TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T97822	Prostaglandin synthetase	D0JY4Y	E-3040	Discontinued in Phase 2	443292	C16H17N3OS	299.4	CC1=C(C2=C(C(=C1O)C)SC(=N2)NC)CC3=CN=CC=C3	IC50 ~ 100000 nM	Poor binder
T97822	Prostaglandin synthetase	D0DP8P	BW755C	Terminated	47795	C10H10F3N3	229.2	C1CN(N=C1N)C2=CC=CC(=C2)C(F)(F)F	IC50 = 97000 nM	Poor binder
T97822	Prostaglandin synthetase	B0QY7G	12-(2,5-Dioxopyrrol-1-yl)dodecanoic acid	Investigative	15256755	C16H25NO4	295.37	C1=CC(=O)N(C1=O)CCCCCCCCCCCC(=O)O	IC50 = 140000 nM	Poor binder
T97822	Prostaglandin synthetase	B4V2UD	2-[(3-Pyridinylmethyl)amino]-4,5,7-trimethylbenzothiazol-6-ol	Investigative	10063338	C16H17N3OS	299.4	CC1=C(C(=C(C2=C1N=C(S2)NCC3=CN=CC=C3)C)O)C	IC50 ~ 100000 nM	Poor binder
T97822	Prostaglandin synthetase	B7FWN2	4,7-Dimethyl-2-[(3-pyridinylmethyl)amino]-1,3-benzothiazol-6-ol	Investigative	10334136	C15H15N3OS	285.4	CC1=CC(=C(C2=C1N=C(S2)NCC3=CN=CC=C3)C)O	IC50 ~ 100000 nM	Poor binder
T97822	Prostaglandin synthetase	B7KL2G	2-(Ethylamino)-4,5-dimethyl-7-(3-pyridinylmethyl)-1,3-benzothiazol-6-ol	Investigative	10335738	C17H19N3OS	313.4	CCNC1=NC2=C(S1)C(=C(C(=C2C)C)O)CC3=CN=CC=C3	IC50 ~ 100000 nM	Poor binder
T97822	Prostaglandin synthetase	BC40PE	2-Amino-4,5-dimethyl-7-pyridin-3-ylmethyl-benzothiazol-6-ol; dihydrochloride	Investigative	19044748	C15H17Cl2N3OS	358.3	CC1=C(C(=C(C2=C1N=C(S2)N)CC3=CN=CC=C3)O)C.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T97822	Prostaglandin synthetase	BD2G6S	7-Ethyl-5-methoxy-2-(methylamino)-4-(3-pyridinylmethyl)-1,3-benzothiazol-6-ol	Investigative	10042219	C17H19N3O2S	329.4	CCC1=C(C(=C(C2=C1SC(=N2)NC)CC3=CN=CC=C3)OC)O	IC50 ~ 100000 nM	Poor binder
T97822	Prostaglandin synthetase	BE67QD	2-Amino-5-methoxy-7-methyl-4-pyridin-3-ylmethyl-benzothiazol-6-ol; dihydrochloride	Investigative	19934882	C15H17Cl2N3O2S	374.3	CC1=C(C(=C(C2=C1SC(=N2)N)CC3=CN=CC=C3)OC)O.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T97822	Prostaglandin synthetase	BHR79L	(E)-3-(4-Hydroxy-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one	Investigative	5973690	C16H14O4	270.28	COC1=C(C=CC(=C1)/C=C/C(=O)C2=CC=CC=C2O)O	IC50 = 63000 nM	Poor binder
T97822	Prostaglandin synthetase	BJ0AD4	2'-Chloro-3,4-dihydroxychalcone	Investigative	14977360	C15H11ClO3	274.7	C1=CC=C(C(=C1)C(=O)/C=C/C2=CC(=C(C=C2)O)O)Cl	IC50 = 71000 nM	Poor binder
T97822	Prostaglandin synthetase	BLUP17	Isoliquiritigenin	Investigative	638278	C15H12O4	256.25	C1=CC(=CC=C1/C=C/C(=O)C2=C(C=C(C=C2)O)O)O	IC50 = 130000 nM	Poor binder
