TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T99954	Prostacyclin receptor	D0GC5H	Ramatroban	Phase 2/3	123879	C21H21FN2O4S	416.5	C1CC2=C(C[C@@H]1NS(=O)(=O)C3=CC=C(C=C3)F)C4=CC=CC=C4N2CCC(=O)O	IC50 ~ 100000 nM	Poor binder
T99954	Prostacyclin receptor	D06EYC	BI-671800	Phase 2	45270144	C25H26F3N5O3	501.5	CN(C)C1=C(C(=NC(=N1)CC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)C(F)(F)F)N(C)C)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T99954	Prostacyclin receptor	D0X7EG	OC-000459	Phase 2	11462174	C21H17FN2O2	348.4	CC1=C(C2=C(N1CC(=O)O)C=CC(=C2)F)CC3=NC4=CC=CC=C4C=C3	IC50 = 57900 nM	Poor binder
T99954	Prostacyclin receptor	D0I3TU	MK-7246	Phase 1	45268455	C21H21FN2O4S	416.5	CN([C@@H]1CCC2=C(C3=CC=CC=C3N2C1)CC(=O)O)S(=O)(=O)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T99954	Prostacyclin receptor	D00HTY	PGF2alpha	Clinical trial	5280363	C20H34O5	354.5	CCCCC[C@@H](/C=C/[C@H]1[C@@H](C[C@@H]([C@@H]1C/C=C\\CCCC(=O)O)O)O)O	IC50 ~ 100000 nM	Poor binder
T99954	Prostacyclin receptor	B13TJU	2-[(6R)-6-[(4-Fluorophenyl)sulfonyl-methylamino]-5,6,7,8-tetrahydropyrido[2,3-b]indol-9-yl]acetic acid	Investigative	45270148	C20H20FN3O4S	417.5	CN([C@@H]1CCC2=C(C1)C3=C(N2CC(=O)O)N=CC=C3)S(=O)(=O)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T99954	Prostacyclin receptor	B1WL0H	(R)-2-(8-(4-Fluoro-N-methylphenylsulfonamido)-6,7,8,9-tetrahydro-5H-pyrido[3,2-b]indol-5-yl)acetic acid	Investigative	45270983	C20H20FN3O4S	417.5	CN([C@@H]1CCC2=C(C1)C3=C(N2CC(=O)O)C=CC=N3)S(=O)(=O)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T99954	Prostacyclin receptor	B2IO7L	(R)-2-(3-(4-Fluoro-N-methylphenylsulfonamido)-1,2,3,4-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid	Investigative	45272700	C21H21FN2O4S	416.5	CN([C@@H]1CCC2=C(C1)N3C=CC=CC3=C2CC(=O)O)S(=O)(=O)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T99954	Prostacyclin receptor	B2L6AG	(E)-3-[2-(4-Methylsulfanyl-benzyl)-phenyl]-acrylic acid	Investigative	9817292	C17H16O2S	284.4	CSC1=CC=C(C=C1)CC2=CC=CC=C2/C=C/C(=O)O	Ki ~ 76000 nM	Poor binder
T99954	Prostacyclin receptor	B2XA0R	2-[(6R)-6-[(4-Fluorophenyl)sulfonyl-methylamino]-5,6,7,8-tetrahydropyrido[3,4-b]indol-9-yl]acetic acid	Investigative	45270987	C20H20FN3O4S	417.5	CN([C@@H]1CCC2=C(C1)C3=C(N2CC(=O)O)C=NC=C3)S(=O)(=O)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T99954	Prostacyclin receptor	B9ZA1M	2-[(3R)-3-[(4-Fluorophenyl)sulfonyl-methylamino]-1,2,3,4,4b,8a-hexahydrocarbazol-9-yl]acetic acid	Investigative	45269307	C21H23FN2O4S	418.5	CN([C@@H]1CCC2=C(C1)C3C=CC=CC3N2CC(=O)O)S(=O)(=O)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T99954	Prostacyclin receptor	BC5MS0	2-[(9R)-9-[(4-Fluorophenyl)sulfonyl-methylamino]-7,8,9,10-tetrahydropyrido[1,2-b]isoindol-6-yl]acetic acid	Investigative	45268456	C21H21FN2O4S	416.5	CN([C@@H]1CCC2=C(N3C=CC=CC3=C2C1)CC(=O)O)S(=O)(=O)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T99954	Prostacyclin receptor	BM56JK	[2'-[(Cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetic acid sodium salt	Investigative	50901657	C29H31N2NaO5	510.6	CCN(CC1=C(C=CC(=C1)C2=CN=C(C=C2)OCC)C3=C(C=CC(=C3)CC(=O)[O-])OC)C(=O)C4CC4.[Na+]	IC50 ~ 100000 nM	Poor binder
T99954	Prostacyclin receptor	BQ01TY	1-Methyl-3-[2-[4-[(6-oxo-11,12-dihydrobenzo[c][1]benzazocin-5-yl)methyl]phenyl]phenyl]sulfonyl-1-(2-phenylethyl)urea	Investigative	9874010	C38H35N3O4S	629.8	CN(CCC1=CC=CC=C1)C(=O)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)CN4C5=CC=CC=C5CCC6=CC=CC=C6C4=O	Ki = 52000 nM	Poor binder
T99954	Prostacyclin receptor	BW1F4A	2-[(8R)-8-[(4-Fluorophenyl)sulfonyl-methylamino]-6,7,8,9-tetrahydropyrazino[2,3-b]indol-5-yl]acetic acid	Investigative	45272704	C19H19FN4O4S	418.4	CN([C@@H]1CCC2=C(C1)C3=NC=CN=C3N2CC(=O)O)S(=O)(=O)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T99954	Prostacyclin receptor	BX6C7A	{2'-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid	Investigative	44159530	C27H26F3NO5	501.5	CCN(CC1=C(C=CC(=C1)C(F)(F)F)C2=C(C=CC(=C2)CC(=O)O)OC)C(=O)OCC3=CC=CC=C3	IC50 = 56200 nM	Poor binder
T99954	Prostacyclin receptor	BXC50J	2-[(7R)-7-[(4-Fluorophenyl)sulfonyl-methylamino]-6,7,8,9-tetrahydropyrido[2,3-b]indolizin-10-yl]acetic acid	Investigative	45273637	C20H20FN3O4S	417.5	CN([C@@H]1CCC2=C(C3=C(N2C1)C=CC=N3)CC(=O)O)S(=O)(=O)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T99954	Prostacyclin receptor	D0J9PG	AH6809	Investigative	119461	C17H14O5	298.29	CC(C)OC1=CC2=C(C=C1)C(=O)C3=C(O2)C=CC(=C3)C(=O)O	Ki ~ 100000 nM	Poor binder
T99954	Prostacyclin receptor	D0Z3XJ	3-(2-(naphthalen-2-ylmethyl)phenyl)acrylic acid	Investigative	9817405	C20H16O2	288.3	C1=CC=C2C=C(C=CC2=C1)CC3=CC=CC=C3/C=C/C(=O)O	Ki ~ 100000 nM	Poor binder