TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T94823	Xaa-Pro dipeptidase	D01XGX	JTP-4819	Discontinued in Phase 2	178060	C19H25N3O4	359.4	C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)NCC3=CC=CC=C3)C(=O)CO	IC50 ~ 100000 nM	Poor binder
T94823	Xaa-Pro dipeptidase	BFM61Q	(2S)-1-[(2S,3S)-3-Amino-2-hydroxy-5-methylhexanoyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide	Investigative	10592387	C15H28N4O4	328.41	C[C@@H](C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H]([C@H](CC(C)C)N)O	IC50 = 59000 nM	Poor binder
T94823	Xaa-Pro dipeptidase	BH2YG8	(2S)-1-[3-Amino-4-(2-fluorophenyl)butanoyl]-N-[[4-(trifluoromethyl)phenyl]methyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid	Investigative	49796945	C25H26F7N3O4	565.5	C1C[C@H](N(C1)C(=O)CC(CC2=CC=CC=C2F)N)C(=O)NCC3=CC=C(C=C3)C(F)(F)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T94823	Xaa-Pro dipeptidase	BJF84U	(2S)-1-[3-Amino-4-(2-fluorophenyl)butanoyl]-N-[4-(2H-tetrazol-5-yl)butyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid	Investigative	49796942	C22H29F4N7O4	531.5	C1C[C@H](N(C1)C(=O)CC(CC2=CC=CC=C2F)N)C(=O)NCCCCC3=NNN=N3.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T94823	Xaa-Pro dipeptidase	BV7Q2F	(2R)-2-[4-[[[(2S)-1-[3-Amino-4-(2,3,4,5,6-pentafluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid	Investigative	49796955	C29H31F8N3O7	685.6	CC(C)[C@H](C(=O)O)OC1=CC=C(C=C1)CNC(=O)[C@@H]2CCCN2C(=O)CC(CC3=C(C(=C(C(=C3F)F)F)F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T94823	Xaa-Pro dipeptidase	BYT61V	Methyl 2-[4-[[[(4R)-3-[3-amino-4-(2-fluorophenyl)butanoyl]-1,3-thiazolidine-4-carbonyl]amino]methyl]phenyl]acetate;2,2,2-trifluoroacetic acid	Investigative	49796933	C26H29F4N3O6S	587.6	COC(=O)CC1=CC=C(C=C1)CNC(=O)[C@@H]2CSCN2C(=O)CC(CC3=CC=CC=C3F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T94823	Xaa-Pro dipeptidase	BZ9B1P	(2S)-1-[(2S)-1-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]pyrrolidine-2-carbonyl]-N-[(2S)-1-[[(2S)-1-[[(2R)-1-amino-1-oxo-3-sulfanylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]pyrrolidine-2-carboxamide	Investigative	44317216	C29H43N7O7S	633.8	C[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](CC3=CC=CC=C3)N)O	IC50 = 130000 nM	Poor binder
T94823	Xaa-Pro dipeptidase	BZW21B	(2S)-1-[(2S,4R)-1-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-4-hydroxypyrrolidine-2-carbonyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide	Investigative	10624384	C23H33N5O6	475.5	C[C@@H](C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]2C[C@H](CN2C(=O)[C@H]([C@@H](CC3=CC=CC=C3)N)O)O	IC50 = 110000 nM	Poor binder
T94823	Xaa-Pro dipeptidase	BZYP13	(2R)-2-[4-[[[(2S)-1-[3-Amino-4-(2,5-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid	Investigative	49796953	C29H34F5N3O7	631.6	CC(C)[C@H](C(=O)O)OC1=CC=C(C=C1)CNC(=O)[C@@H]2CCCN2C(=O)CC(CC3=C(C=CC(=C3)F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder