TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T99402	Metabotropic glutamate receptor 4	D0U5CS	LY354740	Discontinued in Phase 2	213056	C8H11NO4	185.18	C1C[C@]([C@H]2[C@@H]1[C@@H]2C(=O)O)(C(=O)O)N	Ki ~ 100000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	B0A5EK	(3-Amino-3-methylbutyl)phosphonic acid	Investigative	18756981	C5H14NO3P	167.14	CC(C)(CCP(=O)(O)O)N	Ki = 88000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	B1ST5P	(2S)-2-Amino-4-[hydroxy-[hydroxy-(4-methylsulfonylphenyl)methyl]phosphoryl]butanoic acid	Investigative	24780092	C12H18NO7PS	351.31	CS(=O)(=O)C1=CC=C(C=C1)C(O)P(=O)(CC[C@@H](C(=O)O)N)O	EC50 = 59000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	B3KS7C	(1S,3S)-1-Amino-3-phosphonocyclopentanecarboxylic acid	Investigative	44282281	C6H12NO5P	209.14	C1C[C@](C[C@H]1P(=O)(O)O)(C(=O)O)N	EC50 = 86000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	B4PCS2	(S)-2-Amino-3-(1-(carboxymethyl)-1H-1,2,3-triazol-5-yl)propanoic acid	Investigative	52947499	C7H10N4O4	214.18	C1=C(N(N=N1)CC(=O)O)C[C@@H](C(=O)O)N	EC50 ~ 100000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	B4WA0S	(S)-2-Amino-3-(1-((S)-1-carboxy-2-phenylethyl)-1H-1,2,3-triazol-5-yl)propanoic acid	Investigative	52947232	C14H16N4O4	304.3	C1=CC=C(C=C1)C[C@@H](C(=O)O)N2C(=CN=N2)C[C@@H](C(=O)O)N	EC50 ~ 100000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	B56RAI	2-(2,6-Dichloro-phenyl)-7-ethyl-5-(2-methoxy-phenyl)-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid dimethylaminomethyl ester	Investigative	44322537	C25H25Cl2N3O3S	518.5	CCC1=C(C(N2C=C(SC2=N1)C3=C(C=CC=C3Cl)Cl)C4=CC=CC=C4OC)C(=O)OCN(C)C	Ki ~ 100000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	B6BH5N	4-Amino-2-thia-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid	Investigative	10198133	C7H9NO4S	203.22	C1[C@]([C@@H]2[C@H]([C@@H]2S1)C(=O)O)(C(=O)O)N	EC50 ~ 100000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	B6X9QI	(S)-1-(2-Amino-2-carboxyethyl)-1H-1,2,3-triazole-4-carboxylic acid	Investigative	52941386	C6H8N4O4	200.15	C1=C(N=NN1C[C@@H](C(=O)O)N)C(=O)O	EC50 ~ 100000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	B7O6AS	3-[[[(3S)-3-Amino-3-carboxypropyl]-hydroxyphosphoryl]methyl]benzoic acid	Investigative	24780089	C12H16NO6P	301.23	C1=CC(=CC(=C1)C(=O)O)CP(=O)(CC[C@@H](C(=O)O)N)O	EC50 ~ 100000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	B89BZX	(1S,2S,3R)-2-[(S)-Amino(carboxy)methyl]-3-cyclopropylcyclopropane-1-carboxylic acid	Investigative	46927956	C9H13NO4	199.2	C1CC1[C@@H]2[C@@H]([C@H]2C(=O)O)[C@@H](C(=O)O)N	EC50 ~ 100000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	BB3QZ8	(4r)-4-[3-(Methylamino)-3-Oxopropyl]-L-Glutamic Acid	Investigative	24905647	C9H16N2O5	232.23	CNC(=O)CC[C@H](C[C@@H](C(=O)O)N)C(=O)O	EC50 ~ 100000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	BF8R7M	(2S,4R)-4-(3-Amino-3-oxopropyl)glutamic acid	Investigative	24905646	C8H14N2O5	218.21	C(CC(=O)N)[C@H](C[C@@H](C(=O)O)N)C(=O)O	EC50 ~ 100000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	BJ9L3T	(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-ethyl-cyclopropanecarboxylic acid	Investigative	44329042	C22H23NO5	381.4	CC[C@@H]1[C@@H]([C@H]1C(CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O	IC50 = 60350 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	BK8NL7	(1S,3S)-1-Aminocyclopentane-1,3-dicarboxylic acid	Investigative	