0 0 0 0 0 9.4110 20.5653 -0.0962 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0192 23.3266 1.1882 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1114 24.0602 -0.4398 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6702 21.5848 1.3681 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5135 21.3113 -1.7346 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8636 23.0547 -1.8972 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5536 20.6669 3.4124 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.2029 20.0512 -3.5652 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.3383 11.1554 0.8873 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5808 10.4670 1.0398 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6563 8.4978 1.2073 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0895 18.0603 -0.0193 N 0 0 3 0 0 0 0 0 0 0 0 0 2.8208 7.7788 1.3666 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0771 5.1407 0.2434 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1949 3.1852 0.5198 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2782 3.1695 1.6520 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1604 5.1251 1.3756 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8933 5.8881 1.5274 N 0 0 0 0 0 0 0 0 0 0 0 0 2.4620 2.4222 0.3680 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5345 0.5314 0.5288 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4054 16.9189 0.0101 C 0 0 0 0 0 0 0 0 0 0 0 0 15.0488 17.4806 -0.1265 N 0 0 3 0 0 0 0 0 0 0 0 0 16.3819 14.9019 -1.3785 C 0 0 0 0 0 0 0 0 0 0 0 0 18.2003 17.2344 -0.0812 C 0 0 0 0 0 0 0 0 0 0 0 0 12.9893 14.7557 0.2212 S 0 0 0 0 0 0 0 0 0 0 0 0 16.4850 16.2597 0.0557 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3724 15.3678 1.8173 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2666 16.4696 0.5282 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2764 19.0218 0.2048 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2202 24.1175 2.3209 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3851 25.4226 -0.5738 H 0 0 0 0 0 0 0 0 0 0 0 0 9.9433 23.6338 -3.1649 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3204 10.3761 0.9033 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9604 11.0120 2.1814 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8396 10.8126 -0.1075 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2767 7.9528 0.0657 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3974 8.1520 2.3547 H 0 0 0 0 0 0 0 0 0 0 0 0 12.3253 19.2860 -0.1388 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2004 8.3238 2.5082 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0797 8.1245 0.2192 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3554 5.7144 0.3924 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5916 5.4037 -1.0529 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0431 2.6230 -0.4546 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7136 2.9223 1.8032 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7637 2.9065 2.9482 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.5959 1.5029 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6418 5.3880 0.0922 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3122 5.6873 2.3501 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0713 0.1872 1.7852 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2349 0.0000 0.4117 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3512 0.0044 -0.4912 H 0 0 0 0 0 0 0 0 0 0 0 0 15.2807 18.6932 -0.3457 H 0 0 0 0 0 0 0 0 0 0 0 0 16.2807 15.5451 -2.6279 H 0 0 0 0 0 0 0 0 0 0 0 0 17.5429 14.1037 -1.3538 H 0 0 0 0 0 0 0 0 0 0 0 0 15.2489 14.0892 -1.1754 H 0 0 0 0 0 0 0 0 0 0 0 0 18.2737 18.2018 0.9405 H 0 0 0 0 0 0 0 0 0 0 0 0 19.2688 16.3261 0.0544 H 0 0 0 0 0 0 0 0 0 0 0 0 18.2804 17.8699 -1.3362 H 0 0 0 0 0 0 0 0 0 0 0 0 15.2359 14.5357 1.8508 H 0 0 0 0 0 0 0 0 0 0 0 0 17.5294 14.5910 2.0253 H 0 0 0 0 0 0 0 0 0 0 0 0 16.2718 16.3412 2.8310 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 38 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 19 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 39 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 22 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 40 1 0 0 0 0 13 16 1 0 0 0 0 13 41 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 42 1 0 0 0 0 19 20 1 0 0 0 0 19 43 1 0 0 0 0 20 21 1 0 0 0 0 20 44 1 0 0 0 0 20 45 1 0 0 0 0 21 23 1 0 0 0 0 21 46 1 0 0 0 0 21 47 1 0 0 0 0 22 31 1 0 0 0 0 22 48 1 0 0 0 0 23 28 1 0 0 0 0 23 49 1 0 0 0 0 23 50 1 0 0 0 0 24 28 1 0 0 0 0 24 25 1 0 0 0 0 24 51 1 0 0 0 0 24 52 1 0 0 0 0 25 29 1 0 0 0 0 25 53 1 0 0 0 0 25 54 1 0 0 0 0 26 29 1 0 0 0 0 26 27 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 27 28 1 0 0 0 0 27 57 1 0 0 0 0 27 58 1 0 0 0 0 29 30 1 0 0 0 0 30 59 1 0 0 0 0 30 60 1 0 0 0 0 30 61 1 0 0 0 0 31 35 2 0 0 0 0 31 32 1 0 0 0 0 32 36 1 0 0 0 0 32 62 1 0 0 0 0 33 36 1 0 0 0 0 33 63 1 0 0 0 0 33 64 1 0 0 0 0 33 65 1 0 0 0 0 34 36 1 0 0 0 0 34 66 1 0 0 0 0 34 67 1 0 0 0 0 34 68 1 0 0 0 0 36 37 1 0 0 0 0 37 69 1 0 0 0 0 37 70 1 0 0 0 0 37 71 1 0 0 0 0 M END > (464) 6-arylpyrido[2,3-d]pyrimidine deriv. 82 > (464) PDGFR-beta > (464) 1900 > (464) -1 > (464) P > (464) PDGFR-P462 $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 54 csChFnd70/05150717532D 65 68 0 0 0 0 0 0 0 0999 V2000 12.1030 10.8821 1.9108 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0718 8.0521 1.8077 C 0 0 0 0 0 0 0 0 0 0 0 0 13.8172 11.4278 2.1889 C 0 0 0 0 0 0 0 0 0 0 0 0 15.1385 10.1616 2.2635 C 0 0 0 0 0 0 0 0 0 0 0 0 14.2282 13.2034 2.3914 C 0 0 0 0 0 0 0 0 0 0 0 0 17.2600 12.3243 2.7299 C 0 0 0 0 0 0 0 0 0 0 0 0 18.7692 12.7285 2.9668 O 0 0 0 0 0 0 0 0 0 0 0 0 15.9210 13.6703 2.6595 C 0 0 0 0 0 0 0 0 0 0 0 0 16.8313 10.6419 2.5327 N 0 0 3 0 0 0 0 0 0 0 0 0 14.7089 8.5045 2.0677 N 0 0 0 0 0 0 0 0 0 0 0 0 11.7951 9.2075 1.7302 N 0 0 0 0 0 0 0 0 0 0 0 0 12.6772 6.3153 1.6102 N 0 0 3 0 0 0 0 0 0 0 0 0 10.9447 5.7879 1.4682 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5149 4.3725 0.4398 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8058 3.8528 0.3010 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9480 6.1540 2.2215 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6563 6.6754 2.3617 C 0 0 0 0 0 0 0 0 0 0 0 0 18.1863 9.3111 2.6065 C 0 0 0 0 0 0 0 0 0 0 0 0 18.9087 9.0005 0.7839 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3939 15.5209 2.8759 C 0 0 0 0 0 0 0 0 0 0 0 0 16.2378 18.1736 4.5015 C 0 0 0 0 0 0 0 0 0 0 0 0 15.7924 16.4507 4.3067 C 0 0 0 0 0 0 0 0 0 0 0 0 17.4484 16.3377 1.6536 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8848 18.0612 1.8625 C 0 0 0 0 0 0 0 0 0 0 0 0 17.2787 18.9787 3.2809 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5187 4.7446 1.1880 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8362 4.2324 1.0502 O 0 0 0 0 0 0 0 0 0 0 0 0 4.5785 5.2098 1.9988 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7734 4.4461 1.6853 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6941 2.6849 2.4093 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8481 2.7198 4.3087 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2812 0.8993 4.9709 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0971 1.7959 1.8699 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2674 1.2195 -0.0219 C 0 0 0 0 0 0 0 0 0 0 0 0 11.0569 11.8123 1.8516 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2222 14.1771 2.3350 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6004 5.4610 1.5698 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5167 3.6785 -0.2515 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4714 2.7521 -0.4987 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9453 6.8475 2.9119 H 0 0 0 0 0 0 0 0 0 0 0 0 9.9903 7.7728 3.1663 H 0 0 0 0 0 0 0 0 0 0 0 0 19.2278 9.7455 3.4586 H 0 0 0 0 0 0 0 0 0 0 0 0 17.6383 8.1076 3.1077 H 0 0 0 0 0 0 0 0 0 0 0 0 19.4567 10.2039 0.2827 H 0 0 0 0 0 0 0 0 0 0 0 0 19.9167 8.0103 0.8389 H 0 0 0 0 0 0 0 0 0 0 0 0 17.8670 8.5660 -0.0682 H 0 0 0 0 0 0 0 0 0 0 0 0 15.7727 18.8951 5.6090 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9794 15.8235 5.2600 H 0 0 0 0 0 0 0 0 0 0 0 0 17.9228 15.6227 0.5459 H 0 0 0 0 0 0 0 0 0 0 0 0 18.7017 18.6951 0.9168 H 0 0 0 0 0 0 0 0 0 0 0 0 17.6238 20.3275 3.4389 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8809 5.1535 3.3791 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6027 6.5557 1.5655 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8020 5.2586 2.3146 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5174 4.3962 0.2954 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8777 3.6145 4.6818 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6242 3.1479 4.8730 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2634 0.0000 4.5772 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5169 0.4808 4.4252 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3720 0.9202 6.3819 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8876 0.6635 2.6906 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.6792 1.9965 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3500 2.3585 -0.8561 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4366 0.4386 -0.1733 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1370 0.4510 -0.3841 H 0 0 0 0 0 0 0 0 0 0 0 0 1 11 1 0 0 0 0 1 3 2 0 0 0 0 1 35 1 0 0 0 0 2 11 2 0 0 0 0 2 10 1 0 0 0 0 2 12 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 10 2 0 0 0 0 4 9 1 0 0 0 0 5 8 2 0 0 0 0 5 36 1 0 0 0 0 6 9 1 0 0 0 0 6 8 1 0 0 0 0 6 7 2 0 0 0 0 8 20 1 0 0 0 0 9 18 1 0 0 0 0 12 13 1 0 0 0 0 12 37 1 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 14 15 1 0 0 0 0 14 38 1 0 0 0 0 15 26 2 0 0 0 0 15 39 1 0 0 0 0 16 26 1 0 0 0 0 16 17 2 0 0 0 0 16 40 1 0 0 0 0 17 41 1 0 0 0 0 18 19 1 0 0 0 0 18 42 1 0 0 0 0 18 43 1 0 0 0 0 19 44 1 0 0 0 0 19 45 1 0 0 0 0 19 46 1 0 0 0 0 20 22 1 0 0 0 0 20 23 2 0 0 0 0 21 22 2 0 0 0 0 21 25 1 0 0 0 0 21 47 1 0 0 0 0 22 48 1 0 0 0 0 23 24 1 0 0 0 0 23 49 1 0 0 0 0 24 25 2 0 0 0 0 24 50 1 0 0 0 0 25 51 1 0 0 0 0 26 27 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 28 52 1 0 0 0 0 28 53 1 0 0 0 0 29 30 1 0 0 0 0 29 54 1 0 0 0 0 29 55 1 0 0 0 0 30 31 1 0 0 0 0 30 33 1 0 0 0 0 31 32 1 0 0 0 0 31 56 1 0 0 0 0 31 57 1 0 0 0 0 32 58 1 0 0 0 0 32 59 1 0 0 0 0 32 60 1 0 0 0 0 33 34 1 0 0 0 0 33 61 1 0 0 0 0 33 62 1 0 0 0 0 34 63 1 0 0 0 0 34 64 1 0 0 0 0 34 65 1 0 0 0 0 M END > (48) pyrido[2,3-d]pyrimidin-7-one deriv. 54 > (48) PDGFR-beta > (48) 31 > (48) -1 > (48) P > (48) PDGFR-P46 $$$$ 3-substituted indolin-2-one 9a csChFnd70/05150717532D 41 43 0 0 0 0 0 0 0 0999 V2000 6.2244 3.2240 -0.0939 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2729 1.7145 -0.6543 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5822 1.1827 -1.4380 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8497 2.1496 -1.6689 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8229 3.6736 -1.1134 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4953 4.2076 -0.3204 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8166 5.8468 0.1169 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3892 6.1683 -0.4833 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9170 4.8681 -1.1833 N 0 0 3 0 0 0 0 0 0 0 0 0 10.0925 7.3983 -0.3665 O 0 0 0 0 0 0 0 0 0 0 0 0 6.8469 6.8566 0.9171 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4102 8.3231 1.4072 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5536 9.6916 1.5120 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9118 8.6577 1.8769 N 0 0 3 0 0 0 0 0 0 0 0 0 4.8502 9.8911 1.1235 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8671 9.5824 2.5816 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1636 9.7819 2.1931 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7756 10.1346 0.8844 O 0 0 0 0 0 0 0 0 0 0 0 0 1.0773 9.5676 3.3011 O 0 0 0 0 0 0 0 0 0 0 0 0 8.9914 10.1925 2.2580 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5674 10.8500 2.0453 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1518 12.5336 2.3374 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7974 3.8059 0.7534 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2885 0.9469 -0.4808 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6121 0.0000 -1.8724 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8641 1.7214 -2.2820 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9315 4.7759 -1.6767 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6577 6.5226 1.1670 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7682 7.9194 1.9270 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6442 11.0786 0.7168 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5242 9.0677 0.2104 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0731 8.3950 2.9883 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1929 10.4058 3.4948 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 9.7086 2.9965 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0211 10.7926 2.6677 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7620 12.6716 3.5403 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1738 13.2637 2.1365 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2189 12.8834 1.5467 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9757 3.6976 2.0081 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5969 5.0266 0.4574 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7874 3.1144 0.4074 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 6 2 0 0 0 0 1 23 1 0 0 0 0 2 3 2 0 0 0 0 2 24 1 0 0 0 0 3 4 1 0 0 0 0 3 25 1 0 0 0 0 4 5 2 0 0 0 0 4 26 1 0 0 0 0 5 9 1 0 0 0 0 5 6 1 0 0 0 0 6 7 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 9 1 0 0 0 0 8 10 2 0 0 0 0 9 27 1 0 0 0 0 11 12 1 0 0 0 0 11 28 1 0 0 0 0 12 13 2 0 0 0 0 12 14 1 0 0 0 0 13 21 1 0 0 0 0 13 15 1 0 0 0 0 14 20 1 0 0 0 0 14 29 1 0 0 0 0 15 16 1 0 0 0 0 15 30 1 0 0 0 0 15 31 1 0 0 0 0 16 17 1 0 0 0 0 16 32 1 0 0 0 0 16 33 1 0 0 0 0 17 19 1 0 0 0 0 17 18 2 0 0 0 0 19 34 1 0 0 0 0 20 21 2 0 0 0 0 20 35 1 0 0 0 0 21 22 1 0 0 0 0 22 36 1 0 0 0 0 22 37 1 0 0 0 0 22 38 1 0 0 0 0 23 39 1 0 0 0 0 23 40 1 0 0 0 0 23 41 1 0 0 0 0 M END > (478) 3-substituted indolin-2-one 9a > (478) PDGFR-beta > (478) 2110 > (478) -1 > (478) P > (478) PDGFR-P476 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 83 csChFnd70/05150717532D 69 73 0 0 0 0 0 0 0 0999 V2000 3.8898 15.7752 -1.2741 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4474 13.1939 -1.4703 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9406 14.0661 -1.4897 N 0 0 0 0 0 0 0 0 0 0 0 0 6.9711 13.9698 -1.2372 N 0 0 0 0 0 0 0 0 0 0 0 0 5.4726 16.6742 -1.0200 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0554 15.7038 -1.0067 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5272 18.4951 -0.7816 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6657 18.2237 -0.5428 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1464 19.2723 -0.5405 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5806 16.5176 -0.7691 N 0 0 0 0 0 0 0 0 0 0 0 0 7.2821 21.1894 -0.2833 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3370 23.6826 1.6284 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5354 24.7715 0.1976 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2100 21.8954 1.3975 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4899 22.2940 -1.7201 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6153 24.0790 -1.4717 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9602 20.5307 3.1949 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.5912 21.4272 -3.8162 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.4143 11.4018 -1.7032 N 0 0 3 0 0 0 0 0 0 0 0 0 3.7439 10.5005 -1.9647 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0722 8.5391 -2.1878 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2836 19.0065 -0.3017 N 0 0 3 0 0 0 0 0 0 0 0 0 2.3276 7.5978 -2.4607 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0877 5.3932 -3.9010 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4420 3.4260 -4.0081 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4003 2.8425 -3.3528 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0460 4.8097 -3.2457 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6427 5.7146 -2.6751 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8454 2.5210 -4.5787 N 0 0 0 0 0 0 0 0 0 0 0 0 3.1605 0.6380 -4.7931 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7469 18.0238 -0.3009 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6080 15.8088 -0.5974 S 0 0 0 0 0 0 0 0 0 0 0 0 13.3196 18.7847 -0.0667 N 0 0 3 0 0 0 0 0 0 0 0 0 14.8261 17.7537 0.0509 C 0 0 0 0 0 0 0 0 0 0 0 0 15.1002 16.4042 -1.1337 C 0 0 0 0 0 0 0 0 0 0 0 0 16.5895 15.3890 -1.0144 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8067 15.7146 0.2830 C 0 0 0 0 0 0 0 0 0 0 0 0 17.5377 17.0573 1.4644 C 0 0 0 0 0 0 0 0 0 0 0 0 16.0548 18.0822 1.3477 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6603 16.4701 -1.2981 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3433 19.2655 -0.7863 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2818 24.2307 2.9290 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6338 26.1680 0.3850 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7758 24.9356 -2.5832 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4971 10.7409 -1.6937 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9053 10.7160 -0.8322 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1059 11.0113 -3.1326 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9108 8.3235 -3.3203 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7102 8.0282 -1.0199 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3623 20.2616 -0.1338 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4890 7.8133 -1.3283 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6895 8.1086 -3.6287 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2592 6.0631 -3.4414 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7342 5.8838 -5.1918 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4881 3.1815 -4.9452 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8301 2.9420 -2.7245 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7539 2.3519 -2.0619 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2289 2.1725 -3.8124 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6580 5.2936 -4.5293 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.0541 -2.3086 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5813 0.0820 -3.5495 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9577 0.0000 -5.2160 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1760 0.4345 -5.7725 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4065 20.0473 0.0203 H 0 0 0 0 0 0 0 0 0 0 0 0 14.1495 16.1485 -2.1466 H 0 0 0 0 0 0 0 0 0 0 0 0 16.8033 14.3393 -1.9350 H 0 0 0 0 0 0 0 0 0 0 0 0 18.9698 14.9183 0.3740 H 0 0 0 0 0 0 0 0 0 0 0 0 18.4907 17.3080 2.4764 H 0 0 0 0 0 0 0 0 0 0 0 0 15.8483 19.1343 2.2672 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 40 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 19 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 41 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 22 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 42 1 0 0 0 0 13 16 1 0 0 0 0 13 43 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 44 1 0 0 0 0 19 20 1 0 0 0 0 19 45 1 0 0 0 0 20 21 1 0 0 0 0 20 46 1 0 0 0 0 20 47 1 0 0 0 0 21 23 1 0 0 0 0 21 48 1 0 0 0 0 21 49 1 0 0 0 0 22 31 1 0 0 0 0 22 50 1 0 0 0 0 23 28 1 0 0 0 0 23 51 1 0 0 0 0 23 52 1 0 0 0 0 24 28 1 0 0 0 0 24 25 1 0 0 0 0 24 53 1 0 0 0 0 24 54 1 0 0 0 0 25 29 1 0 0 0 0 25 55 1 0 0 0 0 25 56 1 0 0 0 0 26 29 1 0 0 0 0 26 27 1 0 0 0 0 26 57 1 0 0 0 0 26 58 1 0 0 0 0 27 28 1 0 0 0 0 27 59 1 0 0 0 0 27 60 1 0 0 0 0 29 30 1 0 0 0 0 30 61 1 0 0 0 0 30 62 1 0 0 0 0 30 63 1 0 0 0 0 31 32 2 0 0 0 0 31 33 1 0 0 0 0 33 34 1 0 0 0 0 33 64 1 0 0 0 0 34 35 2 0 0 0 0 34 39 1 0 0 0 0 35 36 1 0 0 0 0 35 65 1 0 0 0 0 36 37 2 0 0 0 0 36 66 1 0 0 0 0 37 38 1 0 0 0 0 37 67 1 0 0 0 0 38 39 2 0 0 0 0 38 68 1 0 0 0 0 39 69 1 0 0 0 0 M END > (481) 6-arylpyrido[2,3-d]pyrimidine deriv. 83 > (481) PDGFR-beta > (481) 2200 > (481) -1 > (481) P > (481) PDGFR-P479 $$$$ Indolin-2-one deriv. 9f csChFnd70/05150717532D 55 59 0 0 0 0 0 0 0 0999 V2000 5.7734 8.3798 -0.1461 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7479 6.8063 -0.3815 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9517 6.0916 -1.1819 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1817 6.9604 -1.7454 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2164 8.5461 -1.5132 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0012 9.2544 -0.7076 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3685 10.9222 -0.6527 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8465 11.0768 -1.4715 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2844 9.6648 -1.9447 N 0 0 3 0 0 0 0 0 0 0 0 0 9.5522 12.2755 -1.6841 O 0 0 0 0 0 0 0 0 0 0 0 0 6.5067 12.0845 0.0229 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1157 13.5911 0.1328 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2840 14.9594 0.0435 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6467 13.9754 0.3559 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5657 15.1142 -0.1884 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7587 15.1366 1.3839 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0402 15.2913 1.1519 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5149 15.3751 -0.1384 O 0 0 0 0 0 0 0 0 0 0 0 0 1.0931 15.3361 2.3790 O 0 0 0 0 0 0 0 0 0 0 0 0 8.7685 15.5327 0.3967 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3381 16.1598 0.2093 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0121 17.8718 0.1987 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2213 16.4748 0.6127 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8901 18.1383 0.1027 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4120 18.7114 0.8868 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9202 4.3971 -1.4324 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1216 3.6749 -2.2248 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0860 2.0977 -2.4547 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8609 1.2339 -1.9009 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6655 1.9444 -1.1137 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6922 3.5199 -0.8708 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8403 8.9350 0.4683 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7969 6.1258 0.0531 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1095 6.4001 -2.3632 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2255 9.4532 -2.5149 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3668 11.8385 0.4665 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4938 13.2501 0.4651 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3197 16.1860 -0.8017 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1436 14.1383 -0.8629 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0046 14.0647 1.9972 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1807 16.1124 2.0584 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 15.4363 2.1725 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8238 18.2603 -0.9842 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9895 18.1130 0.8927 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5581 16.4624 1.8259 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1478 15.9924 -0.0902 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8534 18.8783 0.4340 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7456 18.1728 -1.1477 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2907 19.9510 0.7018 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4773 18.4758 2.1221 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0781 4.3483 -2.6583 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0163 1.5369 -3.0684 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8376 0.0000 -2.0841 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7120 1.2642 -0.6839 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7610 4.0726 -0.2512 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 6 2 0 0 0 0 1 32 1 0 0 0 0 2 3 2 0 0 0 0 2 33 1 0 0 0 0 3 4 1 0 0 0 0 3 26 1 0 0 0 0 4 5 2 0 0 0 0 4 34 1 0 0 0 0 5 9 1 0 0 0 0 5 6 1 0 0 0 0 6 7 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 9 1 0 0 0 0 8 10 2 0 0 0 0 9 35 1 0 0 0 0 11 12 1 0 0 0 0 11 36 1 0 0 0 0 12 13 2 0 0 0 0 12 14 1 0 0 0 0 13 21 1 0 0 0 0 13 15 1 0 0 0 0 14 20 1 0 0 0 0 14 37 1 0 0 0 0 15 16 1 0 0 0 0 15 38 1 0 0 0 0 15 39 1 0 0 0 0 16 17 1 0 0 0 0 16 40 1 0 0 0 0 16 41 1 0 0 0 0 17 19 1 0 0 0 0 17 18 2 0 0 0 0 19 42 1 0 0 0 0 20 23 1 0 0 0 0 20 21 2 0 0 0 0 21 22 1 0 0 0 0 22 25 1 0 0 0 0 22 43 1 0 0 0 0 22 44 1 0 0 0 0 23 24 1 0 0 0 0 23 45 1 0 0 0 0 23 46 1 0 0 0 0 24 25 1 0 0 0 0 24 47 1 0 0 0 0 24 48 1 0 0 0 0 25 49 1 0 0 0 0 25 50 1 0 0 0 0 26 31 1 0 0 0 0 26 27 2 0 0 0 0 27 28 1 0 0 0 0 27 51 1 0 0 0 0 28 29 2 0 0 0 0 28 52 1 0 0 0 0 29 30 1 0 0 0 0 29 53 1 0 0 0 0 30 31 2 0 0 0 0 30 54 1 0 0 0 0 31 55 1 0 0 0 0 M END > (49) Indolin-2-one deriv. 9f > (49) PDGFR-beta > (49) 40 > (49) -1 > (49) P > (49) PDGFR-P47 $$$$ 3-substituted indolin-2-one 16h csChFnd70/05150717532D 55 58 0 0 0 0 0 0 0 0999 V2000 2.1679 9.4999 0.1766 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2976 7.7553 0.1447 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2865 9.5378 0.0905 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7077 10.4090 0.1064 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1197 12.2636 0.0378 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0048 12.3473 -0.0161 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6134 10.7316 0.0173 N 0 0 3 0 0 0 0 0 0 0 0 0 6.8658 13.6531 -0.0799 O 0 0 0 0 0 0 0 0 0 0 0 0 2.9776 13.6241 0.0259 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5910 15.3234 0.1662 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8861 16.7663 -0.6061 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9971 15.8568 1.1024 N 0 0 3 0 0 0 0 0 0 0 0 0 1.3244 16.8127 -1.7506 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1687 17.5820 0.9143 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1899 7.7308 0.2307 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7544 6.8525 0.2153 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5477 18.6709 1.7287 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8961 18.1683 -0.1227 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6190 20.0094 -0.6562 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4449 20.8995 0.6459 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1678 22.7405 0.1124 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8404 23.2849 -1.1768 O 0 0 0 0 0 0 0 0 0 0 0 0 1.1739 23.7757 1.0698 O 0 0 0 0 0 0 0 0 0 0 0 0 3.7728 4.9482 0.2737 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8092 4.0736 1.5140 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8335 2.2941 1.5588 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8070 1.3873 0.3812 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7614 2.2486 -0.8470 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7439 4.0215 -0.9109 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8536 4.9661 2.6708 O 0 0 0 0 0 0 0 0 0 0 0 0 0.9028 3.9866 3.8994 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9587 10.1810 0.1942 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5034 7.0682 0.1322 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8243 10.4360 -0.0060 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6152 13.3854 -0.0907 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7396 15.1218 1.7824 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1789 17.0133 -0.9696 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4512 17.8608 -2.6714 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2134 15.5974 -2.4386 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9972 7.0230 0.2856 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6539 18.7412 0.8720 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0506 19.9607 1.9564 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9363 18.0985 2.9467 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8520 20.6725 -0.7029 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0220 20.0437 -1.9230 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2119 20.2362 0.6927 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0418 20.8652 1.9128 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0342 24.9461 0.6759 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0915 1.6144 2.5147 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8228 0.0000 0.4205 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5191 1.5313 -1.7623 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4862 4.6893 -1.8748 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7852 3.2089 4.6602 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1981 4.8541 4.7438 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.1494 3.2313 H 0 0 0 0 0 0 0 0 0 0 0 0 1 15 1 0 0 0 0 1 4 2 0 0 0 0 1 32 1 0 0 0 0 2 16 1 0 0 0 0 2 3 2 0 0 0 0 2 33 1 0 0 0 0 3 7 1 0 0 0 0 3 4 1 0 0 0 0 4 5 1 0 0 0 0 5 6 1 0 0 0 0 5 9 2 0 0 0 0 6 7 1 0 0 0 0 6 8 2 0 0 0 0 7 34 1 0 0 0 0 9 10 1 0 0 0 0 9 35 1 0 0 0 0 10 11 2 0 0 0 0 10 12 1 0 0 0 0 11 18 1 0 0 0 0 11 13 1 0 0 0 0 12 14 1 0 0 0 0 12 36 1 0 0 0 0 13 37 1 0 0 0 0 13 38 1 0 0 0 0 13 39 1 0 0 0 0 14 18 2 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 40 1 0 0 0 0 16 24 1 0 0 0 0 17 41 1 0 0 0 0 17 42 1 0 0 0 0 17 43 1 0 0 0 0 18 19 1 0 0 0 0 19 20 1 0 0 0 0 19 44 1 0 0 0 0 19 45 1 0 0 0 0 20 21 1 0 0 0 0 20 46 1 0 0 0 0 20 47 1 0 0 0 0 21 23 1 0 0 0 0 21 22 2 0 0 0 0 23 48 1 0 0 0 0 24 29 2 0 0 0 0 24 25 1 0 0 0 0 25 26 2 0 0 0 0 25 30 1 0 0 0 0 26 27 1 0 0 0 0 26 49 1 0 0 0 0 27 28 2 0 0 0 0 27 50 1 0 0 0 0 28 29 1 0 0 0 0 28 51 1 0 0 0 0 29 52 1 0 0 0 0 30 31 1 0 0 0 0 31 53 1 0 0 0 0 31 54 1 0 0 0 0 31 55 1 0 0 0 0 M END > (487) 3-substituted indolin-2-one 16h > (487) PDGFR-beta > (487) 2220 > (487) -1 > (487) P > (487) PDGFR-P485 $$$$ PD089828 analog 6 csChFnd70/05150717532D 45 47 0 0 0 0 0 0 0 0999 V2000 1.2015 4.9967 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6959 2.4336 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7761 5.8792 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3208 4.9106 -0.0184 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8589 7.6812 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4675 8.4428 0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2244 3.3043 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2102 3.1945 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8373 5.7090 -0.0280 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6349 0.6596 -0.0250 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6318 10.3400 0.0103 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4922 12.9574 -1.3811 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0775 11.2824 1.4278 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2338 13.0485 1.4311 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9389 13.8849 0.0315 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9482 7.3974 -0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5564 8.1650 -0.0307 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9831 7.1848 -0.0502 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8609 5.6281 -0.0579 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5454 7.9304 -0.0613 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0960 5.7397 -1.6935 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6852 8.0212 -0.0913 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0962 6.8650 -0.0824 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1272 5.7213 1.5154 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3485 11.1880 -1.3960 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0501 10.0245 -3.1641 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.3835 14.0169 -3.1290 Cl 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.6896 0.0327 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7042 8.4498 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5351 0.0741 -0.0177 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6917 0.0000 -0.0386 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5263 10.6318 2.5218 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8040 13.7789 2.5292 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0537 15.2673 0.0386 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6539 9.4070 -0.0245 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6429 9.1725 -0.0551 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0738 6.5544 -2.8318 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2497 4.9470 -1.7093 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9639 4.9159 -1.6872 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6854 8.8228 1.0564 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8391 7.2285 -0.1071 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6632 8.8359 -1.2296 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9952 4.8975 1.5217 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2811 4.9286 1.4996 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1274 6.5229 2.6631 H 0 0 0 0 0 0 0 0 0 0 0 0 1 7 2 0 0 0 0 1 3 1 0 0 0 0 1 28 1 0 0 0 0 2 7 1 0 0 0 0 2 8 2 0 0 0 0 2 10 1 0 0 0 0 3 5 1 0 0 0 0 3 4 2 0 0 0 0 4 8 1 0 0 0 0 4 9 1 0 0 0 0 5 6 2 0 0 0 0 5 29 1 0 0 0 0 6 16 1 0 0 0 0 6 11 1 0 0 0 0 9 16 2 0 0 0 0 10 30 1 0 0 0 0 10 31 1 0 0 0 0 11 25 1 0 0 0 0 11 13 2 0 0 0 0 12 25 2 0 0 0 0 12 15 1 0 0 0 0 12 27 1 0 0 0 0 13 14 1 0 0 0 0 13 32 1 0 0 0 0 14 15 2 0 0 0 0 14 33 1 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 17 18 1 0 0 0 0 17 35 1 0 0 0 0 18 20 1 0 0 0 0 18 19 2 0 0 0 0 20 23 1 0 0 0 0 20 36 1 0 0 0 0 21 23 1 0 0 0 0 21 37 1 0 0 0 0 21 38 1 0 0 0 0 21 39 1 0 0 0 0 22 23 1 0 0 0 0 22 40 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 24 1 0 0 0 0 24 43 1 0 0 0 0 24 44 1 0 0 0 0 24 45 1 0 0 0 0 25 26 1 0 0 0 0 M END > (488) PD089828 analog 6 > (488) PDGFR-beta > (488) 2260 > (488) -1 > (488) P > (488) PDGFR-P486 $$$$ Structure108 csChFnd70/05150717532D 31 33 0 0 0 0 0 0 0 0999 V2000 1.0380 10.6793 0.0107 N 0 0 0 0 0 0 0 0 0 0 0 0 2.3335 11.4874 0.0026 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7055 10.8290 -0.0145 N 0 0 0 0 0 0 0 0 0 0 0 0 3.8359 9.3078 -0.0240 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4844 8.4100 -0.0153 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0586 9.1623 0.0023 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2528 8.6160 -0.0413 N 0 0 3 0 0 0 0 0 0 0 0 0 5.3782 7.0730 -0.0507 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9992 6.1079 -0.0416 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5803 6.7880 -0.0255 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1383 4.4107 -0.0515 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1900 3.6150 -1.4430 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3203 2.0329 -1.4442 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3988 1.2372 -0.0700 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3481 2.0191 1.3135 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2247 3.6016 1.3306 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6451 6.4773 -0.0655 O 0 0 0 0 0 0 0 0 0 0 0 0 2.2461 13.0717 0.0119 N 0 0 0 0 0 0 0 0 0 0 0 0 4.0902 4.6112 -3.1689 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.6436 9.5651 -0.0500 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1619 4.5809 3.0680 Cl 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 8.5141 0.0093 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5499 6.0960 -0.0190 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3604 1.4155 -2.5203 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4999 0.0000 -0.0771 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4096 1.3911 2.3824 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2514 13.5751 0.0243 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1795 13.6815 0.0063 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0001 9.7946 1.1289 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5593 8.9586 -0.6526 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4063 10.6483 -0.6328 H 0 0 0 0 0 0 0 0 0 0 0 0 1 6 1 0 0 0 0 1 2 2 0 0 0 0 2 3 1 0 0 0 0 2 18 1 0 0 0 0 3 4 2 0 0 0 0 4 7 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 5 6 2 0 0 0 0 6 22 1 0 0 0 0 7 8 1 0 0 0 0 7 20 1 0 0 0 0 8 9 1 0 0 0 0 8 17 2 0 0 0 0 9 11 1 0 0 0 0 9 10 2 0 0 0 0 10 23 1 0 0 0 0 11 12 2 0 0 0 0 11 16 1 0 0 0 0 12 13 1 0 0 0 0 12 19 1 0 0 0 0 13 14 2 0 0 0 0 13 24 1 0 0 0 0 14 15 1 0 0 0 0 14 25 1 0 0 0 0 15 16 2 0 0 0 0 15 26 1 0 0 0 0 16 21 1 0 0 0 0 18 27 1 0 0 0 0 18 28 1 0 0 0 0 20 29 1 0 0 0 0 20 30 1 0 0 0 0 20 31 1 0 0 0 0 M END > (493) 17964795-1 > (493) PDGFR-beta > (493) 2310 > (493) -1 > (493) P > (493) PDGFR-P491 $$$$ PD0173958 csChFnd70/05150717532D 48 51 0 0 0 0 0 0 0 0999 V2000 3.5539 16.8603 -0.7314 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1242 19.5986 -0.8017 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1345 17.7882 -0.6744 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9729 17.7690 -0.9238 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9810 19.5796 -1.0497 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5519 20.4919 -0.9860 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1090 16.6695 -0.4432 Cl 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.6264 -1.0055 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.4472 6.9303 1.3052 N 0 0 3 0 0 0 0 0 0 0 0 0 3.4759 6.0793 2.9364 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4323 5.9663 5.9372 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5330 4.3967 6.1619 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6114 3.6657 4.7693 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5824 4.5041 3.1601 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4045 6.8064 4.3290 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5549 14.9181 -0.5962 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4291 14.1200 1.0113 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6825 13.8346 -2.1817 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7887 14.5339 -3.6176 O 0 0 0 0 0 0 0 0 0 0 0 0 3.6835 12.0688 -2.0600 N 0 0 3 0 0 0 0 0 0 0 0 0 3.8202 11.0038 -3.6579 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4428 8.7439 1.2276 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5649 11.2575 -0.4542 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4330 12.2645 1.0983 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3069 11.3834 2.7129 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3168 9.6490 2.7152 N 0 0 0 0 0 0 0 0 0 0 0 0 3.5646 9.5167 -0.3269 N 0 0 0 0 0 0 0 0 0 0 0 0 3.5609 3.5703 7.7461 O 0 0 0 0 0 0 0 0 0 0 0 0 2.6063 1.9590 7.8841 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7900 1.2289 9.7484 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3467 20.3184 -0.7578 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7582 20.2846 -1.1987 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5512 21.9078 -1.0849 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4301 6.2463 0.2297 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1492 6.5348 7.0223 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9116 2.4436 4.9452 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8643 3.9351 2.0763 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1050 8.0281 4.1541 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3290 14.8964 2.1952 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5080 10.7262 -4.1604 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5685 11.7205 -4.6468 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4859 9.7722 -3.3552 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2046 12.1091 3.9284 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2230 2.1978 7.5989 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1305 1.0116 6.9465 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0617 0.0000 9.8537 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1732 0.9902 10.0335 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2658 2.1764 10.6860 H 0 0 0 0 0 0 0 0 0 0 0 0 1 16 1 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 2 3 1 0 0 0 0 2 6 2 0 0 0 0 2 31 1 0 0 0 0 3 7 1 0 0 0 0 4 5 2 0 0 0 0 4 8 1 0 0 0 0 5 6 1 0 0 0 0 5 32 1 0 0 0 0 6 33 1 0 0 0 0 9 22 1 0 0 0 0 9 10 1 0 0 0 0 9 34 1 0 0 0 0 10 14 2 0 0 0 0 10 15 1 0 0 0 0 11 12 1 0 0 0 0 11 15 2 0 0 0 0 11 35 1 0 0 0 0 12 13 2 0 0 0 0 12 28 1 0 0 0 0 13 14 1 0 0 0 0 13 36 1 0 0 0 0 14 37 1 0 0 0 0 15 38 1 0 0 0 0 16 18 1 0 0 0 0 16 17 2 0 0 0 0 17 24 1 0 0 0 0 17 39 1 0 0 0 0 18 20 1 0 0 0 0 