TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T98691	HUMAN cathepsin L	B06KHG	Arylaminoethyl carbamate, 17	Investigative	23648378	C27H40FN3O4	489.6	C[C@@H](CN1C2=C(CC1(C)C)C=C(C=C2)F)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N4CCOCC4	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B0E6ZK	(E)-3-(3-Bromo-4-methoxyphenyl)-1-(furan-2-yl)prop-2-en-1-one	Investigative	71624732	C14H11BrO3	307.14	COC1=C(C=C(C=C1)/C=C/C(=O)C2=CC=CO2)Br	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B0I2GH	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(1,3-thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70281073	C19H25N5O2S	387.5	C1CC[C@H]([C@@H](C1)C(=O)NC2(CC2)C#N)C(=O)N3CCN(CC3)C4=NC=CS4	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B0IUZ1	Benzyl (3S)-3-[(2S)-4-cyclohexyl-2-[(3-methoxyphenyl)formamido]butanamido]-4-(5-fluoro-2,3-dihydro-1H-indol-1-yl)butanoate	Investigative	11456379	C37H44FN3O5	629.8	COC1=CC=CC(=C1)C(=O)N[C@@H](CCC2CCCCC2)C(=O)N[C@@H](CC(=O)OCC3=CC=CC=C3)CN4CCC5=C4C=CC(=C5)F	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B0KF1T	1-(5,7-Dihydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-yl)-3-(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1-propanone	Investigative	101889645	C25H30O5	410.5	CC1(CCC2=C(O1)C=CC(=C2)CCC(=O)C3=C(C4=C(C=C3O)OC(CC4)(C)C)O)C	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B0LA8M	(2S)-2-[[2-(3,5-Dichlorophenyl)acetyl]amino]-3,3-dimethyl-N-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]butanamide	Investigative	118720237	C20H27Cl2N3O5S	492.4	CC(C)(C)[C@@H](C(=O)NCC(=O)NC/C=C/S(=O)(=O)C)NC(=O)CC1=CC(=CC(=C1)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B0NQB2	(R)-3,3-Dimethyl-1-(5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-yl)butan-2-yl(S)-1-(1H-pyrazol-5-ylamino)-1,2-dioxoheptan-3-ylcarbamate	Investigative	10231447	C26H31F3N6O5	564.6	CCCC[C@@H](C(=O)C(=O)NC1=CC=NN1)NC(=O)O[C@H](CC2=NN=C(O2)C3=CC=C(C=C3)C(F)(F)F)C(C)(C)C	IC50 = 69000 nM	Poor binder
T98691	HUMAN cathepsin L	B0PDL2	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-[5-(2-cyanopropan-2-yl)-1,3-thiazol-2-yl]piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70697225	C23H30N6O2S	454.6	CC(C)(C#N)C1=CN=C(S1)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4(CC4)C#N	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B0RVC8	(1R,2R)-N-[(1R)-1-Cyanoethyl]-2-(8-fluoro-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexane-1-carboxamide	Investigative	60195904	C22H25FN4O2	396.5	C[C@H](C#N)NC(=O)[C@@H]1CCCC[C@H]1C(=O)N2CCC3=C(C2)C4=C(N3)C=CC(=C4)F	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B0T2EC	Benzyl N-[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate	Investigative	26794600	C22H27N3O4S	429.5	CSCC[C@@H](C(=O)N)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2	Ki = 64000 nM	Poor binder
T98691	HUMAN cathepsin L	B0ZGO4	Methyl (E)-4-[[2-[(3R)-3-(cyclohexylcarbamoyloxymethyl)-2-oxo-5-phenyl-3H-1,4-benzodiazepin-1-yl]acetyl]amino]but-2-enoate	Investigative	49798902	C30H34N4O6	546.6	COC(=O)/C=C/CNC(=O)CN1C2=CC=CC=C2C(=N[C@@H](C1=O)COC(=O)NC3CCCCC3)C4=CC=CC=C4	Ki = 76500 nM	Poor binder
T98691	HUMAN cathepsin L	B1DKX4	Tert-butyl N-[(2S)-1-[5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-1-oxopentan-2-yl]carbamate	Investigative	44412339	C19H25N3O5	375.4	CCC[C@@H](C(=O)C1=NN=C(O1)C2=CC=CC=C2OC)NC(=O)OC(C)(C)C	Ki ~ 150000 nM	Poor binder
T98691	HUMAN cathepsin L	B1DN0Q	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-[4-(trifluoromethyl)-1,3-thiazol-2-yl]piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70693116	C20H24F3N5O2S	455.5	C1CC[C@H]([C@@H](C1)C(=O)NC2(CC2)C#N)C(=O)N3CCN(CC3)C4=NC(=CS4)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B1GPT5	Tert-butyl N-[(2S)-1-[5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazol-2-yl]-1-oxopentan-2-yl]carbamate	Investigative	44412502	C20H28N4O4	388.5	CCC[C@@H](C(=O)C1=NN=C(O1)C2=CC=C(C=C2)N(C)C)NC(=O)OC(C)(C)C	Ki = 130000 nM	Poor binder
T98691	HUMAN cathepsin L	B1MF2O	Succinamide peptidomimetic, 6	Investigative	11327594	C23H34FN3O3	419.5	C1CCC(CC1)C[C@H](CC(=O)NCCNC2=CC=C(C=C2)F)C(=O)N3CCOCC3	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B1O4QI	5-Nitro-2-(4-phenylmethoxyanilino)benzoic acid	Investigative	70683996	C20H16N2O5	364.4	C1=CC=C(C=C1)COC2=CC=C(C=C2)NC3=C(C=C(C=C3)[N+](=O)[O-])C(=O)O	IC50 ~ 50000 nM	Poor binder
T98691	HUMAN cathepsin L	B1P9BU	N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-methylpiperazine-1-carbonyl)benzamide	Investigative	11517167	C22H29N5O3	411.5	CN1CCN(CC1)C(=O)C2=CC=C(C=C2)C(=O)NC3(CCCCC3)C(=O)NCC#N	Ki ~ 150000 nM	Poor binder