6604704	C7H11NO4	173.17	C1C[C@](C[C@H]1C(=O)O)(C(=O)O)N	EC50 = 50000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	BN0FU3	(2S,4R)-2-Amino-4-(3-(ethylamino)-3-oxopropyl)pentanedioic acid	Investigative	44568312	C10H18N2O5	246.26	CCNC(=O)CC[C@H](C[C@@H](C(=O)O)N)C(=O)O	EC50 ~ 100000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	BP0UA4	1-Amino-3-phosphono-3-cyclopentene-1-carboxylic acid	Investigative	10262421	C6H10NO5P	207.12	C1C=C(CC1(C(=O)O)N)P(=O)(O)O	IC50 ~ 100000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	BQK1P0	(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-methyl-cyclopropanecarboxylic acid	Investigative	44328850	C21H21NO5	367.4	C[C@@H]1[C@@H]([C@H]1C(CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O	IC50 = 62850 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	BTN92G	(S)-2-Amino-3-(1-((S)-1-carboxy-2-phenylethyl)-1H-1,2,3-triazol-4-yl)propanoic acid	Investigative	52948863	C14H16N4O4	304.3	C1=CC=C(C=C1)C[C@@H](C(=O)O)N2C=C(N=N2)C[C@@H](C(=O)O)N	EC50 ~ 100000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	BV17EG	1-Amino-3-phosphono-2-cyclopentene-1-carboxylic acid	Investigative	10375719	C6H10NO5P	207.12	C1CC(C=C1P(=O)(O)O)(C(=O)O)N	IC50 ~ 100000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	BV5UC8	(1S,2S,3R)-2-[(S)-Amino(carboxy)methyl]-3-cyclohexylcyclopropane-1-carboxylic acid	Investigative	52944782	C12H19NO4	241.28	C1CCC(CC1)[C@@H]2[C@@H]([C@H]2C(=O)O)[C@@H](C(=O)O)N	EC50 ~ 100000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	BY3AD0	(S)-2-Amino-3-(1-(carboxymethyl)-1H-1,2,3-triazol-4-yl)propanoic acid	Investigative	52941387	C7H10N4O4	214.18	C1=C(N=NN1CC(=O)O)C[C@@H](C(=O)O)N	EC50 ~ 100000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	BZ10NG	2-(Amino-carboxy-methyl)-3-methyl-cyclopropanecarboxylic acid	Investigative	10176324	C7H11NO4	173.17	C[C@@H]1[C@@H]([C@H]1C(=O)O)[C@@H](C(=O)O)N	EC50 ~ 100000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	BZPS47	L-Homocysteic acid	Investigative	177491	C4H9NO5S	183.19	C(CS(=O)(=O)O)[C@@H](C(=O)O)N	Ki = 53000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	D01EVA	CPCCOEt	Investigative	6278000	C13H13NO4	247.25	CCOC(=O)C12CC1/C(=N\\O)/C3=CC=CC=C3O2	Ki ~ 100000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	D03UIR	(2S,4R)-4-(3-Methoxy-3-oxopropyl)glutamic Acid	Investigative	24905704	C9H15NO6	233.22	COC(=O)CC[C@H](C[C@@H](C(=O)O)N)C(=O)O	EC50 ~ 100000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	D04DKM	(1S,3R)-ACPD	Investigative	104766	C7H11NO4	173.17	C1C[C@](C[C@@H]1C(=O)O)(C(=O)O)N	Ki = 98000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	D05TFE	SIB-1757	Investigative	5218788	C12H11N3O	213.23	.	Ki ~ 100000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	D06DUE	[3H]quisqualate	Investigative	40539	C5H7N3O5	189.13	C([C@@H](C(=O)O)N)N1C(=O)NC(=O)O1	Ki = 112000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	D06PAK	LY-389795	Investigative	10058694	C7H9NO4S	203.22	C1[C@](C2[C@H](C2S1)C(=O)O)(C(=O)O)N	Ki ~ 100000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	D09UBS	Ro64-5229	Investigative	10428048	C17H19Cl2N3O	352.3	C1CCCC(CC1)O/C(=C\\N2C=NC=N2)/C3=C(C=CC=C3Cl)Cl	Ki ~ 100000 nM	Poor binder
T99402	Metabotropic glutamate receptor 4	D0J2WN	PCCG-4	Investigative	5311344	C12H13NO4	235.24	C1=CC=C(C=C1)[C@@H]2[C@@H]([C@H]2C(=O)O)[C@@H](C(=O)O)N	Ki = 50000 nM	Poor binder