18 19 2 0 0 0 0 20 23 1 0 0 0 0 20 21 1 0 0 0 0 21 40 1 0 0 0 0 21 41 1 0 0 0 0 21 42 1 0 0 0 0 22 26 2 0 0 0 0 22 27 1 0 0 0 0 23 27 2 0 0 0 0 23 24 1 0 0 0 0 24 25 2 0 0 0 0 25 26 1 0 0 0 0 25 43 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 29 44 1 0 0 0 0 29 45 1 0 0 0 0 30 46 1 0 0 0 0 30 47 1 0 0 0 0 30 48 1 0 0 0 0 M END > (495) PD173958 > (495) PDGFR-beta > (495) 2340 > (495) -1 > (495) P > (495) PDGFR-P493 $$$$ 3-substituted indolin-2-one 9d csChFnd70/05150717532D 55 58 0 0 0 0 0 0 0 0999 V2000 5.8538 10.8656 0.1580 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6543 9.3038 0.1302 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6449 10.8992 0.0811 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2319 11.6791 0.0954 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6009 13.3389 0.0339 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2880 13.4134 -0.0143 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8326 11.9674 0.0156 N 0 0 3 0 0 0 0 0 0 0 0 0 10.0587 14.5822 -0.0721 O 0 0 0 0 0 0 0 0 0 0 0 0 6.5786 14.5566 0.0236 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1278 16.0774 0.1490 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4970 17.3690 -0.5421 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3867 16.5545 0.9867 N 0 0 3 0 0 0 0 0 0 0 0 0 5.0993 17.4106 -1.5665 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6603 17.6632 -0.5853 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2627 17.7049 -1.6098 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4031 17.5486 -2.9835 O 0 0 0 0 0 0 0 0 0 0 0 0 0.8617 17.9156 -0.9961 O 0 0 0 0 0 0 0 0 0 0 0 0 8.5403 18.0985 0.8183 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4011 18.6234 -0.1095 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1529 20.2714 -0.5863 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8734 9.2820 0.2065 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2735 8.4962 0.1928 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2897 6.7912 0.2445 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9113 5.9757 0.3001 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9342 4.3837 0.3477 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3280 3.6043 0.3400 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6959 4.4125 0.2855 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6839 5.9995 0.2311 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5921 3.5841 0.4023 O 0 0 0 0 0 0 0 0 0 0 0 0 4.7015 1.9448 0.4495 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0856 1.2504 0.5072 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7715 11.4751 0.1738 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7335 8.6887 0.1195 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9162 11.7027 -0.0051 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3594 14.3433 -0.0806 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0513 15.8966 1.5950 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2131 18.3484 -2.3907 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9999 16.3230 -2.1821 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5466 16.7253 0.2388 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7598 18.7509 0.0303 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 17.9339 -1.6991 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4248 18.7969 1.3408 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4048 20.8386 0.2447 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2564 20.8650 -0.6285 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6180 20.3025 -1.7197 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8059 8.6487 0.2556 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8279 6.5835 0.3063 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3435 2.3627 0.3773 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7770 3.8009 0.2802 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7545 6.6276 0.1835 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2956 1.5360 -0.5760 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3422 1.5979 1.4699 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1689 0.0000 0.5432 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4915 1.6592 1.5328 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4449 1.5973 -0.5130 H 0 0 0 0 0 0 0 0 0 0 0 0 1 21 1 0 0 0 0 1 4 2 0 0 0 0 1 32 1 0 0 0 0 2 22 1 0 0 0 0 2 3 2 0 0 0 0 2 33 1 0 0 0 0 3 7 1 0 0 0 0 3 4 1 0 0 0 0 4 5 1 0 0 0 0 5 6 1 0 0 0 0 5 9 2 0 0 0 0 6 7 1 0 0 0 0 6 8 2 0 0 0 0 7 34 1 0 0 0 0 9 10 1 0 0 0 0 9 35 1 0 0 0 0 10 11 2 0 0 0 0 10 12 1 0 0 0 0 11 19 1 0 0 0 0 11 13 1 0 0 0 0 12 18 1 0 0 0 0 12 36 1 0 0 0 0 13 14 1 0 0 0 0 13 37 1 0 0 0 0 13 38 1 0 0 0 0 14 15 1 0 0 0 0 14 39 1 0 0 0 0 14 40 1 0 0 0 0 15 17 1 0 0 0 0 15 16 2 0 0 0 0 17 41 1 0 0 0 0 18 19 2 0 0 0 0 18 42 1 0 0 0 0 19 20 1 0 0 0 0 20 43 1 0 0 0 0 20 44 1 0 0 0 0 20 45 1 0 0 0 0 21 22 2 0 0 0 0 21 46 1 0 0 0 0 22 23 1 0 0 0 0 23 28 2 0 0 0 0 23 24 1 0 0 0 0 24 25 2 0 0 0 0 24 47 1 0 0 0 0 25 26 1 0 0 0 0 25 29 1 0 0 0 0 26 27 2 0 0 0 0 26 48 1 0 0 0 0 27 28 1 0 0 0 0 27 49 1 0 0 0 0 28 50 1 0 0 0 0 29 30 1 0 0 0 0 30 31 1 0 0 0 0 30 51 1 0 0 0 0 30 52 1 0 0 0 0 31 53 1 0 0 0 0 31 54 1 0 0 0 0 31 55 1 0 0 0 0 M END > (497) 3-substituted indolin-2-one 9d > (497) PDGFR-beta > (497) 2380 > (497) -1 > (497) P > (497) PDGFR-P495 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 50 csChFnd70/05150717532D 59 62 0 0 0 0 0 0 0 0999 V2000 3.9766 15.9630 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4847 13.3759 -0.0163 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9998 14.2546 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0134 14.1441 -0.0267 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5656 16.8535 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1249 15.8759 -0.0185 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6491 18.6725 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7673 18.3858 -0.0219 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2728 19.4410 -0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6555 16.6817 -0.0294 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4386 21.3558 0.0054 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6862 24.0370 1.5708 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7483 24.9338 0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5320 22.2530 1.5728 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5094 22.2670 -1.5549 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6639 24.0510 -1.5392 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4535 21.1300 3.5213 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4044 21.1615 -3.5122 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7467 10.6929 -0.0128 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0417 8.7315 -0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4230 11.5854 -0.0247 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2910 7.7994 -0.0132 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3905 19.1605 -0.0337 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8305 18.1714 -0.0528 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7072 16.6001 -0.0595 O 0 0 0 0 0 0 0 0 0 0 0 0 13.4073 18.9239 -0.0644 N 0 0 0 0 0 0 0 0 0 0 0 0 3.8806 5.4309 -1.3245 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2127 3.4773 -1.2253 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2729 3.0285 -0.2240 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9409 4.9820 -0.3232 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5744 5.9163 -0.0255 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5793 2.5430 -1.5230 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8625 0.6599 -1.5352 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7639 16.6625 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4837 19.4484 0.0247 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7591 24.7331 2.7835 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8692 26.3286 0.0247 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7184 24.7582 -2.7464 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0067 11.0654 -1.1575 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0291 11.0537 1.1498 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7592 8.3707 -1.1883 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7817 8.3591 1.1192 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4897 10.9197 -0.0385 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5734 8.1603 1.1494 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5510 8.1719 -1.1579 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4889 20.4142 -0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5057 20.1775 -0.0590 H 0 0 0 0 0 0 0 0 0 0 0 0 14.4437 18.2120 -0.0780 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0830 6.1271 -1.0669 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4095 5.7641 -2.6143 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1535 3.1082 -2.2129 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7172 3.1490 0.0532 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7441 2.6952 1.0658 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0705 2.3322 -0.4816 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4363 5.3102 -1.6015 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3511 0.6645 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3955 0.2557 -0.2905 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6330 0.0000 -1.7579 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7695 0.3267 -2.5663 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 34 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 21 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 35 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 36 1 0 0 0 0 13 16 1 0 0 0 0 13 37 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 38 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 39 1 0 0 0 0 19 40 1 0 0 0 0 20 22 1 0 0 0 0 20 41 1 0 0 0 0 20 42 1 0 0 0 0 21 43 1 0 0 0 0 22 31 1 0 0 0 0 22 44 1 0 0 0 0 22 45 1 0 0 0 0 23 24 1 0 0 0 0 23 46 1 0 0 0 0 24 25 2 0 0 0 0 24 26 1 0 0 0 0 26 47 1 0 0 0 0 26 48 1 0 0 0 0 27 31 1 0 0 0 0 27 28 1 0 0 0 0 27 49 1 0 0 0 0 27 50 1 0 0 0 0 28 32 1 0 0 0 0 28 51 1 0 0 0 0 28 52 1 0 0 0 0 29 32 1 0 0 0 0 29 30 1 0 0 0 0 29 53 1 0 0 0 0 29 54 1 0 0 0 0 30 31 1 0 0 0 0 30 55 1 0 0 0 0 30 56 1 0 0 0 0 32 33 1 0 0 0 0 33 57 1 0 0 0 0 33 58 1 0 0 0 0 33 59 1 0 0 0 0 M END > (498) 6-arylpyrido[2,3-d]pyrimidine deriv. 50 > (498) PDGFR-beta > (498) 2400 > (498) -1 > (498) P > (498) PDGFR-P496 $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7f csChFnd70/05150717532D 58 60 0 0 0 0 0 0 0 0999 V2000 1.2045 15.2118 -2.1479 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6324 12.6082 -1.6925 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2482 13.3522 -1.9783 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7786 16.0661 -2.4544 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3409 15.1108 -2.3671 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8219 17.8594 -2.8484 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3890 18.6425 -3.1402 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9848 17.6141 -3.0396 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3838 18.3042 -3.2967 O 0 0 0 0 0 0 0 0 0 0 0 0 1.1869 13.5437 -1.7845 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9115 15.9080 -2.6616 N 0 0 3 0 0 0 0 0 0 0 0 0 7.5169 14.8938 -2.5642 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4712 20.5181 -3.5556 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7035 23.4847 -2.6226 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6277 21.7381 -2.2263 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3997 21.0719 -5.2786 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4768 22.8224 -5.6571 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6251 24.0256 -4.3328 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7263 21.0622 -0.0792 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.2150 19.5640 -6.9426 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.5250 10.8534 -1.3039 N 0 0 3 0 0 0 0 0 0 0 0 0 4.1074 9.8045 -1.1980 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6296 7.9287 -0.7547 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2823 6.8331 -0.6440 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8045 4.9574 -0.2008 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3912 3.9056 -0.0945 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4784 4.4553 1.3720 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3114 3.7249 1.1476 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9735 2.0489 0.0227 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4425 1.3754 -1.7683 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 15.9266 -2.2044 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4136 12.5774 -1.8992 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6339 18.6001 -2.9182 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8151 14.3593 -3.8396 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5779 15.7297 -2.1434 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3522 13.8380 -1.6372 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8243 24.4304 -1.5949 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4216 23.2528 -6.9901 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6850 25.3929 -4.6358 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4021 10.3210 -1.1024 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7798 9.8384 -2.4421 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9526 10.3265 -0.1907 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9570 7.8947 0.4894 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7844 7.4067 -1.7620 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9547 6.8671 -1.8882 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1275 7.3552 0.3633 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1319 4.9234 1.0434 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9593 4.4354 -1.2081 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5356 5.8683 1.4130 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9222 3.9706 2.5792 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1616 4.2725 2.1369 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2776 2.3169 1.2814 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8006 4.0651 -0.1355 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1095 1.3377 0.4762 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9063 1.8621 0.9323 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3125 2.0930 -2.2259 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5133 1.5533 -2.6755 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1234 0.0000 -1.6794 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 31 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 32 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 33 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 34 1 0 0 0 0 12 35 1 0 0 0 0 12 36 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 37 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 38 1 0 0 0 0 18 39 1 0 0 0 0 21 22 1 0 0 0 0 21 40 1 0 0 0 0 22 23 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 24 1 0 0 0 0 23 43 1 0 0 0 0 23 44 1 0 0 0 0 24 25 1 0 0 0 0 24 45 1 0 0 0 0 24 46 1 0 0 0 0 25 26 1 0 0 0 0 25 47 1 0 0 0 0 25 48 1 0 0 0 0 26 29 1 0 0 0 0 26 27 1 0 0 0 0 27 28 1 0 0 0 0 27 49 1 0 0 0 0 27 50 1 0 0 0 0 28 51 1 0 0 0 0 28 52 1 0 0 0 0 28 53 1 0 0 0 0 29 30 1 0 0 0 0 29 54 1 0 0 0 0 29 55 1 0 0 0 0 30 56 1 0 0 0 0 30 57 1 0 0 0 0 30 58 1 0 0 0 0 M END > (499) 1,6-naphthyridin-2(1H)-one deriv. 7f > (499) PDGFR-beta > (499) 2400 > (499) -1 > (499) P > (499) PDGFR-P497 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 59 csChFnd70/05150717532D 73 76 0 0 0 0 0 0 0 0999 V2000 3.9766 15.9630 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4847 13.3759 -0.0163 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9998 14.2546 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0134 14.1441 -0.0267 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5656 16.8535 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1249 15.8759 -0.0185 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6491 18.6725 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7673 18.3858 -0.0219 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2728 19.4410 -0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6555 16.6817 -0.0294 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4386 21.3558 0.0054 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6862 24.0370 1.5708 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7483 24.9338 0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5320 22.2530 1.5728 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5094 22.2670 -1.5549 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6639 24.0510 -1.5392 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4535 21.1300 3.5213 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4044 21.1615 -3.5122 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7467 10.6929 -0.0128 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0417 8.7315 -0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4230 11.5854 -0.0247 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2910 7.7994 -0.0132 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3905 19.1605 -0.0337 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8305 18.1714 -0.0528 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7072 16.6001 -0.0595 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8806 5.4309 -1.3245 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2127 3.4773 -1.2253 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2729 3.0285 -0.2240 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9409 4.9820 -0.3232 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5744 5.9163 -0.0255 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5793 2.5430 -1.5230 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8625 0.6599 -1.5352 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4073 18.9239 -0.0644 N 0 0 3 0 0 0 0 0 0 0 0 0 14.9725 17.8486 -0.0850 C 0 0 0 0 0 0 0 0 0 0 0 0 16.5763 19.0157 -0.0948 C 0 0 0 0 0 0 0 0 0 0 0 0 18.1459 17.9375 -0.1155 N 0 0 0 0 0 0 0 0 0 0 0 0 19.6968 18.9959 -0.4340 C 0 0 0 0 0 0 0 0 0 0 0 0 18.3156 16.9478 1.5026 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7639 16.6625 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4837 19.4484 0.0247 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7591 24.7331 2.7835 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8692 26.3286 0.0247 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7184 24.7582 -2.7464 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0067 11.0654 -1.1575 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0291 11.0537 1.1498 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7592 8.3707 -1.1883 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7817 8.3591 1.1192 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4897 10.9197 -0.0385 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5734 8.1603 1.1494 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5510 8.1719 -1.1579 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4889 20.4142 -0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0830 6.1271 -1.0669 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4095 5.7641 -2.6143 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1535 3.1082 -2.2129 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7172 3.1490 0.0532 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7441 2.6952 1.0658 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0705 2.3322 -0.4816 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4363 5.3102 -1.6015 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3511 0.6645 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3955 0.2557 -0.2905 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6330 0.0000 -1.7579 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7695 0.3267 -2.5663 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5057 20.1775 -0.0590 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9950 17.0271 1.0643 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9724 17.0387 -1.2430 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5540 19.8372 -1.2443 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5766 19.8255 1.0632 H 0 0 0 0 0 0 0 0 0 0 0 0 19.8250 19.9631 0.5880 H 0 0 0 0 0 0 0 0 0 0 0 0 20.8401 18.1654 -0.4428 H 0 0 0 0 0 0 0 0 0 0 0 0 19.5760 19.6443 -1.6837 H 0 0 0 0 0 0 0 0 0 0 0 0 17.1906 16.1075 1.6609 H 0 0 0 0 0 0 0 0 0 0 0 0 19.4881 16.1609 1.4527 H 0 0 0 0 0 0 0 0 0 0 0 0 18.3938 17.8409 2.5950 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 39 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 21 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 40 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 41 1 0 0 0 0 13 16 1 0 0 0 0 13 42 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 43 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 44 1 0 0 0 0 19 45 1 0 0 0 0 20 22 1 0 0 0 0 20 46 1 0 0 0 0 20 47 1 0 0 0 0 21 48 1 0 0 0 0 22 30 1 0 0 0 0 22 49 1 0 0 0 0 22 50 1 0 0 0 0 23 24 1 0 0 0 0 23 51 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 52 1 0 0 0 0 26 53 1 0 0 0 0 27 31 1 0 0 0 0 27 54 1 0 0 0 0 27 55 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 56 1 0 0 0 0 28 57 1 0 0 0 0 29 30 1 0 0 0 0 29 58 1 0 0 0 0 29 59 1 0 0 0 0 31 32 1 0 0 0 0 32 60 1 0 0 0 0 32 61 1 0 0 0 0 32 62 1 0 0 0 0 33 34 1 0 0 0 0 33 63 1 0 0 0 0 34 35 1 0 0 0 0 34 64 1 0 0 0 0 34 65 1 0 0 0 0 35 36 1 0 0 0 0 35 66 1 0 0 0 0 35 67 1 0 0 0 0 36 37 1 0 0 0 0 36 38 1 0 0 0 0 37 68 1 0 0 0 0 37 69 1 0 0 0 0 37 70 1 0 0 0 0 38 71 1 0 0 0 0 38 72 1 0 0 0 0 38 73 1 0 0 0 0 M END > (500) 6-arylpyrido[2,3-d]pyrimidine deriv. 59 > (500) PDGFR-beta > (500) 2400 > (500) -1 > (500) P > (500) PDGFR-P498 $$$$ SU11248 csChFnd70/05150717532D 56 58 0 0 0 0 0 0 0 0999 V2000 3.8105 3.5384 -3.6298 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8411 1.8413 -4.2793 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1598 1.3276 -5.4280 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4517 2.4973 -5.9343 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1071 4.7251 -4.1340 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4422 4.2088 -5.2941 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0456 7.0513 -4.6838 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4518 6.5889 -3.6958 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5640 5.6228 -5.5849 N 0 0 3 0 0 0 0 0 0 0 0 0 7.7719 8.4786 -4.6838 O 0 0 0 0 0 0 0 0 0 0 0 0 4.4845 7.6615 -2.5966 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1143 9.3520 -2.1592 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9502 11.5366 -1.5452 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2638 12.2109 -1.4588 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0962 10.8219 -1.8460 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8546 9.8230 -1.9624 N 0 0 3 0 0 0 0 0 0 0 0 0 2.1186 10.9235 -1.9063 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6186 12.5542 -1.2202 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7766 14.0392 -1.0394 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6361 15.1177 -2.2112 O 0 0 0 0 0 0 0 0 0 0 0 0 4.4871 14.5154 0.6423 N 0 0 3 0 0 0 0 0 0 0 0 0 4.0031 16.3323 1.0590 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7519 16.5204 3.0457 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2665 18.3423 3.4636 N 0 0 0 0 0 0 0 0 0 0 0 0 1.5314 18.7801 2.7375 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2972 20.7777 2.7183 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3178 18.6526 5.3690 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2304 18.8121 5.9709 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5857 0.6825 -3.7940 F 0 0 0 0 0 0 0 0 0 0 0 0 2.7810 3.9428 -2.7395 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1767 0.0000 -5.9310 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4722 2.0815 -6.8295 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5887 5.5837 -6.3427 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2460 7.2076 -2.0713 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8516 9.0405 -2.1024 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5854 10.6299 -0.6092 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7199 12.2425 -2.2993 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6202 9.9716 -2.8543 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0839 13.1152 -2.4539 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3606 13.6078 -0.2837 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6178 11.6761 -0.6878 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5991 13.6551 1.5769 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0437 17.2157 0.6234 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7812 16.6666 0.3892 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7113 15.6370 3.4813 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9737 16.1861 3.7155 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4316 18.2745 1.4006 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5105 18.1873 3.5497 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3029 21.3684 1.8859 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 21.1016 2.2030 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4220 21.2861 4.0521 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6183 19.8653 5.6744 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6930 17.5566 6.0484 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8909 19.8235 5.2005 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2663 19.1687 7.3583 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8964 17.5573 5.7830 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 5 2 0 0 0 0 1 30 1 0 0 0 0 2 3 2 0 0 0 0 2 29 1 0 0 0 0 3 4 1 0 0 0 0 3 31 1 0 0 0 0 4 6 2 0 0 0 0 4 32 1 0 0 0 0 5 8 1 0 0 0 0 5 6 1 0 0 0 0 6 9 1 0 0 0 0 7 9 1 0 0 0 0 7 8 1 0 0 0 0 7 10 2 0 0 0 0 8 11 2 0 0 0 0 9 33 1 0 0 0 0 11 12 1 0 0 0 0 11 34 1 0 0 0 0 12 15 2 0 0 0 0 12 16 1 0 0 0 0 13 16 1 0 0 0 0 13 14 2 0 0 0 0 13 18 1 0 0 0 0 14 15 1 0 0 0 0 14 19 1 0 0 0 0 15 17 1 0 0 0 0 16 35 1 0 0 0 0 17 36 1 0 0 0 0 17 37 1 0 0 0 0 17 38 1 0 0 0 0 18 39 1 0 0 0 0 18 40 1 0 0 0 0 18 41 1 0 0 0 0 19 20 2 0 0 0 0 19 21 1 0 0 0 0 21 22 1 0 0 0 0 21 42 1 0 0 0 0 22 23 1 0 0 0 0 22 43 1 0 0 0 0 22 44 1 0 0 0 0 23 24 1 0 0 0 0 23 45 1 0 0 0 0 23 46 1 0 0 0 0 24 25 1 0 0 0 0 24 27 1 0 0 0 0 25 26 1 0 0 0 0 25 47 1 0 0 0 0 25 48 1 0 0 0 0 26 49 1 0 0 0 0 26 50 1 0 0 0 0 26 51 1 0 0 0 0 27 28 1 0 0 0 0 27 52 1 0 0 0 0 27 53 1 0 0 0 0 28 54 1 0 0 0 0 28 55 1 0 0 0 0 28 56 1 0 0 0 0 M END > (6) SU11248 > (6) PDGFR-beta > (6) 2 > (6) -1 > (6) P > (6) PDGFR-P4 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 55 csChFnd70/05150717532D 72 76 0 0 0 0 0 0 0 0999 V2000 3.9947 16.0357 0.0121 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5097 13.4368 -0.0164 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0180 14.3195 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0453 14.2084 -0.0268 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5909 16.9302 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1573 15.9481 -0.0186 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6748 18.7575 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8072 18.4695 -0.0220 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3059 19.5295 -0.0020 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6949 16.7576 -0.0296 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4725 21.4530 0.0055 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7212 24.1464 1.5780 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7836 25.0473 0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5662 22.3543 1.5799 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5436 22.3684 -1.5620 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6988 24.1604 -1.5462 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4874 21.2262 3.5374 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4381 21.2578 -3.5281 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7637 10.7416 -0.0129 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0601 8.7713 -0.0258 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4477 11.6381 -0.0249 N 0 0 3 0 0 0 0 0 0 0 0 0 2.3014 7.8349 -0.0133 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4378 19.2477 -0.0338 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8844 18.2541 -0.0530 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7605 16.6757 -0.0598 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8983 5.4557 -1.3305 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2319 3.4931 -1.2309 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2787 3.0423 -0.2250 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9452 5.0047 -0.3246 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5861 5.9432 -0.0256 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5910 2.5546 -1.5299 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8756 0.6629 -1.5421 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4683 19.0101 -0.0647 N 0 0 3 0 0 0 0 0 0 0 0 0 15.0407 17.9298 -0.0854 C 0 0 0 0 0 0 0 0 0 0 0 0 16.6275 19.0847 -0.0951 C 0 0 0 0 0 0 0 0 0 0 0 0 17.3358 19.6281 -1.6583 C 0 0 0 0 0 0 0 0 0 0 0 0 18.7914 20.6874 -1.6672 C 0 0 0 0 0 0 0 0 0 0 0 0 19.5384 21.2036 -0.1128 C 0 0 0 0 0 0 0 0 0 0 0 0 18.8294 20.6611 1.4505 C 0 0 0 0 0 0 0 0 0 0 0 0 17.3706 19.6064 1.4595 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7765 16.7383 0.0217 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5041 19.5370 0.0249 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7944 24.8457 2.7961 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9050 26.4484 0.0249 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7535 24.8709 -2.7589 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0204 11.1158 -1.1628 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0429 11.1041 1.1550 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7809 8.4088 -1.1937 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8034 8.3971 1.1242 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5192 10.9694 -0.0387 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5806 8.1975 1.1546 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5580 8.2091 -1.1632 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5366 20.5072 -0.0285 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1061 6.1550 -1.0718 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4250 5.7904 -2.6262 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1769 3.1224 -2.2230 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7387 3.1634 0.0534 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7521 2.7075 1.0706 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0708 2.3428 -0.4838 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4383 5.3344 -1.6088 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3754 0.6675 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4109 0.2568 -0.2918 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6405 0.0000 -1.7659 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7866 0.3282 -2.5780 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5671 20.2694 -0.0592 H 0 0 0 0 0 0 0 0 0 0 0 0 15.0632 17.1046 1.0692 H 0 0 0 0 0 0 0 0 0 0 0 0 15.0406 17.1163 -1.2486 H 0 0 0 0 0 0 0 0 0 0 0 0 16.7522 19.2248 -2.8728 H 0 0 0 0 0 0 0 0 0 0 0 0 19.3452 21.1113 -2.8886 H 0 0 0 0 0 0 0 0 0 0 0 0 20.6762 22.0304 -0.1197 H 0 0 0 0 0 0 0 0 0 0 0 0 19.4134 21.0640 2.6650 H 0 0 0 0 0 0 0 0 0 0 0 0 16.8138 19.1865 2.6809 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 41 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 21 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 42 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 43 1 0 0 0 0 13 16 1 0 0 0 0 13 44 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 45 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 46 1 0 0 0 0 19 47 1 0 0 0 0 20 22 1 0 0 0 0 20 48 1 0 0 0 0 20 49 1 0 0 0 0 21 50 1 0 0 0 0 22 30 1 0 0 0 0 22 51 1 0 0 0 0 22 52 1 0 0 0 0 23 24 1 0 0 0 0 23 53 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 54 1 0 0 0 0 26 55 1 0 0 0 0 27 31 1 0 0 0 0 27 56 1 0 0 0 0 27 57 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 58 1 0 0 0 0 28 59 1 0 0 0 0 29 30 1 0 0 0 0 29 60 1 0 0 0 0 29 61 1 0 0 0 0 31 32 1 0 0 0 0 32 62 1 0 0 0 0 32 63 1 0 0 0 0 32 64 1 0 0 0 0 33 34 1 0 0 0 0 33 65 1 0 0 0 0 34 35 1 0 0 0 0 34 66 1 0 0 0 0 34 67 1 0 0 0 0 35 40 1 0 0 0 0 35 36 2 0 0 0 0 36 37 1 0 0 0 0 36 68 1 0 0 0 0 37 38 2 0 0 0 0 37 69 1 0 0 0 0 38 39 1 0 0 0 0 38 70 1 0 0 0 0 39 40 2 0 0 0 0 39 71 1 0 0 0 0 40 72 1 0 0 0 0 M END > (502) 6-arylpyrido[2,3-d]pyrimidine deriv. 55 > (502) PDGFR-beta > (502) 2500 > (502) -1 > (502) P > (502) PDGFR-P500 $$$$ csChFnd70/05150717532D 26 28 0 0 0 0 0 0 0 0999 V2000 1.9335 7.5922 0.0099 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4100 7.6581 -0.0138 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2006 5.4780 -0.0135 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4431 6.2198 -0.0218 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5662 4.1006 -0.0248 N 0 0 3 0 0 0 0 0 0 0 0 0 5.4792 5.2812 -0.0379 N 0 0 0 0 0 0 0 0 0 0 0 0 4.9671 4.0426 -0.0387 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1595 8.3344 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9528 6.1732 0.0021 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1256 9.7339 0.0100 O 0 0 0 0 0 0 0 0 0 0 0 0 1.7990 10.3698 0.0259 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6646 2.9774 -0.0220 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8452 1.1790 0.3382 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7260 1.9047 -0.8889 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7201 0.9151 -0.6862 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2810 2.7511 1.1242 S 0 0 0 0 0 0 0 0 0 0 0 0 0.9613 8.1316 0.0267 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3585 8.2384 -0.0198 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5659 3.1056 -0.0495 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9979 5.6034 0.0084 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2416 10.0496 0.9460 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9189 11.4857 0.0308 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2241 10.0594 -0.8866 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.5238 0.6429 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4993 1.8195 -1.6833 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6471 0.0000 -1.3137 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 8 2 0 0 0 0 1 17 1 0 0 0 0 2 8 1 0 0 0 0 2 4 2 0 0 0 0 2 18 1 0 0 0 0 3 9 2 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 12 1 0 0 0 0 6 7 2 0 0 0 0 7 19 1 0 0 0 0 8 10 1 0 0 0 0 9 20 1 0 0 0 0 10 11 1 0 0 0 0 11 21 1 0 0 0 0 11 22 1 0 0 0 0 11 23 1 0 0 0 0 12 16 1 0 0 0 0 12 14 2 0 0 0 0 13 16 1 0 0 0 0 13 15 2 0 0 0 0 13 24 1 0 0 0 0 14 15 1 0 0 0 0 14 25 1 0 0 0 0 15 26 1 0 0 0 0 M END > (504) 1-Phenylbenzimidazole deriv. 94 > (504) PDGFR-beta > (504) 2500 > (504) -1 > (504) P > (504) PDGFR-P502 $$$$ csChFnd70/05150717532D 41 44 0 0 0 0 0 0 0 0999 V2000 4.6787 7.8791 0.0157 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3872 6.2736 -0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6988 6.3527 0.0013 N 0 0 0 0 0 0 0 0 0 0 0 0 6.0939 8.6749 0.0215 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4776 7.8079 0.0117 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1468 10.3092 0.0363 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9699 10.0977 0.0304 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2288 10.7312 0.0348 O 0 0 0 0 0 0 0 0 0 0 0 0 8.8850 8.5419 0.0163 N 0 0 3 0 0 0 0 0 0 0 0 0 7.5564 11.0318 0.0410 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6508 12.7433 0.0563 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6867 13.5657 -1.3323 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7743 15.1611 -1.3097 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8263 15.9435 0.0853 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7916 15.1351 1.4659 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6975 13.5399 1.4597 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6450 12.5281 3.1938 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.6223 12.5859 -3.0843 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.0244 5.5743 -0.0076 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9790 3.9765 -0.0227 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5622 3.2063 0.1089 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9192 1.0692 -0.5479 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3194 1.8275 -0.6798 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3977 3.8153 1.0336 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9998 3.0522 1.1613 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3097 7.6240 0.0066 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7586 1.6820 0.3691 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.7258 0.5323 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.5961 8.5029 0.0178 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0913 10.9779 0.0435 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8027 15.7990 -2.3837 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8948 17.1910 0.0965 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8330 15.7529 2.5512 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9298 3.3892 -0.1244 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7279 0.0000 -1.1654 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2246 1.3489 -1.3959 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5854 4.8843 1.6525 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0921 3.5279 1.8762 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6616 7.4069 -1.1847 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2215 8.2568 0.6055 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1062 6.5257 0.5916 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 29 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 30 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 26 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 31 1 0 0 0 0 14 15 1 0 0 0 0 14 32 1 0 0 0 0 15 16 2 0 0 0 0 15 33 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 34 1 0 0 0 0 21 23 1 0 0 0 0 21 24 2 0 0 0 0 22 27 1 0 0 0 0 22 23 2 0 0 0 0 22 35 1 0 0 0 0 23 36 1 0 0 0 0 24 25 1 0 0 0 0 24 37 1 0 0 0 0 25 27 2 0 0 0 0 25 38 1 0 0 0 0 26 39 1 0 0 0 0 26 40 1 0 0 0 0 26 41 1 0 0 0 0 27 28 1 0 0 0 0 M END > (513) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 44 > (513) PDGFR-beta > (513) 2600 > (513) -1 > (513) P > (513) PDGFR-P511 $$$$ 1,6-naphthyridine-2,7-diamine deriv. 