T98691	HUMAN cathepsin L	B20ZUP	5-((2,3-Dimethylphenoxy)methyl)-3-methyloxazolidin-2-one	Investigative	44426056	C13H17NO3	235.28	CC1=C(C(=CC=C1)OCC2CN(C(=O)O2)C)C	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B24QDK	Arylaminoethyl carbamate, 24	Investigative	23648381	C29H44FN3O4	517.7	C[C@@H]1CN(C[C@@H](O1)C)C(=O)[C@H](CC2CCCCC2)OC(=O)N[C@@H](C)CN3CC(C4=C3C=CC(=C4)F)(C)C	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B29LPH	2-(2,3,4,5,6-Pentafluorophenyl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide	Investigative	44561932	C13H8F5NO3S	353.27	C1CCC2=C(C1)C(=O)N(S2(=O)=O)C3=C(C(=C(C(=C3F)F)F)F)F	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B29TFB	2-Methyl-5-nitroquinoline-8-ol	Investigative	12737307	C10H8N2O3	204.18	CC1=NC2=C(C=CC(=C2C=C1)[N+](=O)[O-])O	Ki = 122000 nM	Poor binder
T98691	HUMAN cathepsin L	B2C1NS	(3S)-N-[1-[[(2R)-Butan-2-yl]amino]-1,2-dioxohexan-3-yl]-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide	Investigative	44394249	C37H57N7O6	695.9	CCCC(C(=O)C(=O)N[C@H](C)CC)NC(=O)[C@@H]1C2CCCC2CN1C(=O)[C@H](C(C)(C)C)NC(=O)[C@H](C3CCCCC3)NC(=O)C4=NC=CN=C4	Ki = 107000 nM	Poor binder
T98691	HUMAN cathepsin L	B2GO3A	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(5,6-dihydro-4H-cyclopenta[d][1,3]thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	25133838	C22H29N5O2S	427.6	C1CC[C@H]([C@@H](C1)C(=O)NC2(CC2)C#N)C(=O)N3CCN(CC3)C4=NC5=C(S4)CCC5	IC50 ~ 50118.72 nM	Poor binder
T98691	HUMAN cathepsin L	B2VAN9	(3R,4R)-4-(2,3-Dimethylphenoxy)piperidin-3-ol	Investigative	13186896	C13H19NO2	221.29	CC1=C(C(=CC=C1)O[C@@H]2CCNC[C@H]2O)C	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B2XQT9	5-Nitro-8-(4-methylpiperidino)quinoline	Investigative	71717313	C15H17N3O2	271.31	CC1CCN(CC1)C2=C3C(=C(C=C2)[N+](=O)[O-])C=CC=N3	Ki = 155000 nM	Poor binder
T98691	HUMAN cathepsin L	B2XWM9	(1r,2r)-N-(1-Cyanocyclopropyl)-2-{[4-(4-Fluorophenyl)piperazin-1-Yl]carbonyl}cyclohexanecarboxamide	Investigative	70278898	C22H27FN4O2	398.5	C1CC[C@H]([C@@H](C1)C(=O)NC2(CC2)C#N)C(=O)N3CCN(CC3)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B2Z3PS	Arylaminoethyl carbamate, 26	Investigative	23648383	C25H38FN3O3	447.6	C[C@@H](CN1CC(C2=C1C=CC(=C2)F)(C)C)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N(C)C	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B30PIS	Succinamide peptidomimetic, 36	Investigative	11376611	C27H31F6N3O4	575.5	CC(C)[C@@H](CNC1=CC=C(C=C1)OC(F)(F)F)NC(=O)[C@@H](CC(=O)N2CCOCC2)C3=CC=C(C=C3)C(F)(F)F	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B36ZIR	2-(6-Bromopyridin-2-yl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide	Investigative	44561892	C12H11BrN2O3S	343.2	C1CCC2=C(C1)C(=O)N(S2(=O)=O)C3=NC(=CC=C3)Br	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B3KYM0	4,5-Dimethyl-2-(2,3,5,6-tetrafluoropyridin-4-yl)-isothiazol-3(2H)-one 1,1-dioxide	Investigative	44561930	C10H6F4N2O3S	310.23	CC1=C(S(=O)(=O)N(C1=O)C2=C(C(=NC(=C2F)F)F)F)C	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B3N9QG	4-Fluoro-2',4'-dihydroxychalcone	Investigative	19540655	C15H11FO3	258.24	C1=CC(=CC=C1/C=C/C(=O)C2=C(C=C(C=C2)O)O)F	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B3POD9	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-([1,3]thiazolo[5,4-b]pyridin-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70276830	C22H26N6O2S	438.5	C1CC[C@H]([C@@H](C1)C(=O)NC2(CC2)C#N)C(=O)N3CCN(CC3)C4=NC5=C(S4)N=CC=C5	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B3SJ4D	Arylaminoethyl carbamate, 27	Investigative	23648384	C26H38FN3O3	459.6	C[C@@H](CN1CC(C2=C1C=CC(=C2)F)(C)C)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N4CCC4	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B3X2DZ	Succinamide peptidomimetic, 35	Investigative	11375856	C27H34F3N3O4	521.6	CC1=CC=C(C=C1)[C@H](CC(=O)N2CCOCC2)C(=O)N[C@H](CNC3=CC=C(C=C3)OC(F)(F)F)C(C)C	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B4ADZ2	2-(2,3,5,6-Tetrafluoropyridin-4-yl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide	Investigative	25141405	C12H8F4N2O3S	336.26	C1CCC2=C(C1)C(=O)N(S2(=O)=O)C3=C(C(=NC(=C3F)F)F)F	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B4OK1I	Arylaminoethyl carbamate, 15	Investigative	23644742	C24H28F3N3O5	495.5	C[C@@H](CNC1=CC=C(C=C1)OC(F)(F)F)NC(=O)O[C@@H](CC2=CC=CC=C2)C(=O)N3CCOCC3	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B4VL8N	3-[2-(3,5-Dichlorophenyl)-2-methylpropanoyl]-4-methoxy-N-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]benzamide	Investigative	118720236	C24H26Cl2N2O6S	541.4	CC(C)(C1=CC(=CC(=C1)Cl)Cl)C(=O)C2=C(C=CC(=C2)C(=O)NCC(=O)NC/C=C/S(=O)(=O)C)OC	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B4ZB6F	Benzyl N-[(2R)-1-(cyanomethylamino)-4-methyl-1-oxopentan-2-yl]carbamate	Investigative	11551229	C16H21N3O3	303.36	CC(C)C[C@H](C(=O)NCC#N)NC(=O)OCC1=CC=CC=C1	Ki ~ 150000 nM	Poor binder
T98691	HUMAN cathepsin L	B59BKW	Diethylcyanamide	Investigative	12050	C5H10N2	98.15	CCN(CC)C#N	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B5EC2P	(2E)-3-(3-Bromo-4-methoxyphenyl)-1-(4-fluorophenyl)prop-2-EN-1-one	Investigative	8194707	C16H12BrFO2	335.17	COC1=C(C=C(C=C1)/C=C/C(=O)C2=CC=C(C=C2)F)Br	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B5G0QS	Chembl365415	Investigative	15955412	C34H51N7O6	653.8	CCC[C@@H](C(=O)C(=O)NC1CC1)NC(=O)[C@@H]2C3CCCC3CN2C(=O)[C@H](C(C)(C)C)NC(=O)[C@H](C(C)(C)C)NC(=O)C4=NC=CN=C4	Ki = 123000 nM	Poor binder