T97822	Prostaglandin synthetase	BN4U7A	4,7-Dimethyl-2-methylamino-5-pyridin-3-ylmethyl-benzothiazol-6-ol; dihydrochloride	Investigative	90664380	C16H19Cl2N3OS	372.3	CC1=C(C(=C(C2=C1N=C(S2)NC)C)O)CC3=CN=CC=C3.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T97822	Prostaglandin synthetase	BN96YJ	1,1-Diethyl-3-{2-hydroxy-2-[3-(quinolin-2-ylmethoxy)-phenyl]-ethyl}-3-methyl-urea	Investigative	13914227	C24H29N3O3	407.5	CCN(CC)C(=O)N(C)C[C@@H](C1=CC(=CC=C1)OCC2=NC3=CC=CC=C3C=C2)O	IC50 ~ 100000 nM	Poor binder
T97822	Prostaglandin synthetase	BOP84S	2-[(3-Pyridinylmethyl)amino]-5,7-dimethoxybenzothiazol-6-ol	Investigative	11723348	C15H15N3O3S	317.4	COC1=C(C(=C2C(=C1)N=C(S2)NCC3=CN=CC=C3)OC)O	IC50 ~ 100000 nM	Poor binder
T97822	Prostaglandin synthetase	BU3HK1	(5R)-3-Methyl-5-[3-(quinolin-2-ylmethoxy)phenyl]-1,3-oxazolidin-2-one	Investigative	13914253	C20H18N2O3	334.4	CN1C[C@H](OC1=O)C2=CC(=CC=C2)OCC3=NC4=CC=CC=C4C=C3	IC50 ~ 100000 nM	Poor binder
T97822	Prostaglandin synthetase	BW9GF3	1-((2-Methylphenyl)methyl)-1h-pyrrole-2,5-dione	Investigative	3253091	C12H11NO2	201.22	CC1=CC=CC=C1CN2C(=O)C=CC2=O	IC50 = 50000 nM	Poor binder
T97822	Prostaglandin synthetase	BX9E5V	2-Ethylamino-5,7-dimethyl-4-pyridin-3-ylmethyl-benzothiazol-6-ol; dihydrochloride	Investigative	19044744	C17H21Cl2N3OS	386.3	CCNC1=NC2=C(S1)C(=C(C(=C2CC3=CN=CC=C3)C)O)C.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T97822	Prostaglandin synthetase	BYW6A3	5,7-Dimethyl-2-propylamino-4-pyridin-3-ylmethyl-benzothiazol-6-ol; dihydrochloride	Investigative	19044753	C18H23Cl2N3OS	400.4	CCCNC1=NC2=C(S1)C(=C(C(=C2CC3=CN=CC=C3)C)O)C.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T97822	Prostaglandin synthetase	BZ97SH	2-(Ethylamino)-4,7-dimethyl-5-(3-pyridinylmethyl)-1,3-benzothiazol-6-ol	Investigative	10425738	C17H19N3OS	313.4	CCNC1=NC2=C(S1)C(=C(C(=C2C)CC3=CN=CC=C3)O)C	IC50 ~ 100000 nM	Poor binder
T97822	Prostaglandin synthetase	D01TOR	Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine	Investigative	667555	C20H16N4	312.4	C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)C4=CN=CC=C4	IC50 = 50000 nM	Poor binder
T97822	Prostaglandin synthetase	D09AUL	Benzyl-(2-imidazol-1-yl-quinazolin-4-yl)-amine	Investigative	10266864	C18H15N5	301.3	C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)N4C=CN=C4	IC50 = 51000 nM	Poor binder
T97822	Prostaglandin synthetase	D0EW3L	BUTEIN	Investigative	5281222	C15H12O5	272.25	C1=CC(=C(C=C1/C=C/C(=O)C2=C(C=C(C=C2)O)O)O)O	IC50 = 120000 nM	Poor binder
T97822	Prostaglandin synthetase	D0P1LP	PHENIDONE	Investigative	7090	C9H10N2O	162.19	C1CN(NC1=O)C2=CC=CC=C2	IC50 = 94000 nM	Poor binder