8 csChFnd70/05150717532D 46 48 0 0 0 0 0 0 0 0999 V2000 2.7233 7.7428 0.0126 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8265 7.6490 -0.0176 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2820 8.5994 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3533 5.0692 -0.0173 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7479 5.9367 0.0026 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2300 4.9679 0.0113 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7791 2.4251 -0.0171 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3407 3.2663 -0.0281 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3003 3.2825 0.0015 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8207 5.9582 -0.0272 N 0 0 0 0 0 0 0 0 0 0 0 0 2.7509 0.6398 -0.0271 N 0 0 0 0 0 0 0 0 0 0 0 0 4.3289 10.5033 0.0114 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3936 13.2040 -1.1467 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3448 11.4321 -1.1612 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3516 11.3715 1.1974 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3902 13.1437 1.1998 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4160 14.0585 0.0288 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4043 9.7621 -0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3847 8.5163 -0.0284 N 0 0 3 0 0 0 0 0 0 0 0 0 8.8701 7.6274 -0.0486 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8454 6.0661 -0.0571 O 0 0 0 0 0 0 0 0 0 0 0 0 10.3827 8.4693 -0.0591 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0673 6.3808 -1.6928 C 0 0 0 0 0 0 0 0 0 0 0 0 13.5107 8.7564 -0.0891 C 0 0 0 0 0 0 0 0 0 0 0 0 11.9971 7.5030 -0.0809 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0997 6.3625 1.5162 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5247 8.4408 0.0334 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.6091 0.0265 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5291 2.5509 -0.0447 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6624 0.0339 -0.0203 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8200 0.0000 -0.0407 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6320 13.9250 -2.0548 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5461 10.7664 -2.0794 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1119 10.6585 2.1128 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1820 13.8176 2.1181 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4506 15.4453 0.0351 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4023 9.7150 -0.0521 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9942 7.1933 -2.8306 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2685 5.6619 -1.7090 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9889 5.4878 -1.6869 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4609 9.5559 1.0592 H 0 0 0 0 0 0 0 0 0 0 0 0 14.7120 8.0375 -0.1055 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4377 9.5690 -1.2269 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0214 5.4696 1.5221 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3010 5.6435 1.5000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0498 7.1620 2.6645 H 0 0 0 0 0 0 0 0 0 0 0 0 1 5 1 0 0 0 0 1 3 2 0 0 0 0 1 27 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 19 1 0 0 0 0 3 12 1 0 0 0 0 4 10 1 0 0 0 0 4 8 2 0 0 0 0 4 5 1 0 0 0 0 5 6 2 0 0 0 0 6 9 1 0 0 0 0 6 28 1 0 0 0 0 7 9 2 0 0 0 0 7 8 1 0 0 0 0 7 11 1 0 0 0 0 8 29 1 0 0 0 0 11 30 1 0 0 0 0 11 31 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 32 1 0 0 0 0 14 33 1 0 0 0 0 15 16 1 0 0 0 0 15 34 1 0 0 0 0 16 17 2 0 0 0 0 16 35 1 0 0 0 0 17 36 1 0 0 0 0 18 19 1 0 0 0 0 19 20 1 0 0 0 0 20 21 2 0 0 0 0 20 22 1 0 0 0 0 22 25 1 0 0 0 0 22 37 1 0 0 0 0 23 25 1 0 0 0 0 23 38 1 0 0 0 0 23 39 1 0 0 0 0 23 40 1 0 0 0 0 24 25 1 0 0 0 0 24 41 1 0 0 0 0 24 42 1 0 0 0 0 24 43 1 0 0 0 0 25 26 1 0 0 0 0 26 44 1 0 0 0 0 26 45 1 0 0 0 0 26 46 1 0 0 0 0 M END > (514) 1,6-naphthyridine deriv. 8 > (514) PDGFR-beta > (514) 2600 > (514) -1 > (514) P > (514) PDGFR-P512 $$$$ 1,6-naphthyridin 23 csChFnd70/05150717532D 80 82 0 0 0 0 0 0 0 0999 V2000 1.2248 14.9576 1.6925 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7352 12.4049 1.2866 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3207 13.2098 1.4273 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7684 15.8897 1.8535 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3664 14.9983 1.7182 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7766 17.6824 2.1444 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8942 17.5305 2.1381 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3589 18.5028 2.2868 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2644 13.2839 1.4206 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8578 15.8529 1.8651 N 0 0 0 0 0 0 0 0 0 0 0 0 4.4408 20.3913 2.5930 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5657 23.2782 1.8501 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4865 21.5144 1.5605 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4665 21.0463 3.9186 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5399 22.8115 4.2013 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5940 23.9265 3.1662 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6358 24.3745 0.8434 O 0 0 0 0 0 0 0 0 0 0 0 0 2.7784 26.1769 1.2137 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5395 23.4514 5.4941 O 0 0 0 0 0 0 0 0 0 0 0 0 6.5549 25.2837 5.7128 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6743 10.6343 0.9984 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2797 9.6445 0.8473 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8527 7.7407 0.5350 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5294 6.7072 0.3772 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1026 4.8034 0.0651 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7123 3.8110 -0.0864 N 0 0 0 0 0 0 0 0 0 0 0 0 6.3644 1.9461 -0.0802 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9521 1.3591 1.7608 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6793 4.3170 -1.6380 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5378 3.6604 -1.4991 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4763 18.3616 2.2816 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9533 17.4516 2.1413 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9002 15.9029 1.8891 O 0 0 0 0 0 0 0 0 0 0 0 0 10.4893 18.2585 2.2805 N 0 0 3 0 0 0 0 0 0 0 0 0 12.1692 16.4041 0.3532 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0948 17.2694 2.1280 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6392 18.4845 2.3337 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1527 15.8861 3.5379 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 15.6163 1.7981 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5022 12.4770 1.3158 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5842 18.3977 2.2529 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6860 21.0105 0.5354 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2028 20.1788 4.7252 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6535 25.3021 3.3892 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9732 26.9051 0.3177 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3510 26.4200 2.5326 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1196 26.5801 1.0732 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2495 25.7347 5.9854 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4014 25.6213 6.7855 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0252 25.8930 4.5342 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5688 10.0538 0.8973 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0358 10.1390 -0.2322 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0220 9.7701 2.0367 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0966 7.2463 1.6145 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1104 7.6152 -0.6544 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2855 7.2017 -0.7021 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2717 6.8327 1.5666 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3463 4.3089 1.1446 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3602 4.6778 -1.1243 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2668 1.6707 -0.9174 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4976 1.2558 -0.5500 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5857 0.0000 1.7491 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0880 1.5319 2.5739 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8885 2.1274 2.2711 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0677 3.7570 -2.7755 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6846 5.7201 -1.7509 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2869 4.1375 -2.5912 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1104 4.1234 -0.2995 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5400 2.2529 -1.5076 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5187 19.5973 2.4828 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5317 19.4942 2.4817 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1280 17.3896 -0.6513 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3638 15.6681 0.2397 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0691 15.5385 0.2066 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5861 19.1009 3.5982 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8337 17.7485 2.2202 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5979 19.4698 1.3293 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0524 15.0205 3.3913 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3473 15.1501 3.4244 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0996 16.5025 4.8023 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 39 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 40 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 41 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 31 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 17 1 0 0 0 0 13 42 1 0 0 0 0 14 15 1 0 0 0 0 14 43 1 0 0 0 0 15 16 2 0 0 0 0 15 19 1 0 0 0 0 16 44 1 0 0 0 0 17 18 1 0 0 0 0 18 45 1 0 0 0 0 18 46 1 0 0 0 0 18 47 1 0 0 0 0 19 20 1 0 0 0 0 20 48 1 0 0 0 0 20 49 1 0 0 0 0 20 50 1 0 0 0 0 21 22 1 0 0 0 0 21 51 1 0 0 0 0 22 23 1 0 0 0 0 22 52 1 0 0 0 0 22 53 1 0 0 0 0 23 24 1 0 0 0 0 23 54 1 0 0 0 0 23 55 1 0 0 0 0 24 25 1 0 0 0 0 24 56 1 0 0 0 0 24 57 1 0 0 0 0 25 26 1 0 0 0 0 25 58 1 0 0 0 0 25 59 1 0 0 0 0 26 27 1 0 0 0 0 26 29 1 0 0 0 0 27 28 1 0 0 0 0 27 60 1 0 0 0 0 27 61 1 0 0 0 0 28 62 1 0 0 0 0 28 63 1 0 0 0 0 28 64 1 0 0 0 0 29 30 1 0 0 0 0 29 65 1 0 0 0 0 29 66 1 0 0 0 0 30 67 1 0 0 0 0 30 68 1 0 0 0 0 30 69 1 0 0 0 0 31 32 1 0 0 0 0 31 70 1 0 0 0 0 32 33 2 0 0 0 0 32 34 1 0 0 0 0 34 36 1 0 0 0 0 34 71 1 0 0 0 0 35 36 1 0 0 0 0 35 72 1 0 0 0 0 35 73 1 0 0 0 0 35 74 1 0 0 0 0 36 37 1 0 0 0 0 36 38 1 0 0 0 0 37 75 1 0 0 0 0 37 76 1 0 0 0 0 37 77 1 0 0 0 0 38 78 1 0 0 0 0 38 79 1 0 0 0 0 38 80 1 0 0 0 0 M END > (515) 1,6-naphthyridine 23 > (515) PDGFR-beta > (515) 2600 > (515) -1 > (515) P > (515) PDGFR-P513 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 70 csChFnd70/05150717532D 75 80 0 0 0 0 0 0 0 0999 V2000 3.5391 14.2194 0.0666 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8782 11.9202 0.1046 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5589 12.7020 0.0985 N 0 0 0 0 0 0 0 0 0 0 0 0 6.2367 12.6014 0.0795 N 0 0 0 0 0 0 0 0 0 0 0 0 4.9518 15.0096 0.0387 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3367 14.1401 0.0461 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0268 16.6254 0.0035 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7974 16.3688 -0.0136 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4699 17.3071 -0.0229 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6971 14.8549 0.0197 N 0 0 0 0 0 0 0 0 0 0 0 0 6.6181 19.0081 -0.0612 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8376 21.4263 1.2665 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8960 22.1862 -0.1327 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6992 19.8419 1.3099 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6837 19.7807 -1.4684 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8224 21.3655 -1.4963 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6253 18.8903 3.0672 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.5920 18.7526 -3.1812 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.3326 9.5378 0.1671 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5940 7.7952 0.2019 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8226 10.3296 0.1387 N 0 0 3 0 0 0 0 0 0 0 0 0 2.0378 6.9683 0.2318 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2399 17.0559 -0.0405 N 0 0 3 0 0 0 0 0 0 0 0 0 10.5190 16.1759 -0.0326 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4087 14.7803 -0.0017 O 0 0 0 0 0 0 0 0 0 0 0 0 3.4514 4.8332 -0.8752 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7453 3.1000 -0.7412 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1314 2.7259 0.1538 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8375 4.4590 0.0198 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2887 5.2952 0.2652 N 0 0 0 0 0 0 0 0 0 0 0 0 2.2940 2.2640 -0.9866 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5449 0.5908 -0.9532 C 0 0 0 0 0 0 0 0 0 0 0 0 11.9204 16.8435 -0.0587 N 0 0 3 0 0 0 0 0 0 0 0 0 13.2449 15.9369 0.0446 C 0 0 0 0 0 0 0 0 0 0 0 0 15.8770 14.0835 0.2335 C 0 0 0 0 0 0 0 0 0 0 0 0 14.5302 13.5074 -0.3273 C 0 0 0 0 0 0 0 0 0 0 0 0 13.2165 14.4208 -0.4254 C 0 0 0 0 0 0 0 0 0 0 0 0 15.9564 15.6257 0.7187 C 0 0 0 0 0 0 0 0 0 0 0 0 14.6264 16.5668 0.6248 C 0 0 0 0 0 0 0 0 0 0 0 0 14.7073 18.1069 1.1109 C 0 0 0 0 0 0 0 0 0 0 0 0 16.0595 18.6760 1.6651 C 0 0 0 0 0 0 0 0 0 0 0 0 17.3684 17.7514 1.7579 C 0 0 0 0 0 0 0 0 0 0 0 0 17.3325 16.2533 1.2973 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4619 14.8414 0.0569 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9916 17.3154 -0.0033 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9010 22.0733 2.3273 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0041 23.4254 -0.1606 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8729 21.9652 -2.5852 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6772 9.8423 -0.8595 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6934 9.8857 1.1904 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2333 7.4473 -0.8212 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2494 7.4908 1.2286 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7701 9.7374 0.1436 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3985 7.3161 1.2549 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3824 7.2728 -0.7949 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3279 18.1694 -0.0652 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5196 5.4571 -0.6607 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0350 5.0995 -2.0294 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5829 2.7489 -1.6084 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1915 2.8381 0.4028 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5478 2.4597 1.3080 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0631 2.1020 -0.0608 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3913 4.7211 -1.1243 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 4.8101 0.8869 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0162 0.2604 0.1628 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4526 0.0000 -1.1377 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3523 0.2706 -1.8599 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0089 17.9536 -0.1495 H 0 0 0 0 0 0 0 0 0 0 0 0 16.8846 13.3570 0.3011 H 0 0 0 0 0 0 0 0 0 0 0 0 14.4794 12.3208 -0.6976 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1626 13.9359 -0.8745 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7020 18.8367 1.0451 H 0 0 0 0 0 0 0 0 0 0 0 0 16.1187 19.8615 2.0378 H 0 0 0 0 0 0 0 0 0 0 0 0 18.4271 18.2308 2.2015 H 0 0 0 0 0 0 0 0 0 0 0 0 18.3557 15.5502 1.3762 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 44 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 21 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 45 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 46 1 0 0 0 0 13 16 1 0 0 0 0 13 47 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 48 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 49 1 0 0 0 0 19 50 1 0 0 0 0 20 22 1 0 0 0 0 20 51 1 0 0 0 0 20 52 1 0 0 0 0 21 53 1 0 0 0 0 22 30 1 0 0 0 0 22 54 1 0 0 0 0 22 55 1 0 0 0 0 23 24 1 0 0 0 0 23 56 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 57 1 0 0 0 0 26 58 1 0 0 0 0 27 31 1 0 0 0 0 27 59 1 0 0 0 0 27 60 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 61 1 0 0 0 0 28 62 1 0 0 0 0 29 30 1 0 0 0 0 29 63 1 0 0 0 0 29 64 1 0 0 0 0 31 32 1 0 0 0 0 32 65 1 0 0 0 0 32 66 1 0 0 0 0 32 67 1 0 0 0 0 33 34 1 0 0 0 0 33 68 1 0 0 0 0 34 39 2 0 0 0 0 34 37 1 0 0 0 0 35 38 2 0 0 0 0 35 36 1 0 0 0 0 35 69 1 0 0 0 0 36 37 2 0 0 0 0 36 70 1 0 0 0 0 37 71 1 0 0 0 0 38 43 1 0 0 0 0 38 39 1 0 0 0 0 39 40 1 0 0 0 0 40 41 2 0 0 0 0 40 72 1 0 0 0 0 41 42 1 0 0 0 0 41 73 1 0 0 0 0 42 43 2 0 0 0 0 42 74 1 0 0 0 0 43 75 1 0 0 0 0 M END > (516) 6-arylpyrido[2,3-d]pyrimidine deriv. 70 > (516) PDGFR-beta > (516) 2600 > (516) -1 > (516) P > (516) PDGFR-P514 $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 28 csChFnd70/05150717532D 62 65 0 0 0 0 0 0 0 0999 V2000 8.8303 12.5831 -2.8137 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6432 10.6806 -1.4325 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1942 13.7616 -2.9183 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8057 13.2895 -2.2247 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9752 15.3898 -3.6986 C 0 0 0 0 0 0 0 0 0 0 0 0 12.9999 15.9647 -3.0377 C 0 0 0 0 0 0 0 0 0 0 0 0 14.2264 16.9391 -3.0961 O 0 0 0 0 0 0 0 0 0 0 0 0 11.3461 16.4945 -3.7693 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1721 14.4050 -2.3015 N 0 0 3 0 0 0 0 0 0 0 0 0 11.9687 11.7499 -1.5008 N 0 0 0 0 0 0 0 0 0 0 0 0 9.1088 11.0812 -2.0714 N 0 0 0 0 0 0 0 0 0 0 0 0 10.8643 9.0909 -0.6690 N 0 0 3 0 0 0 0 0 0 0 0 0 9.4524 7.9935 -0.4480 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6704 6.2232 -0.5560 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2774 5.1418 -0.3373 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4428 7.5916 0.1056 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8345 8.6747 -0.1130 C 0 0 0 0 0 0 0 0 0 0 0 0 14.8354 13.8944 -1.5755 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1581 18.2102 -4.5795 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8961 21.0303 -4.6132 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0653 19.4344 -3.8532 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0789 18.6098 -6.0669 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8989 20.2101 -6.8152 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8078 21.4169 -6.0925 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6604 5.8236 -0.0099 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2892 4.7578 0.2049 O 0 0 0 0 0 0 0 0 0 0 0 0 3.6622 5.5476 0.5380 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2858 4.1544 0.7413 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6571 3.1217 2.2805 N 0 0 0 0 0 0 0 0 0 0 0 0 1.1449 2.1138 2.8009 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3897 1.4676 4.6446 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1539 2.0017 2.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8615 0.9063 0.3904 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5774 12.9006 -3.3248 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7452 15.7570 -4.2315 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9976 8.7346 -0.2861 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9290 5.6922 -0.8119 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4467 3.7649 -0.4213 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1835 8.1213 0.3608 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6649 10.0511 -0.0229 H 0 0 0 0 0 0 0 0 0 0 0 0 15.6001 13.2557 -2.5627 H 0 0 0 0 0 0 0 0 0 0 0 0 15.5162 15.0331 -1.1205 H 0 0 0 0 0 0 0 0 0 0 0 0 14.6271 13.0145 -0.5033 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0501 21.9795 -4.0519 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3526 19.1339 -2.6985 H 0 0 0 0 0 0 0 0 0 0 0 0 12.9315 17.6688 -6.6320 H 0 0 0 0 0 0 0 0 0 0 0 0 12.6117 20.5213 -7.9670 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6711 22.6677 -6.6828 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7416 6.3021 1.7179 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3224 6.3879 -0.5324 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0265 4.7575 0.8754 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2892 3.3253 -0.3900 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.9215 2.7368 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9933 1.0185 1.9379 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3162 0.6356 4.9949 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5889 0.7452 4.7315 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4384 2.5617 5.5209 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3015 2.7895 1.8273 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3252 1.1633 3.1114 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9218 0.0000 0.2427 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6567 0.1995 0.5183 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7977 1.7389 -0.7366 H 0 0 0 0 0 0 0 0 0 0 0 0 1 11 1 0 0 0 0 1 3 2 0 0 0 0 1 34 1 0 0 0 0 2 11 2 0 0 0 0 2 10 1 0 0 0 0 2 12 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 10 2 0 0 0 0 4 9 1 0 0 0 0 5 8 2 0 0 0 0 5 35 1 0 0 0 0 6 9 1 0 0 0 0 6 8 1 0 0 0 0 6 7 2 0 0 0 0 8 19 1 0 0 0 0 9 18 1 0 0 0 0 12 13 1 0 0 0 0 12 36 1 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 14 15 1 0 0 0 0 14 37 1 0 0 0 0 15 25 2 0 0 0 0 15 38 1 0 0 0 0 16 25 1 0 0 0 0 16 17 2 0 0 0 0 16 39 1 0 0 0 0 17 40 1 0 0 0 0 18 41 1 0 0 0 0 18 42 1 0 0 0 0 18 43 1 0 0 0 0 19 21 1 0 0 0 0 19 22 2 0 0 0 0 20 21 2 0 0 0 0 20 24 1 0 0 0 0 20 44 1 0 0 0 0 21 45 1 0 0 0 0 22 23 1 0 0 0 0 22 46 1 0 0 0 0 23 24 2 0 0 0 0 23 47 1 0 0 0 0 24 48 1 0 0 0 0 25 26 1 0 0 0 0 26 27 1 0 0 0 0 27 28 1 0 0 0 0 27 49 1 0 0 0 0 27 50 1 0 0 0 0 28 29 1 0 0 0 0 28 51 1 0 0 0 0 28 52 1 0 0 0 0 29 30 1 0 0 0 0 29 32 1 0 0 0 0 30 31 1 0 0 0 0 30 53 1 0 0 0 0 30 54 1 0 0 0 0 31 55 1 0 0 0 0 31 56 1 0 0 0 0 31 57 1 0 0 0 0 32 33 1 0 0 0 0 32 58 1 0 0 0 0 32 59 1 0 0 0 0 33 60 1 0 0 0 0 33 61 1 0 0 0 0 33 62 1 0 0 0 0 M END > (53) pyrido[2,3-d]pyrimidin-7-one deriv. 28 > (53) PDGFR-beta > (53) 42 > (53) -1 > (53) P > (53) PDGFR-P51 $$$$ csChFnd70/05150717532D 57 60 0 0 0 0 0 0 0 0999 V2000 3.9367 15.9988 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9720 14.2010 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 3.9598 14.2881 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5218 16.8911 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0726 15.9203 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5803 18.7227 0.0104 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7436 18.4871 -0.0216 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1539 19.1975 -0.0319 O 0 0 0 0 0 0 0 0 0 0 0 0 8.6490 16.7436 -0.0296 N 0 0 3 0 0 0 0 0 0 0 0 0 10.2459 15.7159 -0.0497 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1593 19.5330 -0.0009 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2643 21.4509 0.0083 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2909 22.3667 -1.5515 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3883 24.1544 -1.5337 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4600 25.0370 0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4347 24.1369 1.5764 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3295 22.3495 1.5769 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2884 21.2227 3.5247 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.2024 21.2615 -3.5098 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.4455 13.4167 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3954 11.6276 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 3.7248 10.7244 -0.0156 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0326 8.7650 -0.0296 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2879 7.8217 -0.0187 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2597 3.4995 1.1098 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9619 4.9924 0.2865 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5834 5.9405 -0.0321 N 0 0 0 0 0 0 0 0 0 0 0 0 3.9173 5.4496 1.2363 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3044 3.0422 0.1600 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6384 2.5515 1.4285 N 0 0 0 0 0 0 0 0 0 0 0 0 2.9338 0.6702 1.4150 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7233 16.6971 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3974 19.4714 0.0253 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6292 15.4672 -1.3868 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2728 16.4280 0.6099 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0240 14.4876 0.6128 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4090 24.8648 -2.7400 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5366 26.4350 0.0324 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4917 24.8336 2.7895 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4664 10.9688 -0.0398 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0046 11.0797 1.1470 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9831 11.0928 -1.1602 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7528 8.4096 -1.1921 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7745 8.3965 1.1151 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5676 8.1771 1.1439 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5460 8.1901 -1.1633 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7418 3.1883 -0.1815 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2216 3.1262 2.0752 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4798 5.3035 1.5778 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3658 -0.6789 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4688 5.7661 2.5384 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1101 6.1564 0.9634 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1116 2.3354 0.4328 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7528 2.7257 -1.1421 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8622 0.3320 2.4250 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7129 0.0000 1.6539 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4452 0.2827 0.1561 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 32 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 33 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 34 1 0 0 0 0 10 35 1 0 0 0 0 10 36 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 37 1 0 0 0 0 15 16 1 0 0 0 0 15 38 1 0 0 0 0 16 17 2 0 0 0 0 16 39 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 40 1 0 0 0 0 22 23 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 24 1 0 0 0 0 23 43 1 0 0 0 0 23 44 1 0 0 0 0 24 27 1 0 0 0 0 24 45 1 0 0 0 0 24 46 1 0 0 0 0 25 28 1 0 0 0 0 25 30 1 0 0 0 0 25 47 1 0 0 0 0 25 48 1 0 0 0 0 26 27 1 0 0 0 0 26 29 1 0 0 0 0 26 49 1 0 0 0 0 26 50 1 0 0 0 0 27 28 1 0 0 0 0 28 51 1 0 0 0 0 28 52 1 0 0 0 0 29 30 1 0 0 0 0 29 53 1 0 0 0 0 29 54 1 0 0 0 0 30 31 1 0 0 0 0 31 55 1 0 0 0 0 31 56 1 0 0 0 0 31 57 1 0 0 0 0 M END > (525) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 31 > (525) PDGFR-beta > (525) 2800 > (525) -1 > (525) P > (525) PDGFR-P523 $$$$ Structure20 csChFnd70/05150717532D 83 89 0 0 0 0 0 0 0 0999 V2000 7.7714 4.3167 0.0144 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8003 2.1953 0.0028 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7617 5.0508 -0.0006 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7454 5.0194 -1.7042 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7932 1.5112 -1.7426 C 0 0 2 0 0 0 0 0 0 0 0 0 10.7546 4.3667 -1.7460 C 0 0 1 0 0 0 0 0 0 0 0 0 7.7384 4.3352 -3.4496 C 0 0 2 0 0 0 0 0 0 0 0 0 10.7835 2.2455 -1.7576 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7672 2.2139 -3.4613 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7287 5.0696 -3.4648 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0262 14.9515 4.6794 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5891 15.3117 1.9068 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7454 16.0235 3.3860 N 0 0 0 0 0 0 0 0 0 0 0 0 6.7594 13.5099 1.6374 N 0 0 0 0 0 0 0 0 0 0 0 0 5.1650 13.0197 4.4683 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0732 12.3073 2.8735 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4344 11.7854 5.7860 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5547 9.2947 3.8472 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6356 9.9019 5.4645 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2289 10.4797 2.6316 N 0 0 0 0 0 0 0 0 0 0 0 0 3.8921 8.5358 6.8087 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3996 6.6024 7.8795 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5030 5.9834 9.3208 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0840 7.8750 6.6224 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0005 7.9001 8.2606 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2998 6.6274 9.5087 C 0 0 0 0 0 0 0 0 0 0 0 0 0.6967 8.6509 4.8149 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.2562 8.7060 8.4983 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.1469 18.5171 0.8554 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0584 19.5176 -0.7783 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3147 16.5090 0.5984 N 0 0 3 0 0 0 0 0 0 0 0 0 7.8832 21.6147 -0.5100 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7532 7.4076 3.5306 N 0 0 3 0 0 0 0 0 0 0 0 0 6.6279 6.8049 1.9932 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2430 7.9148 0.8836 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5830 21.7722 -2.5005 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3982 22.7356 -4.2067 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7262 25.5381 -3.4232 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9111 24.5749 -1.7170 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7584 22.5753 -2.0785 N 0 0 0 0 0 0 0 0 0 0 0 0 11.5507 24.7350 -3.8452 N 0 0 0 0 0 0 0 0 0 0 0 0 12.4259 25.6958 -5.4136 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8207 4.9717 1.6858 N 0 0 3 0 0 0 0 0 0 0 0 0 8.5313 1.6948 1.2272 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3824 1.6722 0.0136 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7412 6.5621 0.0078 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4927 4.5503 1.2238 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3275 4.4962 -1.6936 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7250 6.5306 -1.6959 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8137 0.0000 -1.7509 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1725 4.8899 -1.7568 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0074 4.8359 -4.6741 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5145 1.7448 -0.5333 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4909 1.7582 -3.0011 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4746 1.7265 -4.7048 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3492 1.6909 -3.4506 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7082 6.5808 -3.4564 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4360 4.5820 -4.7082 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3501 15.5444 5.8768 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7372 12.2890 7.0119 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 6.0894 7.7364 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9614 4.9883 10.3001 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1564 6.1343 10.6336 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8341 18.9199 2.1397 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6853 18.8956 0.9258 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5199 19.1391 -0.8487 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3711 19.1148 -2.0627 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9350 16.0199 -0.4900 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4218 21.9932 -0.4394 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5704 22.0175 0.7744 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2624 6.5220 4.4159 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4310 20.2948 -2.7801 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5062 21.9703 -1.3204 H 0 0 0 0 0 0 0 0 0 0 0 0 12.7689 22.1699 -4.4983 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4938 22.5057 -5.3957 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8029 25.3401 -4.6031 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8780 27.0156 -3.1435 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8152 24.8047 -0.5280 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5402 25.1406 -1.4253 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5934 25.4904 -6.6582 H 0 0 0 0 0 0 0 0 0 0 0 0 12.5217 27.1730 -5.1096 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8122 25.1364 -5.6370 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3300 4.0861 2.5710 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 3 1 0 0 0 0 1 4 1 0 0 0 0 1 43 1 0 0 0 0 2 5 1 0 0 0 0 2 44 1 0 0 0 0 2 45 1 0 0 0 0 3 6 1 0 0 0 0 3 46 1 0 0 0 0 3 47 1 0 0 0 0 4 7 1 0 0 0 0 4 48 1 0 0 0 0 4 49 1 0 0 0 0 5 8 1 0 0 0 0 5 9 1 0 0 0 0 5 50 1 0 0 0 0 6 10 1 0 0 0 0 6 8 1 0 0 0 0 6 51 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 52 1 0 0 0 0 8 53 1 0 0 0 0 8 54 1 0 0 0 0 9 55 1 0 0 0 0 9 56 1 0 0 0 0 10 57 1 0 0 0 0 10 58 1 0 0 0 0 11 13 1 0 0 0 0 11 15 2 0 0 0 0 11 59 1 0 0 0 0 12 13 2 0 0 0 0 12 14 1 0 0 0 0 12 31 1 0 0 0 0 14 16 2 0 0 0 0 15 17 1 0 0 0 0 15 16 1 0 0 0 0 16 20 1 0 0 0 0 17 19 2 0 0 0 0 17 60 1 0 0 0 0 18 20 2 0 0 0 0 18 19 1 0 0 0 0 18 33 1 0 0 0 0 19 21 1 0 0 0 0 21 24 2 0 0 0 0 21 25 1 0 0 0 0 22 24 1 0 0 0 0 22 23 2 0 0 0 0 22 61 1 0 0 0 0 23 26 1 0 0 0 0 23 62 1 0 0 0 0 24 27 1 0 0 0 0 25 26 2 0 0 0 0 25 28 1 0 0 0 0 26 63 1 0 0 0 0 29 31 1 0 0 0 0 29 30 1 0 0 0 0 29 64 1 0 0 0 0 29 65 1 0 0 0 0 30 32 1 0 0 0 0 30 66 1 0 0 0 0 30 67 1 0 0 0 0 31 68 1 0 0 0 0 32 40 1 0 0 0 0 32 69 1 0 0 0 0 32 70 1 0 0 0 0 33 34 1 0 0 0 0 33 71 1 0 0 0 0 34 35 2 0 0 0 0 34 43 1 0 0 0 0 36 40 1 0 0 0 0 36 37 1 0 0 0 0 36 72 1 0 0 0 0 36 73 1 0 0 0 0 37 41 1 0 0 0 0 37 74 1 0 0 0 0 37 75 1 0 0 0 0 38 41 1 0 0 0 0 38 39 1 0 0 0 0 38 76 1 0 0 0 0 38 77 1 0 0 0 0 39 40 1 0 0 0 0 39 78 1 0 0 0 0 39 79 1 0 0 0 0 41 42 1 0 0 0 0 42 80 1 0 0 0 0 42 81 1 0 0 0 0 42 82 1 0 0 0 0 43 83 1 0 0 0 0 M END > (526) 6-arylpyrido[2,3-d]pyrimidine deriv. 57 > (526) PDGFR-beta > (526) 2800 > (526) -1 > (526) P > (526) PDGFR-P524 $$$$ Pyrazine-Pyridine Biheteroaryl 39 csChFnd70/05150717532D 46 48 0 0 0 0 0 0 0 0999 V2000 1.0071 12.0563 -0.0812 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2612 9.9721 -0.3371 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5369 10.7387 -0.3670 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2781 12.8308 -0.1101 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0321 10.6508 -0.1951 N 0 0 0 0 0 0 0 0 0 0 0 0 3.5148 12.1550 -0.2523 N 0 0 0 0 0 0 0 0 0 0 0 0 4.9175 9.9766 -0.5259 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1996 10.7337 -0.5569 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5027 8.6606 -0.8139 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2747 7.8265 -0.7868 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9526 8.4895 -0.6402 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4283 10.0625 -0.6978 N 0 0 0 0 0 0 0 0 0 0 0 0 3.5273 15.0770 0.1142 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6390 16.4242 -0.4973 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6865 14.4942 0.8354 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9477 15.2527 0.9372 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0585 16.5917 0.3226 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9045 17.1782 -0.3918 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0462 18.8625 -1.1555 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.2495 14.3116 0.0095 N 0 0 3 0 0 0 0 0 0 0 0 0 6.3661 6.3416 -0.9112 N 0 0 3 0 0 0 0 0 0 0 0 0 7.7632 5.6544 -1.0718 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5645 4.0358 -1.1848 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0235 3.3181 -1.3525 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8248 1.6996 -1.4655 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1875 1.0292 -1.6221 O 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 12.6066 0.0394 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2774 8.8222 -0.4303 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1852 11.8838 -0.4650 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5326 8.1530 -0.9276 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9792 7.8705 -0.6151 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7385 16.8821 -1.0548 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6009 13.4488 1.3164 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8488 14.7997 1.4978 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0460 17.1828 0.4045 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3426 14.8131 0.0204 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5047 5.7659 -0.8915 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2819 6.0502 -2.0363 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4255 5.9005 -0.1460 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0457 3.6401 -0.2202 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9022 3.7898 -2.1106 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5422 3.7138 -2.3171 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6858 3.5641 -0.4267 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3061 1.3039 -0.5010 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1625 1.4535 -2.3913 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1431 0.0000 -1.7002 H 0 0 0 0 0 0 0 0 0 0 0 0 1 5 1 0 0 0 0 1 4 2 0 0 0 0 1 27 1 0 0 0 0 2 5 2 0 0 0 0 2 3 1 0 0 0 0 2 28 1 0 0 0 0 3 6 2 0 0 0 0 3 7 1 0 0 0 0 4 6 1 0 0 0 0 4 20 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 12 2 0 0 0 0 8 29 1 0 0 0 0 9 12 1 0 0 0 0 9 10 2 0 0 0 0 9 30 1 0 0 0 0 10 11 1 0 0 0 0 10 21 1 0 0 0 0 11 31 1 0 0 0 0 13 20 1 0 0 0 0 13 14 2 0 0 0 0 13 15 1 0 0 0 0 14 18 1 0 0 0 0 14 32 1 0 0 0 0 15 16 2 0 0 0 0 15 33 1 0 0 0 0 16 17 1 0 0 0 0 16 34 1 0 0 0 0 17 18 2 0 0 0 0 17 35 1 0 0 0 0 18 19 1 0 0 0 0 20 36 1 0 0 0 0 21 22 1 0 0 0 0 21 37 1 0 0 0 0 22 23 1 0 0 0 0 22 38 1 0 0 0 0 22 39 1 0 0 0 0 23 24 1 0 0 0 0 23 40 1 0 0 0 0 23 41 1 0 0 0 0 24 25 1 0 0 0 0 24 42 1 0 0 0 0 24 43 1 0 0 0 0 25 26 1 0 0 0 0 25 44 1 0 0 0 0 25 45 1 0 0 0 0 26 46 1 0 0 0 0 M END > (528) Pyrazine-Pyridine Biheteroaryl 39 > (528) PDGFR-beta > (528) 2800 > (528) -1 > (528) P > (528) PDGFR-P526 $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7h csChFnd70/05150717532D 58 61 0 0 0 0 0 0 0 0999 V2000 1.2249 16.2605 0.0121 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7195 13.6544 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3206 14.4806 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7817 17.1978 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3706 16.2833 -0.0179 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7815 19.0345 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3329 19.8989 -0.0006 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9571 18.9111 -0.0214 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3423 19.6734 -0.0304 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2481 14.5533 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9252 17.1623 -0.0285 N 0 0 3 0 0 0 0 0 0 0 0 0 7.5588 16.1894 -0.0488 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3695 21.8216 0.0073 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4362 24.5165 1.5756 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4022 22.7242 1.5773 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3790 22.7376 -1.5552 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4131 24.5298 -1.5387 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4386 25.4169 0.0222 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3993 21.5966 3.5282 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.3488 21.6268 -3.5155 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6546 11.8550 -0.0260 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2661 10.8456 -0.0467 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8331 8.9074 -0.0537 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5159 7.8533 -0.0755 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7603 5.5867 1.2133 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2910 3.6599 1.0944 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1962 3.0146 0.0875 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6654 4.9412 0.2064 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1002 5.9924 -0.0823 N 0 0 0 0 0 0 0 0 0 0 0 0 4.8564 2.6088 1.3830 N 0 0 0 0 0 0 0 0 0 0 0 0 4.4407 0.7479 1.3764 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.9418 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5075 13.7347 -0.0420 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5729 19.7445 0.0257 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9512 15.9543 -1.3877 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5615 16.9373 0.6121 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3792 14.9524 0.6141 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4610 25.2167 2.7898 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4205 25.2403 -2.7471 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4652 26.8184 0.0279 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5424 11.2651 -0.0188 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0089 11.1671 -1.2071 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0306 11.1539 1.1030 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0901 8.5860 1.1067 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0686 8.5991 -1.2036 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2588 8.1747 -1.2359 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2804 8.1616 1.0743 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6087 6.3694 0.9625 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2535 5.8733 2.5081 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3247 3.3479 2.0795 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7648 3.3806 -0.1888 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7031 2.7279 -1.2073 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3477 2.2319 0.3382 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1916 5.2205 1.4896 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6319 5.2533 -0.7786 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8808 0.3942 0.1260 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6219 0.0000 1.5926 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5107 0.4687 2.4053 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 32 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 33 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 34 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 35 1 0 0 0 0 12 36 1 0 0 0 0 12 37 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 38 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 39 1 0 0 0 0 18 40 1 0 0 0 0 21 22 1 0 0 0 0 21 41 1 0 0 0 0 22 23 1 0 0 0 0 22 42 1 0 0 0 0 22 43 1 0 0 0 0 23 24 1 0 0 0 0 23 44 1 0 0 0 0 23 45 1 0 0 0 0 24 29 1 0 0 0 0 24 46 1 0 0 0 0 24 47 1 0 0 0 0 25 29 1 0 0 0 0 25 26 1 0 0 0 0 25 48 1 0 0 0 0 25 49 1 0 0 0 0 26 30 1 0 0 0 0 26 50 1 0 0 0 0 26 51 1 0 0 0 0 27 30 1 0 0 0 0 27 28 1 0 0 0 0 27 52 1 0 0 0 0 27 53 1 0 0 0 0 28 29 1 0 0 0 0 28 54 1 0 0 0 0 28 55 1 0 0 0 0 30 31 1 0 0 0 0 31 56 1 0 0 0 0 31 57 1 0 0 0 0 31 58 1 0 0 0 0 M END > (529) 1,6-naphthyridin-2(1H)-one deriv. 