T98691	HUMAN cathepsin L	B5I6RB	(2R)-2-Amino-N-[(1S,2S)-1-cyano-2-phenylcyclopropyl]-3-thiophen-2-ylpropanamide;2,2,2-trifluoroacetic acid	Investigative	49797572	C19H18F3N3O3S	425.4	C1[C@H]([C@@]1(C#N)NC(=O)[C@@H](CC2=CC=CS2)N)C3=CC=CC=C3.C(=O)(C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T98691	HUMAN cathepsin L	B5PJY7	3-Methoxy-2-(3-nitro-4-phenylmethoxyanilino)benzoic acid	Investigative	70692441	C21H18N2O6	394.4	COC1=CC=CC(=C1NC2=CC(=C(C=C2)OCC3=CC=CC=C3)[N+](=O)[O-])C(=O)O	IC50 ~ 50000 nM	Poor binder
T98691	HUMAN cathepsin L	B5Q6ZX	Tert-butyl N-[(2S)-1-oxo-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)pentan-2-yl]carbamate	Investigative	44412341	C16H21N3O4S	351.4	CCC[C@@H](C(=O)C1=NN=C(O1)C2=CC=CS2)NC(=O)OC(C)(C)C	Ki = 63000 nM	Poor binder
T98691	HUMAN cathepsin L	B5RKW8	Arylaminoethyl carbamate, 29	Investigative	23648386	C28H42FN3O3	487.6	C[C@@H](CN1CC(C2=C1C=CC(=C2)F)(C)C)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N4CCCCC4	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B5T0WC	N-[2-(Cyanomethylamino)-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[2-(dimethylamino)ethoxy]benzamide	Investigative	118720233	C25H28Cl2N4O4	519.4	CC(C)(C1=CC(=CC(=C1)Cl)Cl)C(=O)C2=C(C=CC(=C2)C(=O)NCC(=O)NCC#N)OCCN(C)C	IC50 = 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B5U9FI	N-[(1R)-7-(Azepan-1-ylmethylideneamino)-1,2,3,4-tetrahydronaphthalen-1-yl]-4-bromobenzamide	Investigative	118716560	C24H28BrN3O	454.4	C1CCCN(CC1)C=NC2=CC3=C(CCC[C@H]3NC(=O)C4=CC=C(C=C4)Br)C=C2	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B5WEG3	Methyl (E)-4-[[2-[(3R)-3-(1-adamantylcarbamoyloxymethyl)-2-oxo-5-phenyl-3H-1,4-benzodiazepin-1-yl]acetyl]amino]but-2-enoate	Investigative	49798903	C34H38N4O6	598.7	COC(=O)/C=C/CNC(=O)CN1C2=CC=CC=C2C(=N[C@@H](C1=O)COC(=O)NC34CC5CC(C3)CC(C5)C4)C6=CC=CC=C6	Ki = 65000 nM	Poor binder
T98691	HUMAN cathepsin L	B5WQ6L	Arylaminoethyl carbamate, 9	Investigative	23648372	C25H36FN3O5	477.6	C1CCC(CC1)C[C@@H](C(=O)N2CCOCC2)OC(=O)N[C@H](CN3CCC4=C3C=CC(=C4)F)CO	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B5YS4X	N-[(2S)-1-[5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl]-1-oxopentan-2-yl]-2-phenylacetamide	Investigative	44412437	C19H19N3O4	353.4	CCC[C@@H](C(=O)C1=NN=C(O1)C2=CC=CO2)NC(=O)CC3=CC=CC=C3	Ki = 150000 nM	Poor binder
T98691	HUMAN cathepsin L	B64GYX	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(4,5-dimethyl-1,3-thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70688897	C21H29N5O2S	415.6	CC1=C(SC(=N1)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4(CC4)C#N)C	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B67UKE	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-([1,3]thiazolo[4,5-c]pyridin-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70695171	C22H26N6O2S	438.5	C1CC[C@H]([C@@H](C1)C(=O)NC2(CC2)C#N)C(=O)N3CCN(CC3)C4=NC5=C(S4)C=CN=C5	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B6M4IT	(2E)-2-[(E)-1-Phenoxypropan-2-ylidenehydrazinylidene]-3-phenyl-1,3-thiazolidin-4-one	Investigative	71452029	C18H17N3O2S	339.4	C/C(=N\\N=C\\1/N(C(=O)CS1)C2=CC=CC=C2)/COC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B6P2WD	N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(2-morpholin-4-yl-1,3-thiazol-4-yl)benzamide	Investigative	10161284	C23H27N5O3S	453.6	C1CCC(CC1)(C(=O)NCC#N)NC(=O)C2=CC=C(C=C2)C3=CSC(=N3)N4CCOCC4	Ki = 74000 nM	Poor binder
T98691	HUMAN cathepsin L	B70YSP	1-(5,7-Dihydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-yl)-3-(1,1,4a-trimethyl-1,2,3,4,4a,9a-hexahydro-9H-xanthene-7-yl)-1-propanone	Investigative	101889646	C30H38O5	478.6	CC1(CCCC2(C1CC3=C(O2)C=CC(=C3)CCC(=O)C4=C(C5=C(C=C4O)OC(CC5)(C)C)O)C)C	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B7BSG8	7-(Cyanomethylaminomethyl)-5-nitro-8-quinolinol	Investigative	71520324	C12H10N4O3	258.23	C1=CC2=C(C=C(C(=C2N=C1)O)CNCC#N)[N+](=O)[O-]	Ki = 124000 nM	Poor binder
T98691	HUMAN cathepsin L	B7PCJ5	Succinamide peptidomimetic, 33	Investigative	11238059	C26H31ClF3N3O4	542	CC(C)[C@@H](CNC1=CC=C(C=C1)OC(F)(F)F)NC(=O)[C@@H](CC(=O)N2CCOCC2)C3=CC=C(C=C3)Cl	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B7PJ6N	2-Anilino-3-methoxybenzoic acid	Investigative	12262704	C14H13NO3	243.26	COC1=CC=CC(=C1NC2=CC=CC=C2)C(=O)O	IC50 ~ 50000 nM	Poor binder
T98691	HUMAN cathepsin L	B7PMG1	2-(6-Chloropyridin-2-yl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide	Investigative	44561891	C12H11ClN2O3S	298.75	C1CCC2=C(C1)C(=O)N(S2(=O)=O)C3=NC(=CC=C3)Cl	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B7PW2U	Arylaminoethyl amide deriv. 32	Investigative	23648405	C23H27F3N4O4	480.5	C1COCCN1C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)NCCNC3=CC=C(C=C3)OC(F)(F)F	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B7PZ8I	(1R,2R)-2-[4-(4-Tert-butyl-1,3-thiazol-2-yl)piperazine-1-carbonyl]-N-(1-cyanocyclopropyl)cyclohexane-1-carboxamide	Investigative	70693115	C23H33N5O2S	443.6	CC(C)(C)C1=CSC(=N1)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4(CC4)C#N	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B7WH9Y	N-(Cyanomethyl)-1-(3-phenylpropanoylamino)cyclohexane-1-carboxamide	Investigative	11594784	C18H23N3O2	313.4	C1CCC(CC1)(C(=O)NCC#N)NC(=O)CCC2=CC=CC=C2	Ki ~ 150000 nM	Poor binder
T98691	HUMAN cathepsin L	B81UVG	Succinamide peptidomimetic, 7	Investigative	23648362	C23H34FN3O3	419.5	C1CCC(CC1)C[C@@H](CC(=O)NCCNC2=CC=C(C=C2)F)C(=O)N3CCOCC3	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B87VBM	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(4-phenyl-1,3-thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70693117	C25H29N5O2S	463.6	C1CC[C@H]([C@@H](C1)C(=O)NC2(CC2)C#N)C(=O)N3CCN(CC3)C4=NC(=CS4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B8RS5T	1,1-Dioxo-2-pyridin-4-yl-4,5,6,7-tetrahydro-1,2-benzothiazol-3-one;perchloric acid	Investigative	49797481	C12H13ClN2O7S	364.76	C1CCC2=C(C1)C(=O)N(S2(=O)=O)C3=CC=NC=C3.OCl(=O)(=O)=O	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	B8SDZ1	Methyl (E,4S)-4-[[2-[(3R)-3-[[4-chloro-2-(trifluoromethyl)phenyl]carbamoyloxymethyl]-2-oxo-5-phenyl-3H-1,4-benzodiazepin-1-yl]acetyl]amino]-6-methylhept-2-enoate	Investigative	49798904	C35H34ClF3N4O6	699.1	CC(C)C[C@@H](/C=C/C(=O)OC)NC(=O)CN1C2=CC=CC=C2C(=N[C@@H](C1=O)COC(=O)NC3=C(C=C(C=C3)Cl)C(F)(F)F)C4=CC=CC=C4	Ki ~ 150000 nM	Poor binder
T98691	HUMAN cathepsin L	B9AN2E	Gold trichloride	Investigative	26030	AuCl3	303.32	Cl[Au](Cl)Cl	IC50 = 60000 nM	Poor binder
T98691	HUMAN cathepsin L	B9BMZ0	(E)-3-(3-Bromo-4-methoxyphenyl)-1-thiophen-2-ylprop-2-en-1-one	Investigative	8854795	C14H11BrO2S	323.21	COC1=C(C=C(C=C1)/C=C/C(=O)C2=CC=CS2)Br	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BA1C3D	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(4-cyclopropyl-1,3-thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70274815	C22H29N5O2S	427.6	C1CC[C@H]([C@@H](C1)C(=O)NC2(CC2)C#N)C(=O)N3CCN(CC3)C4=NC(=CS4)C5CC5	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BAE10O	(2S)-2-(3,5-Dichlorophenyl)-N-[(3S)-1-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]-2-oxopyrrolidin-3-yl]butanamide	Investigative	118720239	C20H25Cl2N3O5S	490.4	CC[C@@H](C1=CC(=CC(=C1)Cl)Cl)C(=O)N[C@H]2CCN(C2=O)CC(=O)NC/C=C/S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BAH54I	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-[5-methyl-4-(trifluoromethyl)-1,3-thiazol-2-yl]piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70276811	C21H26F3N5O2S	469.5	CC1=C(N=C(S1)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4(CC4)C#N)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BAV5R3	S-Tert-Butyl Phenylmethanesulfinothioate	Investigative	13184126	C11H16OS2	228.4	CC(C)(C)SS(=O)CC1=CC=CC=C1	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BB84EI	Succinamide peptidomimetic, 41	Investigative	23648369	C24H25F6N3O4	533.5	C1COCCN1C(=O)C[C@@H](C2=CC=C(C=C2)C(F)(F)F)C(=O)NCCNC3=CC=C(C=C3)OC(F)(F)F	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BC2HK1	Tert-butyl N-[(2S)-1-oxo-1-(5-propan-2-yl-1,3,4-oxadiazol-2-yl)pentan-2-yl]carbamate	Investigative	44412340	C15H25N3O4	311.38	CCC[C@@H](C(=O)C1=NN=C(O1)C(C)C)NC(=O)OC(C)(C)C	Ki ~ 150000 nM	Poor binder
T98691	HUMAN cathepsin L	BC78ID	N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-2-pyridin-4-yl-1,3-thiazole-4-carboxamide	Investigative	11588744	C18H19N5O2S	369.4	C1CCC(CC1)(C(=O)NCC#N)NC(=O)C2=CSC(=N2)C3=CC=NC=C3	Ki ~ 150000 nM	Poor binder
T98691	HUMAN cathepsin L	BCXB42	Methyl (E)-4-[[2-[(3R)-3-[[4-chloro-2-(trifluoromethyl)phenyl]carbamoyloxymethyl]-5-(4-methoxyphenyl)-2-oxo-3H-1,4-benzodiazepin-1-yl]acetyl]amino]but-2-enoate	Investigative	49798882	C32H28ClF3N4O7	673	COC1=CC=C(C=C1)C2=N[C@@H](C(=O)N(C3=CC=CC=C32)CC(=O)NC/C=C/C(=O)OC)COC(=O)NC4=C(C=C(C=C4)Cl)C(F)(F)F	Ki = 59900 nM	Poor binder
T98691	HUMAN cathepsin L	BD0RH7	Arylaminoethyl carbamate, 16	Investigative	23648377	C22H32F3N3O5	475.5	C[C@@H](CNC1=CC=C(C=C1)OC(F)(F)F)NC(=O)O[C@@H](CC(C)(C)C)C(=O)N2CCOCC2	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BD24YJ	4-Cyclohexanesulfonylamino-N-[1-(2S-ethyl-4-oxotetrahydro-furan-3S-ylcarbamoyl)-2S-(1-methyl-cyclopentyl)-ethyl]-benzamide	Investigative	44570672	C28H41N3O6S	547.7	CC[C@H]1[C@@H](C(=O)CO1)NC(=O)[C@H](CC2(CCCC2)C)NC(=O)C3=CC=C(C=C3)NS(=O)(=O)C4CCCCC4	Ki = 64000 nM	Poor binder
T98691	HUMAN cathepsin L	BDC9Z8	2-((2S,3S)-2-Acetoxy-4-oxo-azetidin-3-ylcarbamoyl)-pyrrolidine-1-carboxylic acid benzyl ester	Investigative	44304591	C18H21N3O6	375.4	CC(=O)O[C@H]1[C@@H](C(=O)N1)NC(=O)C2CCCN2C(=O)OCC3=CC=CC=C3	Ki ~ 150000 nM	Poor binder