7h > (529) PDGFR-beta > (529) 2800 > (529) -1 > (529) P > (529) PDGFR-P527 $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7v csChFnd70/05150717532D 55 59 0 0 0 0 0 0 0 0999 V2000 7.9972 9.9229 0.8205 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2042 7.7189 0.1761 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5510 8.4521 -0.0870 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3088 10.7504 0.5805 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6195 9.9947 0.1148 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3358 12.3210 0.7971 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6415 13.0861 0.5493 C 0 0 0 0 0 0 0 0 0 0 0 0 11.9806 12.2684 0.0668 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1463 12.9433 -0.1551 O 0 0 0 0 0 0 0 0 0 0 0 0 7.9910 8.4635 0.6137 N 0 0 0 0 0 0 0 0 0 0 0 0 11.9281 10.7722 -0.1320 N 0 0 3 0 0 0 0 0 0 0 0 0 13.2752 9.9671 -0.6144 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7004 14.7310 0.7670 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1339 16.8600 2.3581 C 0 0 0 0 0 0 0 0 0 0 0 0 11.0812 15.3254 2.1626 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3815 15.6928 -0.4242 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4383 17.2253 -0.2136 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8108 17.8072 1.1742 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4870 14.1385 3.6498 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.9151 14.9649 -2.1671 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.1233 6.1786 -0.0218 N 0 0 3 0 0 0 0 0 0 0 0 0 7.7432 5.4425 0.1058 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3232 3.2657 0.7917 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0735 5.4354 -0.2073 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4343 6.1611 -0.3333 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6840 3.9914 0.6657 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0136 3.9867 0.3585 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1450 1.0273 -0.1150 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9114 3.3921 0.1881 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4017 4.2132 -0.0326 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6478 1.8244 -0.3388 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6344 3.2509 0.4858 N 0 0 0 0 0 0 0 0 0 0 0 0 0.9582 1.9929 -0.5923 O 0 0 0 0 0 0 0 0 0 0 0 0 6.9878 10.4847 1.1817 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5290 7.8339 -0.4423 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3390 12.9083 1.1528 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3089 9.9239 -1.8347 H 0 0 0 0 0 0 0 0 0 0 0 0 14.2670 10.5477 -0.2000 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2524 8.8306 -0.1672 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4284 17.3213 3.4377 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1918 17.9709 -1.1346 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8536 19.0064 1.3330 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0227 5.6118 -0.2487 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2767 2.1391 1.2318 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0551 5.9963 -0.5438 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4808 7.2879 -0.7731 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7025 3.4306 1.0021 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1259 0.0000 -0.7758 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9995 0.7556 1.0670 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7299 3.1891 1.3789 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 4.0751 -0.2536 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5547 4.4695 -1.2172 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3952 5.2507 0.6122 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5510 1.1181 0.0827 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8209 2.0425 -1.5282 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 34 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 35 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 36 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 37 1 0 0 0 0 12 38 1 0 0 0 0 12 39 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 40 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 41 1 0 0 0 0 18 42 1 0 0 0 0 21 22 1 0 0 0 0 21 43 1 0 0 0 0 22 25 2 0 0 0 0 22 26 1 0 0 0 0 23 27 1 0 0 0 0 23 26 2 0 0 0 0 23 44 1 0 0 0 0 24 27 2 0 0 0 0 24 25 1 0 0 0 0 24 45 1 0 0 0 0 25 46 1 0 0 0 0 26 47 1 0 0 0 0 27 32 1 0 0 0 0 28 33 1 0 0 0 0 28 31 1 0 0 0 0 28 48 1 0 0 0 0 28 49 1 0 0 0 0 29 33 1 0 0 0 0 29 30 1 0 0 0 0 29 50 1 0 0 0 0 29 51 1 0 0 0 0 30 32 1 0 0 0 0 30 52 1 0 0 0 0 30 53 1 0 0 0 0 31 32 1 0 0 0 0 31 54 1 0 0 0 0 31 55 1 0 0 0 0 M END > (530) 1,6-naphthyridin-2(1H)-one deriv. 7v > (530) PDGFR-beta > (530) 2800 > (530) -1 > (530) P > (530) PDGFR-P528 $$$$ PD089828 analog 26 csChFnd70/05150717532D 49 51 0 0 0 0 0 0 0 0999 V2000 1.2015 4.9971 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6961 2.4339 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7763 5.8797 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3211 4.9112 -0.0184 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8589 7.6820 0.0118 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4678 8.4436 0.0018 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2245 3.3047 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2105 3.1948 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8377 5.7097 -0.0280 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6351 0.6597 -0.0244 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6321 10.3410 0.0125 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8616 13.0930 -1.1467 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7185 11.1409 1.1900 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8686 12.9060 1.1966 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9486 7.3980 -0.0181 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5569 8.1656 -0.0294 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9837 7.1854 -0.0503 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8615 5.6287 -0.0593 O 0 0 0 0 0 0 0 0 0 0 0 0 3.7059 11.3285 -1.1600 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5461 7.9311 -0.0614 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0970 6.8656 -0.0841 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0961 5.7415 -1.6963 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6862 8.0219 -0.0927 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1287 5.7206 1.5128 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9390 13.8861 0.0324 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0900 15.6251 0.0419 O 0 0 0 0 0 0 0 0 0 0 0 0 6.2208 16.3566 1.2890 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.6902 0.0327 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7042 8.4507 0.0266 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5352 0.0741 -0.0167 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6919 0.0000 -0.0382 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1446 13.8586 -2.0546 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4417 10.3792 2.0963 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7095 13.5266 2.1088 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6545 9.4078 -0.0223 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8679 10.7122 -2.0778 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6437 9.1732 -0.0543 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0735 6.5573 -2.8340 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2500 4.9487 -1.7132 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9640 4.9177 -1.6902 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6870 8.8227 1.0557 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8401 7.2291 -0.1097 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6636 8.8376 -1.2304 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9966 4.8968 1.5189 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2826 4.9278 1.4959 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1294 6.5213 2.6614 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2221 17.7504 1.1571 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7856 16.0098 2.5738 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5171 15.8674 1.0875 H 0 0 0 0 0 0 0 0 0 0 0 0 1 7 2 0 0 0 0 1 3 1 0 0 0 0 1 28 1 0 0 0 0 2 7 1 0 0 0 0 2 8 2 0 0 0 0 2 10 1 0 0 0 0 3 5 1 0 0 0 0 3 4 2 0 0 0 0 4 8 1 0 0 0 0 4 9 1 0 0 0 0 5 6 2 0 0 0 0 5 29 1 0 0 0 0 6 15 1 0 0 0 0 6 11 1 0 0 0 0 9 15 2 0 0 0 0 10 30 1 0 0 0 0 10 31 1 0 0 0 0 11 19 1 0 0 0 0 11 13 2 0 0 0 0 12 19 2 0 0 0 0 12 25 1 0 0 0 0 12 32 1 0 0 0 0 13 14 1 0 0 0 0 13 33 1 0 0 0 0 14 25 2 0 0 0 0 14 34 1 0 0 0 0 15 16 1 0 0 0 0 16 17 1 0 0 0 0 16 35 1 0 0 0 0 17 20 1 0 0 0 0 17 18 2 0 0 0 0 19 36 1 0 0 0 0 20 21 1 0 0 0 0 20 37 1 0 0 0 0 21 22 1 0 0 0 0 21 23 1 0 0 0 0 21 24 1 0 0 0 0 22 38 1 0 0 0 0 22 39 1 0 0 0 0 22 40 1 0 0 0 0 23 41 1 0 0 0 0 23 42 1 0 0 0 0 23 43 1 0 0 0 0 24 44 1 0 0 0 0 24 45 1 0 0 0 0 24 46 1 0 0 0 0 25 26 1 0 0 0 0 26 27 1 0 0 0 0 27 47 1 0 0 0 0 27 48 1 0 0 0 0 27 49 1 0 0 0 0 M END > (532) PD089828 analog 26 > (532) PDGFR-beta > (532) 2890 > (532) -1 > (532) P > (532) PDGFR-P530 $$$$ PD089828 analog 7 csChFnd70/05150717532D 45 47 0 0 0 0 0 0 0 0999 V2000 1.2015 4.9970 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6960 2.4337 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7763 5.8795 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3211 4.9109 -0.0184 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8590 7.6818 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4678 8.4433 0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2245 3.3045 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2105 3.1947 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8377 5.7094 -0.0280 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6350 0.6596 -0.0244 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6320 10.3406 0.0103 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8850 12.9956 1.5648 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6875 11.2466 -1.5343 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8408 13.0145 -1.5174 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9392 13.8866 0.0268 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9485 7.3978 -0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5568 8.1654 -0.0307 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9837 7.1851 -0.0502 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8614 5.6284 -0.0579 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5460 7.9308 -0.0613 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0967 5.7399 -1.6936 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6861 8.0216 -0.0913 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0969 6.8653 -0.0825 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1280 5.7215 1.5154 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7244 11.2273 1.5644 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6465 10.1118 3.4937 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.0002 14.1023 3.4971 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5649 10.1546 -3.4747 Cl 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.6901 0.0327 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7041 8.4503 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5352 0.0741 -0.0167 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6919 0.0000 -0.0381 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8842 13.7168 -2.7129 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0647 15.2682 0.0330 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6545 9.4076 -0.0245 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6436 9.1729 -0.0551 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0746 6.5548 -2.8319 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2507 4.9472 -1.7094 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9645 4.9162 -1.6873 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6864 8.8234 1.0565 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8400 7.2288 -0.1071 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6640 8.8365 -1.2297 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9959 4.8978 1.5218 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2819 4.9289 1.4996 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1281 6.5233 2.6633 H 0 0 0 0 0 0 0 0 0 0 0 0 1 7 2 0 0 0 0 1 3 1 0 0 0 0 1 29 1 0 0 0 0 2 7 1 0 0 0 0 2 8 2 0 0 0 0 2 10 1 0 0 0 0 3 5 1 0 0 0 0 3 4 2 0 0 0 0 4 8 1 0 0 0 0 4 9 1 0 0 0 0 5 6 2 0 0 0 0 5 30 1 0 0 0 0 6 16 1 0 0 0 0 6 11 1 0 0 0 0 9 16 2 0 0 0 0 10 31 1 0 0 0 0 10 32 1 0 0 0 0 11 25 1 0 0 0 0 11 13 2 0 0 0 0 12 25 2 0 0 0 0 12 15 1 0 0 0 0 12 27 1 0 0 0 0 13 14 1 0 0 0 0 13 28 1 0 0 0 0 14 15 2 0 0 0 0 14 33 1 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 17 18 1 0 0 0 0 17 35 1 0 0 0 0 18 20 1 0 0 0 0 18 19 2 0 0 0 0 20 23 1 0 0 0 0 20 36 1 0 0 0 0 21 23 1 0 0 0 0 21 37 1 0 0 0 0 21 38 1 0 0 0 0 21 39 1 0 0 0 0 22 23 1 0 0 0 0 22 40 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 24 1 0 0 0 0 24 43 1 0 0 0 0 24 44 1 0 0 0 0 24 45 1 0 0 0 0 25 26 1 0 0 0 0 M END > (533) PD089828 analog 7 > (533) PDGFR-beta > (533) 2960 > (533) -1 > (533) P > (533) PDGFR-P531 $$$$ 3-substituted indolin-2-one 11h csChFnd70/05150717532D 52 55 0 0 0 0 0 0 0 0999 V2000 1.7813 10.8258 0.1580 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5837 9.2636 0.1295 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5739 10.8598 0.0804 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1601 11.6399 0.0951 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5292 13.3006 0.0342 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2170 13.3754 -0.0140 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7621 11.9286 0.0154 N 0 0 3 0 0 0 0 0 0 0 0 0 5.9881 14.5449 -0.0712 O 0 0 0 0 0 0 0 0 0 0 0 0 2.5063 14.5189 0.0247 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0558 16.0405 0.1506 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4244 17.3330 -0.5401 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3154 16.5177 0.9886 N 0 0 3 0 0 0 0 0 0 0 0 0 1.0250 17.3751 -1.5636 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4695 18.0624 0.8201 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3296 18.5879 -0.1078 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8010 9.2415 0.2063 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2020 8.4552 0.1923 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0812 20.2368 -0.5844 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9194 20.9928 0.5014 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6710 22.6417 0.0249 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3532 23.1591 -1.0708 O 0 0 0 0 0 0 0 0 0 0 0 0 0.6919 23.5357 0.8175 O 0 0 0 0 0 0 0 0 0 0 0 0 3.2183 6.7497 0.2440 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6252 4.3719 0.2711 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2490 3.5632 0.3399 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8572 4.3479 0.3539 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8381 5.9340 0.3064 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6139 5.9581 0.2235 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2640 2.0003 0.3868 O 0 0 0 0 0 0 0 0 0 0 0 0 1.8066 1.2415 0.4567 C 0 0 0 0 0 0 0 0 0 0 0 0 0.6985 11.4356 0.1740 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6634 8.6483 0.1190 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8462 11.6640 -0.0063 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2864 14.3053 -0.0790 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9803 15.8592 1.5972 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 17.5549 -0.8633 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1382 18.3136 -2.3881 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9248 16.2870 -2.1797 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3547 18.7610 1.3428 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7331 8.6078 0.2556 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1703 20.8567 -0.5288 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6402 20.2708 -1.7581 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8303 20.3729 0.4458 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3605 20.9588 1.6751 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5705 24.5853 0.4684 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7058 3.7582 0.2554 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7885 3.7155 0.4070 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7552 6.5437 0.3182 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6849 6.5865 0.1700 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1299 1.5419 -0.5557 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9828 0.0000 0.4886 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1958 1.6038 1.4906 H 0 0 0 0 0 0 0 0 0 0 0 0 1 16 1 0 0 0 0 1 4 2 0 0 0 0 1 31 1 0 0 0 0 2 17 1 0 0 0 0 2 3 2 0 0 0 0 2 32 1 0 0 0 0 3 7 1 0 0 0 0 3 4 1 0 0 0 0 4 5 1 0 0 0 0 5 6 1 0 0 0 0 5 9 2 0 0 0 0 6 7 1 0 0 0 0 6 8 2 0 0 0 0 7 33 1 0 0 0 0 9 10 1 0 0 0 0 9 34 1 0 0 0 0 10 11 2 0 0 0 0 10 12 1 0 0 0 0 11 15 1 0 0 0 0 11 13 1 0 0 0 0 12 14 1 0 0 0 0 12 35 1 0 0 0 0 13 36 1 0 0 0 0 13 37 1 0 0 0 0 13 38 1 0 0 0 0 14 15 2 0 0 0 0 14 39 1 0 0 0 0 15 18 1 0 0 0 0 16 17 2 0 0 0 0 16 40 1 0 0 0 0 17 23 1 0 0 0 0 18 19 1 0 0 0 0 18 41 1 0 0 0 0 18 42 1 0 0 0 0 19 20 1 0 0 0 0 19 43 1 0 0 0 0 19 44 1 0 0 0 0 20 22 1 0 0 0 0 20 21 2 0 0 0 0 22 45 1 0 0 0 0 23 27 2 0 0 0 0 23 28 1 0 0 0 0 24 28 2 0 0 0 0 24 25 1 0 0 0 0 24 46 1 0 0 0 0 25 26 2 0 0 0 0 25 29 1 0 0 0 0 26 27 1 0 0 0 0 26 47 1 0 0 0 0 27 48 1 0 0 0 0 28 49 1 0 0 0 0 29 30 1 0 0 0 0 30 50 1 0 0 0 0 30 51 1 0 0 0 0 30 52 1 0 0 0 0 M END > (536) 3-substituted indolin-2-one 11h > (536) PDGFR-beta > (536) 3080 > (536) -1 > (536) P > (536) PDGFR-P534 $$$$ csChFnd70/05150717532D 41 44 0 0 0 0 0 0 0 0999 V2000 4.0147 8.6821 0.0156 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7232 7.0765 -0.0028 N 0 0 0 0 0 0 0 0 0 0 0 0 4.0348 7.1556 0.0013 N 0 0 0 0 0 0 0 0 0 0 0 0 5.4300 9.4779 0.0214 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8137 8.6108 0.0116 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4829 11.1123 0.0361 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3061 10.9008 0.0323 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5651 11.5341 0.0372 O 0 0 0 0 0 0 0 0 0 0 0 0 8.2210 9.3448 0.0173 N 0 0 3 0 0 0 0 0 0 0 0 0 6.8925 11.8349 0.0407 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9870 13.5464 0.0561 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0229 14.3689 -1.3326 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1105 15.9643 -1.3101 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1625 16.7468 0.0849 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1278 15.9384 1.4656 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0336 14.3432 1.4595 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9810 13.3313 3.1937 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.9585 13.3890 -3.0847 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.3605 6.3772 -0.0076 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3150 4.7793 -0.0232 N 0 0 3 0 0 0 0 0 0 0 0 0 3.8988 4.0092 0.1077 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6558 2.6305 -0.6814 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7339 4.6177 1.0325 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3356 3.8544 1.1596 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6460 8.4270 0.0075 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0943 2.4859 0.3678 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2546 1.8724 -0.5495 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9187 0.0000 -1.6303 Br 0 0 0 0 0 0 0 0 0 0 0 0 2.9321 9.3059 0.0176 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4274 11.7810 0.0433 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1388 16.6022 -2.3842 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2309 17.9944 0.0961 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1691 16.5562 2.5510 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2658 4.1918 -0.1249 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5610 2.1518 -1.3977 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9213 5.6866 1.6518 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4278 4.3300 1.8745 H 0 0 0 0 0 0 0 0 0 0 0 0 9.9984 8.2105 -1.1838 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5574 9.0594 0.6072 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4422 7.3282 0.5919 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.8912 0.4696 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 29 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 30 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 25 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 31 1 0 0 0 0 14 15 1 0 0 0 0 14 32 1 0 0 0 0 15 16 2 0 0 0 0 15 33 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 34 1 0 0 0 0 21 22 1 0 0 0 0 21 23 2 0 0 0 0 22 27 2 0 0 0 0 22 35 1 0 0 0 0 23 24 1 0 0 0 0 23 36 1 0 0 0 0 24 26 2 0 0 0 0 24 37 1 0 0 0 0 25 38 1 0 0 0 0 25 39 1 0 0 0 0 25 40 1 0 0 0 0 26 27 1 0 0 0 0 26 41 1 0 0 0 0 27 28 1 0 0 0 0 M END > (538) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 45 > (538) PDGFR-beta > (538) 3100 > (538) -1 > (538) P > (538) PDGFR-P536 $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7l csChFnd70/05150717532D 57 60 0 0 0 0 0 0 0 0999 V2000 1.2234 15.5673 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7163 12.9644 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3154 13.7895 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7784 16.5035 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3653 15.5901 -0.0179 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7781 18.3380 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3277 19.2013 -0.0006 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9499 18.2148 -0.0214 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3335 18.9761 -0.0303 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2466 13.8621 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9180 16.4681 -0.0285 N 0 0 3 0 0 0 0 0 0 0 0 0 7.5497 15.4963 -0.0487 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3643 21.1217 0.0072 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4309 23.8134 1.5737 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3970 22.0233 1.5754 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3738 22.0366 -1.5534 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4078 23.8267 -1.5369 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4333 24.7127 0.0222 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3940 20.8971 3.5239 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.3435 20.9272 -3.5112 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6514 11.1672 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2609 10.1589 -0.0467 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8285 8.2231 -0.0537 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5093 7.1703 -0.0755 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0768 5.2344 -0.0825 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3421 2.3741 0.1983 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9333 4.8941 1.1768 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6204 3.8553 1.0577 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0451 1.3607 0.0893 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6906 4.2235 -0.1033 N 0 0 0 0 0 0 0 0 0 0 0 0 9.2505 2.0568 1.3141 O 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.2478 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5009 13.0446 -0.0420 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5710 19.0472 0.0257 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9416 15.2615 -1.3860 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5512 16.2433 0.6114 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3703 14.2608 0.6133 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4557 24.5128 2.7864 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4152 24.5364 -2.7438 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4598 26.1126 0.0279 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5405 10.5779 -0.0188 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0029 10.4800 -1.2057 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0245 10.4668 1.1017 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0864 7.9021 1.1053 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0649 7.9152 -1.2022 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2512 7.4913 -1.2345 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2729 7.4782 1.0730 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3348 4.9133 1.0766 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3132 4.9265 -1.2310 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4451 1.8967 -0.7836 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7732 2.2043 1.4808 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3899 4.7645 2.4747 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1979 6.2561 0.9089 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1999 4.0408 -0.2177 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5189 4.2989 2.0542 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8043 0.0000 0.3852 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5787 1.4736 -1.2143 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 32 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 33 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 34 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 35 1 0 0 0 0 12 36 1 0 0 0 0 12 37 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 38 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 39 1 0 0 0 0 18 40 1 0 0 0 0 21 22 1 0 0 0 0 21 41 1 0 0 0 0 22 23 1 0 0 0 0 22 42 1 0 0 0 0 22 43 1 0 0 0 0 23 24 1 0 0 0 0 23 44 1 0 0 0 0 23 45 1 0 0 0 0 24 25 1 0 0 0 0 24 46 1 0 0 0 0 24 47 1 0 0 0 0 25 30 1 0 0 0 0 25 48 1 0 0 0 0 25 49 1 0 0 0 0 26 30 1 0 0 0 0 26 29 1 0 0 0 0 26 50 1 0 0 0 0 26 51 1 0 0 0 0 27 30 1 0 0 0 0 27 28 1 0 0 0 0 27 52 1 0 0 0 0 27 53 1 0 0 0 0 28 31 1 0 0 0 0 28 54 1 0 0 0 0 28 55 1 0 0 0 0 29 31 1 0 0 0 0 29 56 1 0 0 0 0 29 57 1 0 0 0 0 M END > (540) 1,6-naphthyridin-2(1H)-one deriv. 7l > (540) PDGFR-beta > (540) 3100 > (540) -1 > (540) P > (540) PDGFR-P538 $$$$ csChFnd70/05150717532D 40 42 0 0 0 0 0 0 0 0999 V2000 2.1116 7.7439 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1190 5.9626 -0.0263 N 0 0 0 0 0 0 0 0 0 0 0 0 2.1346 6.0489 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 3.6822 8.6279 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2187 7.6661 -0.0181 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7401 10.4427 0.0103 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8743 10.2093 -0.0214 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2716 10.9132 -0.0316 O 0 0 0 0 0 0 0 0 0 0 0 0 6.7807 8.4819 -0.0293 N 0 0 3 0 0 0 0 0 0 0 0 0 8.3628 7.4636 -0.0492 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3046 11.2456 -0.0009 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4086 13.1458 0.0082 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4350 14.0533 -1.5372 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5315 15.8245 -1.5196 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6026 16.6990 0.0254 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5775 15.8072 1.5619 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4732 14.0362 1.5624 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4325 12.9198 3.4923 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.3474 12.9582 -3.4775 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.6065 5.1855 -0.0161 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5570 3.4129 -0.0257 N 0 0 3 0 0 0 0 0 0 0 0 0 1.9017 2.5180 -0.0154 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2315 2.3590 -1.8559 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1314 0.7248 0.7554 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9094 8.4358 0.0214 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5681 11.1846 0.0250 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7426 7.2172 -1.3741 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3802 8.1691 0.6043 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1429 6.2466 0.6072 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5520 16.5284 -2.7148 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6785 18.0841 0.0321 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6339 16.4974 2.7639 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6180 2.7601 -0.0394 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9841 3.2428 0.7545 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.6931 -1.8482 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0679 3.6365 -2.4050 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1491 1.6342 -2.6258 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6089 0.8381 2.0665 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8999 0.0589 0.7631 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0490 0.0000 -0.0145 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 25 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 26 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 27 1 0 0 0 0 10 28 1 0 0 0 0 10 29 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 30 1 0 0 0 0 15 16 1 0 0 0 0 15 31 1 0 0 0 0 16 17 2 0 0 0 0 16 32 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 33 1 0 0 0 0 22 23 1 0 0 0 0 22 24 1 0 0 0 0 22 34 1 0 0 0 0 23 35 1 0 0 0 0 23 36 1 0 0 0 0 23 37 1 0 0 0 0 24 38 1 0 0 0 0 24 39 1 0 0 0 0 24 40 1 0 0 0 0 M END > (545) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 23 > (545) PDGFR-beta > (545) 3200 > (545) -1 > (545) P > (545) PDGFR-P543 $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7m csChFnd70/05150717532D 48 51 0 0 0 0 0 0 0 0999 V2000 1.2234 14.0011 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7163 11.3982 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3154 12.2233 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7784 14.9373 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3653 14.0239 -0.0179 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7781 16.7718 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3277 17.6351 -0.0006 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9499 16.6485 -0.0214 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3335 17.4099 -0.0303 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2466 12.2959 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9180 14.9019 -0.0285 N 0 0 3 0 0 0 0 0 0 0 0 0 7.5497 13.9301 -0.0487 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3643 19.5555 0.0072 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4309 22.2472 1.5737 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3970 20.4571 1.5754 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3738 20.4704 -1.5534 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4078 22.2605 -1.5369 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4333 23.1465 0.0222 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3940 19.3308 3.5239 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.3435 19.3609 -3.5112 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6514 9.6009 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2609 8.5927 -0.0467 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8285 6.6569 -0.0537 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5093 5.6041 -0.0755 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8813 2.7287 1.3234 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4985 1.1224 -0.9348 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8523 2.7309 -1.5141 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5247 1.1587 0.8034 N 0 0 0 0 0 0 0 0 0 0 0 0 5.0952 3.7504 -0.0822 N 0 0 3 0 0 0 0 0 0 0 0 0 0.0000 14.6816 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5009 11.4784 -0.0420 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5710 17.4810 0.0257 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9416 13.6953 -1.3860 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5512 14.6771 0.6114 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3703 12.6946 0.6133 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4557 22.9466 2.7864 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4152 22.9702 -2.7438 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4598 24.5464 0.0279 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5405 9.0117 -0.0188 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0029 8.9138 -1.2057 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0245 8.9006 1.1017 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0864 6.3359 1.1053 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0649 6.3490 -1.2022 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2512 5.9250 -1.2345 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2729 5.9120 1.0730 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9825 3.1434 2.6568 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2387 0.0000 -1.7306 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9294 3.1383 -2.8515 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 30 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 31 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 32 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 33 1 0 0 0 0 12 34 1 0 0 0 0 12 35 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 36 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 37 1 0 0 0 0 18 38 1 0 0 0 0 21 22 1 0 0 0 0 21 39 1 0 0 0 0 22 23 1 0 0 0 0 22 40 1 0 0 0 0 22 41 1 0 0 0 0 23 24 1 0 0 0 0 23 42 1 0 0 0 0 23 43 1 0 0 0 0 24 29 1 0 0 0 0 24 44 1 0 0 0 0 24 45 1 0 0 0 0 25 29 1 0 0 0 0 25 28 2 0 0 0 0 25 46 1 0 0 0 0 26 28 1 0 0 0 0 26 27 2 0 0 0 0 26 47 1 0 0 0 0 27 29 1 0 0 0 0 27 48 1 0 0 0 0 M END > (548) 1,6-naphthyridin-2(1H)-one deriv. 7m > (548) PDGFR-beta > (548) 3200 > (548) -1 > (548) P > (548) PDGFR-P546 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 41 csChFnd70/05150717532D 68 70 0 0 0 0 0 0 0 0999 V2000 1.3987 10.2160 0.5064 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9279 8.6170 0.3524 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2055 8.7112 0.4237 N 0 0 0 0 0 0 0 0 0 0 0 0 4.9312 10.0038 0.3593 N 0 0 0 0 0 0 0 0 0 0 0 0 2.3990 11.7394 0.5180 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2331 11.5917 0.4404 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6359 13.3916 0.6033 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5354 14.5764 0.5278 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7233 14.8227 0.6078 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2207 13.0131 0.4485 N 0 0 0 0 0 0 0 0 0 0 0 0 1.9891 16.5979 0.6954 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0193 19.0390 2.3721 C 0 0 0 0 0 0 0 0 0 0 0 0 0.6170 19.9149 0.8589 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7037 17.3848 2.2993 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5878 17.4909 -0.8261 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9039 19.1446 -0.7358 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2070 16.2874 4.2000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 1.9475 16.5267 -2.8288 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.6202 5.4347 0.2586 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7850 3.8308 0.1592 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6600 2.1960 0.1493 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3769 1.4447 -2.8869 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5164 2.2210 -1.3744 N 0 0 0 0 0 0 0 0 0 0 0 0 0.8654 1.3450 -1.0037 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6973 7.0002 0.2681 N 0 0 3 0 0 0 0 0 0 0 0 0 5.8656 3.9004 -1.5038 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9939 3.7927 1.7325 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6195 16.0128 0.5326 N 0 0 3 0 0 0 0 0 0 0 0 0 7.3530 15.7999 0.4568 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9668 14.3491 0.3842 O 0 0 0 0 0 0 0 0 0 0 0 0 8.4061 17.1952 0.4615 N 0 0 3 0 0 0 0 0 0 0 0 0 10.2904 16.9638 0.3791 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7671 16.0090 -1.2941 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1767 18.7393 0.4031 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8953 15.9014 1.9424 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 10.2770 0.5580 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2444 13.5419 0.6629 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7981 19.6499 3.6132 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0822 21.2080 0.9226 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5921 19.8373 -1.9128 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7589 5.4619 -0.8622 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8504 5.3852 1.4434 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4904 1.0529 0.0966 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8770 2.1556 1.3258 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6146 0.0728 -2.6411 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5474 1.5830 -4.0235 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6069 2.1021 -3.1183 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2125 2.0023 0.0642 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0435 1.3823 -2.1533 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1155 0.0000 -0.6466 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9506 6.9018 0.2152 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8408 4.9177 -1.3901 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5048 2.6550 -1.7029 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0212 4.1777 -2.6034 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2287 3.8921 2.9173 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7191 2.5790 1.7403 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8951 4.8797 1.6609 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1299 17.1703 0.5906 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9164 18.3527 0.5195 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3362 16.7660 -2.4078 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1691 15.8369 -1.3553 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1358 14.7441 -1.3112 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8371 19.4195 1.5952 H 0 0 0 0 0 0 0 0 0 0 0 0 12.5786 18.5671 0.3418 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7457 19.4963 -0.7105 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2641 14.6364 1.9253 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2974 15.7291 1.8810 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5558 16.5815 3.1344 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 36 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 25 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 37 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 28 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 38 1 0 0 0 0 13 16 1 0 0 0 0 13 39 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 40 1 0 0 0 0 19 25 1 0 0 0 0 19 20 1 0 0 0 0 19 41 1 0 0 0 0 19 42 1 0 0 0 0 20 21 1 0 0 0 0 20 26 1 0 0 0 0 20 27 1 0 0 0 0 21 23 1 0 0 0 0 21 43 1 0 0 0 0 21 44 1 0 0 0 0 22 23 1 0 0 0 0 22 45 1 0 0 0 0 22 46 1 0 0 0 0 22 47 1 0 0 0 0 23 24 1 0 0 0 0 24 48 1 0 0 0 0 24 49 1 0 0 0 0 24 50 1 0 0 0 0 25 51 1 0 0 0 0 26 52 1 0 0 0 0 26 53 1 0 0 0 0 26 54 1 0 0 0 0 27 55 1 0 0 0 0 27 56 1 0 0 0 0 27 57 1 0 0 0 0 28 29 1 0 0 0 0 28 58 1 0 0 0 0 29 31 1 0 0 0 0 29 30 2 0 0 0 0 31 32 1 0 0 0 0 31 59 1 0 0 0 0 32 33 1 0 0 0 0 32 34 1 0 0 0 0 32 35 1 0 0 0 0 33 60 1 0 0 0 0 33 61 1 0 0 0 0 33 62 1 0 0 0 0 34 63 1 0 0 0 0 34 64 1 0 0 0 0 34 65 1 0 0 0 0 35 66 1 0 0 0 0 35 67 1 0 0 0 0 35 68 1 0 0 0 0 M END > (549) 6-arylpyrido[2,3-d]pyrimidine deriv. 