T98691	HUMAN cathepsin L	BE0MT1	(1R,2R)-N-[(1S)-1-Cyano-2,2-dimethylpropyl]-2-(8-fluoro-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexane-1-carboxamide	Investigative	60195906	C25H31FN4O2	438.5	CC(C)(C)[C@@H](C#N)NC(=O)[C@@H]1CCCC[C@H]1C(=O)N2CCC3=C(C2)C4=C(N3)C=CC(=C4)F	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BE6I2L	Benzyl 1-((cyanomethyl)carbamoyl)cyclopropylcarbamate	Investigative	11680631	C14H15N3O3	273.29	C1CC1(C(=O)NCC#N)NC(=O)OCC2=CC=CC=C2	Ki ~ 150000 nM	Poor binder
T98691	HUMAN cathepsin L	BEB9O5	5-Methyl-4-phenyl-2-(2,3,5,6-tetrafluoropyridin-4-yl)-isothiazol-3(2H)-one 1,1-dioxide	Investigative	44561931	C15H8F4N2O3S	372.3	CC1=C(C(=O)N(S1(=O)=O)C2=C(C(=NC(=C2F)F)F)F)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BEL7M2	Acetic acid (2S,3S)-3-{[(R)-2-((S)-benzyloxycarbonylamino)-cyclopentanecarbonyl]-amino}-4-oxo-azetidin-2-yl ester	Investigative	44304634	C19H23N3O6	389.4	CC(=O)O[C@H]1[C@@H](C(=O)N1)NC(=O)[C@@H]2CCC[C@@H]2NC(=O)OCC3=CC=CC=C3	Ki ~ 150000 nM	Poor binder
T98691	HUMAN cathepsin L	BF8LE3	Arylaminoethyl carbamate, 25	Investigative	23648382	C27H42FN3O4	491.6	C[C@@H](CN1CC(C2=C1C=CC(=C2)F)(C)C)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N(C)CCOC	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BF9C4I	(3S,4R)-4-(2,3-Dimethylphenoxy)piperidin-3-ol	Investigative	6917747	C13H19NO2	221.29	CC1=C(C(=CC=C1)O[C@@H]2CCNC[C@@H]2O)C	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BFXT28	N-[2-(Cyanomethylamino)-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide	Investigative	118720232	C22H21Cl2N3O4	462.3	CC(C)(C1=CC(=CC(=C1)Cl)Cl)C(=O)C2=C(C=CC(=C2)C(=O)NCC(=O)NCC#N)OC	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BG9A4X	Benzyl N-[(2S)-1-(cyanomethylamino)-3,3-dimethyl-1-oxobutan-2-yl]carbamate	Investigative	11695166	C16H21N3O3	303.36	CC(C)(C)[C@@H](C(=O)NCC#N)NC(=O)OCC1=CC=CC=C1	Ki ~ 150000 nM	Poor binder
T98691	HUMAN cathepsin L	BG9F7J	(1R,2R)-N-(Cyanomethyl)-2-(4-phenylpiperazine-1-carbonyl)cyclohexane-1-carboxamide	Investigative	60195902	C20H26N4O2	354.4	C1CC[C@H]([C@@H](C1)C(=O)NCC#N)C(=O)N2CCN(CC2)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BH9RJ8	Succinamide peptidomimetic, 39	Investigative	11432773	C25H27F6N3O4	547.5	C[C@@H](CNC1=CC=C(C=C1)OC(F)(F)F)NC(=O)[C@@H](CC(=O)N2CCOCC2)C3=CC=C(C=C3)C(F)(F)F	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BHR9E2	N-[(2S)-1-[5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl]-1-oxopentan-2-yl]-3-phenylpropanamide	Investigative	44412354	C20H21N3O4	367.4	CCC[C@@H](C(=O)C1=NN=C(O1)C2=CC=CO2)NC(=O)CCC3=CC=CC=C3	Ki = 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BHS06D	(3S)-3-[(2S)-2-[(6-Chloro-1,3-benzoxazol-2-yl)amino]-3-cyclohexylpropanamido]-4-(5-fluoro-2,3-dihydro-1H-indol-1-yl)butanoic acid	Investigative	11376188	C28H32ClFN4O4	543	C1CCC(CC1)C[C@@H](C(=O)N[C@@H](CC(=O)O)CN2CCC3=C2C=CC(=C3)F)NC4=NC5=C(O4)C=C(C=C5)Cl	Ki ~ 70000 nM	Poor binder
T98691	HUMAN cathepsin L	BHYT56	2-((4-Methoxyphenyl)amino)benzoic acid	Investigative	202918	C14H13NO3	243.26	COC1=CC=C(C=C1)NC2=CC=CC=C2C(=O)O	IC50 ~ 50000 nM	Poor binder
T98691	HUMAN cathepsin L	BI06QJ	(2E)-3-(4-Fluorophenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one	Investigative	5728928	C15H11FO2	242.24	C1=CC(=CC=C1/C=C/C(=O)C2=CC=C(C=C2)O)F	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BI6C1A	Arylaminoethyl carbamate, 33	Investigative	23648390	C28H43FN4O5S	566.7	C[C@@H](CN1CC(C2=C1C=CC(=C2)F)(C)C)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N4CCN(CC4)S(=O)(=O)C	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BIR0W4	(2E)-2-[(E)-1-Phenoxypropan-2-ylidenehydrazinylidene]-3-phenyl-5-propan-2-yl-1,3-thiazolidin-4-one	Investigative	71455561	C21H23N3O2S	381.5	CC(C)C1C(=O)N(/C(=N\\N=C(/C)\\COC2=CC=CC=C2)/S1)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BJ0Z7M	(E)-1-(4-Fluorophenyl)-3-(4-pyrrolidin-1-ylphenyl)prop-2-en-1-one	Investigative	38864634	C19H18FNO	295.3	C1CCN(C1)C2=CC=C(C=C2)/C=C/C(=O)C3=CC=C(C=C3)F	IC50 = 56510 nM	Poor binder
T98691	HUMAN cathepsin L	BJ4IA0	Succinamide peptidomimetic, 5	Investigative	23648361	C23H34FN3O3	419.5	C1CCC(CC1)C[C@@H](CC(=O)N2CCOCC2)C(=O)NCCNC3=CC=C(C=C3)F	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BJ4U5B	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-([1,3]thiazolo[5,4-c]pyridin-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70682584	C22H26N6O2S	438.5	C1CC[C@H]([C@@H](C1)C(=O)NC2(CC2)C#N)C(=O)N3CCN(CC3)C4=NC5=C(S4)C=NC=C5	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BJ6FS9	2-Bromo-4-nitronaphthalen-1-amine	Investigative	22988664	C10H7BrN2O2	267.08	C1=CC=C2C(=C1)C(=CC(=C2N)Br)[N+](=O)[O-]	Ki = 182000 nM	Poor binder