41 > (549) PDGFR-beta > (549) 3200 > (549) -1 > (549) P > (549) PDGFR-P547 $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7a csChFnd70/05150717532D 32 34 0 0 0 0 0 0 0 0999 V2000 1.0846 4.4926 0.0107 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4080 2.1851 -0.0144 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8257 2.9166 -0.0239 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4631 5.3225 0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8699 4.5128 -0.0157 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4628 6.9489 0.0101 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8366 7.7142 0.0006 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2747 6.8396 -0.0178 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5013 7.5146 -0.0258 O 0 0 0 0 0 0 0 0 0 0 0 0 2.3506 0.5918 -0.0218 N 0 0 0 0 0 0 0 0 0 0 0 0 1.1052 2.9809 0.0023 N 0 0 0 0 0 0 0 0 0 0 0 0 5.2464 5.2911 -0.0253 N 0 0 3 0 0 0 0 0 0 0 0 0 6.6930 4.4296 -0.0431 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8690 9.4167 0.0082 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9277 11.8024 1.3977 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8976 10.2153 1.3986 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8779 10.2282 -1.3750 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9081 11.8152 -1.3599 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9297 12.6002 0.0224 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8946 9.2165 3.1258 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.8514 9.2452 -3.1112 Cl 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.0959 0.0294 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8766 2.2562 -0.0375 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3927 7.5776 0.0232 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3657 0.0694 -0.0149 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2953 0.0000 -0.0340 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0404 4.2214 -1.2285 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5807 5.0919 0.5421 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5338 3.3343 0.5440 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9495 12.4220 2.4729 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9153 12.4446 -2.4296 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9532 13.8412 0.0280 H 0 0 0 0 0 0 0 0 0 0 0 0 1 11 1 0 0 0 0 1 4 2 0 0 0 0 1 22 1 0 0 0 0 2 11 2 0 0 0 0 2 3 1 0 0 0 0 2 10 1 0 0 0 0 3 5 2 0 0 0 0 3 23 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 12 1 0 0 0 0 6 7 2 0 0 0 0 6 24 1 0 0 0 0 7 8 1 0 0 0 0 7 14 1 0 0 0 0 8 12 1 0 0 0 0 8 9 2 0 0 0 0 10 25 1 0 0 0 0 10 26 1 0 0 0 0 12 13 1 0 0 0 0 13 27 1 0 0 0 0 13 28 1 0 0 0 0 13 29 1 0 0 0 0 14 16 1 0 0 0 0 14 17 2 0 0 0 0 15 16 2 0 0 0 0 15 19 1 0 0 0 0 15 30 1 0 0 0 0 16 20 1 0 0 0 0 17 18 1 0 0 0 0 17 21 1 0 0 0 0 18 19 2 0 0 0 0 18 31 1 0 0 0 0 19 32 1 0 0 0 0 M END > (563) 1,6-naphthyridin-2(1H)-one deriv. 7a > (563) PDGFR-beta > (563) 3600 > (563) -1 > (563) P > (563) PDGFR-P561 $$$$ 1,6-naphthyridin 20 csChFnd70/05150717532D 83 86 0 0 0 0 0 0 0 0999 V2000 1.2227 15.9678 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7133 13.3587 -0.0163 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3127 14.1631 -0.0272 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7815 16.9023 0.0021 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3766 15.9815 -0.0181 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8075 18.7250 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9353 18.5429 -0.0203 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4041 19.5453 -0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2458 14.2655 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8820 16.8372 -0.0284 N 0 0 0 0 0 0 0 0 0 0 0 0 4.5050 21.4648 0.0078 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6346 24.2205 -1.1645 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5378 22.4271 -1.1759 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5617 22.3107 1.2041 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6525 24.1045 1.2085 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6930 25.0584 0.0237 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6915 25.1601 -2.3185 O 0 0 0 0 0 0 0 0 0 0 0 0 2.8534 27.0035 -2.2340 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6822 24.9304 2.3752 O 0 0 0 0 0 0 0 0 0 0 0 0 6.7140 26.7813 2.3068 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5317 19.3740 -0.0323 N 0 0 3 0 0 0 0 0 0 0 0 0 9.0052 18.4353 -0.0520 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9363 16.8608 -0.0592 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5549 19.2421 -0.0635 N 0 0 3 0 0 0 0 0 0 0 0 0 12.1565 18.2217 -0.0850 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1953 17.0861 -1.7107 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7189 19.4437 -0.0946 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2282 17.0698 1.5280 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6343 11.5584 -0.0258 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2359 10.5379 -0.0467 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7884 8.6055 -0.0534 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4609 7.5397 -0.0752 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0134 5.6073 -0.0820 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9454 1.7054 0.0649 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2566 2.7382 0.1989 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8687 5.2478 1.1730 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5574 4.2151 1.0392 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6193 4.5840 -0.1029 N 0 0 0 0 0 0 0 0 0 0 0 0 9.1947 2.3694 1.3408 N 0 0 0 0 0 0 0 0 0 0 0 0 10.8007 1.3459 1.3199 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.6496 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4914 13.4075 -0.0421 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6179 19.4630 0.0259 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7138 21.7757 -2.1017 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3086 21.5689 2.1271 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7665 26.4565 0.0297 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0349 27.5942 -3.2229 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4488 27.4538 -0.9572 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2001 27.3689 -2.4574 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1702 27.1980 1.0358 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4117 27.2833 2.5275 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5844 27.2747 3.3046 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5866 20.6302 -0.0264 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6098 20.4984 -0.0578 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1443 17.9068 -2.8599 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3870 16.3269 -1.7266 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0824 16.2156 -1.7038 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6913 20.2526 1.0635 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9105 18.6845 -0.1106 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6678 20.2644 -1.2437 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1151 16.1991 1.5349 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4198 16.3105 1.5121 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2005 17.8787 2.6862 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5189 10.9780 -0.0187 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9802 10.8530 -1.2056 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0019 10.8398 1.1018 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0440 8.2904 1.1055 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0225 8.3035 -1.2019 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2053 7.8548 -1.2341 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2269 7.8417 1.0731 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2690 5.2922 1.0770 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2475 5.3054 -1.2304 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6856 0.3411 0.3254 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4809 1.8440 -1.2353 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3413 2.2728 -0.7717 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7028 2.5712 1.4881 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3331 5.1094 2.4733 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1285 6.6121 0.9125 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1112 4.3821 -0.2501 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4728 4.6804 2.0098 H 0 0 0 0 0 0 0 0 0 0 0 0 11.3856 1.4136 0.0355 H 0 0 0 0 0 0 0 0 0 0 0 0 11.7023 1.8650 2.2762 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5055 0.0000 1.6329 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 41 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 29 1 0 0 0 0 3 5 2 0 0 0 0 3 42 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 43 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 21 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 17 1 0 0 0 0 13 44 1 0 0 0 0 14 15 1 0 0 0 0 14 45 1 0 0 0 0 15 16 2 0 0 0 0 15 19 1 0 0 0 0 16 46 1 0 0 0 0 17 18 1 0 0 0 0 18 47 1 0 0 0 0 18 48 1 0 0 0 0 18 49 1 0 0 0 0 19 20 1 0 0 0 0 20 50 1 0 0 0 0 20 51 1 0 0 0 0 20 52 1 0 0 0 0 21 22 1 0 0 0 0 21 53 1 0 0 0 0 22 23 2 0 0 0 0 22 24 1 0 0 0 0 24 25 1 0 0 0 0 24 54 1 0 0 0 0 25 26 1 0 0 0 0 25 27 1 0 0 0 0 25 28 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 26 57 1 0 0 0 0 27 58 1 0 0 0 0 27 59 1 0 0 0 0 27 60 1 0 0 0 0 28 61 1 0 0 0 0 28 62 1 0 0 0 0 28 63 1 0 0 0 0 29 30 1 0 0 0 0 29 64 1 0 0 0 0 30 31 1 0 0 0 0 30 65 1 0 0 0 0 30 66 1 0 0 0 0 31 32 1 0 0 0 0 31 67 1 0 0 0 0 31 68 1 0 0 0 0 32 33 1 0 0 0 0 32 69 1 0 0 0 0 32 70 1 0 0 0 0 33 38 1 0 0 0 0 33 71 1 0 0 0 0 33 72 1 0 0 0 0 34 39 1 0 0 0 0 34 35 1 0 0 0 0 34 73 1 0 0 0 0 34 74 1 0 0 0 0 35 38 1 0 0 0 0 35 75 1 0 0 0 0 35 76 1 0 0 0 0 36 38 1 0 0 0 0 36 37 1 0 0 0 0 36 77 1 0 0 0 0 36 78 1 0 0 0 0 37 39 1 0 0 0 0 37 79 1 0 0 0 0 37 80 1 0 0 0 0 39 40 1 0 0 0 0 40 81 1 0 0 0 0 40 82 1 0 0 0 0 40 83 1 0 0 0 0 M END > (564) 1,6-naphthyridine 20 > (564) PDGFR-beta > (564) 3600 > (564) -1 > (564) P > (564) PDGFR-P562 $$$$ Structure114 csChFnd70/05150717532D 62 65 0 0 0 0 0 0 0 0999 V2000 7.2326 5.8706 -1.0128 N 0 0 0 0 0 0 0 0 0 0 0 0 7.2003 4.3669 -0.2013 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5350 3.3084 -0.1863 N 0 0 0 0 0 0 0 0 0 0 0 0 9.9802 3.7223 -0.9985 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0634 5.3101 -1.8761 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6147 6.3862 -1.8532 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3692 2.6333 -0.9902 N 0 0 3 0 0 0 0 0 0 0 0 0 12.8314 3.0594 -1.8166 C 0 0 0 0 0 0 0 0 0 0 0 0 12.9604 4.6968 -2.7395 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5813 5.7923 -2.7539 C 0 0 0 0 0 0 0 0 0 0 0 0 14.5695 5.1645 -3.6477 C 0 0 0 0 0 0 0 0 0 0 0 0 15.8590 6.0705 -2.7882 C 0 0 0 0 0 0 0 0 0 0 0 0 17.3561 6.5020 -3.6421 C 0 0 0 0 0 0 0 0 0 0 0 0 17.5786 6.0386 -5.3458 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3050 5.1410 -6.2053 C 0 0 0 0 0 0 0 0 0 0 0 0 14.8050 4.6944 -5.3640 C 0 0 0 0 0 0 0 0 0 0 0 0 14.0525 2.0774 -1.7968 O 0 0 0 0 0 0 0 0 0 0 0 0 15.5818 6.6547 -0.6505 Cl 0 0 0 0 0 0 0 0 0 0 0 0 11.2613 0.9908 -0.0725 C 0 0 0 0 0 0 0 0 0 0 0 0 13.2083 3.5679 -6.4450 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.7197 3.8899 0.6589 N 0 0 3 0 0 0 0 0 0 0 0 0 4.3443 5.0414 0.7882 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6643 4.4319 0.7896 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3052 5.5700 0.9180 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6127 7.3162 1.0447 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2886 7.9325 1.0441 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6557 6.7948 0.9229 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5889 9.6503 1.1682 O 0 0 0 0 0 0 0 0 0 0 0 0 2.1193 10.7474 1.2956 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7082 12.6210 1.4234 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5611 13.1245 -0.1860 N 0 0 0 0 0 0 0 0 0 0 0 0 3.7027 15.0043 -0.3180 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1134 15.5024 -2.1774 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2571 12.3051 -0.3388 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3296 12.7138 1.2602 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6304 7.6109 -2.5092 H 0 0 0 0 0 0 0 0 0 0 0 0 11.6517 7.0058 -3.4267 H 0 0 0 0 0 0 0 0 0 0 0 0 18.3552 7.2032 -2.9785 H 0 0 0 0 0 0 0 0 0 0 0 0 18.7514 6.3795 -6.0077 H 0 0 0 0 0 0 0 0 0 0 0 0 16.4862 4.7837 -7.5357 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7838 0.0000 -0.9423 H 0 0 0 0 0 0 0 0 0 0 0 0 12.5341 0.6306 0.3925 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3856 1.1197 1.0150 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6347 2.7562 1.1732 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4204 3.0678 0.6898 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.0940 0.9189 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5475 8.2027 1.1440 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9605 7.2719 0.9221 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3160 10.5866 0.1574 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3819 10.4101 2.4395 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5961 13.4467 1.6412 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6073 12.7565 2.4910 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4894 15.5926 0.0664 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7287 15.4561 0.5242 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3196 16.8871 -2.2558 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2722 14.8328 -2.5956 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0407 15.1419 -3.0056 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0970 10.9168 -0.4519 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9117 12.7946 -1.4782 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6234 12.1977 1.0996 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3990 14.1034 1.4339 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7304 12.1313 2.3862 H 0 0 0 0 0 0 0 0 0 0 0 0 1 6 1 0 0 0 0 1 2 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 4 2 0 0 0 0 4 7 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 5 6 2 0 0 0 0 6 36 1 0 0 0 0 7 8 1 0 0 0 0 7 19 1 0 0 0 0 8 9 1 0 0 0 0 8 17 2 0 0 0 0 9 11 1 0 0 0 0 9 10 2 0 0 0 0 10 37 1 0 0 0 0 11 12 2 0 0 0 0 11 16 1 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 38 1 0 0 0 0 14 15 1 0 0 0 0 14 39 1 0 0 0 0 15 16 2 0 0 0 0 15 40 1 0 0 0 0 16 20 1 0 0 0 0 19 41 1 0 0 0 0 19 42 1 0 0 0 0 19 43 1 0 0 0 0 21 22 1 0 0 0 0 21 44 1 0 0 0 0 22 23 2 0 0 0 0 22 27 1 0 0 0 0 23 24 1 0 0 0 0 23 45 1 0 0 0 0 24 25 2 0 0 0 0 24 46 1 0 0 0 0 25 26 1 0 0 0 0 25 47 1 0 0 0 0 26 27 2 0 0 0 0 26 28 1 0 0 0 0 27 48 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 29 49 1 0 0 0 0 29 50 1 0 0 0 0 30 31 1 0 0 0 0 30 51 1 0 0 0 0 30 52 1 0 0 0 0 31 32 1 0 0 0 0 31 34 1 0 0 0 0 32 33 1 0 0 0 0 32 53 1 0 0 0 0 32 54 1 0 0 0 0 33 55 1 0 0 0 0 33 56 1 0 0 0 0 33 57 1 0 0 0 0 34 35 1 0 0 0 0 34 58 1 0 0 0 0 34 59 1 0 0 0 0 35 60 1 0 0 0 0 35 61 1 0 0 0 0 35 62 1 0 0 0 0 M END > (574) 17964795-7 > (574) PDGFR-beta > (574) 3990 > (574) -1 > (574) P > (574) PDGFR-P572 $$$$ csChFnd70/05150717532D 37 39 0 0 0 0 0 0 0 0999 V2000 1.2022 7.8332 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2096 6.0519 -0.0263 N 0 0 0 0 0 0 0 0 0 0 0 0 1.2252 6.1382 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 2.7728 8.7173 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3093 7.7555 -0.0181 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8308 10.5320 0.0103 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9649 10.2987 -0.0214 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3623 11.0025 -0.0316 O 0 0 0 0 0 0 0 0 0 0 0 0 5.8713 8.5712 -0.0293 N 0 0 3 0 0 0 0 0 0 0 0 0 7.4535 7.5529 -0.0492 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3952 11.3350 -0.0009 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4992 13.2352 0.0082 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5256 14.1426 -1.5372 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6222 15.9139 -1.5196 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6932 16.7883 0.0254 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6682 15.8965 1.5619 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5639 14.1255 1.5624 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5232 13.0091 3.4923 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.4380 13.0475 -3.4775 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6972 5.2748 -0.0161 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6476 3.5022 -0.0257 N 0 0 3 0 0 0 0 0 0 0 0 0 0.9924 2.6073 -0.0154 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2973 0.6659 -0.0293 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 8.5251 0.0214 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6587 11.2739 0.0250 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8333 7.3065 -1.3741 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4709 8.2585 0.6043 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2336 6.3359 0.6072 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6426 16.6177 -2.7148 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7691 18.1734 0.0321 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7246 16.5868 2.7639 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7087 2.8494 -0.0394 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2787 2.9594 1.1365 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2574 2.9723 -1.1496 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0109 0.3138 -1.1812 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0323 0.3008 1.1049 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0658 0.0000 -0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 24 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 25 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 26 1 0 0 0 0 10 27 1 0 0 0 0 10 28 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 29 1 0 0 0 0 15 16 1 0 0 0 0 15 30 1 0 0 0 0 16 17 2 0 0 0 0 16 31 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 32 1 0 0 0 0 22 23 1 0 0 0 0 22 33 1 0 0 0 0 22 34 1 0 0 0 0 23 35 1 0 0 0 0 23 36 1 0 0 0 0 23 37 1 0 0 0 0 M END > (575) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 22 > (575) PDGFR-beta > (575) 4000 > (575) -1 > (575) P > (575) PDGFR-P573 $$$$ 1,6-naphthyridin 35 csChFnd70/05150717532D 56 58 0 0 0 0 0 0 0 0999 V2000 1.2040 15.2435 -2.1470 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6303 12.6328 -1.6936 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2457 13.3568 -1.9772 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7815 16.0959 -2.4556 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3521 15.1328 -2.3703 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8500 17.8781 -2.8476 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9684 17.5772 -3.0280 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4619 18.6181 -3.1351 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1868 13.5775 -1.7848 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8752 15.9104 -2.6590 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6066 20.4909 -3.5534 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9299 23.4505 -2.6237 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7950 21.7073 -2.2253 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5627 21.0435 -5.2774 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6989 22.7903 -5.6587 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8786 23.9906 -4.3353 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5093 10.8751 -1.3034 N 0 0 3 0 0 0 0 0 0 0 0 0 4.0840 9.8140 -1.1973 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5920 7.9416 -0.7530 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3380 19.5390 -6.9401 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.8590 21.0320 -0.0762 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.5759 18.3251 -3.3168 N 0 0 0 0 0 0 0 0 0 0 0 0 5.2365 6.8334 -0.6422 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7445 4.9610 -0.1981 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3236 3.8971 -0.0916 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4155 4.4393 1.3747 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2430 3.6948 1.1502 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8918 2.0433 0.0265 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3552 1.3731 -1.7646 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 15.9597 -2.2015 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4046 12.5718 -1.8983 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6794 18.6461 -2.9225 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0758 24.3936 -1.5966 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6656 23.2198 -6.9928 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9845 25.3550 -4.6401 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3823 10.3510 -1.1014 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7566 9.8422 -2.4418 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9335 10.3300 -0.1901 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9193 7.9132 0.4915 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7425 7.4256 -1.7602 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6187 17.6228 -3.2466 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6598 19.5516 -3.5894 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9092 6.8618 -1.8869 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0860 7.3494 0.3649 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0719 4.9327 1.0464 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8950 4.4450 -1.2052 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4834 5.8521 1.4153 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8557 3.9593 2.5824 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1986 2.2870 1.2847 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7347 4.0306 -0.1335 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0977 4.2364 2.1392 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0225 1.3237 0.4801 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8230 1.8651 0.9365 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4274 1.5426 -2.6722 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0257 0.0000 -1.6750 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2304 2.0993 -2.2223 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 30 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 17 1 0 0 0 0 3 5 2 0 0 0 0 3 31 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 32 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 22 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 33 1 0 0 0 0 13 21 1 0 0 0 0 14 15 1 0 0 0 0 14 20 1 0 0 0 0 15 16 2 0 0 0 0 15 34 1 0 0 0 0 16 35 1 0 0 0 0 17 18 1 0 0 0 0 17 36 1 0 0 0 0 18 19 1 0 0 0 0 18 37 1 0 0 0 0 18 38 1 0 0 0 0 19 23 1 0 0 0 0 19 39 1 0 0 0 0 19 40 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 24 1 0 0 0 0 23 43 1 0 0 0 0 23 44 1 0 0 0 0 24 25 1 0 0 0 0 24 45 1 0 0 0 0 24 46 1 0 0 0 0 25 28 1 0 0 0 0 25 26 1 0 0 0 0 26 27 1 0 0 0 0 26 47 1 0 0 0 0 26 48 1 0 0 0 0 27 49 1 0 0 0 0 27 50 1 0 0 0 0 27 51 1 0 0 0 0 28 29 1 0 0 0 0 28 52 1 0 0 0 0 28 53 1 0 0 0 0 29 54 1 0 0 0 0 29 55 1 0 0 0 0 29 56 1 0 0 0 0 M END > (578) 1,6-naphthyridine 35 > (578) PDGFR-beta > (578) 4000 > (578) -1 > (578) P > (578) PDGFR-P576 $$$$ Structure119 csChFnd70/05150717532D 62 65 0 0 0 0 0 0 0 0999 V2000 11.9058 10.7882 -1.0926 N 0 0 0 0 0 0 0 0 0 0 0 0 13.0094 11.7356 -1.9851 C 0 0 0 0 0 0 0 0 0 0 0 0 14.5512 11.1677 -2.4250 N 0 0 0 0 0 0 0 0 0 0 0 0 15.0570 9.6003 -1.9800 C 0 0 0 0 0 0 0 0 0 0 0 0 13.9195 8.5550 -1.0305 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3002 9.2159 -0.5962 C 0 0 0 0 0 0 0 0 0 0 0 0 16.6524 9.0016 -2.4296 N 0 0 3 0 0 0 0 0 0 0 0 0 17.1589 7.4112 -1.9743 C 0 0 0 0 0 0 0 0 0 0 0 0 16.0102 6.2940 -0.9893 C 0 0 0 0 0 0 0 0 0 0 0 0 14.4152 6.8799 -0.5357 C 0 0 0 0 0 0 0 0 0 0 0 0 16.5687 4.5451 -0.4883 C 0 0 0 0 0 0 0 0 0 0 0 0 16.2494 3.1534 -1.5719 C 0 0 0 0 0 0 0 0 0 0 0 0 16.7740 1.5266 -1.0977 C 0 0 0 0 0 0 0 0 0 0 0 0 17.6136 1.2748 0.4479 C 0 0 0 0 0 0 0 0 0 0 0 0 17.9335 2.6488 1.5281 C 0 0 0 0 0 0 0 0 0 0 0 0 17.4227 4.2835 1.0654 C 0 0 0 0 0 0 0 0 0 0 0 0 18.5800 6.9002 -2.3831 O 0 0 0 0 0 0 0 0 0 0 0 0 15.1946 3.4665 -3.5113 Cl 0 0 0 0 0 0 0 0 0 0 0 0 17.8167 10.1032 -3.4156 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8255 6.0061 2.4229 Cl 0 0 0 0 0 0 0 0 0 0 0 0 12.5305 13.3730 -2.4727 N 0 0 3 0 0 0 0 0 0 0 0 0 10.8623 13.9579 -2.1423 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5773 15.6792 -1.7713 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9315 16.2550 -1.4455 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5632 15.1147 -1.4892 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8468 13.3951 -1.8597 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4908 12.8186 -2.1929 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9431 15.6827 -1.1677 O 0 0 0 0 0 0 0 0 0 0 0 0 2.8787 15.3105 -0.8411 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4782 16.5534 -2.2031 N 0 0 0 0 0 0 0 0 0 0 0 0 2.1717 15.6796 -3.8470 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2709 16.9860 -5.3118 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0043 17.6297 -1.7242 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5730 18.9696 -0.4040 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5954 14.4384 -1.2342 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3955 8.4541 0.1286 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5497 6.0752 0.1906 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5277 0.4484 -1.9350 H 0 0 0 0 0 0 0 0 0 0 0 0 18.0206 0.0000 0.8129 H 0 0 0 0 0 0 0 0 0 0 0 0 18.5893 2.4435 2.7332 H 0 0 0 0 0 0 0 0 0 0 0 0 18.6027 10.8570 -2.5357 H 0 0 0 0 0 0 0 0 0 0 0 0 18.6449 9.3080 -4.2168 H 0 0 0 0 0 0 0 0 0 0 0 0 17.0687 10.9642 -4.2276 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3501 14.1176 -3.0439 H 0 0 0 0 0 0 0 0 0 0 0 0 11.6425 16.5672 -1.7368 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7098 17.5936 -1.1564 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7809 12.5081 -1.8930 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7114 11.4799 -2.4815 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9640 15.9761 0.3876 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8677 14.3440 -0.7791 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1436 14.6899 -4.0379 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9019 15.0900 -3.8327 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3149 17.9884 -5.1085 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5483 17.5584 -5.3410 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0200 16.3420 -6.5294 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5097 18.2770 -2.8629 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.8264 -1.1710 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9500 18.3263 0.7809 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6610 19.6909 -0.9100 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5131 19.8461 -0.1424 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5480 13.8696 -2.5126 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8377 13.4368 -0.2864 H 0 0 0 0 0 0 0 0 0 0 0 0 1 6 1 0 0 0 0 1 2 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 4 2 0 0 0 0 4 7 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 5 6 2 0 0 0 0 6 36 1 0 0 0 0 7 8 1 0 0 0 0 7 19 1 0 0 0 0 8 9 1 0 0 0 0 8 17 2 0 0 0 0 9 11 1 0 0 0 0 9 10 2 0 0 0 0 10 37 1 0 0 0 0 11 12 2 0 0 0 0 11 16 1 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 38 1 0 0 0 0 14 15 1 0 0 0 0 14 39 1 0 0 0 0 15 16 2 0 0 0 0 15 40 1 0 0 0 0 16 20 1 0 0 0 0 19 41 1 0 0 0 0 19 42 1 0 0 0 0 19 43 1 0 0 0 0 21 22 1 0 0 0 0 21 44 1 0 0 0 0 22 23 2 0 0 0 0 22 27 1 0 0 0 0 23 24 1 0 0 0 0 23 45 1 0 0 0 0 24 25 2 0 0 0 0 24 46 1 0 0 0 0 25 26 1 0 0 0 0 25 28 1 0 0 0 0 26 27 2 0 0 0 0 26 47 1 0 0 0 0 27 48 1 0 0 0 0 28 35 1 0 0 0 0 29 30 1 0 0 0 0 29 35 1 0 0 0 0 29 49 1 0 0 0 0 29 50 1 0 0 0 0 30 31 1 0 0 0 0 30 33 1 0 0 0 0 31 32 1 0 0 0 0 31 51 1 0 0 0 0 31 52 1 0 0 0 0 32 53 1 0 0 0 0 32 54 1 0 0 0 0 32 55 1 0 0 0 0 33 34 1 0 0 0 0 33 56 1 0 0 0 0 33 57 1 0 0 0 0 34 58 1 0 0 0 0 34 59 1 0 0 0 0 34 60 1 0 0 0 0 35 61 1 0 0 0 0 35 62 1 0 0 0 0 M END > (583) 17964795-21 > (583) PDGFR-beta > (583) 4020 > (583) -1 > (583) P > (583) PDGFR-P581 $$$$ Structure115 csChFnd70/05150717532D 47 50 0 0 0 0 0 0 0 0999 V2000 6.1669 10.1577 -0.6065 N 0 0 0 0 0 0 0 0 0 0 0 0 7.3562 10.8963 -0.1948 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6395 10.2479 0.0253 N 0 0 0 0 0 0 0 0 0 0 0 0 8.7843 8.8082 -0.1618 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5445 7.9857 -0.5992 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2096 8.7241 -0.8181 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1096 8.1271 0.0642 N 0 0 3 0 0 0 0 0 0 0 0 0 10.2500 6.6666 -0.1269 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9856 5.7812 -0.5800 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6590 6.4515 -0.8097 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1410 4.1748 -0.7897 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5325 3.6117 -2.1605 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6760 2.1131 -2.3483 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4321 1.1710 -1.1814 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0431 1.7219 0.1801 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9026 3.2187 0.3845 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4344 6.0791 0.0794 O 0 0 0 0 0 0 0 0 0 0 0 0 9.8380 4.7922 -3.6266 Cl 0 0 0 0 0 0 0 0 0 0 0 0 11.3853 8.9972 0.5171 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4145 3.9081 2.0941 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.2503 12.3964 0.0110 N 0 0 3 0 0 0 0 0 0 0 0 0 5.8842 13.0906 -0.0886 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6220 12.3633 0.3656 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2742 13.0522 0.2656 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1801 14.4645 -0.2859 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4344 15.1914 -0.7396 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7865 14.5114 -0.6362 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7075 15.2128 -0.3935 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4034 16.0366 1.0098 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2914 16.0180 1.9960 O 0 0 0 0 0 0 0 0 0 0 0 0 0.1460 16.7910 1.1642 O 0 0 0 0 0 0 0 0 0 0 0 0 5.2378 8.1320 -1.1532 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7138 5.8174 -1.1441 H 0 0 0 0 0 0 0 0 0 0 0 0 9.9790 1.6759 -3.4088 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5453 0.0000 -1.3342 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8537 0.9805 1.0866 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4311 9.0457 1.7126 H 0 0 0 0 0 0 0 0 0 0 0 0 12.3849 8.4872 0.0999 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2889 10.1062 0.0761 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1239 12.9678 0.2245 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6947 11.2602 0.7959 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2924 12.4872 0.6181 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3572 16.2942 -1.1702 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7657 15.0797 -0.9907 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7156 15.9797 -1.3128 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8539 14.3910 -0.5667 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 17.3020 2.0838 H 0 0 0 0 0 0 0 0 0 0 0 0 1 6 1 0 0 0 0 1 2 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 4 2 0 0 0 0 4 7 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 5 6 2 0 0 0 0 6 32 1 0 0 0 0 7 8 1 0 0 0 0 7 19 1 0 0 0 0 8 9 1 0 0 0 0 8 17 2 0 0 0 0 9 11 1 0 0 0 0 9 10 2 0 0 0 0 10 33 1 0 0 0 0 11 12 2 0 0 0 0 11 16 1 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 34 1 0 0 0 0 14 15 1 0 0 0 0 14 35 1 0 0 0 0 15 16 2 0 0 0 0 15 36 1 0 0 0 0 16 20 1 0 0 0 0 19 37 1 0 0 0 0 19 38 1 0 0 0 0 19 39 1 0 0 0 0 21 22 1 0 0 0 0 21 40 1 0 0 0 0 22 23 2 0 0 0 0 22 27 1 0 0 0 0 23 24 1 0 0 0 0 23 41 1 0 0 0 0 24 25 2 0 0 0 0 24 42 1 0 0 0 0 25 26 1 0 0 0 0 25 28 1 0 0 0 0 26 27 2 0 0 0 0 26 43 1 0 0 0 0 27 44 1 0 0 0 0 28 29 1 0 0 0 0 28 45 1 0 0 0 0 28 46 1 0 0 0 0 29 30 2 0 0 0 0 29 31 1 0 0 0 0 31 47 1 0 0 0 0 M END > (586) 17964795-8 > (586) PDGFR-beta > (586) 4150 > (586) -1 > (586) P > (586) PDGFR-P584 $$$$ 3-substituted indolin-2-one 11b csChFnd70/05150717532D 41 43 0 0 0 0 0 0 0 0999 V2000 2.3699 4.6176 -0.1496 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7644 3.1788 -1.7444 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8054 4.7671 -1.5091 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5947 5.4807 -0.7053 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9721 7.1440 -0.6488 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4485 7.2859 -1.4642 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8741 5.8737 -1.9358 N 0 0 3 0 0 0 0 0 0 0 0 0 6.1625 8.4762 -1.6759 O 0 0 0 0 0 0 0 0 0 0 0 0 3.1203 8.3092 0.0242 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7388 9.8083 0.1350 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9205 11.1781 0.0466 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2672 10.1809 0.3578 N 0 0 3 0 0 0 0 0 0 0 0 0 1.2070 11.3441 -0.1849 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3996 11.7386 0.4003 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9837 12.3744 0.2129 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3433 3.0271 -0.3929 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5511 2.3192 -1.1942 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6216 14.0731 0.1918 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1331 14.5901 1.8055 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7708 16.2888 1.7844 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8910 17.0117 0.6002 O 0 0 0 0 0 0 0 0 0 0 0 0 2.3146 16.9986 3.0812 O 0 0 0 0 0 0 0 0 0 0 0 0 1.0470 2.0962 0.1929 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.7133 0.8887 O 0 0 0 0 0 0 0 0 0 0 0 0 1.0241 0.5613 -0.0433 O 0 0 0 0 0 0 0 0 0 0 0 0 1.4446 5.1716 0.4722 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6898 2.6200 -2.3615 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8123 5.6563 -2.5037 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9807 8.0718 0.4655 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1074 9.4514 0.4667 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6335 11.3635 0.9327 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9689 12.4154 -0.7965 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7794 10.3735 -0.8582 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4604 12.3700 0.5606 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5304 1.0888 -1.3822 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6421 14.7145 -0.1624 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6870 14.2920 -0.6188 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1125 13.9486 2.1598 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0675 14.3712 2.6162 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0954 18.0892 3.0108 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1508 0.0000 0.3620 H 0 0 0 0 0 0 0 0 0 0 0 0 1 16 1 0 0 0 0 1 4 2 0 0 0 0 1 26 1 0 0 0 0 2 17 1 0 0 0 0 2 3 2 0 0 0 0 2 27 1 0 0 0 0 3 7 1 0 0 0 0 3 4 1 0 0 0 0 4 5 1 0 0 0 0 5 6 1 0 0 0 0 5 9 2 0 0 0 0 6 7 1 0 0 0 0 6 8 2 0 0 0 0 7 28 1 0 0 0 0 9 10 1 0 0 0 0 9 29 1 0 0 0 0 10 11 2 0 0 0 0 10 12 1 0 0 0 0 11 15 1 0 0 0 0 11 13 1 0 0 0 0 12 14 1 0 0 0 0 12 30 1 0 0 0 0 13 31 1 0 0 0 0 13 32 1 0 0 0 0 13 33 1 0 0 0 0 14 15 2 0 0 0 0 14 34 1 0 0 0 0 15 18 1 0 0 0 0 16 17 2 0 0 0 0 16 23 1 0 0 0 0 17 35 1 0 0 0 0 18 19 1 0 0 0 0 18 36 1 0 0 0 0 18 37 1 0 0 0 0 19 20 1 0 0 0 0 19 38 1 0 0 0 0 19 39 1 0 0 0 0 20 22 1 0 0 0 0 20 21 2 0 0 0 0 22 40 1 0 0 0 0 23 25 1 0 0 0 0 23 24 2 0 0 0 0 25 41 1 0 0 0 0 M END > (587) 3-substituted indolin-2-one 11b > (587) PDGFR-beta > (587) 4190 > (587) -1 > (587) P > (587) PDGFR-P585 $$$$ csChFnd70/05150717532D 59 62 0 0 0 0 0 0 0 0999 V2000 10.5311 15.3748 0.0176 C 0 0 0 0 0 0 0 0 0 0 0 0 13.5661 13.5757 -0.0030 N 0 0 0 0 0 0 0 0 0 0 0 0 10.5536 13.6644 0.0014 N 0 0 0 0 0 0 0 0 0 0 0 0 12.1170 16.2665 0.0241 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6675 15.2950 0.0131 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1762 18.0979 0.0407 C 0 0 0 0 0 0 0 0 0 0 0 0 15.3397 17.8610 0.0346 C 0 0 0 0 0 0 0 0 0 0 0 0 16.7505 18.5707 0.0401 O 0 0 0 0 0 0 0 0 0 0 0 0 15.2444 16.1176 0.0183 N 0 0 3 0 0 0 0 0 0 0 0 0 13.7558 18.9077 0.0458 C 0 0 0 0 0 0 0 0 0 0 0 0 13.8617 20.8254 0.0625 C 0 0 0 0 0 0 0 0 0 0 0 0 13.9023 21.7465 -1.4940 C 0 0 0 0 0 0 0 0 0 0 0 0 14.0003 23.5342 -1.4693 C 0 0 0 0 0 0 0 0 0 0 0 0 14.0584 24.4116 0.0936 C 0 0 0 0 0 0 0 0 0 0 0 0 14.0192 23.5062 1.6411 C 0 0 0 0 0 0 0 0 0 0 0 0 13.9137 21.7188 1.6346 C 0 0 0 0 0 0 0 0 0 0 0 0 13.8546 20.5855 3.5782 Cl 0 0 0 0 0 0 0 0 0 0 0 0 13.8303 20.6480 -3.4569 Cl 0 0 0 0 0 0 0 0 0 0 0 0 12.0391 12.7921 -0.0085 C 0 0 0 0 0 0 0 0 0 0 0 0 11.9881 11.0017 -0.0260 N 0 0 3 0 0 0 0 0 0 0 0 0 10.4012 10.1388 0.1207 C 0 0 0 0 0 0 0 0 0 0 0 0 16.8411 15.0890 0.0067 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1288 8.5939 -0.7636 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0957 10.8205 1.1570 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5298 9.9644 1.2996 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5598 7.7445 -0.6153 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2605 8.4303 0.4121 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5502 7.4994 0.5713 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6278 6.2294 2.0929 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8914 5.2844 2.2546 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5818 3.0559 4.1423 O 0 0 0 0 0 0 0 0 0 0 0 0 3.9678 4.0334 3.7532 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2768 3.9104 4.6047 O 0 0 0 0 0 0 0 0 0 0 0 0 2.7481 1.8797 5.6024 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0506 0.8830 5.8454 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3180 16.0739 0.0198 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9935 18.8473 0.0487 H 0 0 0 0 0 0 0 0 0 0 0 0 14.0323 24.2487 -2.6731 H 0 0 0 0 0 0 0 0 0 0 0 0 14.1350 25.8095 0.1058 H 0 0 0 0 0 0 0 0 0 0 0 0 14.0653 24.1988 2.8570 H 0 0 0 0 0 0 0 0 0 0 0 0 13.0535 10.3434 -0.1400 H 0 0 0 0 0 0 0 0 0 0 0 0 17.2352 14.8460 -1.3284 H 0 0 0 0 0 0 0 0 0 0 0 0 17.8629 15.7977 0.6779 H 0 0 0 0 0 0 0 0 0 0 0 0 16.6132 13.8579 0.6619 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1429 8.0578 -1.5664 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3054 12.0185 1.8507 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5125 10.4965 2.1012 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3452 6.5462 -1.3070 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5206 8.4409 0.7956 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2874 6.7894 -0.6219 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6574 5.2879 1.8685 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8905 6.9394 3.2861 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8618 6.2259 