T98691	HUMAN cathepsin L	BJ8US7	(1R,2R)-2-[4-[5-Chloro-4-(trifluoromethyl)-1,3-thiazol-2-yl]piperazine-1-carbonyl]-N-(1-cyanocyclopropyl)cyclohexane-1-carboxamide	Investigative	70276365	C20H23ClF3N5O2S	489.9	C1CC[C@H]([C@@H](C1)C(=O)NC2(CC2)C#N)C(=O)N3CCN(CC3)C4=NC(=C(S4)Cl)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BJLG65	Arylaminoethyl carbamate, 11	Investigative	23648373	C24H34F3N3O5	501.5	C[C@@H](CNC1=CC=C(C=C1)OC(F)(F)F)NC(=O)O[C@@H](CC2CCCCC2)C(=O)N3CCOCC3	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BJT97U	Ethyl (3S)-3-[(2S)-2-[(6-chloro-1,3-benzoxazol-2-yl)amino]-3-cyclohexylpropanamido]-4-(5-fluoro-2,3-dihydro-1H-indol-1-yl)butanoate	Investigative	11238468	C30H36ClFN4O4	571.1	CCOC(=O)C[C@@H](CN1CCC2=C1C=CC(=C2)F)NC(=O)[C@H](CC3CCCCC3)NC4=NC5=C(O4)C=C(C=C5)Cl	Ki ~ 50000 nM	Poor binder
T98691	HUMAN cathepsin L	BK2T4S	Acetic acid (2S,3S)-3-[(1-benzyloxycarbonylamino-cyclopentanecarbonyl)-amino]-4-oxo-azetidin-2-yl ester	Investigative	44304563	C19H23N3O6	389.4	CC(=O)O[C@H]1[C@@H](C(=O)N1)NC(=O)C2(CCCC2)NC(=O)OCC3=CC=CC=C3	Ki = 140000 nM	Poor binder
T98691	HUMAN cathepsin L	BK36QG	Arylaminoethyl carbamate, 31	Investigative	23648388	C27H40FN3O5S	537.7	C[C@@H](CN1CC(C2=C1C=CC(=C2)F)(C)C)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N4CCS(=O)(=O)CC4	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BK91LA	2-((2S,3S)-2-Acetoxy-4-oxo-azetidin-3-ylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester	Investigative	44304611	C19H23N3O6	389.4	CC(=O)O[C@H]1[C@@H](C(=O)N1)NC(=O)C2CCCCN2C(=O)OCC3=CC=CC=C3	Ki ~ 150000 nM	Poor binder
T98691	HUMAN cathepsin L	BKYI81	Arylaminoethyl carbamate, 18	Investigative	16046125	C27H40FN3O4	489.6	C[C@@H](CN1CC(C2=C1C=CC(=C2)F)(C)C)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N4CCOCC4	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BL0OR7	N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-[2-[4-(oxan-4-yl)piperazin-1-yl]-1,3-thiazol-4-yl]benzamide	Investigative	11533910	C28H36N6O3S	536.7	C1CCC(CC1)(C(=O)NCC#N)NC(=O)C2=CC=C(C=C2)C3=CSC(=N3)N4CCN(CC4)C5CCOCC5	Ki ~ 150000 nM	Poor binder
T98691	HUMAN cathepsin L	BL5AU8	(1R)-2,2-Dimethyl-1-({5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-YL}methyl)propyl (1S)-1-{oxo[(2-oxo-1,3-oxazolidin-3-YL)amino]acetyl}pentylcarbamate	Investigative	5287498	C26H32F3N5O7	583.6	CCCC[C@@H](C(=O)C(=O)NN1CCOC1=O)NC(=O)O[C@H](CC2=NN=C(O2)C3=CC=C(C=C3)C(F)(F)F)C(C)(C)C	IC50 = 160000 nM	Poor binder
T98691	HUMAN cathepsin L	BLF0C6	N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-methylpiperazin-1-yl)sulfonylbenzamide	Investigative	11561418	C21H29N5O4S	447.6	CN1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C(=O)NC3(CCCCC3)C(=O)NCC#N	Ki = 71000 nM	Poor binder
T98691	HUMAN cathepsin L	BLP2Q6	[(S)-1-(Pyridin-3-ylmethyl)-aminooxalyl]-pentyl)-carbamic acid (R)-1-[5-(4-fluoro-phenyl)-[1,3,4]oxadiazol-2-ylmethyl]-2,2-dimethyl-propyl ester	Investigative	44397693	C28H34FN5O5	539.6	CCCC[C@@H](C(=O)C(=O)NCC1=CN=CC=C1)NC(=O)O[C@H](CC2=NN=C(O2)C3=CC=C(C=C3)F)C(C)(C)C	IC50 = 130000 nM	Poor binder
T98691	HUMAN cathepsin L	BM0O2J	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(7,7-dimethyl-4,6-dihydropyrano[4,3-d][1,3]thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70686822	C24H33N5O3S	471.6	CC1(COCC2=C1N=C(S2)N3CCN(CC3)C(=O)[C@@H]4CCCC[C@H]4C(=O)NC5(CC5)C#N)C	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BM6D3K	(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-Acetamido-4-methylsulfanylbutanoyl]amino]-4-amino-4-oxobutanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]pentanediamide	Investigative	44366435	C27H40N8O8S	636.7	CC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(=O)N)C(=O)N	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BM78SE	Benzyl 1-((cyanomethyl)carbamoyl)cyclopentylcarbamate	Investigative	11507712	C16H19N3O3	301.34	C1CCC(C1)(C(=O)NCC#N)NC(=O)OCC2=CC=CC=C2	Ki ~ 150000 nM	Poor binder
T98691	HUMAN cathepsin L	BM8N4U	Methyl (E)-4-[[2-[(3R)-5-(4-bromophenyl)-3-[[4-chloro-2-(trifluoromethyl)phenyl]carbamoyloxymethyl]-2-oxo-3H-1,4-benzodiazepin-1-yl]acetyl]amino]but-2-enoate	Investigative	49798881	C31H25BrClF3N4O6	721.9	COC(=O)/C=C/CNC(=O)CN1C2=CC=CC=C2C(=N[C@@H](C1=O)COC(=O)NC3=C(C=C(C=C3)Cl)C(F)(F)F)C4=CC=C(C=C4)Br	Ki ~ 150000 nM	Poor binder
T98691	HUMAN cathepsin L	BMB1L4	(2S)-N-[(2S)-1-Amino-4-methylsulfanyl-1-oxobutan-2-yl]-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide	Investigative	16661526	C26H34F3N3O4S2	573.7	CC(C)C[C@@H](C(=O)N[C@@H](CCSC)C(=O)N)N[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)S(=O)(=O)C)C(F)(F)F	IC50 = 55728 nM	Poor binder
T98691	HUMAN cathepsin L	BNET60	Succinamide peptidomimetic, 38	Investigative	23648368	C27H31F6N3O4	575.5	CC(C)[C@@H](CNC1=CC=C(C=C1)OC(F)(F)F)NC(=O)[C@@H](CC(=O)N2CCOCC2)C3=CC=CC=C3C(F)(F)F	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BNW18G	Benzyl 1-((cyanomethyl)carbamoyl)cyclohexylcarbamate	Investigative	11602113	C17H21N3O3	315.37	C1CCC(CC1)(C(=O)NCC#N)NC(=O)OCC2=CC=CC=C2	Ki = 95000 nM	Poor binder
T98691	HUMAN cathepsin L	BO1ZP0	Succinamide peptidomimetic, 40	Investigative	11410560	C27H29F6N3O4	573.5	C1CC1[C@@H](CNC2=CC=C(C=C2)OC(F)(F)F)NC(=O)[C@@H](CC(=O)N3CCOCC3)C4=CC=C(C=C4)C(F)(F)F	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BO2A9N	Succinamide peptidomimetic, 34	Investigative	11203484	C27H34F3N3O5	537.6	CC(C)[C@@H](CNC1=CC=C(C=C1)OC(F)(F)F)NC(=O)[C@@H](CC(=O)N2CCOCC2)C3=CC=C(C=C3)OC	Ki ~ 65000 nM	Poor binder