2.4788 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6287 4.5744 1.0614 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7987 0.9676 5.3553 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0318 2.6190 6.7728 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.7951 6.0926 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7668 0.1436 4.6750 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1755 0.0000 6.9416 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 36 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 37 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 38 1 0 0 0 0 14 15 1 0 0 0 0 14 39 1 0 0 0 0 15 16 2 0 0 0 0 15 40 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 41 1 0 0 0 0 21 23 1 0 0 0 0 21 24 2 0 0 0 0 22 42 1 0 0 0 0 22 43 1 0 0 0 0 22 44 1 0 0 0 0 23 26 2 0 0 0 0 23 45 1 0 0 0 0 24 25 1 0 0 0 0 24 46 1 0 0 0 0 25 27 2 0 0 0 0 25 47 1 0 0 0 0 26 27 1 0 0 0 0 26 48 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 28 49 1 0 0 0 0 28 50 1 0 0 0 0 29 30 1 0 0 0 0 29 51 1 0 0 0 0 29 52 1 0 0 0 0 30 32 1 0 0 0 0 30 53 1 0 0 0 0 30 54 1 0 0 0 0 31 32 1 0 0 0 0 31 34 1 0 0 0 0 32 33 2 0 0 0 0 34 35 1 0 0 0 0 34 55 1 0 0 0 0 34 56 1 0 0 0 0 35 57 1 0 0 0 0 35 58 1 0 0 0 0 35 59 1 0 0 0 0 M END > (588) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 57 > (588) PDGFR-beta > (588) 4200 > (588) -1 > (588) P > (588) PDGFR-P586 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 58 csChFnd70/05150717532D 82 85 0 0 0 0 0 0 0 0999 V2000 3.9765 15.9625 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4845 13.3755 -0.0163 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9997 14.2542 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0132 14.1436 -0.0267 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5654 16.8530 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1247 15.8754 -0.0185 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6489 18.6720 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7670 18.3852 -0.0219 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2726 19.4405 -0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6553 16.6812 -0.0294 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4384 21.3552 0.0054 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6860 24.0363 1.5708 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7481 24.9331 0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5317 22.2524 1.5727 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5092 22.2663 -1.5548 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6637 24.0502 -1.5391 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4533 21.1293 3.5212 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4042 21.1608 -3.5120 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7465 10.6926 -0.0128 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0416 8.7313 -0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4228 11.5850 -0.0247 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2909 7.7992 -0.0132 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3902 19.1599 -0.0337 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8301 18.1708 -0.0528 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7069 16.5996 -0.0595 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8805 5.4308 -1.3245 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2126 3.4772 -1.2253 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2729 3.0284 -0.2240 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9409 4.9819 -0.3232 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5743 5.9161 -0.0255 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5792 2.5429 -1.5229 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8625 0.6598 -1.5351 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4069 18.9234 -0.0644 N 0 0 3 0 0 0 0 0 0 0 0 0 14.9721 17.8480 -0.0850 C 0 0 0 0 0 0 0 0 0 0 0 0 16.5758 19.0151 -0.0947 C 0 0 0 0 0 0 0 0 0 0 0 0 18.1411 17.9398 -0.1155 N 0 0 3 0 0 0 0 0 0 0 0 0 19.7179 18.6925 -0.1270 C 0 0 0 0 0 0 0 0 0 0 0 0 19.8412 20.2627 -0.1203 O 0 0 0 0 0 0 0 0 0 0 0 0 21.1564 17.7043 -0.1461 O 0 0 0 0 0 0 0 0 0 0 0 0 22.9607 19.7318 1.4662 C 0 0 0 0 0 0 0 0 0 0 0 0 24.2838 17.2753 -0.1788 C 0 0 0 0 0 0 0 0 0 0 0 0 22.8103 18.6028 -0.1576 C 0 0 0 0 0 0 0 0 0 0 0 0 22.9292 19.7482 -1.7726 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7638 16.6620 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4835 19.4478 0.0247 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7588 24.7324 2.7834 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8689 26.3278 0.0247 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7181 24.7574 -2.7463 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0066 11.0651 -1.1575 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0290 11.0534 1.1497 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7591 8.3705 -1.1882 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7815 8.3588 1.1191 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4895 10.9193 -0.0385 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5734 8.1601 1.1493 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5509 8.1716 -1.1579 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4886 20.4136 -0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0828 6.1269 -1.0669 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4094 5.7639 -2.6142 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1533 3.1081 -2.2129 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7171 3.1489 0.0532 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7441 2.6951 1.0657 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0705 2.3321 -0.4816 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4363 5.3101 -1.6015 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3509 0.6645 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3954 0.2557 -0.2905 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6330 0.0000 -1.7578 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7694 0.3267 -2.5662 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5053 20.1769 -0.0590 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9945 17.0265 1.0643 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9720 17.0382 -1.2429 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5535 19.8366 -1.2442 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5761 19.8249 1.0631 H 0 0 0 0 0 0 0 0 0 0 0 0 18.0427 16.6863 -0.1208 H 0 0 0 0 0 0 0 0 0 0 0 0 22.8760 18.9158 2.6165 H 0 0 0 0 0 0 0 0 0 0 0 0 24.2023 20.4064 1.4573 H 0 0 0 0 0 0 0 0 0 0 0 0 21.9110 20.6776 1.4811 H 0 0 0 0 0 0 0 0 0 0 0 0 24.1766 16.4711 -1.3356 H 0 0 0 0 0 0 0 0 0 0 0 0 25.5253 17.9499 -0.1875 H 0 0 0 0 0 0 0 0 0 0 0 0 24.1992 16.4594 0.9717 H 0 0 0 0 0 0 0 0 0 0 0 0 21.8794 20.6939 -1.7576 H 0 0 0 0 0 0 0 0 0 0 0 0 24.1707 20.4227 -1.7813 H 0 0 0 0 0 0 0 0 0 0 0 0 22.8219 18.9438 -2.9293 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 44 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 21 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 45 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 46 1 0 0 0 0 13 16 1 0 0 0 0 13 47 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 48 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 49 1 0 0 0 0 19 50 1 0 0 0 0 20 22 1 0 0 0 0 20 51 1 0 0 0 0 20 52 1 0 0 0 0 21 53 1 0 0 0 0 22 30 1 0 0 0 0 22 54 1 0 0 0 0 22 55 1 0 0 0 0 23 24 1 0 0 0 0 23 56 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 57 1 0 0 0 0 26 58 1 0 0 0 0 27 31 1 0 0 0 0 27 59 1 0 0 0 0 27 60 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 61 1 0 0 0 0 28 62 1 0 0 0 0 29 30 1 0 0 0 0 29 63 1 0 0 0 0 29 64 1 0 0 0 0 31 32 1 0 0 0 0 32 65 1 0 0 0 0 32 66 1 0 0 0 0 32 67 1 0 0 0 0 33 34 1 0 0 0 0 33 68 1 0 0 0 0 34 35 1 0 0 0 0 34 69 1 0 0 0 0 34 70 1 0 0 0 0 35 36 1 0 0 0 0 35 71 1 0 0 0 0 35 72 1 0 0 0 0 36 37 1 0 0 0 0 36 73 1 0 0 0 0 37 39 1 0 0 0 0 37 38 2 0 0 0 0 39 42 1 0 0 0 0 40 42 1 0 0 0 0 40 74 1 0 0 0 0 40 75 1 0 0 0 0 40 76 1 0 0 0 0 41 42 1 0 0 0 0 41 77 1 0 0 0 0 41 78 1 0 0 0 0 41 79 1 0 0 0 0 42 43 1 0 0 0 0 43 80 1 0 0 0 0 43 81 1 0 0 0 0 43 82 1 0 0 0 0 M END > (589) 6-arylpyrido[2,3-d]pyrimidine deriv. 58 > (589) PDGFR-beta > (589) 4200 > (589) -1 > (589) P > (589) PDGFR-P587 $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 12 csChFnd70/05150717532D 41 44 0 0 0 0 0 0 0 0999 V2000 1.2132 5.0301 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7216 2.4479 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7978 5.9221 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3488 4.9512 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8566 7.7537 0.0115 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0197 7.5177 -0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4355 8.5639 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2364 3.3192 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2484 3.2322 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4300 8.2281 -0.0285 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9252 5.7743 -0.0284 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5408 10.4815 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7028 13.1678 1.5789 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6049 11.3801 1.5793 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5837 11.3964 -1.5491 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6817 13.1840 -1.5313 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7374 14.0674 0.0281 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5609 10.2536 3.5268 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5147 10.2903 -3.5077 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6714 0.6589 -0.0254 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5221 4.7466 -0.0485 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0527 4.4042 -1.8971 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1360 5.5520 -2.7457 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4623 2.9383 -2.7418 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9490 2.6241 -4.4375 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0259 3.7761 -5.2888 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6227 5.2379 -4.4414 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.7285 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6738 8.5025 0.0264 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7521 13.8649 2.7920 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7155 13.8937 -2.7376 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8141 15.4652 0.0349 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5654 0.0609 -0.0180 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7423 0.0000 -0.0391 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5486 5.4584 0.6120 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3000 3.5181 0.6130 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6017 6.6946 -2.0839 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6210 2.0383 -2.0769 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4883 1.4784 -5.0972 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4065 3.5303 -6.6133 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4686 6.1350 -5.1046 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 28 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 20 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 11 1 0 0 0 0 5 7 2 0 0 0 0 5 29 1 0 0 0 0 6 11 1 0 0 0 0 6 7 1 0 0 0 0 6 10 2 0 0 0 0 7 12 1 0 0 0 0 11 21 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 30 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 31 1 0 0 0 0 17 32 1 0 0 0 0 20 33 1 0 0 0 0 20 34 1 0 0 0 0 21 22 1 0 0 0 0 21 35 1 0 0 0 0 21 36 1 0 0 0 0 22 23 2 0 0 0 0 22 24 1 0 0 0 0 23 27 1 0 0 0 0 23 37 1 0 0 0 0 24 25 2 0 0 0 0 24 38 1 0 0 0 0 25 26 1 0 0 0 0 25 39 1 0 0 0 0 26 27 2 0 0 0 0 26 40 1 0 0 0 0 27 41 1 0 0 0 0 M END > (590) pyrido[2,3-d]pyrimidin-7-one deriv. 12 > (590) PDGFR-beta > (590) 4200 > (590) -1 > (590) P > (590) PDGFR-P588 $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 29 csChFnd70/05150717532D 59 62 0 0 0 0 0 0 0 0999 V2000 8.6752 12.3758 -2.7690 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4592 10.5047 -1.4137 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0153 13.5344 -2.8726 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6003 13.0706 -2.1929 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7986 15.1368 -3.6395 C 0 0 0 0 0 0 0 0 0 0 0 0 12.7727 15.7020 -2.9925 C 0 0 0 0 0 0 0 0 0 0 0 0 13.9779 16.6611 -3.0501 O 0 0 0 0 0 0 0 0 0 0 0 0 11.1452 16.2225 -3.7100 C 0 0 0 0 0 0 0 0 0 0 0 0 12.9436 14.1682 -2.2696 N 0 0 3 0 0 0 0 0 0 0 0 0 11.7618 11.5562 -1.4819 N 0 0 0 0 0 0 0 0 0 0 0 0 8.9501 10.8983 -2.0400 N 0 0 0 0 0 0 0 0 0 0 0 0 10.6780 8.9402 -0.6636 N 0 0 3 0 0 0 0 0 0 0 0 0 9.2902 7.8608 -0.4451 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5051 6.1203 -0.5522 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1357 5.0565 -0.3359 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3317 7.4647 0.1020 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6996 8.5300 -0.1140 C 0 0 0 0 0 0 0 0 0 0 0 0 14.5799 13.6668 -1.5572 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5460 5.7264 -0.0124 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1981 4.6781 0.1994 O 0 0 0 0 0 0 0 0 0 0 0 0 3.5986 5.4540 0.5288 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2458 4.0838 0.7291 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6122 3.0675 2.2415 N 0 0 0 0 0 0 0 0 0 0 0 0 1.1260 2.0757 2.7538 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3684 1.4393 4.5660 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0841 1.9668 1.9639 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7956 0.8906 0.3807 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9587 17.9108 -4.5060 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1030 19.3648 -3.6298 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6269 18.1248 -6.2252 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4984 19.7260 -6.7287 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8045 21.0922 -5.0001 S 0 0 0 0 0 0 0 0 0 0 0 0 7.4426 12.6879 -3.2700 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5886 15.4978 -4.1619 H 0 0 0 0 0 0 0 0 0 0 0 0 11.7928 8.5900 -0.2886 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7425 5.5986 -0.8050 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3026 3.7028 -0.4191 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0937 7.9851 0.3544 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5326 9.8834 -0.0251 H 0 0 0 0 0 0 0 0 0 0 0 0 15.3314 13.0393 -2.5287 H 0 0 0 0 0 0 0 0 0 0 0 0 15.2493 14.7868 -1.1102 H 0 0 0 0 0 0 0 0 0 0 0 0 14.3765 12.8014 -0.5028 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6775 6.1952 1.6893 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2633 6.2808 -0.5228 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0074 4.6763 0.8622 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2482 3.2692 -0.3839 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.8697 2.6922 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9767 0.9993 1.9047 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3134 0.6206 4.9107 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5478 0.7292 4.6500 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4168 2.5145 5.4284 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2122 2.7418 1.7937 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2537 1.1417 3.0560 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7318 1.7102 -0.7268 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8384 0.0000 0.2340 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6113 0.1952 0.5070 H 0 0 0 0 0 0 0 0 0 0 0 0 11.3619 19.4560 -2.2911 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4851 17.0707 -7.0831 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2439 20.1273 -8.0100 H 0 0 0 0 0 0 0 0 0 0 0 0 1 11 1 0 0 0 0 1 3 2 0 0 0 0 1 33 1 0 0 0 0 2 11 2 0 0 0 0 2 10 1 0 0 0 0 2 12 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 10 2 0 0 0 0 4 9 1 0 0 0 0 5 8 2 0 0 0 0 5 34 1 0 0 0 0 6 9 1 0 0 0 0 6 8 1 0 0 0 0 6 7 2 0 0 0 0 8 28 1 0 0 0 0 9 18 1 0 0 0 0 12 13 1 0 0 0 0 12 35 1 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 14 15 1 0 0 0 0 14 36 1 0 0 0 0 15 19 2 0 0 0 0 15 37 1 0 0 0 0 16 19 1 0 0 0 0 16 17 2 0 0 0 0 16 38 1 0 0 0 0 17 39 1 0 0 0 0 18 40 1 0 0 0 0 18 41 1 0 0 0 0 18 42 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 43 1 0 0 0 0 21 44 1 0 0 0 0 22 23 1 0 0 0 0 22 45 1 0 0 0 0 22 46 1 0 0 0 0 23 24 1 0 0 0 0 23 26 1 0 0 0 0 24 25 1 0 0 0 0 24 47 1 0 0 0 0 24 48 1 0 0 0 0 25 49 1 0 0 0 0 25 50 1 0 0 0 0 25 51 1 0 0 0 0 26 27 1 0 0 0 0 26 52 1 0 0 0 0 26 53 1 0 0 0 0 27 54 1 0 0 0 0 27 55 1 0 0 0 0 27 56 1 0 0 0 0 28 29 2 0 0 0 0 28 30 1 0 0 0 0 29 32 1 0 0 0 0 29 57 1 0 0 0 0 30 31 2 0 0 0 0 30 58 1 0 0 0 0 31 32 1 0 0 0 0 31 59 1 0 0 0 0 M END > (60) pyrido[2,3-d]pyrimidin-7-one deriv. 29 > (60) PDGFR-beta > (60) 54 > (60) -1 > (60) P > (60) PDGFR-P58 $$$$ Sorafenib (BAY 439006) csChFnd70/05150717532D 48 50 0 0 0 0 0 0 0 0999 V2000 2.7774 9.5771 -1.7353 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9837 8.5203 -3.1700 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6254 8.1823 -3.8108 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0622 8.8995 -3.0191 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8588 9.9607 -1.5788 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2105 10.2978 -0.9385 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9875 9.9488 -1.0459 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1101 11.0393 0.3984 F 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 10.7595 -2.3335 F 0 0 0 0 0 0 0 0 0 0 0 0 0.1903 8.3928 -0.5627 F 0 0 0 0 0 0 0 0 0 0 0 0 1.1801 7.6160 -4.1677 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.3132 10.6890 -0.7735 N 0 0 3 0 0 0 0 0 0 0 0 0 8.8116 9.7931 -0.7005 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8665 8.3051 -1.2185 O 0 0 0 0 0 0 0 0 0 0 0 0 10.2494 10.5464 -0.0533 N 0 0 3 0 0 0 0 0 0 0 0 0 11.7635 9.5685 0.1739 C 0 0 0 0 0 0 0 0 0 0 0 0 14.8627 9.4141 0.3716 C 0 0 0 0 0 0 0 0 0 0 0 0 13.3710 10.3784 0.1469 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6565 7.7903 0.4337 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1489 6.8274 0.6583 C 0 0 0 0 0 0 0 0 0 0 0 0 14.7552 7.6364 0.6248 C 0 0 0 0 0 0 0 0 0 0 0 0 16.2243 6.6875 0.8455 O 0 0 0 0 0 0 0 0 0 0 0 0 16.7794 5.6993 -0.5007 C 0 0 0 0 0 0 0 0 0 0 0 0 18.3430 4.8004 -0.4056 C 0 0 0 0 0 0 0 0 0 0 0 0 15.7966 5.5530 -2.0073 C 0 0 0 0 0 0 0 0 0 0 0 0 16.4013 4.5340 -3.3539 C 0 0 0 0 0 0 0 0 0 0 0 0 18.8638 3.8019 -1.8136 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8870 3.7046 -3.2286 N 0 0 0 0 0 0 0 0 0 0 0 0 20.5236 2.8379 -1.7348 C 0 0 0 0 0 0 0 0 0 0 0 0 21.4228 2.9217 -0.4438 O 0 0 0 0 0 0 0 0 0 0 0 0 21.0360 1.8678 -3.0948 N 0 0 3 0 0 0 0 0 0 0 0 0 22.6772 0.9144 -3.0168 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7829 7.3565 -4.9306 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3430 8.6350 -3.5193 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0488 11.1227 0.1813 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2426 11.8385 -0.2680 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2360 11.7656 0.2550 H 0 0 0 0 0 0 0 0 0 0 0 0 16.1131 10.0438 0.3504 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4548 11.7621 -0.0503 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4061 7.1606 0.4607 H 0 0 0 0 0 0 0 0 0 0 0 0 13.0658 5.4444 0.8602 H 0 0 0 0 0 0 0 0 0 0 0 0 19.1388 4.8781 0.7439 H 0 0 0 0 0 0 0 0 0 0 0 0 14.5749 6.2275 -2.1236 H 0 0 0 0 0 0 0 0 0 0 0 0 15.6427 4.4171 -4.5250 H 0 0 0 0 0 0 0 0 0 0 0 0 20.3182 1.8007 -4.1253 H 0 0 0 0 0 0 0 0 0 0 0 0 23.7416 1.8241 -2.8259 H 0 0 0 0 0 0 0 0 0 0 0 0 22.6399 0.0000 -1.9400 H 0 0 0 0 0 0 0 0 0 0 0 0 22.8706 0.2100 -4.2266 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 2 0 0 0 0 1 6 1 0 0 0 0 1 7 1 0 0 0 0 2 3 1 0 0 0 0 2 11 1 0 0 0 0 3 4 2 0 0 0 0 3 33 1 0 0 0 0 4 5 1 0 0 0 0 4 34 1 0 0 0 0 5 6 2 0 0 0 0 5 12 1 0 0 0 0 6 35 1 0 0 0 0 7 8 1 0 0 0 0 7 10 1 0 0 0 0 7 9 1 0 0 0 0 12 13 1 0 0 0 0 12 36 1 0 0 0 0 13 15 1 0 0 0 0 13 14 2 0 0 0 0 15 16 1 0 0 0 0 15 37 1 0 0 0 0 16 18 1 0 0 0 0 16 19 2 0 0 0 0 17 18 2 0 0 0 0 17 21 1 0 0 0 0 17 38 1 0 0 0 0 18 39 1 0 0 0 0 19 20 1 0 0 0 0 19 40 1 0 0 0 0 20 21 2 0 0 0 0 20 41 1 0 0 0 0 21 22 1 0 0 0 0 22 23 1 0 0 0 0 23 24 1 0 0 0 0 23 25 2 0 0 0 0 24 27 2 0 0 0 0 24 42 1 0 0 0 0 25 26 1 0 0 0 0 25 43 1 0 0 0 0 26 28 2 0 0 0 0 26 44 1 0 0 0 0 27 28 1 0 0 0 0 27 29 1 0 0 0 0 29 30 2 0 0 0 0 29 31 1 0 0 0 0 31 32 1 0 0 0 0 31 45 1 0 0 0 0 32 46 1 0 0 0 0 32 47 1 0 0 0 0 32 48 1 0 0 0 0 M END > (61) BAY 439006 > (61) PDGFR-beta > (61) 57 > (61) -1 > (61) P > (61) PDGFR-P59 $$$$ SU11248 analog 12h csChFnd70/05150717532D 55 58 0 0 0 0 0 0 0 0999 V2000 2.6434 3.9877 -0.1697 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6130 2.1999 -0.4445 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9640 1.3972 -1.3514 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3489 2.3674 -1.9873 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0338 4.9745 -0.8066 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4018 4.1664 -1.7228 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1331 7.0297 -1.6758 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4603 6.8626 -0.7428 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6188 5.4273 -2.2133 N 0 0 3 0 0 0 0 0 0 0 0 0 6.9398 8.3832 -1.9171 O 0 0 0 0 0 0 0 0 0 0 0 0 3.4948 8.1817 0.0266 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1954 9.8868 0.1518 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1083 12.0526 0.4560 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4768 12.8058 0.2407 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2599 11.4297 0.0504 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9335 10.3039 0.4048 N 0 0 3 0 0 0 0 0 0 0 0 0 1.3139 11.6092 -0.2134 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8014 13.0312 0.7111 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0823 14.6940 0.2154 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1092 15.4942 -1.1598 O 0 0 0 0 0 0 0 0 0 0 0 0 3.6919 15.5335 1.7166 N 0 0 3 0 0 0 0 0 0 0 0 0 3.2998 17.4099 1.6916 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2663 1.2342 0.1714 F 0 0 0 0 0 0 0 0 0 0 0 0 2.9035 18.0337 3.5525 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8239 20.4989 5.2271 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5065 22.4762 5.1680 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9682 22.3227 2.0838 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2802 20.3438 2.1117 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5104 19.9154 3.5274 N 0 0 0 0 0 0 0 0 0 0 0 0 0.3401 22.8722 3.7589 O 0 0 0 0 0 0 0 0 0 0 0 0 1.5893 4.6161 0.5313 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9329 0.0000 -1.5620 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3939 1.7272 -2.6913 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6818 5.1818 -2.8622 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2036 7.9094 0.5326 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8799 9.4668 0.5271 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6620 11.6299 1.0551 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0384 12.8235 -0.9093 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8335 10.5042 -0.9767 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3988 13.2868 -0.5588 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5407 14.2683 1.3716 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6894 12.2463 1.5049 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6704 14.8952 2.8137 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4238 18.1236 1.1801 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1664 17.6478 0.8590 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7796 17.3200 4.0640 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0371 17.7960 4.3852 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7701 20.1989 6.2515 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5956 19.8273 5.5006 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9274 22.9027 6.3998 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7461 23.1517 4.9644 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1923 22.9937 1.7904 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 22.6381 1.0851 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0432 19.6698 2.3355 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8296 19.9306 0.8620 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 5 2 0 0 0 0 1 31 1 0 0 0 0 2 3 2 0 0 0 0 2 23 1 0 0 0 0 3 4 1 0 0 0 0 3 32 1 0 0 0 0 4 6 2 0 0 0 0 4 33 1 0 0 0 0 5 8 1 0 0 0 0 5 6 1 0 0 0 0 6 9 1 0 0 0 0 7 9 1 0 0 0 0 7 8 1 0 0 0 0 7 10 2 0 0 0 0 8 11 2 0 0 0 0 9 34 1 0 0 0 0 11 12 1 0 0 0 0 11 35 1 0 0 0 0 12 15 2 0 0 0 0 12 16 1 0 0 0 0 13 16 1 0 0 0 0 13 14 2 0 0 0 0 13 18 1 0 0 0 0 14 15 1 0 0 0 0 14 19 1 0 0 0 0 15 17 1 0 0 0 0 16 36 1 0 0 0 0 17 37 1 0 0 0 0 17 38 1 0 0 0 0 17 39 1 0 0 0 0 18 40 1 0 0 0 0 18 41 1 0 0 0 0 18 42 1 0 0 0 0 19 20 2 0 0 0 0 19 21 1 0 0 0 0 21 22 1 0 0 0 0 21 43 1 0 0 0 0 22 24 1 0 0 0 0 22 44 1 0 0 0 0 22 45 1 0 0 0 0 24 29 1 0 0 0 0 24 46 1 0 0 0 0 24 47 1 0 0 0 0 25 29 1 0 0 0 0 25 26 1 0 0 0 0 25 48 1 0 0 0 0 25 49 1 0 0 0 0 26 30 1 0 0 0 0 26 50 1 0 0 0 0 26 51 1 0 0 0 0 27 30 1 0 0 0 0 27 28 1 0 0 0 0 27 52 1 0 0 0 0 27 53 1 0 0 0 0 28 29 1 0 0 0 0 28 54 1 0 0 0 0 28 55 1 0 0 0 0 M END > (7) SU11248 analog 12h > (7) PDGFR-beta > (7) 2 > (7) -1 > (7) P > (7) PDGFR-P5 $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7e csChFnd70/05150717532D 55 57 0 0 0 0 0 0 0 0999 V2000 1.2441 13.5345 1.9649 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8014 10.9437 1.3331 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3926 11.8605 1.0944 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7883 14.5626 1.7491 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4045 13.7026 1.3021 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7487 16.4372 1.9703 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2890 17.3908 1.7455 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9423 16.4574 1.2822 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3179 17.2992 1.0817 O 0 0 0 0 0 0 0 0 0 0 0 0 1.3037 11.7934 1.7532 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9477 14.6713 1.0792 N 0 0 3 0 0 0 0 0 0 0 0 0 7.6101 13.7534 0.6164 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2845 19.3547 1.9685 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6138 21.9387 3.8370 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6201 20.1067 3.6381 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9521 20.4607 0.5083 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9497 22.2905 0.7252 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2764 23.0273 2.3855 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0439 18.7428 5.4615 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.5432 19.5388 -1.5767 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.7745 9.1046 1.1283 N 0 0 3 0 0 0 0 0 0 0 0 0 4.4152 8.1487 0.6651 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0212 6.1509 0.5212 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7347 5.1526 0.0376 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3564 3.2346 -0.1005 N 0 0 0 0 0 0 0 0 0 0 0 0 4.1586 2.8616 -1.6062 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3698 0.9902 -1.4006 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0148 2.2007 -0.2494 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9034 2.0723 1.5839 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 14.1727 2.3123 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6013 11.1540 0.7534 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5190 17.1061 2.3114 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7351 13.6770 -0.8305 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7389 14.4903 1.1620 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5934 12.4101 1.1731 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8729 22.5225 5.1286 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6926 23.1481 -0.4037 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2731 24.4590 2.5481 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6693 8.4514 1.2917 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9172 8.6367 -0.6094 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4146 8.3726 1.6976 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5192 5.6629 1.7959 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0218 5.9271 -0.5111 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2367 5.6408 -1.2370 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7341 5.3766 1.0700 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0840 3.8411 -1.6250 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9064 2.9383 -2.8511 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3482 0.7807 -2.4141 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4225 0.0000 -1.5616 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7767 0.8565 -0.0796 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7107 0.8641 -0.7352 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9161 2.8613 -1.1798 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1984 3.4091 2.0742 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0060 1.4027 2.5118 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1389 1.3135 1.4715 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 30 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 31 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 32 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 33 1 0 0 0 0 12 34 1 0 0 0 0 12 35 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 36 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 37 1 0 0 0 0 18 38 1 0 0 0 0 21 22 1 0 0 0 0 21 39 1 0 0 0 0 22 23 1 0 0 0 0 22 40 1 0 0 0 0 22 41 1 0 0 0 0 23 24 1 0 0 0 0 23 42 1 0 0 0 0 23 43 1 0 0 0 0 24 25 1 0 0 0 0 24 44 1 0 0 0 0 24 45 1 0 0 0 0 25 28 1 0 0 0 0 25 26 1 0 0 0 0 26 27 1 0 0 0 0 26 46 1 0 0 0 0 26 47 1 0 0 0 0 27 48 1 0 0 0 0 27 49 1 0 0 0 0 27 50 1 0 0 0 0 28 29 1 0 0 0 0 28 51 1 0 0 0 0 28 52 1 0 0 0 0 29 53 1 0 0 0 0 29 54 1 0 0 0 0 29 55 1 0 0 0 0 M END > (606) 1,6-naphthyridin-2(1H)-one deriv. 7e > (606) PDGFR-beta > (606) 4600 > (606) -1 > (606) P > (606) PDGFR-P604 $$$$ Structure134 csChFnd70/05150717532D 45 47 0 0 0 0 0 0 0 0999 V2000 2.5953 9.5774 0.0119 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6185 7.8676 0.0026 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0567 6.9713 -0.0154 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5792 7.7710 -0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6015 9.5945 -0.0167 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0503 6.8925 -0.0435 N 0 0 0 0 0 0 0 0 0 0 0 0 8.5494 7.6776 -0.0530 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6706 9.4856 -0.0448 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0422 6.7047 -0.0702 N 0 0 3 0 0 0 0 0 0 0 0 0 9.9488 4.9761 -0.0782 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3989 4.0310 -0.0950 N 0 0 3 0 0 0 0 0 0 0 0 0 8.5564 4.2695 -0.0704 O 0 0 0 0 0 0 0 0 0 0 0 0 1.0726 6.9957 0.0127 N 0 0 0 0 0 0 0 0 0 0 0 0 10.3756 10.3338 -0.0552 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7268 11.6313 -1.2379 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3161 12.4161 -1.2416 C 0 0 0 0 0 0 0 0 0 0 0 0 13.5596 11.9175 -0.0746 C 0 0 0 0 0 0 0 0 0 0 0 0 13.2187 10.6302 1.1016 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6312 9.8417 1.1226 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0277 10.4788 0.0032 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1823 10.4623 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 11.2973 2.1521 -0.1036 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3238 1.5561 -1.7033 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1120 1.3980 -0.1225 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3502 1.5399 1.5056 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1532 7.2685 -0.0766 H 0 0 0 0 0 0 0 0 0 0 0 0 12.5100 4.5947 -0.1013 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0600 5.7498 0.0066 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 7.6294 0.0259 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7571 12.0213 -2.1500 H 0 0 0 0 0 0 0 0 0 0 0 0 12.5897 13.4211 -2.1577 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8016 12.5352 -0.0822 H 0 0 0 0 0 0 0 0 0 0 0 0 14.1946 10.2455 2.0092 H 0 0 0 0 0 0 0 0 0 0 0 0 11.3663 8.8372 2.0418 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9932 11.8656 0.0105 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2369 11.8485 -0.0209 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9984 1.9923 -2.8499 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2481 0.1581 -1.7098 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0310 2.0934 -1.6899 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8055 1.8226 1.0171 H 0 0 0 0 0 0 0 0 0 0 0 0 13.0364 0.0000 -0.1290 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7868 1.8341 -1.2690 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0574 2.0770 1.5190 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2745 0.1419 1.4992 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0438 1.9644 2.6452 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 20 2 0 0 0 0 2 3 2 0 0 0 0 2 13 1 0 0 0 0 3 4 1 0 0 0 0 4 6 2 0 0 0 0 4 5 1 0 0 0 0 5 20 1 0 0 0 0 5 21 2 0 0 0 0 6 7 1 0 0 0 0 7 8 2 0 0 0 0 7 9 1 0 0 0 0 8 14 1 0 0 0 0 8 21 1 0 0 0 0 9 10 1 0 0 0 0 9 26 1 0 0 0 0 10 11 1 0 0 0 0 10 12 2 0 0 0 0 11 22 1 0 0 0 0 11 27 1 0 0 0 0 13 28 1 0 0 0 0 13 29 1 0 0 0 0 14 15 2 0 0 0 0 14 19 1 0 0 0 0 15 16 1 0 0 0 0 15 30 1 0 0 0 0 16 17 2 0 0 0 0 16 31 1 0 0 0 0 17 18 1 0 0 0 0 17 32 1 0 0 0 0 18 19 2 0 0 0 0 18 33 1 0 0 0 0 19 34 1 0 0 0 0 20 35 1 0 0 0 0 21 36 1 0 0 0 0 22 23 1 0 0 0 0 22 24 1 0 0 0 0 22 25 1 0 0 0 0 23 37 1 0 0 0 0 23 38 1 0 0 0 0 23 39 1 0 0 0 0 24 40 1 0 0 0 0 24 41 1 0 0 0 0 24 42 1 0 0 0 0 25 43 1 0 0 0 0 25 44 1 0 0 0 0 25 45 1 0 0 0 0 M END > (609) 9240345-4a > (609) PDGFR-beta > (609) 4670 > (609) -1 > (609) P > (609) PDGFR-P607 $$$$ SU6668 csChFnd70/05150717532D 41 43 0 0 0 0 0 0 0 0999 V2000 1.7576 3.5488 -0.1496 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7307 1.9600 -0.3919 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9335 1.2436 -1.1917 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1693 2.1034 -1.7547 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9971 4.4259 -0.7125 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2173 3.7048 -1.5224 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8681 6.2514 -1.4820 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3775 6.1054 -0.6572 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3014 4.8245 -1.9559 N 0 0 3 0 0 0 0 0 0 0 0 0 5.5874 7.4550 -1.6968 O 0 0 0 0 0 0 0 0 0 0 0 0 2.5159 7.2820 0.0226 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1391 8.7971 0.1334 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8148 10.7489 0.4008 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3838 11.3897 0.2111 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3110 10.1799 0.0433 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6826 9.1753 0.3583 N 0 0 3 0 0 0 0 0 0 0 0 0 0.5801 10.3457 -0.1915 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3090 11.6407 0.6263 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0163 13.1053 0.1865 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1233 13.7116 -1.4852 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7558 15.4273 -1.5097 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4409 16.0963 -0.3130 O 0 0 0 0 0 0 0 0 0 0 0 0 2.7787 16.2121 -2.8612 O 0 0 0 0 0 0 0 0 0 0 0 0 0.8176 4.1090 0.4699 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7704 1.2747 0.0433 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9047 0.0000 -1.3765 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1006 1.5313 -2.3764 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2495 4.6045 -2.5289 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3652 7.0412 0.4690 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5323 8.4393 0.4681 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 10.3661 0.9372 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3387 11.4271 -0.8106 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1493 9.3640 -0.8708 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8378 11.8731 -0.5038 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0618 12.7393 1.2118 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1084 10.9547 1.3344 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8421 13.2929 0.6303 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8486 13.7267 0.9160 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2975 13.5240 -1.9289 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2910 13.0903 -2.2146 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5351 17.3105 -2.8186 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 5 2 0 0 0 0 1 24 1 0 0 0 0 2 3 2 0 0 0 0 2 25 1 0 0 0 0 3 4 1 0 0 0 0 3 26 1 0 0 0 0 4 6 2 0 0 0 0 4 27 1 0 0 0 0 5 8 1 0 0 0 0 5 6 1 0 0 0 0 6 9 1 0 0 0 0 7 9 1 0 0 0 0 7 8 1 0 0 0 0 7 10 2 0 0 0 0 8 11 2 0 0 0 0 9 28 1 0 0 0 0 11 12 1 0 0 0 0 11 29 1 0 0 0 0 12 15 2 0 0 0 0 12 16 1 0 0 0 0 13 16 1 0 0 0 0 13 14 2 0 0 0 0 13 18 1 0 0 0 0 14 15 1 0 0 0 0 14 19 1 0 0 0 0 15 17 1 0 0 0 0 16 30 1 0 0 0 0 17 31 1 0 0 0 0 17 32 1 0 0 0 0 17 33 1 0 0 0 0 18 34 1 0 0 0 0 18 35 1 0 0 0 0 18 36 1 0 0 0 0 19 20 1 0 0 0 0 19 37 1 0 0 0 0 19 38 1 0 0 0 0 20 21 1 0 0 0 0 20 39 1 0 0 0 0 20 40 1 0 0 0 0 21 23 1 0 0 0 0 21 22 2 0 0 0 0 23 41 1 0 0 0 0 M END > (62) SU6668 > (62) PDGFR-beta > (62) 60 > (62) -1 > (62) P > (62) PDGFR-P60 $$$$ 1,6-naphthyridine-2,7-diamine deriv. 17 csChFnd70/05150717532D 59 61 0 0 0 0 0 0 0 0999 V2000 2.7925 10.4535 -0.0076 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8956 10.3600 -0.0229 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3510 11.3104 -0.0130 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4228 7.7802 -0.0223 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8175 8.6475 -0.0123 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2999 7.6779 -0.0080 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8496 5.1361 -0.0220 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4103 5.9766 -0.0281 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3712 5.9928 -0.0126 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8899 8.6693 -0.0277 N 0 0 0 0 0 0 0 0 0 0 0 0 4.3975 13.2143 -0.0088 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4671 15.8628 1.1697 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4858 16.7785 -0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4260 14.0837 1.1699 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4187 14.1379 -1.1887 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4657 15.9168 -1.1819 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5110 16.8186 -2.3318 O 0 0 0 0 0 0 0 0 0 0 0 0 2.6207 18.6490 -2.2524 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4702 16.7118 2.3187 O 0 0 0 0 0 0 0 0 0 0 0 0 6.4507 18.5458 2.2465 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4537 11.2274 -0.0288 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9392 10.3385 -0.0394 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9146 8.7771 -0.0439 O 0 0 0 0 0 0 0 0 0 0 0 0 10.4517 11.1804 -0.0453 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0663 10.2141 -0.0569 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1440 9.0875 -1.6651 C 0 0 0 0 0 0 0 0 0 0 0 0 13.5799 11.4676 -0.0615 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1615 9.0782 1.5439 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8219 3.3459 -0.0265 N 0 0 3 0 0 0 0 0 0 0 0 0 1.2684 0.5744 -0.0405 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3163 2.5032 0.1147 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.2973 0.3664 O 0 0 0 0 0 0 0 0 0 0 0 0 1.5937 11.1514 0.0058 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0695 8.3186 -0.0004 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5987 5.2612 -0.0371 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5197 18.1653 0.0008 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1900 13.3717 2.0830 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6246 13.4677 -2.1079 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2022 19.0873 -0.9903 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9453 19.0469 -2.4691 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7981 19.2091 -3.2372 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8849 18.9677 0.9840 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1483 19.0079 2.4706 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3044 19.0606 3.2296 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4733 12.4731 -0.0253 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4713 12.4262 -0.0417 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0762 9.8967 -2.8056 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3453 8.3685 -1.6737 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0657 8.1945 -1.6618 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5245 12.2703 1.0843 H 0 0 0 0 0 0 0 0 0 0 0 0 14.7812 10.7487 -0.0701 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5120 12.2769 -1.2018 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0832 8.1852 1.5472 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3628 8.3593 1.5353 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1061 9.8808 2.6897 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8861 2.7066 -0.1311 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4401 0.0000 1.2247 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0335 0.1792 -0.5688 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2970 0.1489 -0.8897 H 0 0 0 0 0 0 0 0 0 0 0 0 1 5 1 0 0 0 0 1 3 2 0 0 0 0 1 33 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 11 1 0 0 0 0 4 10 1 0 0 0 0 4 8 2 0 0 0 0 4 5 1 0 0 0 0 5 6 2 0 0 0 0 6 9 1 0 0 0 0 6 34 1 0 0 0 0 7 9 2 0 0 0 0 7 8 1 0 0 0 0 7 29 1 0 0 0 0 8 35 1 0 0 0 0 11 15 1 0 0 0 0 11 14 2 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 19 1 0 0 0 0 13 16 1 0 0 0 0 13 36 1 0 0 0 0 14 37 1 0 0 0 0 15 16 2 0 0 0 0 15 38 1 0 0 0 0 16 17 1 0 0 0 0 17 18 1 0 0 0 0 18 39 1 0 0 0 0 18 40 1 0 0 0 0 18 41 1 0 0 0 0 19 20 1 0 0 0 0 20 42 1 0 0 0 0 20 43 1 0 0 0 0 20 44 1 0 0 0 0 21 22 1 0 0 0 0 21 45 1 0 0 0 0 22 24 1 0 0 0 0 22 23 2 0 0 0 0 24 25 1 0 0 0 0 24 46 1 0 0 0 0 25 26 1 0 0 0 0 25 27 1 0 0 0 0 25 28 1 0 0 0 0 26 47 1 0 0 0 0 26 48 1 0 0 0 0 26 49 1 0 0 0 0 27 50 1 0 0 0 0 27 51 1 0 0 0 0 27 52 1 0 0 0 0 28 53 1 0 0 0 0 28 54 1 0 0 0 0 28 55 1 0 0 0 0 29 31 1 0 0 0 0 29 56 1 0 0 0 0 30 31 1 0 0 0 0 30 57 1 0 0 0 0 30 58 1 0 0 0 0 30 59 1 0 0 0 0 31 32 2 0 0 0 0 M END > (612) 1,6-naphthyridine deriv. 