T98691	HUMAN cathepsin L	BO3HD9	(3S)-2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[1,2-dioxo-1-[[(1R)-1-phenylethyl]amino]hexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide	Investigative	44394250	C41H57N7O6	743.9	CCCC(C(=O)C(=O)N[C@H](C)C1=CC=CC=C1)NC(=O)[C@@H]2C3CCCC3CN2C(=O)[C@H](C(C)(C)C)NC(=O)[C@H](C4CCCCC4)NC(=O)C5=NC=CN=C5	Ki = 51000 nM	Poor binder
T98691	HUMAN cathepsin L	BOCP70	(2S)-2-[[(2S)-2-(3,5-Dichlorophenyl)-2-(ethylamino)acetyl]amino]-3,3-dimethyl-N-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]butanamide	Investigative	118720238	C22H32Cl2N4O5S	535.5	CCN[C@@H](C1=CC(=CC(=C1)Cl)Cl)C(=O)N[C@H](C(=O)NCC(=O)NC/C=C/S(=O)(=O)C)C(C)(C)C	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BOU76V	(E)-3-(4-Fluorophenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one	Investigative	5897251	C16H13FO3	272.27	COC1=CC(=C(C=C1)C(=O)/C=C/C2=CC=C(C=C2)F)O	IC50 = 98680 nM	Poor binder
T98691	HUMAN cathepsin L	BOZ8N7	(2E)-5-Ethyl-2-[(E)-1-phenoxypropan-2-ylidenehydrazinylidene]-3-phenyl-1,3-thiazolidin-4-one	Investigative	71452030	C20H21N3O2S	367.5	CCC1C(=O)N(/C(=N\\N=C(/C)\\COC2=CC=CC=C2)/S1)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BP73OX	1,1-Dioxo-2-(2,3,5,6-tetrafluoropyridin-4-yl)-1,2-benzothiazol-3-one	Investigative	555078	C12H4F4N2O3S	332.23	C1=CC=C2C(=C1)C(=O)N(S2(=O)=O)C3=C(C(=NC(=C3F)F)F)F	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BP8VX6	4-[[(2R)-5-(Diaminomethylideneamino)-1-[[3-(4-hydroxyphenyl)-1-oxo-1-(2-phenylethylamino)propan-2-yl]amino]-1-oxopentan-2-yl]amino]-4-oxo-3-[[2-(4-phenylphenyl)acetyl]amino]butanoic acid	Investigative	44457516	C41H47N7O7	749.9	C1=CC=C(C=C1)CCNC(=O)C(CC2=CC=C(C=C2)O)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)C(CC(=O)O)NC(=O)CC3=CC=C(C=C3)C4=CC=CC=C4	Ki = 57500 nM	Poor binder
T98691	HUMAN cathepsin L	BPQ06W	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	25129041	C22H26N6O2S	438.5	C1CC[C@H]([C@@H](C1)C(=O)NC2(CC2)C#N)C(=O)N3CCN(CC3)C4=NC5=C(S4)C=CC=N5	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BQ17TL	Chembl4228126	Investigative	145970706	C12H8N4O4	272.22	C1=CC2=C(C=C(C(=C2N=C1)O)C(=O)NCC#N)[N+](=O)[O-]	Ki = 155000 nM	Poor binder
T98691	HUMAN cathepsin L	BQEZ40	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(4-ethyl-1,3-thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70686820	C21H29N5O2S	415.6	CCC1=CSC(=N1)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4(CC4)C#N	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BQV2N6	Succinamide peptidomimetic, 24	Investigative	23648364	C24H36F3N3O4	487.6	C[C@@H](CNC1=CC=C(C=C1)OC(F)(F)F)NC(=O)[C@H](CCC(C)(C)C)CC(=O)N2CCOCC2	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BR0D1Z	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(6,7-dihydro-4H-pyrano[4,3-d][1,3]thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70280758	C22H29N5O3S	443.6	C1CC[C@H]([C@@H](C1)C(=O)NC2(CC2)C#N)C(=O)N3CCN(CC3)C4=NC5=C(S4)COCC5	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BR2JP5	(3S,3As,6aR)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide	Investigative	3088969	C36H53N7O6	679.8	CCCC(C(=O)C(=O)NC1CC1)NC(=O)[C@@H]2[C@H]3CCC[C@H]3CN2C(=O)[C@H](C(C)(C)C)NC(=O)[C@H](C4CCCCC4)NC(=O)C5=NC=CN=C5	Ki = 134000 nM	Poor binder
T98691	HUMAN cathepsin L	BR4W8P	Arylaminoethyl carbamate, 32	Investigative	23648389	C29H43FN4O4	530.7	C[C@@H](CN1CC(C2=C1C=CC(=C2)F)(C)C)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N4CCN(CC4)C(=O)C	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BR6S1L	(E)-1-(4-Fluorophenyl)-3-(4-hydroxy-2-methoxyphenyl)prop-2-en-1-one	Investigative	71624733	C16H13FO3	272.27	COC1=C(C=CC(=C1)O)/C=C/C(=O)C2=CC=C(C=C2)F	IC50 = 73220 nM	Poor binder
T98691	HUMAN cathepsin L	BR7N9G	Chembl184525	Investigative	73350210	C33H49N7O7	655.8	CCC[C@@H](C(=O)C(=O)NC1CC1)NC(=O)[C@@H]2C3CCCC3CN2C(=O)[C@H](C(C)(C)C)NC(=O)[C@H]([C@@H](C)OC)NC(=O)C4=NC=CN=C4	Ki = 146000 nM	Poor binder
T98691	HUMAN cathepsin L	BRWG43	N-[(2S)-1-[5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl]-1-oxohexan-2-yl]-3-phenylpropanamide	Investigative	44452965	C21H23N3O4	381.4	CCCC[C@@H](C(=O)C1=NN=C(O1)C2=CC=CO2)NC(=O)CCC3=CC=CC=C3	Ki = 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BS3N2I	(E)-3-(3-Bromo-4-methoxyphenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one	Investigative	71624621	C16H13BrO4	349.17	COC1=C(C=C(C=C1)/C=C/C(=O)C2=C(C=C(C=C2)O)O)Br	IC50 = 67510 nM	Poor binder
T98691	HUMAN cathepsin L	BT0W2L	(1R,2R)-N-(Cyanomethyl)-2-(piperidine-1-carbonyl)cyclohexane-1-carboxamide	Investigative	60195810	C15H23N3O2	277.36	C1CCN(CC1)C(=O)[C@@H]2CCCC[C@H]2C(=O)NCC#N	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BT2Q3C	N-{(1S)-2,2,2-Trifluoro-1-[4'-(methylsulfonyl)biphenyl-4-yl]ethyl}-L-leucylglycinamide	Investigative	16661369	C23H28F3N3O4S	499.5	CC(C)C[C@@H](C(=O)NCC(=O)N)N[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)S(=O)(=O)C)C(F)(F)F	IC50 = 63060 nM	Poor binder