17 > (612) PDGFR-beta > (612) 4700 > (612) -1 > (612) P > (612) PDGFR-P610 $$$$ 1,6-naphthyridin 32 csChFnd70/05150717532D 56 59 0 0 0 0 0 0 0 0999 V2000 1.2246 16.2967 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7175 13.6834 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3193 14.4893 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7853 17.2324 0.0021 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3829 16.3106 -0.0180 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8107 19.0587 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9440 18.8771 -0.0204 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4086 19.8810 -0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2477 14.5914 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8909 17.1678 -0.0284 N 0 0 0 0 0 0 0 0 0 0 0 0 4.5085 21.8031 0.0076 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6643 24.4951 1.5764 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5707 22.7041 1.5777 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5484 22.7182 -1.5548 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6421 24.5092 -1.5386 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6971 25.3951 0.0226 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6388 11.8802 -0.0252 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2430 10.8583 -0.0460 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7950 8.9229 -0.0521 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4705 7.8556 -0.0737 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5372 19.7071 -0.0322 N 0 0 0 0 0 0 0 0 0 0 0 0 4.4810 21.6086 -3.5156 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5297 21.5767 3.5290 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.6974 5.6021 1.2168 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2134 3.6785 1.0987 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1142 3.0104 0.0911 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5983 4.9341 0.2092 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0405 5.9974 -0.0796 N 0 0 0 0 0 0 0 0 0 0 0 0 4.7712 2.6152 1.3876 N 0 0 0 0 0 0 0 0 0 0 0 0 4.3411 0.7570 1.3816 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.9794 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5001 13.7330 -0.0424 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6188 19.7973 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7121 25.1940 2.7910 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6730 25.2192 -2.7474 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7699 26.7954 0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5217 11.2986 -0.0176 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9883 11.1736 -1.2070 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0102 11.1613 1.1040 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0498 8.6074 1.1089 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0278 8.6199 -1.2020 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2157 8.1710 -1.2348 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2377 8.1586 1.0762 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5996 19.0310 -0.0464 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5918 20.9654 -0.0265 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5513 6.3937 0.9657 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1931 5.8857 2.5117 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2445 3.3740 2.0844 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6847 3.4025 -0.1848 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6185 2.7269 -1.2037 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2603 2.2189 0.3421 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1269 5.2100 1.4926 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5671 5.2386 -0.7764 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7783 0.4071 0.1313 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5172 0.0000 1.5982 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4090 0.4852 2.4112 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 31 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 17 1 0 0 0 0 3 5 2 0 0 0 0 3 32 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 33 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 21 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 34 1 0 0 0 0 13 23 1 0 0 0 0 14 15 1 0 0 0 0 14 22 1 0 0 0 0 15 16 2 0 0 0 0 15 35 1 0 0 0 0 16 36 1 0 0 0 0 17 18 1 0 0 0 0 17 37 1 0 0 0 0 18 19 1 0 0 0 0 18 38 1 0 0 0 0 18 39 1 0 0 0 0 19 20 1 0 0 0 0 19 40 1 0 0 0 0 19 41 1 0 0 0 0 20 28 1 0 0 0 0 20 42 1 0 0 0 0 20 43 1 0 0 0 0 21 44 1 0 0 0 0 21 45 1 0 0 0 0 24 28 1 0 0 0 0 24 25 1 0 0 0 0 24 46 1 0 0 0 0 24 47 1 0 0 0 0 25 29 1 0 0 0 0 25 48 1 0 0 0 0 25 49 1 0 0 0 0 26 29 1 0 0 0 0 26 27 1 0 0 0 0 26 50 1 0 0 0 0 26 51 1 0 0 0 0 27 28 1 0 0 0 0 27 52 1 0 0 0 0 27 53 1 0 0 0 0 29 30 1 0 0 0 0 30 54 1 0 0 0 0 30 55 1 0 0 0 0 30 56 1 0 0 0 0 M END > (613) 1,6-naphthyridine 32 > (613) PDGFR-beta > (613) 4700 > (613) -1 > (613) P > (613) PDGFR-P611 $$$$ csChFnd70/05150717532D 43 46 0 0 0 0 0 0 0 0999 V2000 1.2134 12.0669 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2487 10.2691 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 1.2366 10.3562 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 2.7986 12.9592 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3493 11.9885 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8570 14.7908 0.0104 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0203 14.5552 -0.0216 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4306 15.2656 -0.0319 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9258 12.8118 -0.0296 N 0 0 3 0 0 0 0 0 0 0 0 0 7.5226 11.7840 -0.0497 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4360 15.6012 -0.0009 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5410 17.5190 0.0083 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5676 18.4349 -1.5515 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6651 20.2226 -1.5337 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7368 21.1051 0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7115 20.2051 1.5764 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6062 18.4176 1.5769 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5651 17.2908 3.5247 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.4792 17.3296 -3.5098 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.7222 9.4848 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6722 7.6957 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 1.0016 6.7925 -0.0156 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3046 4.8626 -0.0294 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5953 2.1815 1.4893 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8552 1.3806 -0.0984 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8197 2.3703 -1.5918 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3151 3.9570 1.5162 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5499 4.0564 -1.5170 N 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 12.7652 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6741 15.5396 0.0253 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9060 11.5354 -1.3868 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5495 12.4961 0.6099 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3007 10.5557 0.6128 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6857 20.9330 -2.7400 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8134 22.5031 0.0324 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7684 20.9017 2.7895 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7431 7.0369 -0.0398 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2813 7.1479 1.1470 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2598 7.1609 -1.1602 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6160 1.4412 2.6774 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0771 0.0000 -0.1680 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0215 1.7562 -2.8337 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1084 4.6237 2.7299 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 29 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 30 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 31 1 0 0 0 0 10 32 1 0 0 0 0 10 33 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 34 1 0 0 0 0 15 16 1 0 0 0 0 15 35 1 0 0 0 0 16 17 2 0 0 0 0 16 36 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 37 1 0 0 0 0 22 23 1 0 0 0 0 22 38 1 0 0 0 0 22 39 1 0 0 0 0 23 28 1 0 0 0 0 23 27 2 0 0 0 0 24 25 2 0 0 0 0 24 27 1 0 0 0 0 24 40 1 0 0 0 0 25 26 1 0 0 0 0 25 41 1 0 0 0 0 26 28 2 0 0 0 0 26 42 1 0 0 0 0 27 43 1 0 0 0 0 M END > (616) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 34 > (616) PDGFR-beta > (616) 4800 > (616) -1 > (616) P > (616) PDGFR-P614 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 65 csChFnd70/05150717532D 69 73 0 0 0 0 0 0 0 0999 V2000 3.5825 14.3960 1.2786 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9226 12.0665 1.4836 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5973 12.8761 1.5099 N 0 0 0 0 0 0 0 0 0 0 0 0 6.2924 12.7211 1.2280 N 0 0 0 0 0 0 0 0 0 0 0 0 5.0072 15.1586 1.0001 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3982 14.2600 0.9801 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0880 16.7750 0.7426 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8760 16.4617 0.4739 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5430 17.4283 0.4770 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7700 14.9480 0.7185 N 0 0 0 0 0 0 0 0 0 0 0 0 6.6977 19.1284 0.1976 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0709 21.7270 1.1802 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9868 22.3050 -0.3242 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9277 20.1443 1.4482 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6207 19.7179 -1.3173 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7656 21.3030 -1.5697 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0330 19.4212 3.3372 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.3437 18.4621 -2.8821 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.3589 9.7125 2.0230 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6162 7.9623 2.2626 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8614 10.4751 1.7351 N 0 0 3 0 0 0 0 0 0 0 0 0 2.0471 7.1659 2.5632 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3303 17.1204 0.2070 N 0 0 3 0 0 0 0 0 0 0 0 0 10.6148 16.2132 0.1999 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4991 14.8180 0.4273 O 0 0 0 0 0 0 0 0 0 0 0 0 3.3431 4.8490 1.5956 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6436 3.1207 1.9298 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1022 2.9135 3.1437 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8015 4.6417 2.8095 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2941 5.4856 2.7933 N 0 0 0 0 0 0 0 0 0 0 0 0 2.1511 2.2769 1.9460 N 0 0 0 0 0 0 0 0 0 0 0 0 2.3981 0.5964 2.1761 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0276 16.8531 -0.0595 N 0 0 3 0 0 0 0 0 0 0 0 0 13.3726 15.9325 0.0454 C 0 0 0 0 0 0 0 0 0 0 0 0 13.3369 14.3861 -0.4358 C 0 0 0 0 0 0 0 0 0 0 0 0 14.6655 13.4794 -0.3312 C 0 0 0 0 0 0 0 0 0 0 0 0 14.7465 16.5664 0.6249 C 0 0 0 0 0 0 0 0 0 0 0 0 16.0313 14.1105 0.2529 C 0 0 0 0 0 0 0 0 0 0 0 0 16.0727 15.6549 0.7273 C 0 0 0 0 0 0 0 0 0 0 0 0 17.6985 12.9677 0.3833 Cl 0 0 0 0 0 0 0 0 0 0 0 0 17.7888 16.4434 1.4592 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.4996 15.0402 1.2974 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0482 17.4868 0.7510 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2496 22.5148 2.1473 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0995 23.5435 -0.5277 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7057 21.7611 -2.7421 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5925 9.8955 1.0247 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8243 10.2089 3.0646 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1508 7.4659 1.2209 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3826 7.7793 3.2608 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8132 9.8629 1.7210 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5124 7.6624 3.6049 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2806 7.3490 1.5651 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4226 18.2336 0.0255 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4452 5.4831 1.6165 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8038 4.9722 0.4505 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3943 2.6378 1.0239 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2117 2.9999 3.0612 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6414 2.7901 4.2888 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.2792 3.1228 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2335 4.7625 1.6781 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0510 5.1246 3.7154 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9881 0.4028 3.2859 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2749 0.0000 2.1833 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1145 0.1398 1.2298 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1124 17.9514 -0.3190 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2709 13.8921 -0.8913 H 0 0 0 0 0 0 0 0 0 0 0 0 14.6376 12.2766 -0.7056 H 0 0 0 0 0 0 0 0 0 0 0 0 14.7787 17.7706 0.9948 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 42 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 21 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 43 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 44 1 0 0 0 0 13 16 1 0 0 0 0 13 45 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 46 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 47 1 0 0 0 0 19 48 1 0 0 0 0 20 22 1 0 0 0 0 20 49 1 0 0 0 0 20 50 1 0 0 0 0 21 51 1 0 0 0 0 22 30 1 0 0 0 0 22 52 1 0 0 0 0 22 53 1 0 0 0 0 23 24 1 0 0 0 0 23 54 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 27 31 1 0 0 0 0 27 57 1 0 0 0 0 27 58 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 59 1 0 0 0 0 28 60 1 0 0 0 0 29 30 1 0 0 0 0 29 61 1 0 0 0 0 29 62 1 0 0 0 0 31 32 1 0 0 0 0 32 63 1 0 0 0 0 32 64 1 0 0 0 0 32 65 1 0 0 0 0 33 34 1 0 0 0 0 33 66 1 0 0 0 0 34 35 2 0 0 0 0 34 37 1 0 0 0 0 35 36 1 0 0 0 0 35 67 1 0 0 0 0 36 38 2 0 0 0 0 36 68 1 0 0 0 0 37 39 2 0 0 0 0 37 69 1 0 0 0 0 38 39 1 0 0 0 0 38 40 1 0 0 0 0 39 41 1 0 0 0 0 M END > (619) 6-arylpyrido[2,3-d]pyrimidine deriv. 65 > (619) PDGFR-beta > (619) 5000 > (619) -1 > (619) P > (619) PDGFR-P617 $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 9 csChFnd70/05150717532D 37 39 0 0 0 0 0 0 0 0999 V2000 1.2132 5.0301 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7216 2.4479 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7978 5.9221 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3488 4.9512 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8566 7.7537 0.0115 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0197 7.5177 -0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4355 8.5639 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2364 3.3192 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2484 3.2322 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4300 8.2281 -0.0285 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9252 5.7743 -0.0284 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5408 10.4815 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7028 13.1678 1.5789 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6049 11.3801 1.5793 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5837 11.3964 -1.5491 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6817 13.1840 -1.5313 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7374 14.0674 0.0281 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5609 10.2536 3.5268 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5147 10.2903 -3.5077 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6714 0.6589 -0.0254 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5221 4.7466 -0.0485 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0527 4.4042 -1.8971 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1860 4.9613 -3.0768 O 0 0 0 0 0 0 0 0 0 0 0 0 9.4884 3.4802 -2.2333 O 0 0 0 0 0 0 0 0 0 0 0 0 9.9206 3.2010 -4.0438 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.7285 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6738 8.5025 0.0264 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7521 13.8649 2.7920 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7155 13.8937 -2.7376 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8141 15.4652 0.0349 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5654 0.0609 -0.0180 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7423 0.0000 -0.0391 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5486 5.4584 0.6120 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3000 3.5181 0.6130 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1063 2.4378 -4.1326 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8655 2.5077 -4.6783 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1142 4.4480 -4.6794 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 26 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 20 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 11 1 0 0 0 0 5 7 2 0 0 0 0 5 27 1 0 0 0 0 6 11 1 0 0 0 0 6 7 1 0 0 0 0 6 10 2 0 0 0 0 7 12 1 0 0 0 0 11 21 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 28 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 29 1 0 0 0 0 17 30 1 0 0 0 0 20 31 1 0 0 0 0 20 32 1 0 0 0 0 21 22 1 0 0 0 0 21 33 1 0 0 0 0 21 34 1 0 0 0 0 22 23 2 0 0 0 0 22 24 1 0 0 0 0 24 25 1 0 0 0 0 25 35 1 0 0 0 0 25 36 1 0 0 0 0 25 37 1 0 0 0 0 M END > (620) pyrido[2,3-d]pyrimidin-7-one deriv. 9 > (620) PDGFR-beta > (620) 5000 > (620) -1 > (620) P > (620) PDGFR-P618 $$$$ 1,6-naphthyridin 26 csChFnd70/05150717532D 83 85 0 0 0 0 0 0 0 0999 V2000 1.1639 16.9306 1.0803 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4334 14.2060 0.8691 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0982 14.8668 0.9909 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7990 17.7242 1.2136 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3147 16.6697 1.1685 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9782 19.5349 1.3898 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0864 19.0816 1.4577 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6414 20.2117 1.5124 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0441 15.2357 0.9164 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8899 17.3898 1.2913 N 0 0 0 0 0 0 0 0 0 0 0 0 4.9035 22.1122 1.6995 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3197 25.0335 0.7486 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0720 23.2586 0.5703 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9761 22.7559 3.0095 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2181 24.5323 3.1806 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3942 25.6696 2.0496 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5096 26.1524 -0.3527 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8233 27.9650 -0.0944 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2634 25.1613 4.4583 O 0 0 0 0 0 0 0 0 0 0 0 0 7.4546 27.0062 4.5597 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2035 12.4224 0.6929 N 0 0 3 0 0 0 0 0 0 0 0 0 3.7170 11.2680 0.6382 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1078 9.3852 0.4391 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6886 8.1795 0.3822 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0795 6.2968 0.1830 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7505 19.7692 1.5807 N 0 0 3 0 0 0 0 0 0 0 0 0 9.1430 18.7075 1.5291 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9422 17.1476 1.3749 O 0 0 0 0 0 0 0 0 0 0 0 0 10.7584 19.3751 1.6484 N 0 0 3 0 0 0 0 0 0 0 0 0 12.2878 17.2312 -0.1325 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2723 18.2210 1.5924 C 0 0 0 0 0 0 0 0 0 0 0 0 13.9351 19.3004 1.7523 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1749 16.9263 3.0990 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6602 5.0911 0.1260 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1078 2.3444 -2.3284 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5470 2.1234 -0.4330 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0754 3.2834 -0.0653 N 0 0 0 0 0 0 0 0 0 0 0 0 4.1193 2.7060 1.4836 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1051 1.0492 1.0572 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 17.7146 1.1184 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2118 14.0127 0.9508 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8521 20.3724 1.4279 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2357 22.7641 -0.4431 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6174 21.8712 3.8909 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5851 27.0539 2.1858 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1007 28.7113 -1.0579 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4002 28.3371 1.2057 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2083 28.2293 -0.2340 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3203 27.3331 5.6326 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0022 27.4916 3.3464 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1873 27.6012 4.7773 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0408 11.9422 0.6060 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5382 11.6177 -0.4621 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4558 11.4008 1.8400 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2867 9.0356 1.5396 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3691 9.2525 -0.7625 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5098 8.5292 -0.7183 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4275 8.3124 1.5838 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2582 5.9472 1.2834 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3406 6.1640 -1.0187 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9107 21.0139 1.7036 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9188 20.6198 1.7714 H 0 0 0 0 0 0 0 0 0 0 0 0 12.3570 18.1534 -1.2058 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4140 16.3725 -0.1742 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1030 16.4621 -0.2463 H 0 0 0 0 0 0 0 0 0 0 0 0 13.9241 20.0057 2.9811 H 0 0 0 0 0 0 0 0 0 0 0 0 15.0614 18.4418 1.7105 H 0 0 0 0 0 0 0 0 0 0 0 0 14.0044 20.2228 0.6789 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9903 16.1573 2.9851 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3013 16.0676 3.0573 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1639 17.6315 4.3278 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4815 5.4408 -0.9745 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3991 5.2239 1.3276 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2681 1.5682 -2.5711 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0634 1.9129 -3.1832 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3913 3.7094 -2.5808 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1565 0.7798 -0.2097 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6297 2.4488 0.4209 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0345 2.4428 2.5327 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2171 3.7212 1.8875 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3015 0.6886 2.1671 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2778 1.2787 -0.0701 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0132 0.0000 0.7708 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 40 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 41 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 42 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 26 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 17 1 0 0 0 0 13 43 1 0 0 0 0 14 15 1 0 0 0 0 14 44 1 0 0 0 0 15 16 2 0 0 0 0 15 19 1 0 0 0 0 16 45 1 0 0 0 0 17 18 1 0 0 0 0 18 46 1 0 0 0 0 18 47 1 0 0 0 0 18 48 1 0 0 0 0 19 20 1 0 0 0 0 20 49 1 0 0 0 0 20 50 1 0 0 0 0 20 51 1 0 0 0 0 21 22 1 0 0 0 0 21 52 1 0 0 0 0 22 23 1 0 0 0 0 22 53 1 0 0 0 0 22 54 1 0 0 0 0 23 24 1 0 0 0 0 23 55 1 0 0 0 0 23 56 1 0 0 0 0 24 25 1 0 0 0 0 24 57 1 0 0 0 0 24 58 1 0 0 0 0 25 34 1 0 0 0 0 25 59 1 0 0 0 0 25 60 1 0 0 0 0 26 27 1 0 0 0 0 26 61 1 0 0 0 0 27 28 2 0 0 0 0 27 29 1 0 0 0 0 29 31 1 0 0 0 0 29 62 1 0 0 0 0 30 31 1 0 0 0 0 30 63 1 0 0 0 0 30 64 1 0 0 0 0 30 65 1 0 0 0 0 31 32 1 0 0 0 0 31 33 1 0 0 0 0 32 66 1 0 0 0 0 32 67 1 0 0 0 0 32 68 1 0 0 0 0 33 69 1 0 0 0 0 33 70 1 0 0 0 0 33 71 1 0 0 0 0 34 37 1 0 0 0 0 34 72 1 0 0 0 0 34 73 1 0 0 0 0 35 36 1 0 0 0 0 35 74 1 0 0 0 0 35 75 1 0 0 0 0 35 76 1 0 0 0 0 36 37 1 0 0 0 0 36 77 1 0 0 0 0 36 78 1 0 0 0 0 37 38 1 0 0 0 0 38 39 1 0 0 0 0 38 79 1 0 0 0 0 38 80 1 0 0 0 0 39 81 1 0 0 0 0 39 82 1 0 0 0 0 39 83 1 0 0 0 0 M END > (621) 1,6-naphthyridine 26 > (621) PDGFR-beta > (621) 5000 > (621) -1 > (621) P > (621) PDGFR-P619 $$$$ SU5416 analog 5c csChFnd70/05150717532D 58 61 0 0 0 0 0 0 0 0999 V2000 1.9895 4.0170 -0.1694 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9591 2.2186 -0.4436 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3206 1.4076 -1.3490 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7194 2.3810 -1.9862 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3925 5.0099 -0.8065 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7738 4.1936 -1.7233 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5104 7.0762 -1.6775 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8231 6.9110 -0.7439 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0009 5.4610 -2.2140 N 0 0 3 0 0 0 0 0 0 0 0 0 6.3246 8.4387 -1.9207 O 0 0 0 0 0 0 0 0 0 0 0 0 2.8478 8.2428 0.0256 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5533 9.9578 0.1510 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4501 12.1672 0.4537 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8302 12.8925 0.2389 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6160 11.5230 0.0490 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3005 10.3859 0.4055 N 0 0 3 0 0 0 0 0 0 0 0 0 0.6566 11.7107 -0.2168 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1415 13.1766 0.7090 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4143 14.8344 0.2111 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5354 15.5207 -1.6811 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1131 17.4924 -1.7094 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5337 19.9543 -3.6565 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3120 16.9671 -4.7542 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5524 17.6422 -6.6398 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7741 20.6293 -5.5422 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2294 18.1513 -3.5263 N 0 0 0 0 0 0 0 0 0 0 0 0 1.8568 19.4451 -6.7701 N 0 0 0 0 0 0 0 0 0 0 0 0 1.9731 20.1041 -8.5869 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9255 4.6511 0.5319 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8720 1.4428 0.0490 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2880 0.0000 -1.5581 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7736 1.7333 -2.6899 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0741 5.2121 -2.8626 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5453 7.9702 0.5309 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2622 9.5528 0.5298 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 11.7338 1.0608 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3834 12.9348 -0.9176 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1690 10.5995 -0.9857 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7400 13.4397 -0.5703 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8617 14.4202 1.3716 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0463 12.4001 1.5104 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0852 15.0468 0.7134 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3564 15.5378 1.0369 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8645 15.3084 -2.1834 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5933 14.8174 -2.5068 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7840 17.7048 -1.2072 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0552 18.1957 -0.8837 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2449 20.8093 -2.7471 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1366 19.9543 -3.3219 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9124 16.9332 -4.4319 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8616 15.6442 -4.6449 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9495 17.6420 -6.9745 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8413 16.7872 -7.5493 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2246 21.9522 -5.6515 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1737 20.6632 -5.8645 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2091 19.2517 -9.4552 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4495 21.4405 -8.6460 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3467 20.1087 -9.0076 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 5 2 0 0 0 0 1 29 1 0 0 0 0 2 3 2 0 0 0 0 2 30 1 0 0 0 0 3 4 1 0 0 0 0 3 31 1 0 0 0 0 4 6 2 0 0 0 0 4 32 1 0 0 0 0 5 8 1 0 0 0 0 5 6 1 0 0 0 0 6 9 1 0 0 0 0 7 9 1 0 0 0 0 7 8 1 0 0 0 0 7 10 2 0 0 0 0 8 11 2 0 0 0 0 9 33 1 0 0 0 0 11 12 1 0 0 0 0 11 34 1 0 0 0 0 12 15 2 0 0 0 0 12 16 1 0 0 0 0 13 16 1 0 0 0 0 13 14 2 0 0 0 0 13 18 1 0 0 0 0 14 15 1 0 0 0 0 14 19 1 0 0 0 0 15 17 1 0 0 0 0 16 35 1 0 0 0 0 17 36 1 0 0 0 0 17 37 1 0 0 0 0 17 38 1 0 0 0 0 18 39 1 0 0 0 0 18 40 1 0 0 0 0 18 41 1 0 0 0 0 19 20 1 0 0 0 0 19 42 1 0 0 0 0 19 43 1 0 0 0 0 20 21 1 0 0 0 0 20 44 1 0 0 0 0 20 45 1 0 0 0 0 21 26 1 0 0 0 0 21 46 1 0 0 0 0 21 47 1 0 0 0 0 22 26 1 0 0 0 0 22 25 1 0 0 0 0 22 48 1 0 0 0 0 22 49 1 0 0 0 0 23 26 1 0 0 0 0 23 24 1 0 0 0 0 23 50 1 0 0 0 0 23 51 1 0 0 0 0 24 27 1 0 0 0 0 24 52 1 0 0 0 0 24 53 1 0 0 0 0 25 27 1 0 0 0 0 25 54 1 0 0 0 0 25 55 1 0 0 0 0 27 28 1 0 0 0 0 28 56 1 0 0 0 0 28 57 1 0 0 0 0 28 58 1 0 0 0 0 M END > (63) SU5416 analog 5c > (63) PDGFR-beta > (63) 60 > (63) -1 > (63) P > (63) PDGFR-P61 $$$$ diarylurea deriv. 1 csChFnd70/05150717532D 39 42 0 0 0 0 0 0 0 0999 V2000 1.3104 7.4554 -2.6933 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7507 8.1373 -2.6705 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7958 6.0610 -1.3713 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3798 5.3074 -1.3517 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1147 6.0137 -2.0232 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9362 7.4360 -2.0222 N 0 0 0 0 0 0 0 0 0 0 0 0 5.0797 5.3625 -0.6997 N 0 0 3 0 0 0 0 0 0 0 0 0 6.4795 6.0296 -0.8192 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6429 7.1818 -1.6031 O 0 0 0 0 0 0 0 0 0 0 0 0 7.6983 5.4196 -0.0699 N 0 0 3 0 0 0 0 0 0 0 0 0 9.1719 6.0473 -0.2793 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0893 7.3094 -0.6957 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8035 8.2491 -0.7041 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3485 7.6270 -0.4999 C 0 0 0 0 0 0 0 0 0 0 0 0 11.9264 5.7226 -0.4810 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4539 5.0988 -0.2605 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0564 4.4454 -0.4130 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6830 3.3962 -0.0239 C 0 0 1 0 0 0 0 0 0 0 0 0 10.8305 1.1139 -1.6667 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3515 1.4289 -0.7853 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7355 2.4337 -1.1748 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3116 3.0963 -0.4624 N 0 0 3 0 0 0 0 0 0 0 0 0 14.4479 4.5993 -0.3267 O 0 0 0 0 0 0 0 0 0 0 0 0 0.3453 8.0400 -3.2226 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9087 9.2589 -3.1905 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2685 4.1860 -0.8195 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.4561 -2.0254 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9656 4.3962 -0.1461 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5543 4.5457 0.6145 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2229 7.8037 -0.8510 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9342 9.4768 -0.8752 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3473 8.3691 -0.5124 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4562 3.0631 1.1677 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0288 1.1494 -2.9085 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3524 0.0000 -1.3306 H 0 0 0 0 0 0 0 0 0 0 0 0 12.3816 0.7737 0.2880 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3436 1.1436 -1.5039 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7096 1.9672 -0.6161 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4148 3.1319 -2.1707 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 5 2 0 0 0 0 1 24 1 0 0 0 0 2 6 2 0 0 0 0 2 25 1 0 0 0 0 3 6 1 0 0 0 0 3 4 2 0 0 0 0 3 7 1 0 0 0 0 4 5 1 0 0 0 0 4 26 1 0 0 0 0 5 27 1 0 0 0 0 7 8 1 0 0 0 0 7 28 1 0 0 0 0 8 9 2 0 0 0 0 8 10 1 0 0 0 0 10 11 1 0 0 0 0 10 29 1 0 0 0 0 11 14 2 0 0 0 0 11 16 1 0 0 0 0 12 15 1 0 0 0 0 12 13 2 0 0 0 0 12 30 1 0 0 0 0 13 14 1 0 0 0 0 13 31 1 0 0 0 0 14 32 1 0 0 0 0 15 17 1 0 0 0 0 15 16 2 0 0 0 0 16 18 1 0 0 0 0 17 22 1 0 0 0 0 17 23 2 0 0 0 0 18 22 1 0 0 0 0 18 21 1 0 0 0 0 18 33 1 0 0 0 0 19 20 1 0 0 0 0 19 21 1 0 0 0 0 19 34 1 0 0 0 0 19 35 1 0 0 0 0 20 22 1 0 0 0 0 20 36 1 0 0 0 0 20 37 1 0 0 0 0 21 38 1 0 0 0 0 21 39 1 0 0 0 0 M END > (622) diarylurea deriv. 1 > (622) PDGFR-beta > (622) 5000 > (622) -1 > (622) P > (622) PDGFR-P620 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 73 csChFnd70/05150717532D 62 64 0 0 0 0 0 0 0 0999 V2000 4.8604 13.1947 1.1028 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3983 10.6223 1.0370 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9089 11.4927 0.9440 N 0 0 0 0 0 0 0 0 0 0 0 0 7.9062 11.3931 1.2912 N 0 0 0 0 0 0 0 0 0 0 0 0 6.4267 14.0881 1.3757 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9912 13.1196 1.4684 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4824 15.9010 1.5573 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5865 15.6268 1.8997 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0849 16.6729 1.8221 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5006 13.9280 1.7257 N 0 0 0 0 0 0 0 0 0 0 0 0 8.2210 18.5816 2.0217 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2296 21.1137 3.8408 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4760 22.1481 2.3947 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1011 19.3347 3.6635 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4770 19.6313 0.5694 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6033 21.4088 0.7641 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7903 18.0386 5.4798 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.6372 18.7058 -1.4784 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.3639 8.8379 0.8603 N 0 0 3 0 0 0 0 0 0 0 0 0 4.7109 7.9425 0.5768 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0337 5.9892 0.4263 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3074 5.0540 0.1303 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6172 3.1785 -0.0143 N 0 0 0 0 0 0 0 0 0 0 0 0 1.9749 2.2110 0.0092 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2715 2.1458 1.8648 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6276 2.7717 -1.5788 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3582 0.9310 -1.4348 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1876 16.4044 2.1645 N 0 0 3 0 0 0 0 0 0 0 0 0 12.6339 15.4238 2.2413 C 0 0 0 0 0 0 0 0 0 0 0 0 12.4943 13.2184 2.0120 S 0 0 0 0 0 0 0 0 0 0 0 0 14.1902 16.1796 2.4985 N 0 0 3 0 0 0 0 0 0 0 0 0 15.7623 15.1138 2.5820 C 0 0 0 0 0 0 0 0 0 0 0 0 17.3391 16.2825 2.8816 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6451 13.8879 1.0194 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3124 16.6698 1.4917 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1369 21.6983 5.1112 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5755 23.5385 2.5402 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8016 22.2230 -0.3593 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4342 8.1783 0.9240 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8452 8.1948 1.6667 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1171 8.4157 -0.6166 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8995 5.7369 -0.6635 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6276 5.5160 1.6197 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4416 5.3063 1.2200 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7134 5.5272 -1.0632 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0355 2.8562 -0.8287 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1967 0.8941 -0.4576 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1551 3.4613 2.3715 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.5259 1.8656 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1584 1.4035 2.6794 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7912 2.8593 -2.7163 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6931 3.6933 -1.7050 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0958 0.8091 -0.2340 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2933 0.0000 -1.4305 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2060 0.6726 -2.5372 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2667 17.6539 2.2944 H 0 0 0 0 0 0 0 0 0 0 0 0 14.2692 17.4292 2.6284 H 0 0 0 0 0 0 0 0 0 0 0 0 15.6501 14.1908 3.6481 H 0 0 0 0 0 0 0 0 0 0 0 0 15.9207 14.4111 1.3647 H 0 0 0 0 0 0 0 0 0 0 0 0 17.4512 17.2055 1.8155 H 0 0 0 0 0 0 0 0 0 0 0 0 17.1807 16.9852 4.0989 H 0 0 0 0 0 0 0 0 0 0 0 0 18.5088 15.4896 2.9436 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 34 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 19 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 35 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 28 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 36 1 0 0 0 0 13 16 1 0 0 0 0 13 37 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 38 1 0 0 0 0 19 20 1 0 0 0 0 19 39 1 0 0 0 0 20 21 1 0 0 0 0 20 40 1 0 0 0 0 20 41 1 0 0 0 0 21 22 1 0 0 0 0 21 42 1 0 0 0 0 21 43 1 0 0 0 0 22 23 1 0 0 0 0 22 44 1 0 0 0 0 22 45 1 0 0 0 0 23 24 1 0 0 0 0 23 26 1 0 0 0 0 24 25 1 0 0 0 0 24 46 1 0 0 0 0 24 47 1 0 0 0 0 25 48 1 0 0 0 0 25 49 1 0 0 0 0 25 50 1 0 0 0 0 26 27 1 0 0 0 0 26 51 1 0 0 0 0 26 52 1 0 0 0 0 27 53 1 0 0 0 0 27 54 1 0 0 0 0 27 55 1 0 0 0 0 28 29 1 0 0 0 0 28 56 1 0 0 0 0 29 31 1 0 0 0 0 29 30 2 0 0 0 0 31 32 1 0 0 0 0 31 57 1 0 0 0 0 32 33 1 0 0 0 0 32 58 1 0 0 0 0 32 59 1 0 0 0 0 33 60 1 0 0 0 0 33 61 1 0 0 0 0 33 62 1 0 0 0 0 M END > (623) 6-arylpyrido[2,3-d]pyrimidine deriv. 73 > (623) PDGFR-beta > (623) 5000 > (623) -1 > (623) P > (623) PDGFR-P621 $$$$ 3-substituted indolin-2-one 16b csChFnd70/05150717532D 41 43 0 0 0 0 0 0 0 0999 V2000 1.7560 3.5432 -0.1494 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1636 2.1013 -1.7542 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2108 3.7000 -1.5215 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9931 4.4191 -0.7117 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3725 6.0960 -0.6553 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8609 6.2427 -1.4785 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2924 4.8190 -1.9552 N 0 0 3 0 0 0 0 0 0 0 0 0 5.5786 7.4448 -1.6922 O 0 0 0 0 0 0 0 0 0 0 0 0 2.5123 7.2700 0.0244 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1342 8.7827 0.1360 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3072 10.1633 0.0468 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6752 9.1604 0.3608 N 0 0 3 0 0 0 0 0 0 0 0 0 0.5789 10.3287 -0.1870 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8067 10.7316 0.4047 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7296 1.9560 -0.3915 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9312 1.2414 -1.1913 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2985 11.6220 0.6297 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3780 11.3711 0.2156 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0104 13.0839 0.1951 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6571 13.6344 1.8491 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2895 15.3472 1.8285 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3084 16.0549 0.6154 O 0 0 0 0 0 0 0 0 0 0 0 0 1.9414 16.0864 3.1578 O 0 0 0 0 0 0 0 0 0 0 0 0 0.0519 0.7569 0.3700 Br 0 0 0 0 0 0 0 0 0 0 0 0 0.8225 4.1007 0.4785 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0929 1.5311 -2.3766 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2380 4.6002 -2.5292 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3635 7.0292 0.4701 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5236 8.4258 0.4699 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 10.3473 0.9399 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3377 11.4090 -0.8038 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1490 9.3493 -0.8665 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9032 0.0000 -1.3766 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8256 11.8553 -0.4987 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0520 12.7183 1.2154 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0973 10.9366 1.3354 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0050 13.7239 -0.2596 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0017 13.2906 -0.5433 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6625 12.9944 2.3037 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6658 13.4277 2.5876 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7140 17.1850 3.0863 H 0 0 0 0 0 0 0 0 0 0 0 0 1 15 1 0 0 0 0 1 4 2 0 0 0 0 1 25 1 0 0 0 0 2 16 1 0 0 0 0 2 3 2 0 0 0 0 2 26 1 0 0 0 0 3 7 1 0 0 0 0 3 4 1 0 0 0 0 4 5 1 0 0 0 0 5 6 1 0 0 0 0 5 9 2 0 0 0 0 6 7 1 0 0 0 0 6 8 2 0 0 0 0 7 27 1 0 0 0 0 9 10 1 0 0 0 0 9 28 1 0 0 0 0 10 11 2 0 0 0 0 10 12 1 0 0 0 0 11 18 1 0 0 0 0 11 13 1 0 0 0 0 12 14 1 0 0 0 0 12 29 1 0 0 0 0 13 30 1 0 0 0 0 13 31 1 0 0 0 0 13 32 1 0 0 0 0 14 18 2 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 24 1 0 0 0 0 16 33 1 0 0 0 0 17 34 1 0 0 0 0 17 35 1 0 0 0 0 17 36 1 0 0 0 0 18 19 1 0 0 0 0 19 20 1 0 0 0 0 19 37 1 0 0 0 0 19 38 1 0 0 0 0 20 21 1 0 0 0 0 20 39 1 0 0 0 0 20 40 1 0 0 0 0 21 23 1 0 0 0 0 21 22 2 0 0 0 0 23 41 1 0 0 0 0 M END > (64) 3-substituted indolin-2-one 16b > (64) PDGFR-beta > (64) 60 > (64) -1 > (64) P > (64) PDGFR-P62 $$$$ csChFnd70/05150717532D 36 38 0 0 0 0 0 0 0 0999 V2000 1.3130 6.7892 0.0107 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0025 5.1940 -0.0236 N 0 0 0 0 0 0 0 0 0 0 0 0 1.3336 5.2723 0.0023 N 0 0 0 0 0 0 0 0 0 0 0 0 2.7183 7.5798 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0926 6.7185 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7709 9.2042 0.0092 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5753 8.9934 -0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8261 9.6224 -0.0283 O 0 0 0 0 0 0 0 0 0 0 0 0 5.4907 7.4476 -0.0262 N 0 0 3 0 0 0 0 0 0 0 0 0 6.9061 6.5356 -0.0440 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1710 9.9217 -0.0008 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2650 11.6220 0.0072 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2890 12.4338 -1.3757 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3762 14.0188 -1.3600 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4402 14.8014 0.0224 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4174 14.0034 1.3974 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3231 12.4188 1.3979 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2856 11.4200 3.1248 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.2102 11.4539 -3.1120 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6497 4.5000 -0.0144 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6044 2.9072 -0.0225 N 0 0 3 0 0 0 0 0 0 0 0 0 1.2415 2.1710 -0.0134 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1924 0.4396 -0.0223 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0549 2.9017 0.0018 O 0 0 0 0 0 0 0 0 0 0 0 0 0.2372 7.4086 0.0192 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7225 9.8685 0.0223 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2457 6.3151 -1.2296 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8168 7.1665 0.5408 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7086 5.4469 0.5433 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3950 14.6487 -2.4295 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5087 16.0407 0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4681 14.6212 2.4728 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5536 2.3226 -0.0347 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7807 0.0000 0.9927 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.0556 -0.0130 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7611 0.0109 -1.0530 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 25 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 26 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 27 1 0 0 0 0 10 28 1 0 0 0 0 10 29 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 30 1 0 0 0 0 15 16 1 0 0 0 0 15 31 1 0 0 0 0 16 17 2 0 0 0 0 16 32 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 33 1 0 0 0 0 22 23 1 0 0 0 0 22 24 2 0 0 0 0 23 34 1 0 0 0 0 23 35 1 0 0 0 0 23 36 1 0 0 0 0 M END > (632) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 5 > (632) PDGFR-beta > (632) 5200 > (632) -1 > (632) P > (632) PDGFR-P630 $$$$ Indolin-2-one deriv. 9i csChFnd70/05150717532D 59 63 0 0 0 0 0 0 0 0999 V2000 5.8593 10.8262 0.1580 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8790 9.2419 0.2065 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2799 8.4556 0.1925 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6615 9.2639 0.1298 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6519 10.8600 0.0812 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2381 11.6402 0.0952 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6072 13.3009 0.0332 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2951 13.3756 -0.0155 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8401 11.9289 0.0163 N 0 0 3 0 0 0 0 0 0 0 0 0 10.0662 14.5449 -0.0732 O 0 0 0 0 0 0 0 0 0 0 0 0 6.5844 14.5191 0.0228 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1338 16.0408 0.1478 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5012 17.3340 -0.5450 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3949 16.5183 0.9866 N 0 0 3 0 0 0 0 0 0 0 0 0 5.1019 17.3760 -1.5687 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6631 17.6295 -0.5858 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2639 17.6717 -1.6094 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4030 17.5150 -2.9840 O 0 0 0 0 0 0 0 0 0 0 0 0 0.8629 17.8833 -0.9941 O 0 0 0 0 0 0 0 0 0 0 0 0 8.5499 18.0581 0.8166 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4039 18.5829 -0.1144 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1947 20.2471 -0.5624 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7691 19.0784 1.5195 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7851 20.6107 0.6450 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1444 21.2442 0.5414 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2962 6.7500 0.2455 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6922 5.9588 0.2384 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7034 4.3727 0.2876 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9350 4.3483 0.3579 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9160 5.9344 0.3089 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3268 3.5636 0.3435 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3418 2.0008 0.3914 O 0 0 0 0 0 0 0 0 0 0 0 0 5.8841 1.2415 0.4477 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7762 11.4358 0.1635 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8109 8.6081 0.2557 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7414 8.6485 0.1193 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9244 11.6641 -0.0046 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3645 14.3055 -0.0810 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0590 15.8601 1.5962 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2154 18.3142 -2.3936 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0013 16.2878 -2.1843 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5497 16.6915 0.2391 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7638 18.7179 0.0298 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 17.9018 -1.6966 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5939 20.4213 -1.7386 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9827 20.5586 -0.4764 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5023 19.2844 2.7277 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8905 18.5249 1.4224 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5112 21.4322 1.2545 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2395 20.4281 -0.5098 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1761 22.4240 0.1168 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6191 21.2237 1.6804 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7633 6.5875 0.1940 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7843 3.7591 0.2822 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8662 3.7157 0.4019 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8330 6.5441 0.3200 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2631 1.6042 1.4754 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2171 1.5412 -0.5715 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0604 0.0000 0.4820 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 6 2 0 0 0 0 1 34 1 0 0 0 0 2 3 2 0 0 0 0 2 35 1 0 0 0 0 3 4 1 0 0 0 0 3 26 1 0 0 0 0 4 5 2 0 0 0 0 4 36 1 0 0 0 0 5 9 1 0 0 0 0 5 6 1 0 0 0 0 6 7 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 9 1 0 0 0 0 8 10 2 0 0 0 0 9 37 1 0 0 0 0 11 12 1 0 0 0 0 11 38 1 0 0 0 0 12 13 2 0 0 0 0 12 14 1 0 0 0 0 13 21 1 0 0 0 0 13 15 1 0 0 0 0 14 20 1 0 0 0 0 14 39 1 0 0 0 0 15 16 1 0 0 0 0 15 40 1 0 0 0 0 15 41 1 0 0 0 0 16 17 1 0 0 0 0 16 42 1 0 0 0 0 16 43 1 0 0 0 0 17 19 1 0 0 0 0 17 18 2 0 0 0 0 19 44 1 0 0 0 0 20 23 1 0 0 0 0 20 21 2 0 0 0 0 21 22 1 0 0 0 0 22 25 1 0 0 0 0 22 45 1 0 0 0 0 22 46 1 0 0 0 0 23 24 1 0 0 0 0 23 47 1 0 0 0 0 23 48 1 0 0 0 0 24 25 1 0 0 0 0 24 49 1 0 0 0 0 24 50 1 0 0 0 0 25 51 1 0 0 0 0 25 52 1 0 0 0 0 26 30 1 0 0 0 0 26 27 2 0 0 0 0 27 28 1 0 0 0 0 27 53 1 0 0 0 0 28 31 2 0 0 0 0 28 54 1 0 0 0 0 29 31 1 0 0 0 0 29 30 2 0 0 0 0 29 55 1 0 0 0 0 30 56 1 0 0 0 0 31 32 1 0 0 0 0 32 33 1 0 0 0 0 33 57 1 0 0 0 0 33 58 1 0 0 0 0 33 59 1 0 0 0 0 M END > (638) Indolin-2-one deriv. 9i > (638) PDGFR-beta > (638) 5430 > (638) -1 > (638) P > (638) PDGFR-P636 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 64 csChFnd70/05150717532D 72 76 0 0 0 0 0 0 0 0999 V2000 3.9015 15.6761 1.3910 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3609 13.1396 1.6141 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9176 14.0212 1.6427 N 0 0 0 0 0 0 0 0 0 0 0 0 6.8523 13.8524 1.3359 N 0 0 0 0 0 0 0 0 0 0 0 0 5.4529 16.5066 1.0880 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9676 15.5281 1.0663 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5409 18.2668 0.8080 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5768 17.9257 0.5157 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1252 18.9781 0.5190 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4613 16.2774 0.7817 N 0 0 0 0 0 0 0 0 0 0 0 0 7.2938 20.8295 0.2151 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7007 23.6589 1.2853 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6100 24.2885 -0.3528 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5441 21.9355 1.5769 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2100 21.4716 -1.4345 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3686 23.1976 -1.7092 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6576 21.1479 3.6338 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.9079 20.1046 -3.1386 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.6579 10.5759 2.1997 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9379 8.6701 2.4597 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2940 11.4064 1.8870 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2293 7.8027 2.7863 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1603 18.6429 0.2251 N 0 0 3 0 0 0 0 0 0 0 0 0 11.5591 17.6552 0.2174 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4329 16.1358 0.4649 O 0 0 0 0 0 0 0 0 0 0 0 0 3.6408 5.2803 1.7318 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9679 3.3983 2.0949 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2002 3.1719 3.4158 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8730 5.0539 3.0527 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4981 5.9729 3.0359 N 0 0 0 0 0 0 0 0 0 0 0 0 2.3428 2.4793 2.1116 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6117 0.6495 2.3613 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0975 18.3519 -0.0648 N 0 0 3 0 0 0 0 0 0 0 0 0 14.5616 17.3499 0.0494 C 0 0 0 0 0 0 0 0 0 0 0 0 14.5232 15.6657 -0.4745 C 0 0 0 0 0 0 0 0 0 0 0 0 15.9706 14.6802 -0.3607 C 0 0 0 0 0 0 0 0 0 0 0 0 17.4566 15.3687 0.2748 C 0 0 0 0 0 0 0 0 0 0 0 0 17.4989 17.0452 0.7981 C 0 0 0 0 0 0 0 0 0 0 0 0 16.0580 18.0397 0.6802 C 0 0 0 0 0 0 0 0 0 0 0 0 19.0334 14.2896 0.3978 C 0 0 0 0 0 0 0 0 0 0 0 0 18.5715 12.5930 0.6568 F 0 0 0 0 0 0 0 0 0 0 0 0 19.9643 14.4266 -1.1101 F 0 0 0 0 0 0 0 0 0 0 0 0 20.0283 14.8475 1.7609 F 0 0 0 0 0 0 0 0 0 0 0 0 2.7225 16.3775 1.4115 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4088 19.0418 0.8172 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8951 24.5165 2.3386 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7327 25.6371 -0.5741 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3035 23.6965 -2.9857 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8238 10.7757 1.1126 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0754 11.1160 3.3340 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5205 8.1300 1.3253 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7723 8.4702 3.5469 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3305 10.7398 1.8717 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6468 8.3428 3.9205 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3950 8.0026 1.6991 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2610 19.8552 0.0277 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8409 5.9708 1.7553 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0540 5.4151 0.4847 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7856 2.8728 1.1085 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5861 3.2661 3.3270 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7869 3.0371 4.6629 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.4814 3.3923 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2547 5.1861 1.8206 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0553 5.5794 4.0391 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2538 0.4379 3.5699 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3886 0.0000 2.3687 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3920 0.1527 1.3308 H 0 0 0 0 0 0 0 0 0 0 0 0 13.1900 19.5479 -0.3471 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3628 15.1268 -0.9701 H 0 0 0 0 0 0 0 0 0 0 0 0 15.9416 13.3702 -0.7680 H 0 0 0 0 0 0 0 0 0 0 0 0 18.6614 17.5792 1.2943 H 0 0 0 0 0 0 0 0 0 0 0 0 16.0933 19.3505 1.0840 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 44 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 21 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 45 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 46 1 0 0 0 0 13 16 1 0 0 0 0 13 47 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 48 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 49 1 0 0 0 0 19 50 1 0 0 0 0 20 22 1 0 0 0 0 20 51 1 0 0 0 0 20 52 1 0 0 0 0 21 53 1 0 0 0 0 22 30 1 0 0 0 0 22 54 1 0 0 0 0 22 55 1 0 0 0 0 23 24 1 0 0 0 0 23 56 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 57 1 0 0 0 0 26 58 1 0 0 0 0 27 31 1 0 0 0 0 27 59 1 0 0 0 0 27 60 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 61 1 0 0 0 0 28 62 1 0 0 0 0 29 30 1 0 0 0 0 29 63 1 0 0 0 0 29 64 1 0 0 0 0 31 32 1 0 0 0 0 32 65 1 0 0 0 0 32 66 1 0 0 0 0 32 67 1 0 0 0 0 33 34 1 0 0 0 0 33 68 1 0 0 0 0 34 35 2 0 0 0 0 34 39 1 0 0 0 0 35 36 1 0 0 0 0 35 69 1 0 0 0 0 36 37 2 0 0 0 0 36 70 1 0 0 0 0 37 38 1 0 0 0 0 37 40 1 0 0 0 0 38 39 2 0 0 0 0 38 71 1 0 0 0 0 39 72 1 0 0 0 0 40 42 1 0 0 0 0 40 41 1 0 0 0 0 40 43 1 0 0 0 0 M END > (640) 6-arylpyrido[2,3-d]pyrimidine deriv. 64 > (640) PDGFR-beta > (640) 5500 > (640) -1 > (640) P > (640) PDGFR-P638 $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7k csChFnd70/05150717532D 54 57 0 0 0 0 0 0 0 0999 V2000 1.2235 14.0143 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7163 11.4113 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3155 12.2365 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7784 14.9505 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3654 14.0372 -0.0179 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7782 16.7852 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3278 17.6485 -0.0006 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9501 16.6619 -0.0214 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3337 17.4233 -0.0303 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2467 12.3091 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9182 14.9151 -0.0285 N 0 0 3 0 0 0 0 0 0 0 0 0 7.5499 13.9433 -0.0487 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3644 19.5689 0.0072 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4310 22.2606 1.5738 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3971 20.4705 1.5755 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3739 20.4838 -1.5534 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4080 22.2740 -1.5369 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4334 23.1600 0.0222 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3941 19.3442 3.5240 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.3437 19.3743 -3.5113 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6515 9.6141 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2611 8.6058 -0.0467 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8286 6.6699 -0.0537 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5094 5.6171 -0.0755 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7591 3.3520 1.2159 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3109 1.4213 1.1118 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1810 0.7836 0.1123 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6582 2.7079 0.2063 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0942 3.7583 -0.0822 N 0 0 0 0 0 0 0 0 0 0 0 0 4.8533 0.4215 1.3548 O 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 14.6949 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5010 11.4916 -0.0420 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5711 17.4943 0.0257 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9419 13.7085 -1.3860 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5515 14.6903 0.6114 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3705 12.7078 0.6134 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4558 22.9601 2.7865 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4154 22.9837 -2.7438 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4599 24.5599 0.0279 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5406 9.0248 -0.0188 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0031 8.9269 -1.2057 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0247 8.9137 1.1017 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0865 6.3489 1.1054 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0650 6.3620 -1.2022 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2514 5.9380 -1.2345 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2731 5.9250 1.0731 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6010 4.1198 0.9580 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2485 3.6539 2.5067 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3758 1.0989 2.1211 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7565 1.1331 -0.1557 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7101 0.4770 -1.1843 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3216 0.0000 0.3985 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1941 2.9996 1.4809 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6166 3.0056 -0.7888 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 31 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 32 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 33 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 34 1 0 0 0 0 12 35 1 0 0 0 0 12 36 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 37 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 38 1 0 0 0 0 18 39 1 0 0 0 0 21 22 1 0 0 0 0 21 40 1 0 0 0 0 22 23 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 24 1 0 0 0 0 23 43 1 0 0 0 0 23 44 1 0 0 0 0 24 29 1 0 0 0 0 24 45 1 0 0 0 0 24 46 1 0 0 0 0 25 29 1 0 0 0 0 25 26 1 0 0 0 0 25 47 1 0 0 0 0 25 48 1 0 0 0 0 26 30 1 0 0 0 0 26 49 1 0 0 0 0 26 50 1 0 0 0 0 27 30 1 0 0 0 0 27 28 1 0 0 0 0 27 51 1 0 0 0 0 27 52 1 0 0 0 0 28 29 1 0 0 0 0 28 53 1 0 0 0 0 28 54 1 0 0 0 0 M END > (646) 1,6-naphthyridin-2(1H)-one deriv. 7k > (646) PDGFR-beta > (646) 5800 > (646) -1 > (646) P > (646) PDGFR-P644 $$$$ 3-substituted indolin-2-one 11c csChFnd70/05150717532D 43 45 0 0 0 0 0 0 0 0999 V2000 2.8776 4.1124 0.1598 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6878 2.5187 0.1322 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6918 4.1333 0.0823 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2704 4.9294 0.0964 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6531 6.6046 0.0352 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3576 6.6692 -0.0128 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8980 5.2045 0.0171 N 0 0 3 0 0 0 0 0 0 0 0 0 7.1441 7.8447 -0.0703 O 0 0 0 0 0 0 0 0 0 0 0 0 3.6283 7.8407 0.0249 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1925 9.3737 0.1525 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5634 10.6826 -0.5452 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4668 9.8477 0.9991 N 0 0 3 0 0 0 0 0 0 0 0 0 2.1514 10.7337 -1.5797 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6318 11.4064 0.8295 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4846 11.9442 -0.1077 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8973 2.5091 0.2087 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2989 1.7188 0.1954 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2439 13.6107 -0.5887 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0747 14.3807 0.5070 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8341 16.0473 0.0260 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5269 16.5659 -1.0797 O 0 0 0 0 0 0 0 0 0 0 0 0 1.8504 16.9556 0.8258 O 0 0 0 0 0 0 0 0 0 0 0 0 1.4934 0.0000 0.9577 O 0 0 0 0 0 0 0 0 0 0 0 0 0.0129 2.4984 0.9210 O 0 0 0 0 0 0 0 0 0 0 0 0 1.1368 1.4670 0.2890 S 0 0 0 0 0 0 0 0 0 0 0 0 0.5969 1.1204 -1.5251 N 0 0 0 0 0 0 0 0 0 0 0 0 1.7850 4.7298 0.1757 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7733 1.8891 0.1220 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9910 4.9299 -0.0042 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3952 7.6326 -0.0809 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1339 9.1786 1.6138 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1170 10.9214 -0.8732 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2718 11.6809 -2.4118 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0441 9.6359 -2.2021 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5297 12.1063 1.3579 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3054 0.4645 0.2344 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3474 14.2300 -0.5316 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7997 13.6480 -1.7742 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9713 13.7614 0.4498 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5190 14.3434 1.6924 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7343 18.0163 0.4735 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.1957 -1.7686 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8774 1.8419 -2.3443 H 0 0 0 0 0 0 0 0 0 0 0 0 1 16 1 0 0 0 0 1 4 2 0 0 0 0 1 27 1 0 0 0 0 2 17 1 0 0 0 0 2 3 2 0 0 0 0 2 28 1 0 0 0 0 3 7 1 0 0 0 0 3 4 1 0 0 0 0 4 5 1 0 0 0 0 5 6 1 0 0 0 0 5 9 2 0 0 0 0 6 7 1 0 0 0 0 6 8 2 0 0 0 0 7 29 1 0 0 0 0 9 10 1 0 0 0 0 9 30 1 0 0 0 0 10 11 2 0 0 0 0 10 12 1 0 0 0 0 11 15 1 0 0 0 0 11 13 1 0 0 0 0 12 14 1 0 0 0 0 12 31 1 0 0 0 0 13 32 1 0 0 0 0 13 33 1 0 0 0 0 13 34 1 0 0 0 0 14 15 2 0 0 0 0 14 35 1 0 0 0 0 15 18 1 0 0 0 0 16 17 2 0 0 0 0 16 25 1 0 0 0 0 17 36 1 0 0 0 0 18 19 1 0 0 0 0 18 37 1 0 0 0 0 18 38 1 0 0 0 0 19 20 1 0 0 0 0 19 39 1 0 0 0 0 19 40 1 0 0 0 0 20 22 1 0 0 0 0 20 21 2 0 0 0 0 22 41 1 0 0 0 0 23 25 2 0 0 0 0 24 25 2 0 0 0 0 25 26 1 0 0 0 0 26 42 1 0 0 0 0 26 43 1 0 0 0 0 M END > (649) 3-substituted indolin-2-one 11c > (649) PDGFR-beta > (649) 5980 > (649) -1 > (649) P > (649) PDGFR-P647 $$$$ PD089828 analog 16 csChFnd70/05150717532D 51 53 0 0 0 0 0 0 0 0999 V2000 1.2126 5.0427 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7209 2.4561 -0.0163 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8018 5.9334 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3609 4.9560 -0.0185 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8853 7.7522 0.0111 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5089 8.5207 0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2357 3.3349 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2491 3.2239 -0.0268 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8913 5.7618 -0.0282 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6592 0.6658 -0.0253 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6747 10.4356 0.0104 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5417 13.0737 -1.3947 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1152 11.3868 1.4410 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2727 13.1691 1.4430 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9841 14.0111 0.0290 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0032 7.4658 -0.0196 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6261 8.2404 -0.0305 N 0 0 3 0 0 0 0 0 0 0 0 0 9.0660 7.2512 -0.0495 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9428 5.6801 -0.0573 O 0 0 0 0 0 0 0 0 0 0 0 0 5.3975 11.2909 -1.4080 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6429 8.0037 -0.0600 N 0 0 3 0 0 0 0 0 0 0 0 0 12.2080 6.9285 -0.0808 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2084 5.7928 -1.7067 C 0 0 0 0 0 0 0 0 0 0 0 0 13.8117 8.0954 -0.0892 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2386 5.7742 1.5318 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0129 10.2709 -2.9565 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3222 14.0003 -2.9272 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.7422 0.0330 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7199 8.5279 0.0260 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5493 0.0748 -0.0179 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7258 0.0000 -0.0390 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5591 10.7306 2.5455 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8392 13.9074 2.5506 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0999 15.4064 0.0341 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7245 9.4940 -0.0242 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7413 9.2572 -0.0538 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1865 6.6150 -2.8556 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3729 4.9927 -1.7223 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0658 4.9613 -1.7007 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8114 8.9045 1.0692 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9763 7.2953 -0.1046 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7899 8.9176 -1.2380 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0962 4.9429 1.5378 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4032 4.9743 1.5164 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2385 6.5834 2.6902 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9530 10.1325 -3.8806 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0881 10.9509 -3.5712 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4425 8.9918 -2.5372 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3028 14.3255 -3.8500 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9559 15.1846 -2.4887 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2722 13.1609 -3.5512 H 0 0 0 0 0 0 0 0 0 0 0 0 1 7 2 0 0 0 0 1 3 1 0 0 0 0 1 28 1 0 0 0 0 2 7 1 0 0 0 0 2 8 2 0 0 0 0 2 10 1 0 0 0 0 3 5 1 0 0 0 0 3 4 2 0 0 0 0 4 8 1 0 0 0 0 4 9 1 0 0 0 0 5 6 2 0 0 0 0 5 29 1 0 0 0 0 6 16 1 0 0 0 0 6 11 1 0 0 0 0 9 16 2 0 0 0 0 10 30 1 0 0 0 0 10 31 1 0 0 0 0 11 20 1 0 0 0 0 11 13 2 0 0 0 0 12 20 2 0 0 0 0 12 15 1 0 0 0 0 12 27 1 0 0 0 0 13 14 1 0 0 0 0 13 32 1 0 0 0 0 14 15 2 0 0 0 0 14 33 1 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 17 18 1 0 0 0 0 17 35 1 0 0 0 0 18 21 1 0 0 0 0 18 19 2 0 0 0 0 20 26 1 0 0 0 0 21 22 1 0 0 0 0 21 36 1 0 0 0 0 22 23 1 0 0 0 0 22 24 1 0 0 0 0 22 25 1 0 0 0 0 23 37 1 0 0 0 0 23 38 1 0 0 0 0 23 39 1 0 0 0 0 24 40 1 0 0 0 0 24 41 1 0 0 0 0 24 42 1 0 0 0 0 25 43 1 0 0 0 0 25 44 1 0 0 0 0 25 45 1 0 0 0 0 26 46 1 0 0 0 0 26 47 1 0 0 0 0 26 48 1 0 0 0 0 27 49 1 0 0 0 0 27 50 1 0 0 0 0 27 51 1 0 0 0 0 M END > (650) PD089828 analog 16 > (650) PDGFR-beta > (650) 6050 > (650) -1 > (650) P > (650) PDGFR-P648 $$$$ csChFnd70/05150717532D 34 36 0 0 0 0 0 0 0 0999 V2000 1.0757 5.9136 0.0107 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7667 4.3198 -0.0236 N 0 0 0 0 0 0 0 0 0 0 0 0 1.0963 4.3970 0.0023 N 0 0 0 0 0 0 0 0 0 0 0 0 2.4811 6.7047 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8559 5.8441 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5329 8.3286 0.0092 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3374 8.1197 -0.0192 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5877 8.7495 -0.0283 O 0 0 0 0 0 0 0 0 0 0 0 0 5.2536 6.5740 -0.0262 N 0 0 3 0 0 0 0 0 0 0 0 0 6.6693 5.6628 -0.0440 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9328 9.0470 -0.0008 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0259 10.7473 0.0074 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0495 11.5592 -1.3755 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1359 13.1441 -1.3597 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1994 13.9266 0.0228 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1770 13.1286 1.3975 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0837 11.5440 1.3980 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0473 10.5450 3.1248 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.9711 10.5793 -3.1116 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.4134 3.6244 -0.0144 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3690 2.0383 -0.0230 N 0 0 3 0 0 0 0 0 0 0 0 0 0.8880 1.2376 -0.0138 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 6.5328 0.0192 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4842 8.9924 0.0224 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0091 5.4424 -1.2295 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5797 6.2942 0.5407 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4725 4.5739 0.5433 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1542 13.7740 -2.4292 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2674 15.1660 0.0287 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2275 13.7463 2.4731 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3185 1.4542 -0.0353 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2494 1.5526 1.0169 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2303 1.5642 -1.0286 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0823 0.0000 -0.0226 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 23 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 24 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 25 1 0 0 0 0 10 26 1 0 0 0 0 10 27 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 28 1 0 0 0 0 15 16 1 0 0 0 0 15 29 1 0 0 0 0 16 17 2 0 0 0 0 16 30 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 31 1 0 0 0 0 22 32 1 0 0 0 0 22 33 1 0 0 0 0 22 34 1 0 0 0 0 M END > (651) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 21 > (651) PDGFR-beta > (651) 6200 > (651) -1 > (651) P > (651) PDGFR-P649 $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 54 csChFnd70/05150717532D 83 86 0 0 0 0 0 0 0 0999 V2000 3.9952 16.0375 0.0121 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5103 13.4384 -0.0164 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0185 14.3211 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0461 14.2100 -0.0268 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5916 16.9321 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1581 15.9499 -0.0186 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6754 18.7597 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8082 18.4716 -0.0220 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3067 19.5317 -0.0020 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6959 16.7595 -0.0296 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4733 21.4554 0.0055 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7221 24.1491 1.5781 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7845 25.0501 0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5671 22.3569 1.5801 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5444 22.3709 -1.5621 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6997 24.1632 -1.5464 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4883 21.2286 3.5378 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4389 21.2602 -3.5285 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7641 10.7428 -0.0129 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0606 8.7723 -0.0258 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4483 11.6394 -0.0249 N 0 0 3 0 0 0 0 0 0 0 0 0 2.3016 7.8358 -0.0133 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4390 19.2499 -0.0339 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8857 18.2561 -0.0530 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7618 16.6776 -0.0598 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8987 5.4563 -1.3307 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2324 3.4935 -1.2311 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2789 3.0426 -0.2251 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9453 5.0052 -0.3247 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5864 5.9439 -0.0256 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5913 2.5549 -1.5301 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8759 0.6629 -1.5423 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4698 19.0122 -0.0647 N 0 0 3 0 0 0 0 0 0 0 0 0 15.0424 17.9318 -0.0854 C 0 0 0 0 0 0 0 0 0 0 0 0 16.6536 19.1044 -0.0952 C 0 0 0 0 0 0 0 0 0 0 0 0 18.2961 17.9761 -0.1170 C 0 0 0 0 0 0 0 0 0 0 0 0 19.9073 19.1487 -0.1267 C 0 0 0 0 0 0 0 0 0 0 0 0 21.5497 18.0204 -0.1485 C 0 0 0 0 0 0 0 0 0 0 0 0 23.1610 19.1930 -0.1582 C 0 0 0 0 0 0 0 0 0 0 0 0 24.8033 18.0647 -0.1800 C 0 0 0 0 0 0 0 0 0 0 0 0 26.4146 19.2371 -0.1898 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7768 16.7402 0.0217 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5046 19.5392 0.0249 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7953 24.8485 2.7964 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9059 26.4514 0.0249 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7544 24.8737 -2.7592 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0207 11.1170 -1.1629 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0432 11.1053 1.1551 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7815 8.4098 -1.1938 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8040 8.3981 1.1244 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5199 10.9706 -0.0387 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5808 8.1984 1.1547 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5582 8.2100 -1.1633 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5378 20.5095 -0.0285 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1067 6.1557 -1.0719 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4254 5.7910 -2.6265 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1775 3.1227 -2.2232 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7393 3.1637 0.0534 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7523 2.7078 1.0707 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0708 2.3431 -0.4838 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4384 5.3350 -1.6090 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3761 0.6676 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4113 0.2569 -0.2919 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6407 0.0000 -1.7661 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7871 0.3282 -2.5783 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5687 20.2717 -0.0592 H 0 0 0 0 0 0 0 0 0 0 0 0 15.0649 17.1065 1.0693 H 0 0 0 0 0 0 0 0 0 0 0 0 15.0423 17.1182 -1.2488 H 0 0 0 0 0 0 0 0 0 0 0 0 16.6312 19.9298 -1.2501 H 0 0 0 0 0 0 0 0 0 0 0 0 16.6539 19.9180 1.0681 H 0 0 0 0 0 0 0 0 0 0 0 0 18.3185 17.1508 1.0379 H 0 0 0 0 0 0 0 0 0 0 0 0 18.2959 17.1625 -1.2803 H 0 0 0 0 0 0 0 0 0 0 0 0 19.8850 19.9740 -1.2816 H 0 0 0 0 0 0 0 0 0 0 0 0 19.9075 19.9623 1.0366 H 0 0 0 0 0 0 0 0 0 0 0 0 21.5721 17.1951 1.0064 H 0 0 0 0 0 0 0 0 0 0 0 0 21.5496 17.2068 -1.3118 H 0 0 0 0 0 0 0 0 0 0 0 0 23.1385 20.0183 -1.3131 H 0 0 0 0 0 0 0 0 0 0 0 0 23.1612 20.0066 1.0051 H 0 0 0 0 0 0 0 0 0 0 0 0 24.8257 17.2393 0.9749 H 0 0 0 0 0 0 0 0 0 0 0 0 24.8032 17.2511 -1.3433 H 0 0 0 0 0 0 0 0 0 0 0 0 27.5847 18.4334 -0.2052 H 0 0 0 0 0 0 0 0 0 0 0 0 26.3921 20.0626 -1.3446 H 0 0 0 0 0 0 0 0 0 0 0 0 26.4148 20.0509 0.9736 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 42 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 21 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 43 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 44 1 0 0 0 0 13 16 1 0 0 0 0 13 45 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 46 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 47 1 0 0 0 0 19 48 1 0 0 0 0 20 22 1 0 0 0 0 20 49 1 0 0 0 0 20 50 1 0 0 0 0 21 51 1 0 0 0 0 22 30 1 0 0 0 0 22 52 1 0 0 0 0 22 53 1 0 0 0 0 23 24 1 0 0 0 0 23 54 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 27 31 1 0 0 0 0 27 57 1 0 0 0 0 27 58 1 0 0 0 0 28 31 1 0 0 0 0 28 29