T98691	HUMAN cathepsin L	BU3I8Z	(1r)-2,2-Dimethyl-1-({5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}methyl)propyl(1S)-1-(oxo{[(1r)-1-phenylethyl]amino}acetyl)pentylcarbamate	Investigative	10210867	C31H37F3N4O5	602.6	CCCC[C@@H](C(=O)C(=O)N[C@H](C)C1=CC=CC=C1)NC(=O)O[C@H](CC2=NN=C(O2)C3=CC=C(C=C3)C(F)(F)F)C(C)(C)C	IC50 = 190000 nM	Poor binder
T98691	HUMAN cathepsin L	BU95EF	Chembl4228576	Investigative	145970039	C14H10N4O4	298.25	C1CC1(C#N)NC(=O)C2=CC(=C3C=CC=NC3=C2O)[N+](=O)[O-]	Ki = 195000 nM	Poor binder
T98691	HUMAN cathepsin L	BUG9I7	Aryl-morpholino-containing analogue, 13	Investigative	11501571	C20H26N4O3	370.4	C1CCC(CC1)(C(=O)NCC#N)NC(=O)C2=CC=C(C=C2)N3CCOCC3	Ki = 50000 nM	Poor binder
T98691	HUMAN cathepsin L	BUI2O5	Succinamide peptidomimetic, 23	Investigative	23648363	C23H34F3N3O4	473.5	C[C@@H](CNC1=CC=C(C=C1)OC(F)(F)F)NC(=O)[C@@H](CC(=O)N2CCOCC2)CC(C)(C)C	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BUQ4L2	(1R,2R)-N-(Cyanomethyl)-2-(3,6-dihydro-2H-pyridine-1-carbonyl)cyclohexane-1-carboxamide	Investigative	60195811	C15H21N3O2	275.35	C1CC[C@H]([C@@H](C1)C(=O)NCC#N)C(=O)N2CCC=CC2	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BUZ56D	Arylaminoethyl amide, 10	Investigative	23648335	C31H36ClN3O3	534.1	COC1=CC=C(C=C1)NCCNC(=O)[C@H](CC2CCCCC2)NC(=O)C3=CC=C(C=C3)C4=CC(=CC=C4)Cl	Ki ~ 79000 nM	Poor binder
T98691	HUMAN cathepsin L	BV28ZF	Disodium aurothiomalate	Investigative	4479093	C4H3AuO4S-2	344.1	C(C(C(=O)[O-])[S-])C(=O)[O-].[Au+]	IC50 = 90000 nM	Poor binder
T98691	HUMAN cathepsin L	BV2GX4	(3S,3As,6aR)-N-[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-2-[(2S)-3,3-dimethyl-2-[[(2S)-3-methyl-2-(pyrazine-2-carbonylamino)butanoyl]amino]butanoyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide	Investigative	10461790	C33H49N7O6	639.8	CCCC(C(=O)C(=O)NC1CC1)NC(=O)[C@@H]2[C@H]3CCC[C@H]3CN2C(=O)[C@H](C(C)(C)C)NC(=O)[C@H](C(C)C)NC(=O)C4=NC=CN=C4	Ki = 154000 nM	Poor binder
T98691	HUMAN cathepsin L	BV75GZ	Chembl4249139	Investigative	145982654	C14H13FN6O	300.29	C1COCCN1C2=NC(=NC(=N2)NC3=CC=C(C=C3)F)C#N	IC50 = 62000 nM	Poor binder
T98691	HUMAN cathepsin L	BVI9X2	Tert-butyl (3S)-3-[(2S)-2-[(6-chloro-1,3-benzoxazol-2-yl)amino]-3-cyclohexylpropanamido]-4-(5-fluoro-2,3-dihydro-1H-indol-1-yl)butanoate	Investigative	11456165	C32H40ClFN4O4	599.1	CC(C)(C)OC(=O)C[C@@H](CN1CCC2=C1C=CC(=C2)F)NC(=O)[C@H](CC3CCCCC3)NC4=NC5=C(O4)C=C(C=C5)Cl	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BVKR62	3-Acetyl-2-(4-tert-butylphenylamino)-8-chloro-6-nitroquinolin-4(1H)-one	Investigative	44566188	C21H20ClN3O4	413.9	CC(=O)C1=C(NC2=C(C1=O)C=C(C=C2Cl)[N+](=O)[O-])NC3=CC=C(C=C3)C(C)(C)C	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BWR94J	Benzyl N-[(2S)-1-(cyanomethylamino)-2,4-dimethyl-1-oxopentan-2-yl]carbamate	Investigative	44405280	C17H23N3O3	317.4	CC(C)C[C@@](C)(C(=O)NCC#N)NC(=O)OCC1=CC=CC=C1	Ki ~ 150000 nM	Poor binder
T98691	HUMAN cathepsin L	BX0G5F	2-(3,5-Difluoropyridin-2-yl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide	Investigative	44561893	C12H10F2N2O3S	300.28	C1CCC2=C(C1)C(=O)N(S2(=O)=O)C3=C(C=C(C=N3)F)F	IC50 ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BX24RV	Arylaminoethyl carbamate, 28	Investigative	23648385	C27H40FN3O3	473.6	C[C@@H](CN1CC(C2=C1C=CC(=C2)F)(C)C)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N4CCCC4	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BXV37R	Benzyl N-[(1S)-2-(cyanomethylamino)-2-oxo-1-phenylethyl]carbamate	Investigative	11558838	C18H17N3O3	323.3	C1=CC=C(C=C1)COC(=O)N[C@@H](C2=CC=CC=C2)C(=O)NCC#N	Ki = 88000 nM	Poor binder
T98691	HUMAN cathepsin L	BY09LX	3-Methoxy-2-(3-methoxy-4-phenylmethoxyanilino)benzoic acid	Investigative	70696541	C22H21NO5	379.4	COC1=CC=CC(=C1NC2=CC(=C(C=C2)OCC3=CC=CC=C3)OC)C(=O)O	IC50 ~ 50000 nM	Poor binder
T98691	HUMAN cathepsin L	BYI7X2	(2R)-N-[(2S)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)-2-[[(2S)-3-hydroxy-2-[[2-(4-phenylphenyl)acetyl]amino]propanoyl]amino]pentanamide	Investigative	10395274	C41H48N8O6	748.9	C1=CC=C(C=C1)C[C@@H](C(=O)N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)CC3=CC=C(C=C3)C4=CC=CC=C4	Ki = 74000 nM	Poor binder
T98691	HUMAN cathepsin L	BZ0E3O	(E)-3-(4-Fluorophenyl)-1-(4-hydroxy-2-methoxyphenyl)prop-2-en-1-one	Investigative	71624735	C16H13FO3	272.27	COC1=C(C=CC(=C1)O)C(=O)/C=C/C2=CC=C(C=C2)F	IC50 = 91170 nM	Poor binder
T98691	HUMAN cathepsin L	BZ2Q1A	Arylaminoethyl carbamate, 30	Investigative	23648387	C27H40FN3O3S	505.7	C[C@@H](CN1CC(C2=C1C=CC(=C2)F)(C)C)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N4CCSCC4	Ki ~ 100000 nM	Poor binder
T98691	HUMAN cathepsin L	BZ40KM	S-Cyclohexyl cyclohexane-1-sulfinothioate	Investigative	49865938	C12H22OS2	246.4	C1CCC(CC1)SS(=O)C2CCCCC2	Ki ~ 100000 nM	Poor binder